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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SLC12A7
Full Name:
Solute carrier family 12 member 7
Alias:
DKFZP434F076; Electroneutral potassium-chloride cotransporter 4; KCC4; K-Cl cotransporter 4; S12A7; Solute carrier family 12 (potassium/chloride transporters) member 7; Solute carrier family 12, 7
Type:
Transporter; Membrane protein, integral
Mass (Da):
119106
Number AA:
1083
UniProt ID:
Q9Y666
International Prot ID:
IPI00008616
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0030955
GO:0015379
PhosphoSite+
KinaseNET
Biological Process:
GO:0006821
GO:0006813
GO:0006814
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
A
D
G
G
G
D
E
T
A
E
R
T
E
A
P
Site 2
T25
G
D
E
T
A
E
R
T
E
A
P
G
T
P
E
Site 3
T30
E
R
T
E
A
P
G
T
P
E
G
P
E
P
E
Site 4
S40
G
P
E
P
E
R
P
S
P
G
D
G
N
P
R
Site 5
S50
D
G
N
P
R
E
N
S
P
F
L
N
N
V
E
Site 6
S62
N
V
E
V
E
Q
E
S
F
F
E
G
K
N
M
Site 7
S78
L
F
E
E
E
M
D
S
N
P
M
V
S
S
L
Site 8
S84
D
S
N
P
M
V
S
S
L
L
N
K
L
A
N
Site 9
Y92
L
L
N
K
L
A
N
Y
T
N
L
S
Q
G
V
Site 10
S96
L
A
N
Y
T
N
L
S
Q
G
V
V
E
H
E
Site 11
S108
E
H
E
E
D
E
E
S
R
R
R
E
A
K
A
Site 12
S190
G
G
S
Y
Y
M
I
S
R
S
L
G
P
E
F
Site 13
S192
S
Y
Y
M
I
S
R
S
L
G
P
E
F
G
G
Site 14
T314
V
C
L
L
G
N
R
T
L
S
R
R
S
F
D
Site 15
S316
L
L
G
N
R
T
L
S
R
R
S
F
D
A
C
Site 16
S319
N
R
T
L
S
R
R
S
F
D
A
C
V
K
A
Site 17
S333
A
Y
G
I
H
N
N
S
A
T
S
A
L
W
G
Site 18
Y355
P
S
A
A
C
D
E
Y
F
I
Q
N
N
V
T
Site 19
S397
V
E
K
K
G
V
P
S
V
P
V
A
E
E
S
Site 20
S404
S
V
P
V
A
E
E
S
R
A
S
A
L
P
Y
Site 21
S438
V
T
G
I
M
A
G
S
N
R
S
G
D
L
K
Site 22
S450
D
L
K
D
A
Q
K
S
I
P
T
G
T
I
L
Site 23
T604
A
V
Q
T
L
L
R
T
P
N
W
R
P
R
F
Site 24
Y651
I
A
G
C
I
Y
K
Y
I
E
Y
R
G
A
E
Site 25
S669
G
D
G
I
R
G
L
S
L
N
A
A
R
Y
A
Site 26
T687
V
E
H
G
P
P
H
T
K
N
W
R
P
Q
V
Site 27
S713
V
K
H
P
R
L
L
S
F
T
S
Q
L
K
A
Site 28
T715
H
P
R
L
L
S
F
T
S
Q
L
K
A
G
K
Site 29
S716
P
R
L
L
S
F
T
S
Q
L
K
A
G
K
G
Site 30
S751
R
A
E
E
N
I
R
S
L
M
S
T
E
K
T
Site 31
T755
N
I
R
S
L
M
S
T
E
K
T
K
G
F
C
Site 32
T758
S
L
M
S
T
E
K
T
K
G
F
C
Q
L
V
Site 33
S769
C
Q
L
V
V
S
S
S
L
R
D
G
M
S
H
Site 34
S775
S
S
L
R
D
G
M
S
H
L
I
Q
S
A
G
Site 35
T814
S
W
K
N
F
V
D
T
V
R
D
T
T
A
A
Site 36
T818
F
V
D
T
V
R
D
T
T
A
A
H
Q
A
L
Site 37
S833
L
V
A
K
N
V
D
S
F
P
Q
N
Q
E
R
Site 38
T880
K
C
R
M
R
I
F
T
V
A
Q
V
D
D
N
Site 39
S888
V
A
Q
V
D
D
N
S
I
Q
M
K
K
D
L
Site 40
Y900
K
D
L
Q
M
F
L
Y
H
L
R
I
S
A
E
Site 41
S919
E
M
V
E
N
D
I
S
A
F
T
Y
E
R
T
Site 42
Y923
N
D
I
S
A
F
T
Y
E
R
T
L
M
M
E
Site 43
T926
S
A
F
T
Y
E
R
T
L
M
M
E
Q
R
S
Site 44
T958
Q
L
I
H
D
R
N
T
A
S
H
T
A
A
A
Site 45
S960
I
H
D
R
N
T
A
S
H
T
A
A
A
A
R
Site 46
T962
D
R
N
T
A
S
H
T
A
A
A
A
R
T
Q
Site 47
T968
H
T
A
A
A
A
R
T
Q
A
P
P
T
P
D
Site 48
T973
A
R
T
Q
A
P
P
T
P
D
K
V
Q
M
T
Site 49
T980
T
P
D
K
V
Q
M
T
W
T
R
E
K
L
I
Site 50
T982
D
K
V
Q
M
T
W
T
R
E
K
L
I
A
E
Site 51
Y991
E
K
L
I
A
E
K
Y
R
S
R
D
T
S
L
Site 52
S993
L
I
A
E
K
Y
R
S
R
D
T
S
L
S
G
Site 53
T996
E
K
Y
R
S
R
D
T
S
L
S
G
F
K
D
Site 54
S997
K
Y
R
S
R
D
T
S
L
S
G
F
K
D
L
Site 55
S999
R
S
R
D
T
S
L
S
G
F
K
D
L
F
S
Site 56
S1006
S
G
F
K
D
L
F
S
M
K
P
D
Q
S
N
Site 57
T1019
S
N
V
R
R
M
H
T
A
V
K
L
N
G
V
Site 58
Y1054
N
R
Q
G
D
E
N
Y
M
E
F
L
E
V
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation