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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RSKL2
Full Name:
Ribosomal protein S6 kinase-like 1
Alias:
EC 2.7.11.1; RPKL1; RPS6KL1
Type:
Protein-serine kinase, AGC group, RSKL family; Ribosome protein
Mass (Da):
60036
Number AA:
549
UniProt ID:
Q9Y6S9
International Prot ID:
IPI00164583
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005840
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
V
A
C
E
C
L
P
S
P
G
L
E
P
E
P
Site 2
S20
G
L
E
P
E
P
C
S
R
A
R
S
Q
A
H
Site 3
S24
E
P
C
S
R
A
R
S
Q
A
H
V
Y
L
E
Site 4
Y29
A
R
S
Q
A
H
V
Y
L
E
Q
I
R
N
R
Site 5
T45
A
L
G
V
P
D
M
T
K
R
D
Y
L
V
D
Site 6
Y49
P
D
M
T
K
R
D
Y
L
V
D
A
A
T
Q
Site 7
S66
L
A
L
E
R
D
V
S
E
D
Y
E
A
A
F
Site 8
Y69
E
R
D
V
S
E
D
Y
E
A
A
F
N
H
Y
Site 9
Y106
V
K
L
K
I
T
K
Y
L
R
R
A
E
E
I
Site 10
S123
C
H
L
Q
R
P
L
S
S
G
A
S
P
S
A
Site 11
S124
H
L
Q
R
P
L
S
S
G
A
S
P
S
A
G
Site 12
S127
R
P
L
S
S
G
A
S
P
S
A
G
F
S
S
Site 13
S129
L
S
S
G
A
S
P
S
A
G
F
S
S
L
R
Site 14
S133
A
S
P
S
A
G
F
S
S
L
R
L
R
P
I
Site 15
S134
S
P
S
A
G
F
S
S
L
R
L
R
P
I
R
Site 16
T142
L
R
L
R
P
I
R
T
L
S
S
A
V
E
Q
Site 17
S144
L
R
P
I
R
T
L
S
S
A
V
E
Q
L
R
Site 18
S145
R
P
I
R
T
L
S
S
A
V
E
Q
L
R
G
Site 19
T173
Q
D
P
A
T
G
G
T
F
V
V
K
S
L
P
Site 20
Y206
Y
M
T
K
L
L
R
Y
F
V
S
E
D
S
I
Site 21
S212
R
Y
F
V
S
E
D
S
I
F
L
H
L
E
H
Site 22
S227
V
Q
G
G
T
L
W
S
H
L
L
S
Q
A
H
Site 23
S231
T
L
W
S
H
L
L
S
Q
A
H
S
R
H
S
Site 24
S235
H
L
L
S
Q
A
H
S
R
H
S
G
L
S
S
Site 25
S238
S
Q
A
H
S
R
H
S
G
L
S
S
G
S
T
Site 26
S241
H
S
R
H
S
G
L
S
S
G
S
T
Q
E
R
Site 27
S242
S
R
H
S
G
L
S
S
G
S
T
Q
E
R
M
Site 28
T245
S
G
L
S
S
G
S
T
Q
E
R
M
K
A
Q
Site 29
T261
N
P
H
L
N
L
L
T
P
A
R
L
P
S
G
Site 30
S267
L
T
P
A
R
L
P
S
G
H
A
P
G
Q
D
Site 31
S284
A
L
E
P
P
R
T
S
P
N
L
L
L
A
G
Site 32
S295
L
L
A
G
E
A
P
S
T
R
P
Q
R
E
A
Site 33
T296
L
A
G
E
A
P
S
T
R
P
Q
R
E
A
E
Site 34
T307
R
E
A
E
G
E
P
T
A
R
T
S
T
S
G
Site 35
T310
E
G
E
P
T
A
R
T
S
T
S
G
S
S
D
Site 36
S311
G
E
P
T
A
R
T
S
T
S
G
S
S
D
L
Site 37
T312
E
P
T
A
R
T
S
T
S
G
S
S
D
L
P
Site 38
S313
P
T
A
R
T
S
T
S
G
S
S
D
L
P
K
Site 39
S315
A
R
T
S
T
S
G
S
S
D
L
P
K
A
P
Site 40
S316
R
T
S
T
S
G
S
S
D
L
P
K
A
P
G
Site 41
S337
A
R
R
A
G
Q
N
S
D
A
G
P
P
R
G
Site 42
T346
A
G
P
P
R
G
L
T
W
V
P
E
G
A
G
Site 43
S366
C
G
R
G
M
D
Q
S
C
L
S
A
D
G
A
Site 44
S369
G
M
D
Q
S
C
L
S
A
D
G
A
G
R
G
Site 45
T381
G
R
G
C
G
R
A
T
W
S
V
R
E
E
Q
Site 46
S383
G
C
G
R
A
T
W
S
V
R
E
E
Q
V
K
Site 47
Y430
A
G
H
I
R
L
T
Y
F
G
Q
W
S
E
V
Site 48
Y450
G
E
A
V
D
N
L
Y
S
A
P
E
V
G
G
Site 49
S486
T
G
M
A
L
S
Q
S
H
P
S
G
I
Q
A
Site 50
T495
P
S
G
I
Q
A
H
T
Q
L
Q
L
P
E
W
Site 51
T520
E
L
L
Q
F
E
P
T
R
R
L
G
M
G
E
Site 52
S531
G
M
G
E
G
G
V
S
K
L
K
S
H
P
F
Site 53
S535
G
G
V
S
K
L
K
S
H
P
F
F
S
T
I
Site 54
S540
L
K
S
H
P
F
F
S
T
I
Q
W
S
K
L
Site 55
T541
K
S
H
P
F
F
S
T
I
Q
W
S
K
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation