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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MKP5
Full Name:
Dual specificity protein phosphatase 10
Alias:
Dual specificity protein phosphatase 10; DUS10; DUSP10; EC 3.1.3.16; EC 3.1.3.48
Type:
Protein phosphatase, dual-specificity
Mass (Da):
52642
Number AA:
482
UniProt ID:
Q9Y6W6
International Prot ID:
IPI00026987
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0017017
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0007254
GO:0006470
GO:0006950
Phosida
TranscriptoNet
STRING
Kinexus Products
Dual specificity protein phosphatase 10 pan-specific antibody AB-NP047-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP047-1#Dual specificity protein phosphatase 10 pan-specific antibody AB-NP047-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP047-2#Dual specificity protein phosphatase 10 (R384-H398, human) peptide - Powder PE-01BAF70#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BAF70#Dual specificity protein phosphatase 10 (K425-K439, human) peptide - Powder PE-01BAG75#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BAG75#Dual specificity protein phosphatase 10 (L455-R469, human) peptide - Powder PE-01BAH99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BAH99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
P
P
S
P
L
D
D
R
V
V
Site 2
S15
D
R
V
V
V
A
L
S
R
P
V
R
P
Q
D
Site 3
S29
D
L
N
L
C
L
D
S
S
Y
L
G
S
A
N
Site 4
Y31
N
L
C
L
D
S
S
Y
L
G
S
A
N
P
G
Site 5
S34
L
D
S
S
Y
L
G
S
A
N
P
G
S
N
S
Site 6
S39
L
G
S
A
N
P
G
S
N
S
H
P
P
V
I
Site 7
S41
S
A
N
P
G
S
N
S
H
P
P
V
I
A
T
Site 8
T59
S
L
K
A
A
N
L
T
Y
M
P
S
S
S
G
Site 9
Y60
L
K
A
A
N
L
T
Y
M
P
S
S
S
G
S
Site 10
S63
A
N
L
T
Y
M
P
S
S
S
G
S
A
R
S
Site 11
S64
N
L
T
Y
M
P
S
S
S
G
S
A
R
S
L
Site 12
S65
L
T
Y
M
P
S
S
S
G
S
A
R
S
L
N
Site 13
S67
Y
M
P
S
S
S
G
S
A
R
S
L
N
C
G
Site 14
S70
S
S
S
G
S
A
R
S
L
N
C
G
C
S
S
Site 15
T110
T
T
A
I
G
T
S
T
T
C
P
A
N
Q
M
Site 16
T124
M
V
N
N
N
E
N
T
G
S
L
S
P
S
S
Site 17
S126
N
N
N
E
N
T
G
S
L
S
P
S
S
G
V
Site 18
S128
N
E
N
T
G
S
L
S
P
S
S
G
V
G
S
Site 19
S130
N
T
G
S
L
S
P
S
S
G
V
G
S
P
V
Site 20
S131
T
G
S
L
S
P
S
S
G
V
G
S
P
V
S
Site 21
S135
S
P
S
S
G
V
G
S
P
V
S
G
T
P
K
Site 22
S138
S
G
V
G
S
P
V
S
G
T
P
K
Q
L
A
Site 23
T160
N
D
L
A
K
K
M
T
K
C
S
K
S
H
L
Site 24
S163
A
K
K
M
T
K
C
S
K
S
H
L
P
S
Q
Site 25
S165
K
M
T
K
C
S
K
S
H
L
P
S
Q
G
P
Site 26
S169
C
S
K
S
H
L
P
S
Q
G
P
V
I
I
D
Site 27
Y183
D
C
R
P
F
M
E
Y
N
K
S
H
I
Q
G
Site 28
S201
I
N
C
A
D
K
I
S
R
R
R
L
Q
Q
G
Site 29
S217
I
T
V
L
D
L
I
S
C
R
E
G
K
D
S
Site 30
S224
S
C
R
E
G
K
D
S
F
K
R
I
F
S
K
Site 31
S230
D
S
F
K
R
I
F
S
K
E
I
I
V
Y
D
Site 32
Y236
F
S
K
E
I
I
V
Y
D
E
N
T
N
E
P
Site 33
T240
I
I
V
Y
D
E
N
T
N
E
P
S
R
V
M
Site 34
S249
E
P
S
R
V
M
P
S
Q
P
L
H
I
V
L
Site 35
S258
P
L
H
I
V
L
E
S
L
K
R
E
G
K
E
Site 36
S274
L
V
L
K
G
G
L
S
S
F
K
Q
N
H
E
Site 37
S275
V
L
K
G
G
L
S
S
F
K
Q
N
H
E
N
Site 38
T314
L
P
Q
P
I
P
T
T
P
D
I
E
N
A
E
Site 39
T342
Q
D
A
Q
D
L
D
T
M
Q
R
L
N
I
G
Site 40
Y361
V
T
T
H
L
P
L
Y
H
Y
E
K
G
L
F
Site 41
Y363
T
H
L
P
L
Y
H
Y
E
K
G
L
F
N
Y
Site 42
T376
N
Y
K
R
L
P
A
T
D
S
N
K
Q
N
L
Site 43
S378
K
R
L
P
A
T
D
S
N
K
Q
N
L
R
Q
Site 44
Y386
N
K
Q
N
L
R
Q
Y
F
E
E
A
F
E
F
Site 45
T430
L
M
K
H
T
R
M
T
M
T
D
A
Y
K
F
Site 46
T432
K
H
T
R
M
T
M
T
D
A
Y
K
F
V
K
Site 47
Y435
R
M
T
M
T
D
A
Y
K
F
V
K
G
K
R
Site 48
S446
K
G
K
R
P
I
I
S
P
N
L
N
F
M
G
Site 49
T467
E
D
L
N
N
G
V
T
P
R
I
L
T
P
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation