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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OAS3
Full Name:
2'-5'-oligoadenylate synthase 3
Alias:
2-5A synthetase 3
Type:
Transferase; EC 2.7.7.-
Mass (Da):
121165
Number AA:
1087
UniProt ID:
Q9Y6K5
International Prot ID:
IPI00002405
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003723
GO:0016779
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0006139
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
D
L
Y
S
T
P
A
A
A
L
D
R
Site 2
T57
A
A
P
R
V
L
K
T
V
K
G
G
S
S
G
Site 3
S63
K
T
V
K
G
G
S
S
G
R
G
T
A
L
K
Site 4
T67
G
G
S
S
G
R
G
T
A
L
K
G
G
C
D
Site 5
Y87
F
L
D
C
F
K
S
Y
V
D
Q
R
A
R
R
Site 6
S99
A
R
R
A
E
I
L
S
E
M
R
A
S
L
E
Site 7
S104
I
L
S
E
M
R
A
S
L
E
S
W
W
Q
N
Site 8
T119
P
V
P
G
L
R
L
T
F
P
E
Q
S
V
P
Site 9
T134
G
A
L
Q
F
R
L
T
S
V
D
L
E
D
W
Site 10
S135
A
L
Q
F
R
L
T
S
V
D
L
E
D
W
M
Site 11
S158
N
V
L
G
Q
A
G
S
G
V
K
P
K
P
Q
Site 12
T169
P
K
P
Q
V
Y
S
T
L
L
N
S
G
C
Q
Site 13
S173
V
Y
S
T
L
L
N
S
G
C
Q
G
G
E
H
Site 14
S247
G
C
K
K
D
A
F
S
L
A
E
G
L
R
T
Site 15
T302
I
L
D
P
A
D
P
T
W
D
L
G
N
G
A
Site 16
Y324
A
Q
E
A
A
S
C
Y
D
H
P
C
F
L
R
Site 17
S339
G
M
G
D
P
V
Q
S
W
K
G
P
G
L
P
Site 18
T365
Q
L
D
P
N
Q
K
T
P
E
N
S
K
S
L
Site 19
S371
K
T
P
E
N
S
K
S
L
N
A
V
Y
P
R
Site 20
Y376
S
K
S
L
N
A
V
Y
P
R
A
G
S
K
P
Site 21
S381
A
V
Y
P
R
A
G
S
K
P
P
S
C
P
A
Site 22
S385
R
A
G
S
K
P
P
S
C
P
A
P
G
P
T
Site 23
S409
P
G
M
A
L
D
L
S
Q
I
P
T
K
E
L
Site 24
S427
I
Q
D
H
L
K
P
S
P
Q
F
Q
E
Q
V
Site 25
S454
E
N
C
V
H
K
A
S
R
V
S
K
G
G
S
Site 26
S457
V
H
K
A
S
R
V
S
K
G
G
S
F
G
R
Site 27
S461
S
R
V
S
K
G
G
S
F
G
R
G
T
D
L
Site 28
T466
G
G
S
F
G
R
G
T
D
L
R
D
G
C
D
Site 29
Y486
F
L
N
C
F
T
D
Y
K
D
Q
G
P
R
R
Site 30
S516
Q
D
Q
V
P
S
L
S
L
Q
F
P
E
Q
N
Site 31
T535
L
Q
F
Q
L
V
S
T
A
L
K
S
W
T
D
Site 32
Y566
T
K
P
N
P
Q
V
Y
S
R
L
L
T
S
G
Site 33
T571
Q
V
Y
S
R
L
L
T
S
G
C
Q
E
G
E
Site 34
S572
V
Y
S
R
L
L
T
S
G
C
Q
E
G
E
H
Site 35
T705
V
L
D
P
A
D
P
T
W
N
V
G
H
G
S
Site 36
S731
G
M
Q
A
C
F
L
S
R
D
G
T
S
V
Q
Site 37
T735
C
F
L
S
R
D
G
T
S
V
Q
P
W
D
V
Site 38
S736
F
L
S
R
D
G
T
S
V
Q
P
W
D
V
M
Site 39
T750
M
P
A
L
L
Y
Q
T
P
A
G
D
L
D
K
Site 40
S760
G
D
L
D
K
F
I
S
E
F
L
Q
P
N
R
Site 41
T779
Q
V
N
K
A
V
D
T
I
C
S
F
L
K
E
Site 42
S792
K
E
N
C
F
R
N
S
P
I
K
V
I
K
V
Site 43
T809
G
G
S
S
A
K
G
T
A
L
R
G
R
S
D
Site 44
S841
N
K
R
A
E
I
I
S
E
I
R
A
Q
L
E
Site 45
S872
W
E
N
P
R
V
L
S
F
S
L
T
S
Q
T
Site 46
T876
R
V
L
S
F
S
L
T
S
Q
T
M
L
D
Q
Site 47
T879
S
F
S
L
T
S
Q
T
M
L
D
Q
S
V
D
Site 48
S884
S
Q
T
M
L
D
Q
S
V
D
F
D
V
L
P
Site 49
S901
D
A
L
G
Q
L
V
S
G
S
R
P
S
S
Q
Site 50
S903
L
G
Q
L
V
S
G
S
R
P
S
S
Q
V
Y
Site 51
S906
L
V
S
G
S
R
P
S
S
Q
V
Y
V
D
L
Site 52
S907
V
S
G
S
R
P
S
S
Q
V
Y
V
D
L
I
Site 53
Y910
S
R
P
S
S
Q
V
Y
V
D
L
I
H
S
Y
Site 54
S916
V
Y
V
D
L
I
H
S
Y
S
N
A
G
E
Y
Site 55
S918
V
D
L
I
H
S
Y
S
N
A
G
E
Y
S
T
Site 56
S924
Y
S
N
A
G
E
Y
S
T
C
F
T
E
L
Q
Site 57
T928
G
E
Y
S
T
C
F
T
E
L
Q
R
D
F
I
Site 58
S937
L
Q
R
D
F
I
I
S
R
P
T
K
L
K
S
Site 59
T940
D
F
I
I
S
R
P
T
K
L
K
S
L
I
R
Site 60
S944
S
R
P
T
K
L
K
S
L
I
R
L
V
K
H
Site 61
Y953
I
R
L
V
K
H
W
Y
Q
Q
C
T
K
I
S
Site 62
S960
Y
Q
Q
C
T
K
I
S
K
G
R
G
S
L
P
Site 63
S965
K
I
S
K
G
R
G
S
L
P
P
Q
H
G
L
Site 64
T976
Q
H
G
L
E
L
L
T
V
Y
A
W
E
Q
G
Site 65
Y978
G
L
E
L
L
T
V
Y
A
W
E
Q
G
G
K
Site 66
S987
W
E
Q
G
G
K
D
S
Q
F
N
M
A
E
G
Site 67
T1022
N
Y
N
A
K
D
K
T
V
G
D
F
L
K
Q
Site 68
T1045
I
L
D
P
A
D
P
T
G
N
L
G
H
N
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation