PhosphoNET
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Protein Info 
   
Short Name:  AURKA
Full Name:  Serine/threonine-protein kinase 6
Alias:  AIK; ARK1; AurA; Aurora kinase A; Aurora,IPL1-related kinase 1; Aurora/IPL1-related kinase 1; Aurora-1; Aurora-A; Aurora-family kinase 1; Aurora-related kinase 1; AYK1; Breast-tumor-amplified kinase; BTAK; EC 2.7.11.1; IAK1; Ipl1- and aurora-related kinase 1; Kinase AurA; Serine/threonine kinase 15; Serine/threonine kinase 6; Serine/threonine kinase Ayk1; STK15; STK6; STK7
Type:  EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; AUR family
Mass (Da):  45809
Number AA:  403
UniProt ID:  O14965
International Prot ID:  IPI00298940
Sequence:  Retrieve full length sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005813  GO:0005634  GO:0005819 Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0004674   PhosphoSite+ KinaseNET
Biological Process:  GO:0007067  GO:0048015  GO:0006468 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S4____MDRSKENCISG
Site 2S10RSKENCISGPVKATA
Site 3T16ISGPVKATAPVGGPK
Site 4S41QNPLPVNSGQAQRVL
Site 5S51AQRVLCPSNSSQRVP
Site 6S53RVLCPSNSSQRVPLQ
Site 7S54VLCPSNSSQRVPLQA
Site 8S66LQAQKLVSSHKPVQN
Site 9S67QAQKLVSSHKPVQNQ
Site 10T82KQKQLQATSVPHPVS
Site 11S83QKQLQATSVPHPVSR
Site 12S89TSVPHPVSRPLNNTQ
Site 13T95VSRPLNNTQKSKQPL
Site 14S98PLNNTQKSKQPLPSA
Site 15S104KSKQPLPSAPENNPE
Site 16S116NPEEELASKQKNEES
Site 17S123SKQKNEESKKRQWAL
Site 18Y148KGKFGNVYLAREKQS
Site 19S186RREVEIQSHLRHPNI
Site 20Y197HPNILRLYGYFHDAT
Site 21Y199NILRLYGYFHDATRV
Site 22Y212RVYLILEYAPLGTVY
Site 23S226YRELQKLSKFDEQRT
Site 24T235FDEQRTATYITELAN
Site 25Y236DEQRTATYITELANA
Site 26S245TELANALSYCHSKRV
Site 27Y246ELANALSYCHSKRVI
Site 28S266PENLLLGSAGELKIA
Site 29S278KIADFGWSVHAPSSR
Site 30S283GWSVHAPSSRRTTLC
Site 31S284WSVHAPSSRRTTLCG
Site 32T287HAPSSRRTTLCGTLD
Site 33T288APSSRRTTLCGTLDY
Site 34T292RRTTLCGTLDYLPPE
Site 35S314DEKVDLWSLGVLCYE
Site 36Y334PPFEANTYQETYKRI
Site 37Y338ANTYQETYKRISRVE
Site 38S342QETYKRISRVEFTFP
Site 39T347RISRVEFTFPDFVTE
Site 40S361EGARDLISRLLKHNP
Site 41S369RLLKHNPSQRPMLRE
Site 42S391TANSSKPSNCQNKES
Site 43S398SNCQNKESASKQS__
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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