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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GTF3C3
Full Name:
General transcription factor 3C polypeptide 3
Alias:
Eneral transcription factor 3C polypeptide 3; General transcription factor IIIC, polypeptide 3 (102kD); General transcription factor IIIC, polypeptide 3, 102kDa; TF3C3; TF3C-gamma; TFIIIC 102 kDa subunit; TFIIIC102; TFiiiC2-102; TFIIICgamma; Transcription factor IIIC subunit gamma; Transcription factor IIIC, 102 kD; Transcription factor IIIC-gamma subunit
Type:
Transcription factor
Mass (Da):
101272
Number AA:
886
UniProt ID:
Q9Y5Q9
International Prot ID:
IPI00015806
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000127
GO:0005634
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003677
GO:0003709
PhosphoSite+
KinaseNET
Biological Process:
GO:0042791
GO:0042797
GO:0006351
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
D
Y
L
E
G
K
I
S
F
E
E
F
E
R
R
Site 2
T30
R
R
R
E
E
R
K
T
R
E
K
K
S
L
Q
Site 3
S35
R
K
T
R
E
K
K
S
L
Q
E
K
G
K
L
Site 4
S43
L
Q
E
K
G
K
L
S
A
E
E
N
P
D
D
Site 5
S51
A
E
E
N
P
D
D
S
E
V
P
S
S
S
G
Site 6
S55
P
D
D
S
E
V
P
S
S
S
G
I
N
S
T
Site 7
S56
D
D
S
E
V
P
S
S
S
G
I
N
S
T
K
Site 8
S57
D
S
E
V
P
S
S
S
G
I
N
S
T
K
S
Site 9
S61
P
S
S
S
G
I
N
S
T
K
S
Q
D
K
D
Site 10
S64
S
G
I
N
S
T
K
S
Q
D
K
D
V
N
E
Site 11
S75
D
V
N
E
G
E
T
S
D
G
V
R
K
S
V
Site 12
S81
T
S
D
G
V
R
K
S
V
H
K
V
F
A
S
Site 13
T112
E
E
E
E
E
E
E
T
P
E
Q
P
T
A
G
Site 14
T132
E
M
V
L
N
R
E
T
K
K
M
M
K
E
K
Site 15
S143
M
K
E
K
R
P
R
S
K
L
P
R
A
L
R
Site 16
S187
P
L
A
Y
E
P
F
S
T
L
A
M
I
Y
E
Site 17
S202
D
Q
G
D
M
E
K
S
L
Q
F
E
L
I
A
Site 18
S215
I
A
A
H
L
N
P
S
D
T
E
E
W
V
R
Site 19
T217
A
H
L
N
P
S
D
T
E
E
W
V
R
L
A
Site 20
S227
W
V
R
L
A
E
M
S
L
E
Q
D
N
I
K
Site 21
Y246
C
Y
T
K
A
L
K
Y
E
P
T
N
V
R
Y
Site 22
T249
K
A
L
K
Y
E
P
T
N
V
R
Y
L
W
E
Site 23
Y253
Y
E
P
T
N
V
R
Y
L
W
E
R
S
S
L
Site 24
S259
R
Y
L
W
E
R
S
S
L
Y
E
Q
M
G
D
Site 25
Y261
L
W
E
R
S
S
L
Y
E
Q
M
G
D
H
K
Site 26
Y274
H
K
M
A
M
D
G
Y
R
R
I
L
N
L
L
Site 27
S282
R
R
I
L
N
L
L
S
P
S
D
G
E
R
F
Site 28
S284
I
L
N
L
L
S
P
S
D
G
E
R
F
M
Q
Site 29
S299
L
A
R
D
M
A
K
S
Y
Y
E
A
N
D
V
Site 30
Y301
R
D
M
A
K
S
Y
Y
E
A
N
D
V
T
S
Site 31
S325
S
K
H
Q
G
L
V
S
M
E
D
V
N
I
A
Site 32
Y336
V
N
I
A
A
E
L
Y
I
S
N
K
Q
Y
D
Site 33
S338
I
A
A
E
L
Y
I
S
N
K
Q
Y
D
K
A
Site 34
Y342
L
Y
I
S
N
K
Q
Y
D
K
A
L
E
I
I
Site 35
S362
I
V
L
E
K
K
T
S
E
E
G
T
S
E
E
Site 36
S367
K
T
S
E
E
G
T
S
E
E
N
K
A
P
E
Site 37
T377
N
K
A
P
E
N
V
T
C
T
I
P
D
G
V
Site 38
T410
E
P
L
N
P
L
L
T
T
L
V
E
Q
N
P
Site 39
Y424
P
E
D
M
G
D
L
Y
L
D
V
A
E
A
F
Site 40
Y453
A
L
V
C
S
E
R
Y
N
L
A
V
V
W
L
Site 41
Y471
E
C
L
K
A
L
G
Y
M
E
R
A
A
E
S
Site 42
Y479
M
E
R
A
A
E
S
Y
G
K
V
V
D
L
A
Site 43
S495
L
H
L
D
A
R
I
S
L
S
T
L
Q
Q
Q
Site 44
T498
D
A
R
I
S
L
S
T
L
Q
Q
Q
L
G
Q
Site 45
Y517
L
E
A
L
E
P
M
Y
D
P
D
T
L
A
Q
Site 46
T521
E
P
M
Y
D
P
D
T
L
A
Q
D
A
N
A
Site 47
T541
K
L
L
L
H
R
S
T
L
L
F
S
Q
G
K
Site 48
S545
H
R
S
T
L
L
F
S
Q
G
K
M
Y
G
Y
Site 49
Y552
S
Q
G
K
M
Y
G
Y
V
D
T
L
L
T
M
Site 50
S577
R
A
Q
V
C
L
I
S
S
S
K
S
G
E
R
Site 51
S579
Q
V
C
L
I
S
S
S
K
S
G
E
R
H
L
Site 52
S581
C
L
I
S
S
S
K
S
G
E
R
H
L
Y
L
Site 53
Y587
K
S
G
E
R
H
L
Y
L
I
K
V
S
R
D
Site 54
S592
H
L
Y
L
I
K
V
S
R
D
K
I
S
D
S
Site 55
S597
K
V
S
R
D
K
I
S
D
S
N
D
Q
E
S
Site 56
S599
S
R
D
K
I
S
D
S
N
D
Q
E
S
A
N
Site 57
S651
E
A
E
L
L
V
D
S
S
L
E
Y
Y
S
F
Site 58
Y655
L
V
D
S
S
L
E
Y
Y
S
F
Y
D
D
R
Site 59
Y656
V
D
S
S
L
E
Y
Y
S
F
Y
D
D
R
Q
Site 60
S657
D
S
S
L
E
Y
Y
S
F
Y
D
D
R
Q
K
Site 61
Y659
S
L
E
Y
Y
S
F
Y
D
D
R
Q
K
R
K
Site 62
Y670
Q
K
R
K
E
L
E
Y
F
G
L
S
A
A
I
Site 63
Y686
D
K
N
F
R
K
A
Y
N
Y
I
R
I
M
V
Site 64
Y688
N
F
R
K
A
Y
N
Y
I
R
I
M
V
M
E
Site 65
S748
H
N
A
F
V
S
G
S
F
K
H
A
L
G
Q
Site 66
Y756
F
K
H
A
L
G
Q
Y
V
Q
A
F
R
T
H
Site 67
T762
Q
Y
V
Q
A
F
R
T
H
P
D
E
P
L
Y
Site 68
Y769
T
H
P
D
E
P
L
Y
S
F
C
I
G
L
T
Site 69
S782
L
T
F
I
H
M
A
S
Q
K
Y
V
L
R
R
Site 70
Y785
I
H
M
A
S
Q
K
Y
V
L
R
R
H
A
L
Site 71
Y803
G
F
S
F
L
N
R
Y
L
S
L
R
G
P
C
Site 72
S805
S
F
L
N
R
Y
L
S
L
R
G
P
C
Q
E
Site 73
S813
L
R
G
P
C
Q
E
S
F
Y
N
L
G
R
G
Site 74
Y815
G
P
C
Q
E
S
F
Y
N
L
G
R
G
L
H
Site 75
Y861
D
L
R
R
D
I
A
Y
N
L
S
L
I
Y
Q
Site 76
S864
R
D
I
A
Y
N
L
S
L
I
Y
Q
S
S
G
Site 77
Y867
A
Y
N
L
S
L
I
Y
Q
S
S
G
N
T
G
Site 78
S870
L
S
L
I
Y
Q
S
S
G
N
T
G
M
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation