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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SEC23IP
Full Name:
SEC23-interacting protein
Alias:
P125; S23ip; SEC23 interacting protein; Sec23-interacting protein
Type:
Endoplasmic reticulum
Mass (Da):
111076
Number AA:
1000
UniProt ID:
Q9Y6Y8
International Prot ID:
IPI00026969
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005783
GO:0005793
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0043167
PhosphoSite+
KinaseNET
Biological Process:
GO:0006810
GO:0006886
GO:0006996
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
E
R
K
P
N
G
G
S
G
G
A
S
T
S
S
Site 2
S14
N
G
G
S
G
G
A
S
T
S
S
S
G
T
N
Site 3
T15
G
G
S
G
G
A
S
T
S
S
S
G
T
N
L
Site 4
S16
G
S
G
G
A
S
T
S
S
S
G
T
N
L
L
Site 5
S17
S
G
G
A
S
T
S
S
S
G
T
N
L
L
F
Site 6
S18
G
G
A
S
T
S
S
S
G
T
N
L
L
F
S
Site 7
T20
A
S
T
S
S
S
G
T
N
L
L
F
S
S
S
Site 8
S25
S
G
T
N
L
L
F
S
S
S
A
T
E
F
S
Site 9
S27
T
N
L
L
F
S
S
S
A
T
E
F
S
F
N
Site 10
S49
Q
A
S
A
S
P
A
S
L
L
L
P
G
E
D
Site 11
S57
L
L
L
P
G
E
D
S
T
D
V
G
E
E
D
Site 12
T58
L
L
P
G
E
D
S
T
D
V
G
E
E
D
S
Site 13
S65
T
D
V
G
E
E
D
S
F
L
G
Q
T
S
I
Site 14
S71
D
S
F
L
G
Q
T
S
I
H
T
S
A
P
Q
Site 15
T74
L
G
Q
T
S
I
H
T
S
A
P
Q
T
F
S
Site 16
S75
G
Q
T
S
I
H
T
S
A
P
Q
T
F
S
Y
Site 17
T79
I
H
T
S
A
P
Q
T
F
S
Y
F
S
Q
V
Site 18
S81
T
S
A
P
Q
T
F
S
Y
F
S
Q
V
S
S
Site 19
Y82
S
A
P
Q
T
F
S
Y
F
S
Q
V
S
S
S
Site 20
S84
P
Q
T
F
S
Y
F
S
Q
V
S
S
S
S
D
Site 21
S87
F
S
Y
F
S
Q
V
S
S
S
S
D
P
F
G
Site 22
S88
S
Y
F
S
Q
V
S
S
S
S
D
P
F
G
N
Site 23
S89
Y
F
S
Q
V
S
S
S
S
D
P
F
G
N
I
Site 24
S90
F
S
Q
V
S
S
S
S
D
P
F
G
N
I
G
Site 25
S99
P
F
G
N
I
G
Q
S
P
L
T
T
A
A
T
Site 26
S111
A
A
T
S
V
G
Q
S
G
F
P
K
P
L
T
Site 27
S126
A
L
P
F
T
T
G
S
Q
D
V
S
N
A
F
Site 28
S130
T
T
G
S
Q
D
V
S
N
A
F
S
P
S
I
Site 29
S134
Q
D
V
S
N
A
F
S
P
S
I
S
K
A
Q
Site 30
S136
V
S
N
A
F
S
P
S
I
S
K
A
Q
P
G
Site 31
S138
N
A
F
S
P
S
I
S
K
A
Q
P
G
A
P
Site 32
S147
A
Q
P
G
A
P
P
S
S
L
M
G
I
N
S
Site 33
S148
Q
P
G
A
P
P
S
S
L
M
G
I
N
S
Y
Site 34
S154
S
S
L
M
G
I
N
S
Y
L
P
S
Q
P
S
Site 35
Y155
S
L
M
G
I
N
S
Y
L
P
S
Q
P
S
S
Site 36
S158
G
I
N
S
Y
L
P
S
Q
P
S
S
L
P
P
Site 37
S161
S
Y
L
P
S
Q
P
S
S
L
P
P
S
Y
F
Site 38
S162
Y
L
P
S
Q
P
S
S
L
P
P
S
Y
F
G
Site 39
S166
Q
P
S
S
L
P
P
S
Y
F
G
N
Q
P
Q
Site 40
Y167
P
S
S
L
P
P
S
Y
F
G
N
Q
P
Q
G
Site 41
Y180
Q
G
I
P
Q
P
G
Y
N
P
Y
R
H
T
P
Site 42
Y183
P
Q
P
G
Y
N
P
Y
R
H
T
P
G
S
S
Site 43
T186
G
Y
N
P
Y
R
H
T
P
G
S
S
R
A
N
Site 44
S189
P
Y
R
H
T
P
G
S
S
R
A
N
P
Y
I
Site 45
Y195
G
S
S
R
A
N
P
Y
I
A
P
P
Q
L
Q
Site 46
T206
P
Q
L
Q
Q
C
Q
T
P
G
P
P
A
H
P
Site 47
S216
P
P
A
H
P
P
P
S
G
P
P
V
Q
M
Y
Site 48
Y223
S
G
P
P
V
Q
M
Y
Q
M
P
P
G
S
L
Site 49
S229
M
Y
Q
M
P
P
G
S
L
P
P
V
P
S
S
Site 50
S235
G
S
L
P
P
V
P
S
S
V
Q
S
P
A
Q
Site 51
S236
S
L
P
P
V
P
S
S
V
Q
S
P
A
Q
Q
Site 52
S239
P
V
P
S
S
V
Q
S
P
A
Q
Q
Q
V
P
Site 53
S253
P
A
R
P
G
A
P
S
V
Q
V
P
S
P
F
Site 54
S258
A
P
S
V
Q
V
P
S
P
F
L
L
Q
N
Q
Site 55
Y266
P
F
L
L
Q
N
Q
Y
E
P
V
Q
P
H
W
Site 56
S293
M
P
F
S
V
F
D
S
L
N
L
E
E
I
Y
Site 57
Y300
S
L
N
L
E
E
I
Y
N
S
V
Q
P
D
P
Site 58
S302
N
L
E
E
I
Y
N
S
V
Q
P
D
P
E
S
Site 59
S309
S
V
Q
P
D
P
E
S
V
V
L
G
T
D
G
Site 60
Y319
L
G
T
D
G
G
R
Y
D
V
Y
L
Y
D
R
Site 61
Y322
D
G
G
R
Y
D
V
Y
L
Y
D
R
I
R
K
Site 62
Y324
G
R
Y
D
V
Y
L
Y
D
R
I
R
K
A
A
Site 63
Y332
D
R
I
R
K
A
A
Y
W
E
E
E
P
A
E
Site 64
Y347
V
R
R
C
T
W
F
Y
K
G
D
T
D
S
R
Site 65
S353
F
Y
K
G
D
T
D
S
R
F
I
P
Y
T
E
Site 66
Y358
T
D
S
R
F
I
P
Y
T
E
E
F
S
E
K
Site 67
T359
D
S
R
F
I
P
Y
T
E
E
F
S
E
K
L
Site 68
S387
H
R
R
L
E
F
P
S
G
E
T
I
V
M
H
Site 69
S406
I
V
Q
F
Q
P
S
S
V
P
D
E
W
G
T
Site 70
T414
V
P
D
E
W
G
T
T
Q
D
G
Q
T
R
P
Site 71
S463
V
C
D
L
R
F
R
S
I
I
E
C
V
D
D
Site 72
T481
V
S
L
K
L
L
R
T
H
F
K
K
S
L
D
Site 73
S486
L
R
T
H
F
K
K
S
L
D
D
G
K
V
S
Site 74
S493
S
L
D
D
G
K
V
S
R
V
E
F
L
P
V
Site 75
S505
L
P
V
H
W
H
S
S
L
G
G
D
A
T
G
Site 76
T511
S
S
L
G
G
D
A
T
G
V
D
R
N
I
K
Site 77
S524
I
K
K
I
T
L
P
S
I
G
R
F
R
H
F
Site 78
T532
I
G
R
F
R
H
F
T
N
E
T
L
L
D
I
Site 79
Y547
L
F
Y
N
S
P
T
Y
C
Q
T
I
V
E
K
Site 80
S578
P
D
F
K
G
G
V
S
V
A
G
H
S
L
G
Site 81
S602
N
Q
K
D
L
N
L
S
K
C
P
G
P
L
A
Site 82
T632
M
P
E
E
P
K
L
T
L
D
E
S
Y
D
L
Site 83
S636
P
K
L
T
L
D
E
S
Y
D
L
V
V
E
N
Site 84
Y637
K
L
T
L
D
E
S
Y
D
L
V
V
E
N
K
Site 85
T648
V
E
N
K
E
V
L
T
L
Q
E
T
L
E
A
Site 86
S657
Q
E
T
L
E
A
L
S
L
S
E
Y
F
S
T
Site 87
Y661
E
A
L
S
L
S
E
Y
F
S
T
F
E
K
E
Site 88
S663
L
S
L
S
E
Y
F
S
T
F
E
K
E
K
I
Site 89
T664
S
L
S
E
Y
F
S
T
F
E
K
E
K
I
D
Site 90
S712
A
K
L
K
K
A
A
S
E
K
K
A
V
A
A
Site 91
S728
S
T
K
G
Q
E
Q
S
A
Q
K
T
K
D
M
Site 92
T732
Q
E
Q
S
A
Q
K
T
K
D
M
A
S
L
P
Site 93
S737
Q
K
T
K
D
M
A
S
L
P
S
E
S
N
E
Site 94
S742
M
A
S
L
P
S
E
S
N
E
P
K
R
K
L
Site 95
S764
S
V
C
V
N
Y
E
S
F
E
V
G
A
G
Q
Site 96
Y776
A
G
Q
V
S
V
A
Y
N
S
L
D
F
E
P
Site 97
S778
Q
V
S
V
A
Y
N
S
L
D
F
E
P
E
I
Site 98
Y809
V
D
R
I
D
E
N
Y
S
L
P
T
C
K
G
Site 99
S862
L
H
L
E
L
K
E
S
L
S
R
M
G
S
D
Site 100
S864
L
E
L
K
E
S
L
S
R
M
G
S
D
L
K
Site 101
S868
E
S
L
S
R
M
G
S
D
L
K
Q
G
F
I
Site 102
S876
D
L
K
Q
G
F
I
S
S
L
K
S
A
W
Q
Site 103
S877
L
K
Q
G
F
I
S
S
L
K
S
A
W
Q
T
Site 104
S880
G
F
I
S
S
L
K
S
A
W
Q
T
L
N
E
Site 105
T884
S
L
K
S
A
W
Q
T
L
N
E
F
A
R
A
Site 106
T893
N
E
F
A
R
A
H
T
S
S
T
Q
L
Q
E
Site 107
S894
E
F
A
R
A
H
T
S
S
T
Q
L
Q
E
E
Site 108
S895
F
A
R
A
H
T
S
S
T
Q
L
Q
E
E
L
Site 109
S926
E
A
E
K
V
V
E
S
P
D
F
S
K
D
E
Site 110
S930
V
V
E
S
P
D
F
S
K
D
E
D
Y
L
G
Site 111
Y935
D
F
S
K
D
E
D
Y
L
G
K
V
G
M
L
Site 112
Y950
N
G
G
R
R
I
D
Y
V
L
Q
E
K
P
I
Site 113
S959
L
Q
E
K
P
I
E
S
F
N
E
Y
L
F
A
Site 114
Y963
P
I
E
S
F
N
E
Y
L
F
A
L
Q
S
H
Site 115
Y973
A
L
Q
S
H
L
C
Y
W
E
S
E
D
T
A
Site 116
S976
S
H
L
C
Y
W
E
S
E
D
T
A
L
L
L
Site 117
T979
C
Y
W
E
S
E
D
T
A
L
L
L
L
K
E
Site 118
T990
L
L
K
E
I
Y
R
T
M
N
I
S
P
E
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation