PhosphoNET

           
Protein Info 
   
Short Name:  Bcr
Full Name:  Breakpoint cluster region protein
Alias:  ALL; BCR; BCR1; Breakpoint cluster region; CML; D22S11; D22S662; PHL; Renal carcinoma antigen NY-REN-26
Type:  EC 2.7.11.1; GTPase activating protein, Rac/Rho; Protein kinase, Ser/Thr (non-receptor); ATYPICAL group; BCR family
Mass (Da):  142819
Number AA:  1271
UniProt ID:  P11274
International Prot ID:  IPI00004497
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005622     Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0005096  GO:0005089 PhosphoSite+ KinaseNET
Biological Process:  GO:0007242  GO:0006468  GO:0035023 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S18WKAQFPDSEPPRMEL
Site 2S27PPRMELRSVGDIEQE
Site 3S41ELERCKASIRRLEQE
Site 4Y58QERFRMIYLQTLLAK
Site 5S69LLAKEKKSYDRQRWG
Site 6Y70LAKEKKSYDRQRWGF
Site 7S88AQAPDGASEPRASAS
Site 8S93GASEPRASASRPQPA
Site 9S95SEPRASASRPQPAPA
Site 10S122ARPDGEGSPGKARPG
Site 11T130PGKARPGTARRPGAA
Site 12S139RRPGAAASGERDDRG
Site 13S150DDRGPPASVAALRSN
Site 14Y177ADAEKPFYVNVEFHH
Site 15S197KVNDKEVSDRISSLG
Site 16S201KEVSDRISSLGSQAM
Site 17S202EVSDRISSLGSQAMQ
Site 18S205DRISSLGSQAMQMER
Site 19S215MQMERKKSQHGAGSS
Site 20S222SQHGAGSSVGDASRP
Site 21S227GSSVGDASRPPYRGR
Site 22Y231GDASRPPYRGRSSES
Site 23S235RPPYRGRSSESSCGV
Site 24S236PPYRGRSSESSCGVD
Site 25S238YRGRSSESSCGVDGD
Site 26S239RGRSSESSCGVDGDY
Site 27Y246SCGVDGDYEDAELNP
Site 28S267LIDANGGSRPPWPPL
Site 29Y276PPWPPLEYQPYQSIY
Site 30Y279PPLEYQPYQSIYVGG
Site 31S281LEYQPYQSIYVGGMM
Site 32Y283YQPYQSIYVGGMMEG
Site 33S299GKGPLLRSQSTSEQE
Site 34S301GPLLRSQSTSEQEKR
Site 35T302PLLRSQSTSEQEKRL
Site 36S303LLRSQSTSEQEKRLT
Site 37T310SEQEKRLTWPRRSYS
Site 38S315RLTWPRRSYSPRSFE
Site 39Y316LTWPRRSYSPRSFED
Site 40S317TWPRRSYSPRSFEDC
Site 41S320RRSYSPRSFEDCGGG
Site 42Y328FEDCGGGYTPDCSSN
Site 43T329EDCGGGYTPDCSSNE
Site 44S333GGYTPDCSSNENLTS
Site 45S334GYTPDCSSNENLTSS
Site 46S340SSNENLTSSEEDFSS
Site 47S341SNENLTSSEEDFSSG
Site 48S346TSSEEDFSSGQSSRV
Site 49S347SSEEDFSSGQSSRVS
Site 50S350EDFSSGQSSRVSPSP
Site 51S351DFSSGQSSRVSPSPT
Site 52S354SGQSSRVSPSPTTYR
Site 53S356QSSRVSPSPTTYRMF
Site 54T358SRVSPSPTTYRMFRD
Site 55T359RVSPSPTTYRMFRDK
Site 56Y360VSPSPTTYRMFRDKS
Site 57S367YRMFRDKSRSPSQNS
Site 58S369MFRDKSRSPSQNSQQ
Site 59S371RDKSRSPSQNSQQSF
Site 60S374SRSPSQNSQQSFDSS
Site 61S377PSQNSQQSFDSSSPP
Site 62S380NSQQSFDSSSPPTPQ
Site 63S381SQQSFDSSSPPTPQC
Site 64S382QQSFDSSSPPTPQCH
Site 65T385FDSSSPPTPQCHKRH
Site 66T410TIVGVRKTGQIWPND
Site 67S429FHGDADGSFGTPPGY
Site 68T432DADGSFGTPPGYGCA
Site 69Y436SFGTPPGYGCAADRA
Site 70Y455RHQDGLPYIDDSPSS
Site 71S459GLPYIDDSPSSSPHL
Site 72S461PYIDDSPSSSPHLSS
Site 73S462YIDDSPSSSPHLSSK
Site 74S463IDDSPSSSPHLSSKG
Site 75S467PSSSPHLSSKGRGSR
Site 76S468SSSPHLSSKGRGSRD
Site 77S473LSSKGRGSRDALVSG
Site 78S479GSRDALVSGALESTK
Site 79S484LVSGALESTKASELD
Site 80S488ALESTKASELDLEKG
Site 81S504EMRKWVLSGILASEE
Site 82Y513ILASEETYLSHLEAL
Site 83S534LKAAATTSQPVLTSQ
Site 84S540TSQPVLTSQQIETIF
Site 85Y554FFKVPELYEIHKEFY
Site 86Y561YEIHKEFYDGLFPRV
Site 87S572FPRVQQWSHQQRVGD
Site 88S586DLFQKLASQLGVYRA
Site 89Y591LASQLGVYRAFVDNY
Site 90Y598YRAFVDNYGVAMEMA
Site 91S626SENLRARSNKDAKDP
Site 92T634NKDAKDPTTKNSLET
Site 93T635KDAKDPTTKNSLETL
Site 94S638KDPTTKNSLETLLYK
Site 95T641TTKNSLETLLYKPVD
Site 96Y644NSLETLLYKPVDRVT
Site 97T651YKPVDRVTRSTLVLH
Site 98S653PVDRVTRSTLVLHDL
Site 99T664LHDLLKHTPASHPDH
Site 100S667LLKHTPASHPDHPLL
Site 101S687ISQNFLSSINEEITP
Site 102T693SSINEEITPRRQSMT
Site 103S698EITPRRQSMTVKKGE
Site 104T700TPRRQSMTVKKGEHR
Site 105S713HRQLLKDSFMVELVE
Site 106Y751SGGKTQQYDCKWYIP
Site 107Y756QQYDCKWYIPLTDLS
Site 108S792DALKIKISQIKNDIQ
Site 109S808EKRANKGSKATERLK
Site 110S819ERLKKKLSEQESLLL
Site 111S823KKLSEQESLLLLMSP
Site 112S838SMAFRVHSRNGKSYT
Site 113S843VHSRNGKSYTFLISS
Site 114Y844HSRNGKSYTFLISSD
Site 115T845SRNGKSYTFLISSDY
Site 116S850SYTFLISSDYERAEW
Site 117Y852TFLISSDYERAEWRE
Site 118S871QQKKCFRSFSLTSVE
Site 119S873KKCFRSFSLTSVELQ
Site 120S894VKLQTVHSIPLTINK
Site 121T898TVHSIPLTINKEDDE
Site 122S906INKEDDESPGLYGFL
Site 123Y910DDESPGLYGFLNVIV
Site 124Y930FKQSSNLYCTLEVDS
Site 125T932QSSNLYCTLEVDSFG
Site 126Y940LEVDSFGYFVNKAKT
Site 127Y950NKAKTRVYRDTAEPN
Site 128T953KTRVYRDTAEPNWNE
Site 129T971IELEGSQTLRILCYE
Site 130Y977QTLRILCYEKCYNKT
Site 131T984YEKCYNKTKIPKEDG
Site 132S993IPKEDGESTDRLMGK
Site 133T994PKEDGESTDRLMGKG
Site 134T1018QDRDWQRTVIAMNGI
Site 135S1030NGIEVKLSVKFNSRE
Site 136S1035KLSVKFNSREFSLKR
Site 137S1039KFNSREFSLKRMPSR
Site 138S1045FSLKRMPSRKQTGVF
Site 139T1049RMPSRKQTGVFGVKI
Site 140T1060GVKIAVVTKRERSKV
Site 141S1065VVTKRERSKVPYIVR
Site 142Y1069RERSKVPYIVRQCVE
Site 143Y1089GMEEVGIYRVSGVAT
Site 144Y1131IAGTLKLYFRELPEP
Site 145T1141ELPEPLFTDEFYPNF
Site 146Y1145PLFTDEFYPNFAEGI
Site 147S1215GPTLLRPSEKESKLP
Site 148S1219LRPSEKESKLPANPS
Site 149S1226SKLPANPSQPITMTD
Site 150T1230ANPSQPITMTDSWSL
Site 151T1232PSQPITMTDSWSLEV
Site 152S1234QPITMTDSWSLEVMS
Site 153S1260EAIPAPDSKRQSILF
Site 154S1264APDSKRQSILFSTEV
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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