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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC4A7
Full Name:
Sodium bicarbonate cotransporter 3
Alias:
NBC2; NBC3; S4A7; SBC2; SLC4A6; Sodium bicarbonate cotransporter 2; Solute carrier family 4, sodium bicarbonate cotransporter, member 6; Solute carrier family 4, sodium bicarbonate cotransporter, member 7
Type:
Transport protein
Mass (Da):
136044
Number AA:
1214
UniProt ID:
Q9Y6M7
International Prot ID:
IPI00783830
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
GO:0032420
Uniprot
OncoNet
Molecular Function:
GO:0005452
GO:0005515
GO:0031402
PhosphoSite+
KinaseNET
Biological Process:
GO:0015701
GO:0006814
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
V
D
L
G
K
T
S
S
T
V
N
T
K
F
E
Site 2
T27
D
L
G
K
T
S
S
T
V
N
T
K
F
E
K
Site 3
T30
K
T
S
S
T
V
N
T
K
F
E
K
E
E
L
Site 4
S39
F
E
K
E
E
L
E
S
H
R
A
V
Y
I
G
Site 5
Y44
L
E
S
H
R
A
V
Y
I
G
V
H
V
P
F
Site 6
S52
I
G
V
H
V
P
F
S
K
E
S
R
R
R
H
Site 7
S55
H
V
P
F
S
K
E
S
R
R
R
H
R
H
R
Site 8
S76
R
R
R
K
D
K
E
S
D
K
E
D
G
R
E
Site 9
S84
D
K
E
D
G
R
E
S
P
S
Y
D
T
P
S
Site 10
S86
E
D
G
R
E
S
P
S
Y
D
T
P
S
Q
R
Site 11
Y87
D
G
R
E
S
P
S
Y
D
T
P
S
Q
R
V
Site 12
T89
R
E
S
P
S
Y
D
T
P
S
Q
R
V
Q
F
Site 13
S91
S
P
S
Y
D
T
P
S
Q
R
V
Q
F
I
L
Site 14
T114
H
I
P
H
D
L
F
T
E
M
D
E
L
C
Y
Site 15
Y121
T
E
M
D
E
L
C
Y
R
D
G
E
E
Y
E
Site 16
Y127
C
Y
R
D
G
E
E
Y
E
W
K
E
T
A
R
Site 17
T132
E
E
Y
E
W
K
E
T
A
R
W
L
K
F
E
Site 18
S150
E
D
G
G
D
R
W
S
K
P
Y
V
A
T
L
Site 19
Y153
G
D
R
W
S
K
P
Y
V
A
T
L
S
L
H
Site 20
T156
W
S
K
P
Y
V
A
T
L
S
L
H
S
L
F
Site 21
S167
H
S
L
F
E
L
R
S
C
I
L
N
G
T
V
Site 22
S181
V
M
L
D
M
R
A
S
T
L
D
E
I
A
D
Site 23
T182
M
L
D
M
R
A
S
T
L
D
E
I
A
D
M
Site 24
S197
V
L
D
N
M
I
A
S
G
Q
L
D
E
S
I
Site 25
S203
A
S
G
Q
L
D
E
S
I
R
E
N
V
R
E
Site 26
T225
H
Q
N
E
K
R
F
T
S
R
I
P
L
V
R
Site 27
S226
Q
N
E
K
R
F
T
S
R
I
P
L
V
R
S
Site 28
S233
S
R
I
P
L
V
R
S
F
A
D
I
G
K
K
Site 29
S242
A
D
I
G
K
K
H
S
D
P
H
L
L
E
R
Site 30
S255
E
R
N
G
E
G
L
S
A
S
R
H
S
L
R
Site 31
S257
N
G
E
G
L
S
A
S
R
H
S
L
R
T
G
Site 32
S260
G
L
S
A
S
R
H
S
L
R
T
G
L
S
A
Site 33
T263
A
S
R
H
S
L
R
T
G
L
S
A
S
N
L
Site 34
S266
H
S
L
R
T
G
L
S
A
S
N
L
S
L
R
Site 35
S271
G
L
S
A
S
N
L
S
L
R
G
E
S
P
L
Site 36
S289
L
G
H
L
L
P
S
S
R
A
G
T
P
A
G
Site 37
T293
L
P
S
S
R
A
G
T
P
A
G
S
R
C
T
Site 38
S297
R
A
G
T
P
A
G
S
R
C
T
T
P
V
P
Site 39
T300
T
P
A
G
S
R
C
T
T
P
V
P
T
P
Q
Site 40
T301
P
A
G
S
R
C
T
T
P
V
P
T
P
Q
N
Site 41
T305
R
C
T
T
P
V
P
T
P
Q
N
S
P
P
S
Site 42
S309
P
V
P
T
P
Q
N
S
P
P
S
S
P
S
I
Site 43
S312
T
P
Q
N
S
P
P
S
S
P
S
I
S
R
L
Site 44
S313
P
Q
N
S
P
P
S
S
P
S
I
S
R
L
T
Site 45
S315
N
S
P
P
S
S
P
S
I
S
R
L
T
S
R
Site 46
S317
P
P
S
S
P
S
I
S
R
L
T
S
R
S
S
Site 47
T320
S
P
S
I
S
R
L
T
S
R
S
S
Q
E
S
Site 48
S321
P
S
I
S
R
L
T
S
R
S
S
Q
E
S
Q
Site 49
S323
I
S
R
L
T
S
R
S
S
Q
E
S
Q
R
Q
Site 50
S324
S
R
L
T
S
R
S
S
Q
E
S
Q
R
Q
A
Site 51
S327
T
S
R
S
S
Q
E
S
Q
R
Q
A
P
E
L
Site 52
S337
Q
A
P
E
L
L
V
S
P
A
S
D
D
I
P
Site 53
T345
P
A
S
D
D
I
P
T
V
V
I
H
P
P
E
Site 54
T373
N
E
E
N
V
D
L
T
P
G
I
L
A
S
P
Site 55
S379
L
T
P
G
I
L
A
S
P
Q
S
A
P
G
N
Site 56
S382
G
I
L
A
S
P
Q
S
A
P
G
N
L
D
N
Site 57
S390
A
P
G
N
L
D
N
S
K
S
G
E
I
K
G
Site 58
S392
G
N
L
D
N
S
K
S
G
E
I
K
G
N
G
Site 59
S400
G
E
I
K
G
N
G
S
G
G
S
R
E
N
S
Site 60
S403
K
G
N
G
S
G
G
S
R
E
N
S
T
V
D
Site 61
S407
S
G
G
S
R
E
N
S
T
V
D
F
S
K
V
Site 62
T408
G
G
S
R
E
N
S
T
V
D
F
S
K
V
D
Site 63
S412
E
N
S
T
V
D
F
S
K
V
D
M
N
F
M
Site 64
S429
I
P
T
G
A
E
A
S
N
V
L
V
G
E
V
Site 65
T459
A
V
L
L
T
G
L
T
E
V
P
V
P
T
R
Site 66
Y481
P
A
G
K
A
P
Q
Y
H
E
I
G
R
S
I
Site 67
S487
Q
Y
H
E
I
G
R
S
I
A
T
L
M
T
D
Site 68
T490
E
I
G
R
S
I
A
T
L
M
T
D
E
I
F
Site 69
T493
R
S
I
A
T
L
M
T
D
E
I
F
H
D
V
Site 70
Y502
E
I
F
H
D
V
A
Y
K
A
K
D
R
N
D
Site 71
S512
K
D
R
N
D
L
L
S
G
I
D
E
F
L
D
Site 72
T522
D
E
F
L
D
Q
V
T
V
L
P
P
G
E
W
Site 73
S532
P
P
G
E
W
D
P
S
I
R
I
E
P
P
K
Site 74
S540
I
R
I
E
P
P
K
S
V
P
S
Q
E
K
R
Site 75
S543
E
P
P
K
S
V
P
S
Q
E
K
R
K
I
P
Site 76
S556
I
P
V
F
H
N
G
S
T
P
T
L
G
E
T
Site 77
T557
P
V
F
H
N
G
S
T
P
T
L
G
E
T
P
Site 78
T559
F
H
N
G
S
T
P
T
L
G
E
T
P
K
E
Site 79
T563
S
T
P
T
L
G
E
T
P
K
E
A
A
H
H
Site 80
T578
A
G
P
E
L
Q
R
T
G
R
L
F
G
G
L
Site 81
S598
R
K
A
P
F
F
L
S
D
F
K
D
A
L
S
Site 82
S639
E
A
T
E
G
R
I
S
A
I
E
S
L
F
G
Site 83
T663
L
F
A
G
Q
P
L
T
I
L
G
S
T
G
P
Site 84
Y679
L
V
F
E
K
I
L
Y
K
F
C
R
D
Y
Q
Site 85
Y685
L
Y
K
F
C
R
D
Y
Q
L
S
Y
L
S
L
Site 86
S688
F
C
R
D
Y
Q
L
S
Y
L
S
L
R
T
S
Site 87
Y689
C
R
D
Y
Q
L
S
Y
L
S
L
R
T
S
I
Site 88
S691
D
Y
Q
L
S
Y
L
S
L
R
T
S
I
G
L
Site 89
Y718
D
A
S
S
L
V
C
Y
I
T
R
F
T
E
E
Site 90
S763
N
N
L
D
K
L
T
S
Y
S
C
V
C
T
E
Site 91
Y764
N
L
D
K
L
T
S
Y
S
C
V
C
T
E
P
Site 92
T769
T
S
Y
S
C
V
C
T
E
P
P
N
P
S
N
Site 93
T798
N
I
S
W
R
N
L
T
V
S
E
C
K
K
L
Site 94
S800
S
W
R
N
L
T
V
S
E
C
K
K
L
R
G
Site 95
T847
S
F
L
K
Q
F
K
T
K
R
Y
F
P
T
K
Site 96
Y850
K
Q
F
K
T
K
R
Y
F
P
T
K
V
R
S
Site 97
T853
K
T
K
R
Y
F
P
T
K
V
R
S
T
I
S
Site 98
T867
S
D
F
A
V
F
L
T
I
V
I
M
V
T
I
Site 99
S882
D
Y
L
V
G
V
P
S
P
K
L
H
V
P
E
Site 100
S903
P
E
R
G
W
I
I
S
P
L
G
D
N
P
W
Site 101
S986
L
S
I
S
H
V
N
S
L
K
V
E
S
E
C
Site 102
S994
L
K
V
E
S
E
C
S
A
P
G
E
Q
P
K
Site 103
Y1073
K
H
Q
P
D
L
I
Y
L
R
Y
V
P
L
W
Site 104
T1127
K
L
M
D
L
C
F
T
K
R
E
L
S
W
L
Site 105
S1132
C
F
T
K
R
E
L
S
W
L
D
D
L
M
P
Site 106
S1141
L
D
D
L
M
P
E
S
K
K
K
K
E
D
D
Site 107
T1167
M
L
Q
D
D
D
D
T
V
H
L
P
F
E
G
Site 108
S1176
H
L
P
F
E
G
G
S
L
L
Q
I
P
V
K
Site 109
Y1187
I
P
V
K
A
L
K
Y
S
P
D
K
P
V
S
Site 110
S1188
P
V
K
A
L
K
Y
S
P
D
K
P
V
S
V
Site 111
S1194
Y
S
P
D
K
P
V
S
V
K
I
S
F
E
D
Site 112
S1198
K
P
V
S
V
K
I
S
F
E
D
E
P
R
K
Site 113
Y1207
E
D
E
P
R
K
K
Y
V
D
A
E
T
S
L
Site 114
S1213
K
Y
V
D
A
E
T
S
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation