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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NYREN18
Full Name:
NEDD8 ultimate buster 1
Alias:
BS4; NEDD8 ultimate buster-1; Negative regulator of ubiquitin-like proteins 1; NUB1; NY-REN-18 antigen
Type:
Ubiquitin conjugating system
Mass (Da):
70538
Number AA:
615
UniProt ID:
Q9Y5A7
International Prot ID:
IPI00377271
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y6
_
_
M
A
Q
K
K
Y
L
Q
A
K
L
T
Q
Site 2
T12
K
Y
L
Q
A
K
L
T
Q
F
L
R
E
D
R
Site 3
Y27
I
Q
L
W
K
P
P
Y
T
D
E
N
K
K
V
Site 4
T28
Q
L
W
K
P
P
Y
T
D
E
N
K
K
V
G
Site 5
S46
K
D
L
A
K
Q
Y
S
D
R
L
E
C
C
E
Site 6
T72
C
K
A
I
E
R
G
T
G
N
D
N
Y
R
T
Site 7
Y77
R
G
T
G
N
D
N
Y
R
T
T
G
I
A
T
Site 8
T80
G
N
D
N
Y
R
T
T
G
I
A
T
I
E
V
Site 9
T119
L
R
S
K
I
A
E
T
F
G
L
Q
E
N
Y
Site 10
Y126
T
F
G
L
Q
E
N
Y
I
K
I
V
I
N
K
Site 11
T141
K
Q
L
Q
L
G
K
T
L
E
E
Q
G
V
A
Site 12
S161
M
V
L
E
L
K
Q
S
E
E
D
A
R
K
N
Site 13
T210
T
V
V
D
P
E
M
T
P
Y
L
D
I
A
N
Site 14
Y212
V
D
P
E
M
T
P
Y
L
D
I
A
N
Q
T
Site 15
T219
Y
L
D
I
A
N
Q
T
G
R
S
I
R
I
P
Site 16
S222
I
A
N
Q
T
G
R
S
I
R
I
P
P
S
E
Site 17
S228
R
S
I
R
I
P
P
S
E
R
K
A
L
M
L
Site 18
Y239
A
L
M
L
A
M
G
Y
H
E
K
G
R
A
F
Site 19
Y265
C
L
L
D
A
D
K
Y
F
C
E
C
C
R
E
Site 20
Y351
L
L
Q
G
I
R
N
Y
H
S
G
N
D
V
E
Site 21
S353
Q
G
I
R
N
Y
H
S
G
N
D
V
E
A
Y
Site 22
Y360
S
G
N
D
V
E
A
Y
E
Y
L
N
K
A
R
Site 23
Y362
N
D
V
E
A
Y
E
Y
L
N
K
A
R
Q
L
Site 24
Y374
R
Q
L
F
K
E
L
Y
I
D
P
S
K
V
D
Site 25
S378
K
E
L
Y
I
D
P
S
K
V
D
N
L
L
Q
Site 26
T412
D
H
A
A
T
H
I
T
N
R
R
E
E
L
A
Site 27
Y444
R
F
L
K
G
M
G
Y
S
T
H
A
A
Q
Q
Site 28
T483
L
N
D
S
N
P
E
T
D
N
R
Q
E
S
P
Site 29
S489
E
T
D
N
R
Q
E
S
P
S
Q
E
N
I
D
Site 30
S491
D
N
R
Q
E
S
P
S
Q
E
N
I
D
R
L
Site 31
S540
L
P
P
E
L
P
L
S
P
E
D
S
L
S
P
Site 32
S544
L
P
L
S
P
E
D
S
L
S
P
P
A
T
S
Site 33
S546
L
S
P
E
D
S
L
S
P
P
A
T
S
P
S
Site 34
T550
D
S
L
S
P
P
A
T
S
P
S
D
S
A
G
Site 35
S551
S
L
S
P
P
A
T
S
P
S
D
S
A
G
T
Site 36
S553
S
P
P
A
T
S
P
S
D
S
A
G
T
S
S
Site 37
S555
P
A
T
S
P
S
D
S
A
G
T
S
S
A
S
Site 38
S559
P
S
D
S
A
G
T
S
S
A
S
T
D
E
D
Site 39
S560
S
D
S
A
G
T
S
S
A
S
T
D
E
D
M
Site 40
T563
A
G
T
S
S
A
S
T
D
E
D
M
E
T
E
Site 41
T569
S
T
D
E
D
M
E
T
E
A
V
N
E
I
L
Site 42
Y586
I
P
E
H
E
E
D
Y
L
D
S
T
L
E
D
Site 43
T590
E
E
D
Y
L
D
S
T
L
E
D
E
E
I
I
Site 44
Y601
E
E
I
I
I
A
E
Y
L
S
Y
V
E
N
R
Site 45
Y604
I
I
A
E
Y
L
S
Y
V
E
N
R
K
S
A
Site 46
S610
S
Y
V
E
N
R
K
S
A
T
K
K
N
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation