KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
HCFC2
Full Name:
Host cell factor 2
Alias:
C2 factor; HCF2; HCF-2; Host cell factor C2
Type:
Transcription factor
Mass (Da):
86779
Number AA:
792
UniProt ID:
Q9Y5Z7
International Prot ID:
IPI00002469
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0003702
GO:0003712
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006357
GO:0009889
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
L
L
N
W
R
R
V
S
S
F
T
G
P
V
P
Site 2
S14
L
N
W
R
R
V
S
S
F
T
G
P
V
P
R
Site 3
T16
W
R
R
V
S
S
F
T
G
P
V
P
R
A
R
Site 4
Y52
I
A
D
E
L
H
V
Y
N
T
A
T
N
Q
W
Site 5
Y93
V
F
G
G
M
V
E
Y
G
R
Y
S
N
E
L
Site 6
Y96
G
M
V
E
Y
G
R
Y
S
N
E
L
Y
E
L
Site 7
S97
M
V
E
Y
G
R
Y
S
N
E
L
Y
E
L
Q
Site 8
Y101
G
R
Y
S
N
E
L
Y
E
L
Q
A
S
R
W
Site 9
S120
V
K
P
H
P
P
P
S
G
L
P
P
C
P
R
Site 10
S131
P
C
P
R
L
G
H
S
F
S
L
Y
G
N
K
Site 11
S133
P
R
L
G
H
S
F
S
L
Y
G
N
K
C
Y
Site 12
S152
L
A
N
E
S
E
D
S
N
N
N
V
P
R
Y
Site 13
Y159
S
N
N
N
V
P
R
Y
L
N
D
F
Y
E
L
Site 14
Y164
P
R
Y
L
N
D
F
Y
E
L
E
L
Q
H
G
Site 15
S188
V
T
K
G
V
V
P
S
P
R
E
S
H
T
A
Site 16
Y198
E
S
H
T
A
V
I
Y
C
K
K
D
S
G
S
Site 17
S205
Y
C
K
K
D
S
G
S
P
K
M
Y
V
F
G
Site 18
Y209
D
S
G
S
P
K
M
Y
V
F
G
G
M
C
G
Site 19
T229
L
W
Q
L
D
L
E
T
M
S
W
S
K
P
E
Site 20
S231
Q
L
D
L
E
T
M
S
W
S
K
P
E
T
K
Site 21
T237
M
S
W
S
K
P
E
T
K
G
T
V
P
L
P
Site 22
T240
S
K
P
E
T
K
G
T
V
P
L
P
R
S
L
Site 23
S246
G
T
V
P
L
P
R
S
L
H
T
A
S
V
I
Site 24
T249
P
L
P
R
S
L
H
T
A
S
V
I
G
N
K
Site 25
S251
P
R
S
L
H
T
A
S
V
I
G
N
K
M
Y
Site 26
S274
K
G
E
N
T
E
T
S
P
H
D
C
E
W
R
Site 27
Y288
R
C
T
S
S
F
S
Y
L
N
L
D
T
T
E
Site 28
T294
S
Y
L
N
L
D
T
T
E
W
T
T
L
V
S
Site 29
S301
T
E
W
T
T
L
V
S
D
S
Q
E
D
K
K
Site 30
S303
W
T
T
L
V
S
D
S
Q
E
D
K
K
N
S
Site 31
Y328
V
A
I
G
T
R
L
Y
F
W
S
G
R
D
G
Site 32
S331
G
T
R
L
Y
F
W
S
G
R
D
G
Y
K
K
Site 33
Y336
F
W
S
G
R
D
G
Y
K
K
A
L
N
S
Q
Site 34
S342
G
Y
K
K
A
L
N
S
Q
V
C
C
K
D
L
Site 35
Y351
V
C
C
K
D
L
W
Y
L
D
T
E
K
P
P
Site 36
T354
K
D
L
W
Y
L
D
T
E
K
P
P
A
P
S
Site 37
S381
H
V
K
W
D
E
V
S
T
V
E
G
Y
L
L
Site 38
T382
V
K
W
D
E
V
S
T
V
E
G
Y
L
L
Q
Site 39
S391
E
G
Y
L
L
Q
L
S
T
D
L
P
Y
Q
A
Site 40
Y396
Q
L
S
T
D
L
P
Y
Q
A
A
S
S
D
S
Site 41
S400
D
L
P
Y
Q
A
A
S
S
D
S
S
A
A
P
Site 42
S401
L
P
Y
Q
A
A
S
S
D
S
S
A
A
P
N
Site 43
S404
Q
A
A
S
S
D
S
S
A
A
P
N
M
Q
G
Site 44
S421
M
D
P
H
R
Q
G
S
N
N
I
V
P
N
S
Site 45
S428
S
N
N
I
V
P
N
S
I
N
D
T
I
N
S
Site 46
T432
V
P
N
S
I
N
D
T
I
N
S
T
K
T
E
Site 47
T438
D
T
I
N
S
T
K
T
E
Q
P
A
T
K
E
Site 48
T443
T
K
T
E
Q
P
A
T
K
E
T
S
M
K
N
Site 49
T458
K
P
D
F
K
A
L
T
D
S
N
A
I
L
Y
Site 50
S460
D
F
K
A
L
T
D
S
N
A
I
L
Y
P
S
Site 51
Y465
T
D
S
N
A
I
L
Y
P
S
L
A
S
N
A
Site 52
S467
S
N
A
I
L
Y
P
S
L
A
S
N
A
S
N
Site 53
S473
P
S
L
A
S
N
A
S
N
H
N
S
H
V
V
Site 54
S477
S
N
A
S
N
H
N
S
H
V
V
D
M
L
R
Site 55
T491
R
K
N
E
G
P
H
T
S
A
N
V
G
V
L
Site 56
S492
K
N
E
G
P
H
T
S
A
N
V
G
V
L
S
Site 57
S512
R
T
V
I
P
E
T
S
V
S
S
T
V
S
S
Site 58
S514
V
I
P
E
T
S
V
S
S
T
V
S
S
T
Q
Site 59
S515
I
P
E
T
S
V
S
S
T
V
S
S
T
Q
T
Site 60
T516
P
E
T
S
V
S
S
T
V
S
S
T
Q
T
M
Site 61
S518
T
S
V
S
S
T
V
S
S
T
Q
T
M
V
T
Site 62
S519
S
V
S
S
T
V
S
S
T
Q
T
M
V
T
Q
Site 63
T522
S
T
V
S
S
T
Q
T
M
V
T
Q
Q
T
I
Site 64
T531
V
T
Q
Q
T
I
K
T
E
S
S
S
T
N
G
Site 65
S546
A
V
V
K
D
E
T
S
L
T
T
F
S
T
K
Site 66
T548
V
K
D
E
T
S
L
T
T
F
S
T
K
S
E
Site 67
T549
K
D
E
T
S
L
T
T
F
S
T
K
S
E
V
Site 68
S554
L
T
T
F
S
T
K
S
E
V
D
E
T
Y
A
Site 69
T559
T
K
S
E
V
D
E
T
Y
A
L
P
A
T
K
Site 70
Y560
K
S
E
V
D
E
T
Y
A
L
P
A
T
K
I
Site 71
T572
T
K
I
S
R
V
E
T
H
A
T
A
T
P
F
Site 72
T575
S
R
V
E
T
H
A
T
A
T
P
F
S
K
E
Site 73
T577
V
E
T
H
A
T
A
T
P
F
S
K
E
T
P
Site 74
S580
H
A
T
A
T
P
F
S
K
E
T
P
S
N
P
Site 75
T583
A
T
P
F
S
K
E
T
P
S
N
P
V
A
T
Site 76
S585
P
F
S
K
E
T
P
S
N
P
V
A
T
V
K
Site 77
S612
K
N
N
T
A
L
V
S
Q
F
Y
L
L
P
K
Site 78
Y615
T
A
L
V
S
Q
F
Y
L
L
P
K
G
K
Q
Site 79
S623
L
L
P
K
G
K
Q
S
I
S
K
V
G
N
A
Site 80
Y635
G
N
A
D
V
P
D
Y
S
L
L
K
K
Q
D
Site 81
S636
N
A
D
V
P
D
Y
S
L
L
K
K
Q
D
L
Site 82
S665
G
C
G
I
G
P
F
S
K
I
S
E
F
K
T
Site 83
T672
S
K
I
S
E
F
K
T
C
I
P
G
F
P
G
Site 84
S682
P
G
F
P
G
A
P
S
A
V
R
I
S
K
N
Site 85
S687
A
P
S
A
V
R
I
S
K
N
V
E
G
I
H
Site 86
S696
N
V
E
G
I
H
L
S
W
E
P
P
T
S
P
Site 87
S702
L
S
W
E
P
P
T
S
P
S
G
N
I
L
E
Site 88
S704
W
E
P
P
T
S
P
S
G
N
I
L
E
Y
S
Site 89
S726
A
Q
I
Q
D
N
P
S
Q
L
V
F
M
R
I
Site 90
S766
P
A
I
V
F
R
I
S
A
K
N
E
K
G
Y
Site 91
T777
E
K
G
Y
G
P
A
T
Q
V
R
W
L
Q
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation