PhosphoNET

           
Protein Info 
   
Short Name:  Met
Full Name:  Hepatocyte growth factor receptor
Alias:  C-met; EC 2.7.10.1; Hepatocyte growth factor receptor; HGF receptor; HGFR; HGF-SF receptor; Kinase Met; Met proto- oncogene tyrosine kinase; Met proto-oncogene; Met proto-oncogene (hepatocyte growth factor receptor); RCCP2
Type:  Receptor tyrosine kinase; EC 2.7.10.1; TK group; Met family
Mass (Da):  155541
Number AA:  1390
UniProt ID:  P08581
International Prot ID:  IPI00029273
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0009925  GO:0005887   Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0005008  GO:0005515 PhosphoSite+ KinaseNET
Biological Process:  GO:0008283  GO:0048012  GO:0007275 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T17GILVLLFTLVQRSNG
Site 2S637MNKHFNMSIIISNGH
Site 3S641FNMSIIISNGHGTTQ
Site 4Y830LDGILSKYFDLIYVH
Site 5S966KQIKDLGSELVRYDA
Site 6Y971LGSELVRYDARVHTP
Site 7T977RYDARVHTPHLDRLV
Site 8S985PHLDRLVSARSVSPT
Site 9S988DRLVSARSVSPTTEM
Site 10S990LVSARSVSPTTEMVS
Site 11T992SARSVSPTTEMVSNE
Site 12T993ARSVSPTTEMVSNES
Site 13S997SPTTEMVSNESVDYR
Site 14S1000TEMVSNESVDYRATF
Site 15Y1003VSNESVDYRATFPED
Site 16T1006ESVDYRATFPEDQFP
Site 17S1015PEDQFPNSSQNGSCR
Site 18S1016EDQFPNSSQNGSCRQ
Site 19S1020PNSSQNGSCRQVQYP
Site 20Y1026GSCRQVQYPLTDMSP
Site 21T1029RQVQYPLTDMSPILT
Site 22S1032QYPLTDMSPILTSGD
Site 23T1036TDMSPILTSGDSDIS
Site 24S1037DMSPILTSGDSDISS
Site 25S1043TSGDSDISSPLLQNT
Site 26S1044SGDSDISSPLLQNTV
Site 27Y1093RGHFGCVYHGTLLDN
Site 28T1096FGCVYHGTLLDNDGK
Site 29T1116VKSLNRITDIGEVSQ
Site 30Y1159SPLVVLPYMKHGDLR
Site 31T1173RNFIRNETHNPTVKD
Site 32Y1194QVAKGMKYLASKKFV
Site 33S1197KGMKYLASKKFVHRD
Site 34Y1230FGLARDMYDKEYYSV
Site 35Y1234RDMYDKEYYSVHNKT
Site 36Y1235DMYDKEYYSVHNKTG
Site 37S1236MYDKEYYSVHNKTGA
Site 38T1241YYSVHNKTGAKLPVK
Site 39T1257MALESLQTQKFTTKS
Site 40S1264TQKFTTKSDVWSFGV
Site 41Y1284MTRGAPPYPDVNTFD
Site 42T1289PPYPDVNTFDITVYL
Site 43Y1295NTFDITVYLLQGRRL
Site 44Y1307RRLLQPEYCPDPLYE
Site 45Y1313EYCPDPLYEVMLKCW
Site 46S1329PKAEMRPSFSELVSR
Site 47S1331AEMRPSFSELVSRIS
Site 48S1342SRISAIFSTFIGEHY
Site 49T1343RISAIFSTFIGEHYV
Site 50Y1349STFIGEHYVHVNATY
Site 51T1355HYVHVNATYVNVKCV
Site 52Y1356YVHVNATYVNVKCVA
Site 53Y1365NVKCVAPYPSLLSSE
Site 54S1367KCVAPYPSLLSSEDN
Site 55S1370APYPSLLSSEDNADD
Site 56S1371PYPSLLSSEDNADDE
Site 57T1381NADDEVDTRPASFWE
Site 58S1385EVDTRPASFWETS__
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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