PhosphoNET

           
Protein Info 
   
Short Name:  LMTK2
Full Name:  Serine/threonine-protein kinase LMTK2
Alias:  2900041G10Rik; AATYK2; BREK; CDK5,p35-regulated kinase; Cprk; EC 2.7.11.1; KIAA1079; Kinase LMR2; Kinase phosphatase inhibitor 2; KPI2; KPI-2; Lemur tyrosine kinase 2; LMR2
Type:  Receptor tyrosine kinase; EC 2.7.11.1; TK group; Lmr family
Mass (Da):  164900
Number AA:  1503
UniProt ID:  Q8IWU2
International Prot ID:  IPI00217391
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0016021     Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0004864  GO:0005515 PhosphoSite+ KinaseNET
Biological Process:  GO:0046777     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T90FDDEIDFTPPAEDTP
Site 2T96FTPPAEDTPSVQSPA
Site 3S98PPAEDTPSVQSPAEV
Site 4S101EDTPSVQSPAEVFTL
Site 5S119NISLPAPSQFQPSVE
Site 6S124APSQFQPSVEGLKSQ
Site 7S130PSVEGLKSQVARHSL
Site 8S136KSQVARHSLNYIQEI
Site 9Y139VARHSLNYIQEIGNG
Site 10S173IVKELKASANPKEQD
Site 11T181ANPKEQDTFLKNGEP
Site 12Y190LKNGEPYYILQHPNI
Site 13Y225DLGDLKAYLRSEQEH
Site 14S237QEHMRGDSQTMLLQR
Site 15T239HMRGDSQTMLLQRMA
Site 16S264HKLHFLHSDLALRNC
Site 17Y284LNVKVGDYGIGFSRY
Site 18Y291YGIGFSRYKEDYIET
Site 19Y295FSRYKEDYIETDDKK
Site 20S316TAPELVTSFQDRLLT
Site 21T323SFQDRLLTADQTKYS
Site 22T327RLLTADQTKYSNIWS
Site 23Y329LTADQTKYSNIWSLG
Site 24S330TADQTKYSNIWSLGV
Site 25S351DNAAQPYSNLSNLDV
Site 26S354AQPYSNLSNLDVLNQ
Site 27T368QVIRERDTKLPKPQL
Site 28S380PQLEQPYSDRWYEVL
Site 29S393VLQFCWLSPEKRPAA
Site 30T408EDVHRLLTYLRLQSQ
Site 31Y409DVHRLLTYLRLQSQR
Site 32S414LTYLRLQSQRDSEVD
Site 33S418RLQSQRDSEVDFEQQ
Site 34T433WNALKPNTNSRDSSN
Site 35S435ALKPNTNSRDSSNNA
Site 36S438PNTNSRDSSNNAAFP
Site 37S439NTNSRDSSNNAAFPI
Site 38T464REMEEVLTVTETSQG
Site 39S473TETSQGLSFEYVWEA
Site 40Y476SQGLSFEYVWEAAKH
Site 41S499GHLDEGLSYTSIFYP
Site 42Y500HLDEGLSYTSIFYPV
Site 43S512YPVEVFESSLSDPGP
Site 44S513PVEVFESSLSDPGPG
Site 45S515EVFESSLSDPGPGKQ
Site 46S525GPGKQDDSGQDVPLR
Site 47Y551NLSVGSDYYIQLEEK
Site 48Y552LSVGSDYYIQLEEKS
Site 49S559YIQLEEKSGSNLELD
Site 50S561QLEEKSGSNLELDYP
Site 51Y567GSNLELDYPPALLTT
Site 52T582DMDNPERTGPELSQL
Site 53S587ERTGPELSQLTALRS
Site 54T590GPELSQLTALRSVEL
Site 55S594SQLTALRSVELEESS
Site 56S600RSVELEESSTDEDFF
Site 57T602VELEESSTDEDFFQS
Site 58S610DEDFFQSSTDPKDSS
Site 59T611EDFFQSSTDPKDSSL
Site 60S616SSTDPKDSSLPGDLH
Site 61S617STDPKDSSLPGDLHV
Site 62T625LPGDLHVTSGPESPF
Site 63S626PGDLHVTSGPESPFN
Site 64S630HVTSGPESPFNNIFN
Site 65S642IFNDVDKSEDLPSHQ
Site 66S647DKSEDLPSHQKIFDL
Site 67T668QADFKPATLSSSLDN
Site 68S670DFKPATLSSSLDNPK
Site 69S672KPATLSSSLDNPKES
Site 70S679SLDNPKESVITGHFE
Site 71S696KPRKIFDSEPLCLSD
Site 72S702DSEPLCLSDNLMHQD
Site 73S735EKNLLKGSLSSKEHI
Site 74S737NLLKGSLSSKEHIND
Site 75T747EHINDLQTELKNAGF
Site 76T761FTEAMLETSCRNSLD
Site 77S762TEAMLETSCRNSLDT
Site 78S766LETSCRNSLDTELQF
Site 79T769SCRNSLDTELQFAEN
Site 80T794VSTKGDDTDVMLTGD
Site 81T802DVMLTGDTLSTSLQS
Site 82S804MLTGDTLSTSLQSSP
Site 83S806TGDTLSTSLQSSPEV
Site 84S809TLSTSLQSSPEVQVP
Site 85S810LSTSLQSSPEVQVPP
Site 86S819EVQVPPTSFETEETP
Site 87T825TSFETEETPRRVPPD
Site 88S833PRRVPPDSLPTQGET
Site 89T843TQGETQPTCLDVIVP
Site 90S859DCLHQDISPDAVTVP
Site 91S871TVPVEILSTDARTHS
Site 92S878STDARTHSLDNRSQD
Site 93S883THSLDNRSQDSPGES
Site 94S886LDNRSQDSPGESEET
Site 95S890SQDSPGESEETLRLT
Site 96T893SPGESEETLRLTESD
Site 97T897SEETLRLTESDSVLA
Site 98S899ETLRLTESDSVLADD
Site 99S916ASRVSVGSSLPELGQ
Site 100S917SRVSVGSSLPELGQE
Site 101S931ELHNKPFSEDHHSHR
Site 102S936PFSEDHHSHRRLEKN
Site 103T949KNLEAVETLNQLNSK
Site 104S955ETLNQLNSKDAAKEA
Site 105S966AKEAGLVSALSSDST
Site 106S969AGLVSALSSDSTSQD
Site 107S970GLVSALSSDSTSQDS
Site 108S972VSALSSDSTSQDSLL
Site 109T973SALSSDSTSQDSLLE
Site 110S974ALSSDSTSQDSLLED
Site 111S977SDSTSQDSLLEDSLS
Site 112S982QDSLLEDSLSAPFPA
Site 113S984SLLEDSLSAPFPASE
Site 114S990LSAPFPASEPSLETP
Site 115S993PFPASEPSLETPDSL
Site 116T996ASEPSLETPDSLESV
Site 117S999PSLETPDSLESVDVH
Site 118S1002ETPDSLESVDVHEAL
Site 119S1012VHEALLDSLGSHTPQ
Site 120T1017LDSLGSHTPQKLVPP
Site 121S1030PPDKPADSGYETENL
Site 122Y1032DKPADSGYETENLES
Site 123T1034PADSGYETENLESPE
Site 124S1039YETENLESPEWTLHP
Site 125T1043NLESPEWTLHPAPEG
Site 126S1054APEGTADSEPATTGD
Site 127T1058TADSEPATTGDGGHS
Site 128T1059ADSEPATTGDGGHSG
Site 129S1076PNPVIVISDAGDGHR
Site 130T1085AGDGHRGTEVTPETF
Site 131T1088GHRGTEVTPETFTAG
Site 132T1091GTEVTPETFTAGSQG
Site 133S1096PETFTAGSQGSYRDS
Site 134S1099FTAGSQGSYRDSAYF
Site 135Y1100TAGSQGSYRDSAYFS
Site 136S1103SQGSYRDSAYFSDND
Site 137Y1105GSYRDSAYFSDNDSE
Site 138S1107YRDSAYFSDNDSEPE
Site 139S1111AYFSDNDSEPEKRSE
Site 140S1117DSEPEKRSEEVPGTS
Site 141T1123RSEEVPGTSPSALVL
Site 142S1145EPVLPEQSPAAQDSC
Site 143S1158SCLEARKSQPDESCL
Site 144S1163RKSQPDESCLSALHN
Site 145S1166QPDESCLSALHNSSD
Site 146T1179SDLELRATPEPAQTG
Site 147T1185ATPEPAQTGVPQQVH
Site 148S1199HPTEDEASSPWSVLN
Site 149S1200PTEDEASSPWSVLNA
Site 150S1203DEASSPWSVLNAELS
Site 151S1210SVLNAELSSGDDFET
Site 152T1217SSGDDFETQDDRPCT
Site 153T1224TQDDRPCTLASTGTN
Site 154Y1238NTNELLAYTNSALDK
Site 155S1241ELLAYTNSALDKSLS
Site 156S1246TNSALDKSLSSHSEG
Site 157S1248SALDKSLSSHSEGPK
Site 158S1249ALDKSLSSHSEGPKL
Site 159S1251DKSLSSHSEGPKLKE
Site 160Y1265EPDIEGKYLGKLGVS
Site 161S1278VSGMLDLSEDGMDAD
Site 162S1291ADEEDENSDDSDEDL
Site 163S1294EDENSDDSDEDLRAF
Site 164S1305 LRAFNLHSLSSESED
Site 165S1307 AFNLHSLSSESEDET
Site 166S1308 FNLHSLSSESEDETE
Site 167S1310 LHSLSSESEDETEHP
Site 168T1314SSESEDETEHPVPII
Site 169S1323HPVPIILSNEDGRHL
Site 170S1332EDGRHLRSLLKPTAA
Site 171T1357KKEKKAVTFFDDVTV
Site 172Y1365FFDDVTVYLFDQETP
Site 173T1371VYLFDQETPTKELGP
Site 174S1389EACGPDLSGPAPASG
Site 175S1395LSGPAPASGSPYLSR
Site 176S1397GPAPASGSPYLSRCI
Site 177Y1399APASGSPYLSRCINS
Site 178S1401ASGSPYLSRCINSES
Site 179S1408SRCINSESSTDEEGG
Site 180S1409RCINSESSTDEEGGG
Site 181T1410CINSESSTDEEGGGF
Site 182S1424FEWDDDFSPDPFMSK
Site 183S1430FSPDPFMSKTTSNLL
Site 184T1432PDPFMSKTTSNLLSS
Site 185S1434PFMSKTTSNLLSSKP
Site 186S1438KTTSNLLSSKPSLQT
Site 187S1439TTSNLLSSKPSLQTS
Site 188S1442NLLSSKPSLQTSKYF
Site 189S1446SKPSLQTSKYFSPPP
Site 190Y1448PSLQTSKYFSPPPPA
Site 191S1450LQTSKYFSPPPPARS
Site 192S1457SPPPPARSTEQSWPH
Site 193T1458PPPPARSTEQSWPHS
Site 194S1461PARSTEQSWPHSAPY
Site 195S1465TEQSWPHSAPYSRFS
Site 196Y1468SWPHSAPYSRFSISP
Site 197S1469WPHSAPYSRFSISPA
Site 198S1472SAPYSRFSISPANIA
Site 199S1474PYSRFSISPANIASF
Site 200S1482PANIASFSLTHLTDS
Site 201T1487SFSLTHLTDSDIEQG
Site 202S1489SLTHLTDSDIEQGGS
Site 203S1496SDIEQGGSSEDGEKD
Site 204S1497DIEQGGSSEDGEKD_
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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