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Protein Info
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Short Name:
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APP
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Full Name:
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Amyloid beta A4 protein
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Alias:
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A4; ABPP; AD1; Alzheimer disease amyloid protein; Alzheimer's disease amyloid protein; Amyloid beta (A4) precursor protein; APPI; Beta-amyloid protein 40; Beta-amyloid protein 42; C31; C83; Cerebral vascular amyloid peptide; CVAP; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); P3(40); P3(42); Peptidase nexin-II; PN-II; PreA4; Protease nexin-II; Soluble APP-alpha (S-APP- alpha); Soluble APP-beta (S-APP-beta)
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Type:
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Receptor, misc.; Transcription factor; Apoptosis; Cell surface
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Mass (Da):
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86943
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Number AA:
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770
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UniProt ID:
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P05067
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International Prot ID:
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IPI00006608
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Sequence:
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Retrieve full protein sequence
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GO Terms
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External Links
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Internal Links
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Cellular Component:
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GO:0005794
GO:0030424
GO:0009986
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Uniprot
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OncoNet
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Molecular Function:
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GO:0003677
GO:0033130
GO:0005507
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PhosphoSite+
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KinaseNET
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Biological Process:
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GO:0000085
GO:0007219
GO:0008344
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Phosida
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TranscriptoNet
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STRING
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Kinexus Products
Amyloid beta A4 protein pan-specific antibody AB-NN198-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN198-1#Amyloid beta A4 protein isoform j precursor (APP) (I511-P520, human) peptide - Powder PE-01AAH80#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AAH80#Beta- Amyloid (D1-Q15) peptide - Powder PE-01AEW95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AEW95#Beta-Amyloid (D1-K16) peptide - Powder PE-01AEZ95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AEZ95#Beta- Amyloid (E11-E22) peptide - Powder PE-01AFB95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AFB95
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Info Box
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A variety of parameters were considered in the selection of putative P-sites.
Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score
is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr
or P-Tyr sites. The Maximum KInase Score provides the calculated score for
highest match of 500 human protein kinases for the amino acid sequence
surrounding the target P-site as determined with Kinase Substrate Predictor V2.
The Sum KInase Score provides the additive sum of the positive individual Kinase
Substrate Predictor V2 scores from 500 human protein kinases. The Conservation
Score is the average of the percent similarity of the human P-site with the
equivalent P-site in 20 other diverse species. Click the coloured buttons below
to retrieve this and other information in the Info Box, or click the orange
buttons for relevant links. |
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| Phosphosites | |
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| | | -7 | -6 | -5 | -4 | -3 | -2 | -1 | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | | Expt. conf. | Effect | Kinase | PPase | Kinexus Products | | Ref. | Evol. | Kinase Pred. | P-site Match |
| | Site 1 | Y115 | H | P | H | F | V | I | P | Y | R | C | L | V | G | E | F | |  |  | | | | |  | | | |
| | Site 2 | S198 | E | E | S | D | N | V | D | S | A | D | A | E | E | D | D | | | | | | | | | | | |
| | Site 3 | S206 | A | D | A | E | E | D | D | S | D | V | W | W | G | G | A | | | | | | | | | | | |
| | Site 4 | S441 | H | F | Q | E | K | V | E | S | L | E | Q | E | A | A | N | | | | | | | | | | | |
| | Site 5 | S679 | D | A | E | F | R | H | D | S | G | Y | E | V | H | H | Q | | | | | | | | | | | |
| | Site 6 | Y728 | V | M | L | K | K | K | Q | Y | T | S | I | H | H | G | V | | | | | | | | | | | |
| | Site 7 | T729 | M | L | K | K | K | Q | Y | T | S | I | H | H | G | V | V | | | | | | | | | | | |
| | Site 8 | S730 | L | K | K | K | Q | Y | T | S | I | H | H | G | V | V | E | | | | | | | | | | | |
| | Site 9 | T743 | V | E | V | D | A | A | V | T | P | E | E | R | H | L | S | | | | | | | | | | | |
| | Site 10 | S750 | T | P | E | E | R | H | L | S | K | M | Q | Q | N | G | Y | |  | | | | | | | | | |
| | Site 11 | Y757 | S | K | M | Q | Q | N | G | Y | E | N | P | T | Y | K | F | | | | | | | | | | | |
| | Site 12 | T761 | Q | N | G | Y | E | N | P | T | Y | K | F | F | E | Q | M | | | | | | | | | | | |
| | Site 13 | Y762 | N | G | Y | E | N | P | T | Y | K | F | F | E | Q | M | Q | | | | | | | | | | | |
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Legend
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Confirmed in mammals
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Confirmed in related proteins or other species
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Predicted by Kinexus P-Site Prediction algorithm
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No data/link available
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Link available
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Products available
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