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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARFGEF2
Full Name:
Brefeldin A-inhibited guanine nucleotide-exchange protein 2
Alias:
Brefeldin A-inhibited GEP 2; Brefeldin A-inhibited guanine nucleotide-exchange protein 2
Type:
Guanine nucleotide exchange factor for G protein
Mass (Da):
202038
Number AA:
1785
UniProt ID:
Q9Y6D5
International Prot ID:
IPI00002186
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000139
GO:0005829
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005086
GO:0017022
GO:0005086
PhosphoSite+
KinaseNET
Biological Process:
GO:0006887
GO:0007242
GO:0032012
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
Q
E
S
Q
T
K
S
M
F
V
S
R
A
L
Site 2
S12
Q
T
K
S
M
F
V
S
R
A
L
E
K
I
L
Site 3
S30
E
V
K
R
P
Q
H
S
Q
L
R
R
A
C
Q
Site 4
T54
I
E
K
Q
R
L
G
T
A
A
P
P
K
A
N
Site 5
S78
P
F
E
L
A
C
Q
S
K
S
P
R
V
V
S
Site 6
S80
E
L
A
C
Q
S
K
S
P
R
V
V
S
T
S
Site 7
S85
S
K
S
P
R
V
V
S
T
S
L
D
C
L
Q
Site 8
S87
S
P
R
V
V
S
T
S
L
D
C
L
Q
K
L
Site 9
S107
I
T
G
N
A
P
D
S
G
A
P
G
K
R
L
Site 10
T131
S
C
F
Q
G
P
Q
T
D
E
G
V
Q
L
Q
Site 11
T162
H
E
G
T
I
L
Q
T
V
R
T
C
Y
N
I
Site 12
Y167
L
Q
T
V
R
T
C
Y
N
I
Y
L
A
S
K
Site 13
S214
E
L
E
K
P
I
Q
S
K
P
Q
S
P
V
I
Site 14
S218
P
I
Q
S
K
P
Q
S
P
V
I
Q
A
A
A
Site 15
S227
V
I
Q
A
A
A
V
S
P
K
F
V
R
L
K
Site 16
S236
K
F
V
R
L
K
H
S
Q
A
Q
S
K
P
T
Site 17
S240
L
K
H
S
Q
A
Q
S
K
P
T
T
P
E
K
Site 18
T243
S
Q
A
Q
S
K
P
T
T
P
E
K
T
D
L
Site 19
T244
Q
A
Q
S
K
P
T
T
P
E
K
T
D
L
T
Site 20
T251
T
P
E
K
T
D
L
T
N
G
E
H
A
R
S
Site 21
S258
T
N
G
E
H
A
R
S
D
S
G
K
V
S
T
Site 22
S260
G
E
H
A
R
S
D
S
G
K
V
S
T
E
N
Site 23
S264
R
S
D
S
G
K
V
S
T
E
N
G
D
A
P
Site 24
S276
D
A
P
R
E
R
G
S
S
L
S
G
T
D
D
Site 25
S277
A
P
R
E
R
G
S
S
L
S
G
T
D
D
G
Site 26
S279
R
E
R
G
S
S
L
S
G
T
D
D
G
A
Q
Site 27
T281
R
G
S
S
L
S
G
T
D
D
G
A
Q
E
V
Site 28
S335
P
P
G
V
D
E
N
S
Q
T
N
G
I
A
D
Site 29
T337
G
V
D
E
N
S
Q
T
N
G
I
A
D
D
R
Site 30
S346
G
I
A
D
D
R
Q
S
L
S
S
A
D
N
L
Site 31
S348
A
D
D
R
Q
S
L
S
S
A
D
N
L
E
S
Site 32
S349
D
D
R
Q
S
L
S
S
A
D
N
L
E
S
D
Site 33
S367
H
Q
V
A
A
R
F
S
H
V
L
Q
K
D
A
Site 34
S385
F
R
S
L
C
K
L
S
M
K
P
L
G
E
G
Site 35
S398
E
G
P
P
D
P
K
S
H
E
L
R
S
K
V
Site 36
S403
P
K
S
H
E
L
R
S
K
V
V
S
L
Q
L
Site 37
T424
N
A
G
P
V
F
R
T
H
E
M
F
I
N
A
Site 38
S489
F
L
N
I
L
E
T
S
T
S
S
F
E
H
R
Site 39
S491
N
I
L
E
T
S
T
S
S
F
E
H
R
W
M
Site 40
S492
I
L
E
T
S
T
S
S
F
E
H
R
W
M
V
Site 41
S538
E
R
L
V
N
D
L
S
K
I
A
Q
G
R
S
Site 42
T552
S
G
H
E
L
G
M
T
P
L
Q
E
L
S
L
Site 43
S558
M
T
P
L
Q
E
L
S
L
R
K
K
G
L
E
Site 44
S569
K
G
L
E
C
L
V
S
I
L
K
C
M
V
E
Site 45
Y582
V
E
W
S
K
D
L
Y
V
N
P
N
H
Q
T
Site 46
T597
S
L
G
Q
E
R
L
T
D
Q
E
I
G
D
G
Site 47
S614
L
D
M
A
R
R
C
S
V
T
S
M
E
S
T
Site 48
T616
M
A
R
R
C
S
V
T
S
M
E
S
T
V
S
Site 49
S617
A
R
R
C
S
V
T
S
M
E
S
T
V
S
S
Site 50
S620
C
S
V
T
S
M
E
S
T
V
S
S
G
T
Q
Site 51
T621
S
V
T
S
M
E
S
T
V
S
S
G
T
Q
T
Site 52
S623
T
S
M
E
S
T
V
S
S
G
T
Q
T
T
V
Site 53
S624
S
M
E
S
T
V
S
S
G
T
Q
T
T
V
Q
Site 54
T628
T
V
S
S
G
T
Q
T
T
V
Q
D
D
P
E
Site 55
S674
E
Q
G
M
L
G
T
S
V
E
D
I
A
Q
F
Site 56
S690
H
Q
E
E
R
L
D
S
T
Q
V
G
D
F
L
Site 57
T691
Q
E
E
R
L
D
S
T
Q
V
G
D
F
L
G
Site 58
S700
V
G
D
F
L
G
D
S
A
R
F
N
K
E
V
Site 59
Y709
R
F
N
K
E
V
M
Y
A
Y
V
D
Q
L
D
Site 60
Y711
N
K
E
V
M
Y
A
Y
V
D
Q
L
D
F
C
Site 61
S785
M
L
T
T
D
L
H
S
P
Q
V
K
N
K
M
Site 62
Y797
N
K
M
T
K
E
Q
Y
I
K
M
N
R
G
I
Site 63
S807
M
N
R
G
I
N
D
S
K
D
L
P
E
E
Y
Site 64
Y814
S
K
D
L
P
E
E
Y
L
S
S
I
Y
E
E
Site 65
S816
D
L
P
E
E
Y
L
S
S
I
Y
E
E
I
E
Site 66
S817
L
P
E
E
Y
L
S
S
I
Y
E
E
I
E
G
Site 67
Y819
E
E
Y
L
S
S
I
Y
E
E
I
E
G
K
K
Site 68
S841
E
L
T
I
A
T
K
S
T
K
Q
N
V
A
S
Site 69
Y856
E
K
Q
R
R
L
L
Y
N
L
E
M
E
Q
M
Site 70
T866
E
M
E
Q
M
A
K
T
A
K
A
L
M
E
A
Site 71
S875
K
A
L
M
E
A
V
S
H
A
K
A
P
F
T
Site 72
T882
S
H
A
K
A
P
F
T
S
A
T
H
L
D
H
Site 73
Y944
M
Q
L
E
R
D
A
Y
V
Q
A
L
A
R
F
Site 74
S957
R
F
S
L
L
T
A
S
S
S
I
T
E
M
K
Site 75
S958
F
S
L
L
T
A
S
S
S
I
T
E
M
K
Q
Site 76
S959
S
L
L
T
A
S
S
S
I
T
E
M
K
Q
K
Site 77
T961
L
T
A
S
S
S
I
T
E
M
K
Q
K
N
I
Site 78
T976
D
T
I
K
T
L
I
T
V
A
H
T
D
G
N
Site 79
Y984
V
A
H
T
D
G
N
Y
L
G
N
S
W
H
E
Site 80
T1007
E
L
A
Q
L
I
G
T
G
V
K
T
R
Y
L
Site 81
T1011
L
I
G
T
G
V
K
T
R
Y
L
S
G
S
G
Site 82
Y1013
G
T
G
V
K
T
R
Y
L
S
G
S
G
R
E
Site 83
S1015
G
V
K
T
R
Y
L
S
G
S
G
R
E
R
E
Site 84
S1017
K
T
R
Y
L
S
G
S
G
R
E
R
E
G
S
Site 85
S1024
S
G
R
E
R
E
G
S
L
K
G
H
T
L
A
Site 86
T1029
E
G
S
L
K
G
H
T
L
A
G
E
E
F
M
Site 87
S1045
L
G
L
G
N
L
V
S
G
G
V
D
K
R
Q
Site 88
S1055
V
D
K
R
Q
M
A
S
F
Q
E
S
V
G
E
Site 89
S1059
Q
M
A
S
F
Q
E
S
V
G
E
T
S
S
Q
Site 90
T1063
F
Q
E
S
V
G
E
T
S
S
Q
S
V
V
V
Site 91
S1064
Q
E
S
V
G
E
T
S
S
Q
S
V
V
V
A
Site 92
S1067
V
G
E
T
S
S
Q
S
V
V
V
A
V
D
R
Site 93
S1079
V
D
R
I
F
T
G
S
T
R
L
D
G
N
A
Site 94
S1104
V
S
M
D
E
L
A
S
P
H
H
P
R
M
F
Site 95
S1112
P
H
H
P
R
M
F
S
L
Q
K
I
V
E
I
Site 96
Y1121
Q
K
I
V
E
I
S
Y
Y
N
M
N
R
I
R
Site 97
Y1122
K
I
V
E
I
S
Y
Y
N
M
N
R
I
R
L
Site 98
S1165
V
D
S
L
R
Q
L
S
M
K
F
L
E
K
G
Site 99
S1196
H
I
M
K
K
N
R
S
P
T
I
R
D
M
A
Site 100
T1198
M
K
K
N
R
S
P
T
I
R
D
M
A
I
R
Site 101
Y1300
L
I
R
F
C
G
K
Y
V
S
E
R
P
R
V
Site 102
S1302
R
F
C
G
K
Y
V
S
E
R
P
R
V
L
Q
Site 103
Y1311
R
P
R
V
L
Q
E
Y
T
S
D
D
M
N
V
Site 104
S1313
R
V
L
Q
E
Y
T
S
D
D
M
N
V
A
P
Site 105
S1392
M
K
L
P
E
Q
L
S
E
K
S
E
W
M
T
Site 106
S1395
P
E
Q
L
S
E
K
S
E
W
M
T
T
T
C
Site 107
T1448
E
Q
L
A
R
S
G
T
N
C
L
E
N
L
V
Site 108
S1463
I
S
N
G
E
K
F
S
P
E
V
W
D
E
T
Site 109
S1498
P
V
G
M
E
E
D
S
S
E
K
H
L
D
V
Site 110
S1499
V
G
M
E
E
D
S
S
E
K
H
L
D
V
D
Site 111
S1511
D
V
D
L
D
R
Q
S
L
S
S
I
D
K
N
Site 112
S1513
D
L
D
R
Q
S
L
S
S
I
D
K
N
P
S
Site 113
S1514
L
D
R
Q
S
L
S
S
I
D
K
N
P
S
E
Site 114
S1520
S
S
I
D
K
N
P
S
E
R
G
Q
S
Q
L
Site 115
S1525
N
P
S
E
R
G
Q
S
Q
L
S
N
P
T
D
Site 116
S1528
E
R
G
Q
S
Q
L
S
N
P
T
D
D
S
W
Site 117
S1534
L
S
N
P
T
D
D
S
W
K
G
R
P
Y
A
Site 118
Y1540
D
S
W
K
G
R
P
Y
A
N
Q
K
L
F
A
Site 119
Y1569
T
I
D
N
I
V
F
Y
P
A
T
S
K
K
E
Site 120
Y1603
E
T
E
D
Q
G
M
Y
K
Y
M
S
S
Q
H
Site 121
Y1605
E
D
Q
G
M
Y
K
Y
M
S
S
Q
H
L
F
Site 122
S1621
L
L
D
C
L
Q
E
S
H
S
F
S
K
A
F
Site 123
S1623
D
C
L
Q
E
S
H
S
F
S
K
A
F
N
S
Site 124
S1625
L
Q
E
S
H
S
F
S
K
A
F
N
S
N
Y
Site 125
S1630
S
F
S
K
A
F
N
S
N
Y
E
Q
R
T
V
Site 126
Y1632
S
K
A
F
N
S
N
Y
E
Q
R
T
V
L
W
Site 127
S1647
R
A
G
F
K
G
K
S
K
P
N
L
L
K
Q
Site 128
S1657
N
L
L
K
Q
E
T
S
S
L
A
C
C
L
R
Site 129
Y1670
L
R
I
L
F
R
M
Y
V
D
E
N
R
R
D
Site 130
S1678
V
D
E
N
R
R
D
S
W
E
E
I
Q
Q
R
Site 131
T1699
E
A
L
A
Y
F
I
T
V
N
S
E
S
H
R
Site 132
S1704
F
I
T
V
N
S
E
S
H
R
E
A
W
T
S
Site 133
Y1736
K
A
H
A
S
M
Y
Y
P
Y
L
C
E
I
M
Site 134
S1782
S
Q
V
P
A
A
L
S
P
V
W
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation