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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYH4
Full Name:
Myosin-4
Alias:
MYH2B; MyHC-2B; MyHC-IIb; Myosin heavy chain 2b; Myosin heavy chain 4; Myosin heavy chain IIb; Myosin heavy chain, skeletal muscle, fetal; Myosin, heavy chain 4, skeletal muscle
Type:
Motor protein
Mass (Da):
223071
Number AA:
1939
UniProt ID:
Q9Y623
International Prot ID:
IPI00001753
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005859
GO:0032982
GO:0030017
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003779
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0030049
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
A
A
P
F
L
R
K
S
E
K
E
R
I
E
A
Site 2
T36
N
K
P
F
D
A
K
T
S
V
F
V
V
D
P
Site 3
Y47
V
V
D
P
K
E
S
Y
V
K
A
I
V
Q
S
Site 4
T64
G
G
K
V
T
A
K
T
E
A
G
A
T
V
T
Site 5
T69
A
K
T
E
A
G
A
T
V
T
V
K
E
D
Q
Site 6
Y85
F
S
M
N
P
P
K
Y
D
K
I
E
D
M
A
Site 7
Y104
L
H
E
P
A
V
L
Y
N
L
K
E
R
Y
A
Site 8
Y135
P
Y
K
W
L
P
V
Y
N
P
E
V
V
T
A
Site 9
S157
E
A
P
P
H
I
F
S
I
S
D
N
A
Y
Q
Site 10
Y163
F
S
I
S
D
N
A
Y
Q
F
M
L
T
D
R
Site 11
T168
N
A
Y
Q
F
M
L
T
D
R
E
N
Q
S
I
Site 12
T178
E
N
Q
S
I
L
I
T
G
E
S
G
A
G
K
Site 13
T186
G
E
S
G
A
G
K
T
V
N
T
K
R
V
I
Site 14
T189
G
A
G
K
T
V
N
T
K
R
V
I
Q
Y
F
Site 15
S212
K
K
K
E
E
P
A
S
G
K
M
Q
G
T
L
Site 16
T218
A
S
G
K
M
Q
G
T
L
E
D
Q
I
I
S
Site 17
T238
E
A
F
G
N
A
K
T
V
R
N
D
N
S
S
Site 18
S244
K
T
V
R
N
D
N
S
S
R
F
G
K
F
I
Site 19
S245
T
V
R
N
D
N
S
S
R
F
G
K
F
I
R
Site 20
Y269
A
S
A
D
I
E
T
Y
L
L
E
K
S
R
V
Site 21
S274
E
T
Y
L
L
E
K
S
R
V
T
F
Q
L
K
Site 22
T277
L
L
E
K
S
R
V
T
F
Q
L
K
A
E
R
Site 23
Y286
Q
L
K
A
E
R
S
Y
H
I
F
Y
Q
I
L
Site 24
Y290
E
R
S
Y
H
I
F
Y
Q
I
L
S
N
K
K
Site 25
S325
Q
G
E
I
T
V
P
S
I
D
D
Q
E
E
L
Site 26
T335
D
Q
E
E
L
M
A
T
D
S
A
V
D
I
L
Site 27
T356
K
V
A
I
Y
K
L
T
G
A
V
M
H
Y
G
Site 28
Y362
L
T
G
A
V
M
H
Y
G
N
M
K
F
K
Q
Site 29
T381
E
Q
A
E
P
D
G
T
E
V
A
D
K
A
A
Site 30
Y389
E
V
A
D
K
A
A
Y
L
T
S
L
N
S
A
Site 31
S392
D
K
A
A
Y
L
T
S
L
N
S
A
D
L
L
Site 32
S401
N
S
A
D
L
L
K
S
L
C
Y
P
R
V
K
Site 33
Y404
D
L
L
K
S
L
C
Y
P
R
V
K
V
G
N
Site 34
Y424
G
Q
T
V
Q
Q
V
Y
N
A
V
G
A
L
A
Site 35
T452
R
I
N
Q
Q
L
D
T
K
Q
P
R
Q
Y
F
Site 36
Y458
D
T
K
Q
P
R
Q
Y
F
I
G
V
L
D
I
Site 37
T484
E
Q
L
C
I
N
F
T
N
E
K
L
Q
Q
F
Site 38
Y504
F
V
L
E
Q
E
E
Y
K
K
E
G
I
E
W
Site 39
S535
E
K
P
M
G
I
F
S
I
L
E
E
E
C
M
Site 40
S550
F
P
K
A
T
D
T
S
F
K
N
K
L
Y
E
Site 41
Y556
T
S
F
K
N
K
L
Y
E
Q
H
L
G
K
S
Site 42
S581
G
K
P
E
A
H
F
S
L
V
H
Y
A
G
T
Site 43
Y585
A
H
F
S
L
V
H
Y
A
G
T
V
D
Y
N
Site 44
Y591
H
Y
A
G
T
V
D
Y
N
I
A
G
W
L
D
Site 45
T607
N
K
D
P
L
N
E
T
V
V
G
L
Y
Q
K
Site 46
Y612
N
E
T
V
V
G
L
Y
Q
K
S
A
M
K
T
Site 47
T629
F
L
F
S
G
A
Q
T
A
E
A
E
G
G
G
Site 48
S646
K
G
G
K
K
K
G
S
S
F
Q
T
V
S
A
Site 49
S647
G
G
K
K
K
G
S
S
F
Q
T
V
S
A
L
Site 50
T650
K
K
G
S
S
F
Q
T
V
S
A
L
F
R
E
Site 51
T664
E
N
L
N
K
L
M
T
N
L
R
S
T
H
P
Site 52
T669
L
M
T
N
L
R
S
T
H
P
H
F
V
R
C
Site 53
T684
I
I
P
N
E
T
K
T
P
G
A
M
E
H
E
Site 54
Y719
G
F
P
S
R
I
L
Y
A
D
F
K
Q
R
Y
Site 55
S742
P
E
G
Q
F
I
D
S
K
K
A
S
E
K
L
Site 56
S746
F
I
D
S
K
K
A
S
E
K
L
L
G
S
I
Site 57
T758
G
S
I
E
I
D
H
T
Q
Y
K
F
G
H
T
Site 58
Y820
E
S
I
F
C
I
Q
Y
N
I
R
A
F
M
N
Site 59
S846
K
I
K
P
L
L
K
S
A
E
T
E
K
E
M
Site 60
T863
M
K
E
E
F
E
K
T
K
E
E
L
A
K
T
Site 61
T870
T
K
E
E
L
A
K
T
E
A
K
R
K
E
L
Site 62
T883
E
L
E
E
K
M
V
T
L
M
Q
E
K
N
D
Site 63
S952
R
K
L
E
D
E
C
S
E
L
K
K
D
I
D
Site 64
T964
D
I
D
D
L
E
L
T
L
A
K
V
E
K
E
Site 65
T975
V
E
K
E
K
H
A
T
E
N
K
V
K
N
L
Site 66
T983
E
N
K
V
K
N
L
T
E
E
M
A
G
L
D
Site 67
T992
E
M
A
G
L
D
E
T
I
A
K
L
T
K
E
Site 68
S1041
Q
V
D
D
L
E
G
S
L
E
Q
E
K
K
L
Site 69
T1073
A
Q
E
S
T
M
D
T
E
N
D
K
Q
Q
L
Site 70
S1092
K
K
K
E
F
E
M
S
N
L
Q
G
K
I
E
Site 71
S1132
E
I
E
A
E
R
A
S
R
A
K
A
E
K
Q
Site 72
S1141
A
K
A
E
K
Q
R
S
D
L
S
R
E
L
E
Site 73
S1144
E
K
Q
R
S
D
L
S
R
E
L
E
E
I
S
Site 74
S1151
S
R
E
L
E
E
I
S
E
R
L
E
E
A
G
Site 75
S1185
M
R
R
D
L
E
E
S
T
L
Q
H
E
A
T
Site 76
T1192
S
T
L
Q
H
E
A
T
A
A
A
L
R
K
K
Site 77
S1203
L
R
K
K
H
A
D
S
V
A
E
L
G
E
Q
Site 78
S1213
E
L
G
E
Q
I
D
S
L
Q
R
V
K
Q
K
Site 79
S1226
Q
K
L
E
K
E
K
S
E
L
K
M
E
I
N
Site 80
S1237
M
E
I
N
D
L
A
S
N
M
E
T
V
S
K
Site 81
T1241
D
L
A
S
N
M
E
T
V
S
K
A
K
A
N
Site 82
T1255
N
F
E
K
M
C
R
T
L
E
D
Q
L
S
E
Site 83
S1261
R
T
L
E
D
Q
L
S
E
I
K
T
K
E
E
Site 84
T1265
D
Q
L
S
E
I
K
T
K
E
E
E
Q
Q
R
Site 85
S1278
Q
R
L
I
N
E
L
S
A
Q
K
A
R
L
H
Site 86
T1286
A
Q
K
A
R
L
H
T
E
S
G
E
F
S
R
Site 87
S1288
K
A
R
L
H
T
E
S
G
E
F
S
R
Q
L
Site 88
S1292
H
T
E
S
G
E
F
S
R
Q
L
D
E
K
D
Site 89
S1303
D
E
K
D
A
M
V
S
Q
L
S
R
G
K
Q
Site 90
S1339
T
L
A
H
A
L
Q
S
A
R
H
D
C
D
L
Site 91
Y1351
C
D
L
L
R
E
Q
Y
E
E
E
Q
E
A
K
Site 92
S1366
A
E
L
Q
R
G
M
S
K
A
N
S
E
V
A
Site 93
S1370
R
G
M
S
K
A
N
S
E
V
A
Q
W
R
T
Site 94
T1377
S
E
V
A
Q
W
R
T
K
Y
E
T
D
A
I
Site 95
Y1379
V
A
Q
W
R
T
K
Y
E
T
D
A
I
Q
R
Site 96
T1381
Q
W
R
T
K
Y
E
T
D
A
I
Q
R
T
E
Site 97
T1387
E
T
D
A
I
Q
R
T
E
E
L
E
E
A
K
Site 98
S1413
E
H
V
E
A
V
N
S
K
C
A
S
L
E
K
Site 99
S1417
A
V
N
S
K
C
A
S
L
E
K
T
K
Q
R
Site 100
T1421
K
C
A
S
L
E
K
T
K
Q
R
L
Q
N
E
Site 101
Y1464
L
A
E
W
K
Q
K
Y
E
E
T
Q
A
E
L
Site 102
S1474
T
Q
A
E
L
E
A
S
Q
K
E
S
R
S
L
Site 103
S1478
L
E
A
S
Q
K
E
S
R
S
L
S
T
E
L
Site 104
S1480
A
S
Q
K
E
S
R
S
L
S
T
E
L
F
K
Site 105
S1482
Q
K
E
S
R
S
L
S
T
E
L
F
K
V
K
Site 106
T1483
K
E
S
R
S
L
S
T
E
L
F
K
V
K
N
Site 107
Y1492
L
F
K
V
K
N
A
Y
E
E
S
L
D
H
L
Site 108
S1495
V
K
N
A
Y
E
E
S
L
D
H
L
E
T
L
Site 109
T1501
E
S
L
D
H
L
E
T
L
K
R
E
N
K
N
Site 110
S1514
K
N
L
Q
Q
E
I
S
D
L
T
E
Q
I
A
Site 111
T1517
Q
Q
E
I
S
D
L
T
E
Q
I
A
E
G
G
Site 112
S1542
K
Q
L
D
H
E
K
S
E
L
Q
T
S
L
E
Site 113
S1547
E
K
S
E
L
Q
T
S
L
E
E
A
E
A
S
Site 114
S1554
S
L
E
E
A
E
A
S
L
E
H
E
E
G
K
Site 115
S1574
L
E
L
N
Q
V
K
S
E
I
D
R
K
I
A
Site 116
S1600
N
H
L
R
V
V
E
S
M
Q
S
T
L
D
A
Site 117
S1603
R
V
V
E
S
M
Q
S
T
L
D
A
E
I
R
Site 118
T1604
V
V
E
S
M
Q
S
T
L
D
A
E
I
R
S
Site 119
T1650
A
L
R
N
L
R
N
T
Q
G
I
L
K
D
T
Site 120
S1695
E
V
E
E
L
R
A
S
L
E
R
T
E
R
G
Site 121
T1699
L
R
A
S
L
E
R
T
E
R
G
R
K
M
A
Site 122
S1714
E
Q
E
L
L
D
A
S
E
R
V
Q
L
L
H
Site 123
T1722
E
R
V
Q
L
L
H
T
Q
N
T
S
L
I
N
Site 124
T1725
Q
L
L
H
T
Q
N
T
S
L
I
N
T
K
K
Site 125
S1726
L
L
H
T
Q
N
T
S
L
I
N
T
K
K
K
Site 126
S1739
K
K
L
E
T
D
I
S
Q
I
Q
G
E
M
E
Site 127
S1780
L
K
K
E
Q
D
T
S
A
H
L
E
R
M
K
Site 128
S1828
A
R
V
R
E
L
E
S
E
V
E
S
E
Q
K
Site 129
S1832
E
L
E
S
E
V
E
S
E
Q
K
H
N
V
E
Site 130
T1855
E
R
R
V
K
E
L
T
Y
Q
T
E
E
D
R
Site 131
Y1856
R
R
V
K
E
L
T
Y
Q
T
E
E
D
R
K
Site 132
S1919
E
R
A
D
I
A
E
S
Q
V
N
K
L
R
V
Site 133
S1928
V
N
K
L
R
V
K
S
R
E
V
H
T
K
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation