KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ZHX2
Full Name:
Zinc fingers and homeoboxes protein 2
Alias:
AFP regulator 1; AFR1; alpha-fetoprotein regulator 1; KIAA0854; RAF; regulator of AFP; zinc finger and homeodomain protein 2; zinc fingers and homeoboxes 2
Type:
Transcription, coactivator/corepressor
Mass (Da):
92307
Number AA:
837
UniProt ID:
Q9Y6X8
International Prot ID:
IPI00007256
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
S
K
R
K
S
T
T
P
C
M
V
R
Site 2
T8
M
A
S
K
R
K
S
T
T
P
C
M
V
R
T
Site 3
T9
A
S
K
R
K
S
T
T
P
C
M
V
R
T
S
Site 4
S16
T
P
C
M
V
R
T
S
Q
V
V
E
Q
D
V
Site 5
T37
A
K
E
K
G
I
G
T
P
Q
P
D
V
A
K
Site 6
S46
Q
P
D
V
A
K
D
S
W
A
A
E
L
E
N
Site 7
S54
W
A
A
E
L
E
N
S
S
K
E
N
E
V
I
Site 8
S65
N
E
V
I
E
V
K
S
M
G
E
S
Q
S
K
Site 9
S69
E
V
K
S
M
G
E
S
Q
S
K
K
L
Q
G
Site 10
S71
K
S
M
G
E
S
Q
S
K
K
L
Q
G
G
Y
Site 11
Y78
S
K
K
L
Q
G
G
Y
E
C
K
Y
C
P
Y
Site 12
Y82
Q
G
G
Y
E
C
K
Y
C
P
Y
S
T
Q
N
Site 13
T118
V
C
A
E
C
N
F
T
T
K
K
Y
D
S
L
Site 14
Y122
C
N
F
T
T
K
K
Y
D
S
L
S
D
H
N
Site 15
S124
F
T
T
K
K
Y
D
S
L
S
D
H
N
S
K
Site 16
S126
T
K
K
Y
D
S
L
S
D
H
N
S
K
F
H
Site 17
S130
D
S
L
S
D
H
N
S
K
F
H
P
G
E
A
Site 18
T150
L
I
K
R
N
N
Q
T
V
L
E
Q
S
I
E
Site 19
T159
L
E
Q
S
I
E
T
T
N
H
V
V
S
I
T
Site 20
S164
E
T
T
N
H
V
V
S
I
T
T
S
G
P
G
Site 21
S168
H
V
V
S
I
T
T
S
G
P
G
T
G
D
S
Site 22
T172
I
T
T
S
G
P
G
T
G
D
S
D
S
G
I
Site 23
S175
S
G
P
G
T
G
D
S
D
S
G
I
S
V
S
Site 24
S177
P
G
T
G
D
S
D
S
G
I
S
V
S
K
T
Site 25
S180
G
D
S
D
S
G
I
S
V
S
K
T
P
I
M
Site 26
S182
S
D
S
G
I
S
V
S
K
T
P
I
M
K
P
Site 27
T184
S
G
I
S
V
S
K
T
P
I
M
K
P
G
K
Site 28
T207
P
K
K
P
E
E
I
T
P
E
N
H
V
E
G
Site 29
T215
P
E
N
H
V
E
G
T
A
R
L
V
T
D
T
Site 30
T220
E
G
T
A
R
L
V
T
D
T
A
E
I
L
S
Site 31
T222
T
A
R
L
V
T
D
T
A
E
I
L
S
R
L
Site 32
Y267
V
P
L
N
T
T
K
Y
N
S
A
L
D
T
N
Site 33
S269
L
N
T
T
K
Y
N
S
A
L
D
T
N
A
T
Site 34
T273
K
Y
N
S
A
L
D
T
N
A
T
M
I
N
S
Site 35
Y286
N
S
F
N
K
F
P
Y
P
T
Q
A
E
L
S
Site 36
S293
Y
P
T
Q
A
E
L
S
W
L
T
A
A
S
K
Site 37
S299
L
S
W
L
T
A
A
S
K
H
P
E
E
H
I
Site 38
S320
Q
R
L
K
H
G
I
S
W
S
P
E
E
V
E
Site 39
S322
L
K
H
G
I
S
W
S
P
E
E
V
E
E
A
Site 40
T344
T
I
Q
S
V
P
P
T
I
T
V
L
P
A
Q
Site 41
T355
L
P
A
Q
L
A
P
T
K
V
T
Q
P
I
L
Site 42
S385
L
T
Q
V
T
S
G
S
T
T
V
S
C
S
P
Site 43
T411
G
Q
K
R
P
L
V
T
P
Q
A
A
P
E
P
Site 44
T439
K
V
A
N
P
P
L
T
P
A
S
D
R
K
K
Site 45
S442
N
P
P
L
T
P
A
S
D
R
K
K
T
K
E
Site 46
T447
P
A
S
D
R
K
K
T
K
E
Q
I
A
H
L
Site 47
S457
Q
I
A
H
L
K
A
S
F
L
Q
S
Q
F
P
Site 48
S461
L
K
A
S
F
L
Q
S
Q
F
P
D
D
A
E
Site 49
Y470
F
P
D
D
A
E
V
Y
R
L
I
E
V
T
G
Site 50
S481
E
V
T
G
L
A
R
S
E
I
K
K
W
F
S
Site 51
Y492
K
W
F
S
D
H
R
Y
R
C
Q
R
G
I
V
Site 52
S516
D
Q
L
A
I
A
A
S
R
H
G
R
T
Y
H
Site 53
Y522
A
S
R
H
G
R
T
Y
H
A
Y
P
D
F
A
Site 54
Y525
H
G
R
T
Y
H
A
Y
P
D
F
A
P
Q
K
Site 55
S547
Q
V
K
I
L
E
D
S
F
L
K
S
S
F
P
Site 56
S551
L
E
D
S
F
L
K
S
S
F
P
T
Q
A
E
Site 57
S552
E
D
S
F
L
K
S
S
F
P
T
Q
A
E
L
Site 58
T566
L
D
R
L
R
V
E
T
K
L
S
R
R
E
I
Site 59
S569
L
R
V
E
T
K
L
S
R
R
E
I
D
S
W
Site 60
S575
L
S
R
R
E
I
D
S
W
F
S
E
R
R
K
Site 61
S578
R
E
I
D
S
W
F
S
E
R
R
K
L
R
D
Site 62
S586
E
R
R
K
L
R
D
S
M
E
Q
A
V
L
D
Site 63
S594
M
E
Q
A
V
L
D
S
M
G
S
G
K
K
G
Site 64
S612
G
A
P
N
G
A
L
S
R
L
D
Q
L
S
G
Site 65
S618
L
S
R
L
D
Q
L
S
G
A
Q
L
T
S
S
Site 66
S624
L
S
G
A
Q
L
T
S
S
L
P
S
P
S
P
Site 67
S625
S
G
A
Q
L
T
S
S
L
P
S
P
S
P
A
Site 68
S628
Q
L
T
S
S
L
P
S
P
S
P
A
I
A
K
Site 69
S630
T
S
S
L
P
S
P
S
P
A
I
A
K
S
Q
Site 70
S636
P
S
P
A
I
A
K
S
Q
E
Q
V
H
L
L
Site 71
T646
Q
V
H
L
L
R
S
T
F
A
R
T
Q
W
P
Site 72
T650
L
R
S
T
F
A
R
T
Q
W
P
T
P
Q
E
Site 73
T654
F
A
R
T
Q
W
P
T
P
Q
E
Y
D
Q
L
Site 74
T685
E
N
R
C
L
L
K
T
G
T
V
K
W
M
E
Site 75
T687
R
C
L
L
K
T
G
T
V
K
W
M
E
Q
Y
Site 76
Y705
P
M
A
D
D
H
G
Y
D
A
V
A
R
K
A
Site 77
T713
D
A
V
A
R
K
A
T
K
P
M
A
E
S
P
Site 78
S719
A
T
K
P
M
A
E
S
P
K
N
G
G
D
V
Site 79
Y730
G
G
D
V
V
P
Q
Y
Y
K
D
P
K
K
L
Site 80
Y731
G
D
V
V
P
Q
Y
Y
K
D
P
K
K
L
C
Site 81
T747
E
D
L
E
K
L
V
T
R
V
K
V
G
S
E
Site 82
S753
V
T
R
V
K
V
G
S
E
P
A
K
D
C
L
Site 83
S765
D
C
L
P
A
K
P
S
E
A
T
S
D
R
S
Site 84
S769
A
K
P
S
E
A
T
S
D
R
S
E
G
S
S
Site 85
S772
S
E
A
T
S
D
R
S
E
G
S
S
R
D
G
Site 86
S775
T
S
D
R
S
E
G
S
S
R
D
G
Q
G
S
Site 87
S776
S
D
R
S
E
G
S
S
R
D
G
Q
G
S
D
Site 88
S782
S
S
R
D
G
Q
G
S
D
E
N
E
E
S
S
Site 89
S788
G
S
D
E
N
E
E
S
S
V
V
D
Y
V
E
Site 90
Y793
E
E
S
S
V
V
D
Y
V
E
V
T
V
G
E
Site 91
S805
V
G
E
E
D
A
I
S
D
R
S
D
S
W
S
Site 92
S808
E
D
A
I
S
D
R
S
D
S
W
S
Q
A
A
Site 93
S810
A
I
S
D
R
S
D
S
W
S
Q
A
A
A
E
Site 94
S812
S
D
R
S
D
S
W
S
Q
A
A
A
E
G
V
Site 95
S825
G
V
S
E
L
A
E
S
D
S
D
C
V
P
A
Site 96
S827
S
E
L
A
E
S
D
S
D
C
V
P
A
E
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation