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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LAS1L
Full Name:
Protein LAS1 homolog
Alias:
FLJ12525; LAS1-like; MSTP060
Type:
Unknown function
Mass (Da):
83065
Number AA:
734
UniProt ID:
Q9Y4W2
International Prot ID:
IPI00641990
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
K
C
V
K
G
K
G
S
L
P
L
S
A
H
G
Site 2
T74
R
Y
A
L
N
R
I
T
V
W
R
S
R
S
G
Site 3
S80
I
T
V
W
R
S
R
S
G
N
E
L
P
L
A
Site 4
S90
E
L
P
L
A
V
A
S
T
A
D
L
I
R
C
Site 5
T91
L
P
L
A
V
A
S
T
A
D
L
I
R
C
K
Site 6
T103
R
C
K
L
L
D
V
T
G
G
L
G
T
D
E
Site 7
S127
V
R
F
V
N
L
I
S
E
R
K
T
K
F
A
Site 8
T131
N
L
I
S
E
R
K
T
K
F
A
K
V
P
L
Site 9
T159
V
D
L
R
H
E
L
T
H
K
K
M
P
H
I
Site 10
Y184
L
D
W
L
Q
K
T
Y
W
C
R
Q
L
E
N
Site 11
T196
L
E
N
S
L
R
E
T
W
E
L
E
E
F
R
Site 12
T223
N
I
V
V
D
D
I
T
E
Q
K
P
E
P
Q
Site 13
S235
E
P
Q
D
D
G
K
S
T
E
S
D
V
K
A
Site 14
S238
D
D
G
K
S
T
E
S
D
V
K
A
D
G
D
Site 15
S246
D
V
K
A
D
G
D
S
K
G
S
E
E
V
D
Site 16
S254
K
G
S
E
E
V
D
S
H
C
K
K
A
L
S
Site 17
S261
S
H
C
K
K
A
L
S
H
K
E
L
Y
E
R
Site 18
Y266
A
L
S
H
K
E
L
Y
E
R
A
R
E
L
L
Site 19
S275
R
A
R
E
L
L
V
S
Y
E
E
E
Q
F
T
Site 20
T282
S
Y
E
E
E
Q
F
T
V
L
E
K
F
R
Y
Site 21
Y289
T
V
L
E
K
F
R
Y
L
P
K
A
I
K
A
Site 22
S301
I
K
A
W
N
N
P
S
P
R
V
E
C
V
L
Site 23
T351
I
E
Y
E
D
G
Q
T
E
V
Q
R
G
E
G
Site 24
T359
E
V
Q
R
G
E
G
T
D
P
K
S
H
K
N
Site 25
S363
G
E
G
T
D
P
K
S
H
K
N
V
D
L
N
Site 26
S391
P
L
L
R
G
L
H
S
Q
N
F
T
Q
A
L
Site 27
T395
G
L
H
S
Q
N
F
T
Q
A
L
L
E
R
M
Site 28
S404
A
L
L
E
R
M
L
S
E
L
P
A
L
G
I
Site 29
S412
E
L
P
A
L
G
I
S
G
I
R
P
T
Y
I
Site 30
T433
L
I
V
A
N
T
K
T
G
R
N
A
R
R
F
Site 31
S441
G
R
N
A
R
R
F
S
A
G
Q
W
E
A
R
Site 32
S459
R
L
F
N
C
S
A
S
L
D
W
P
R
M
V
Site 33
S472
M
V
E
S
C
L
G
S
P
C
W
A
S
P
Q
Site 34
S505
E
K
L
L
R
I
C
S
I
Y
T
Q
S
G
E
Site 35
Y507
L
L
R
I
C
S
I
Y
T
Q
S
G
E
N
S
Site 36
T508
L
R
I
C
S
I
Y
T
Q
S
G
E
N
S
L
Site 37
S510
I
C
S
I
Y
T
Q
S
G
E
N
S
L
V
Q
Site 38
S514
Y
T
Q
S
G
E
N
S
L
V
Q
E
G
S
E
Site 39
S520
N
S
L
V
Q
E
G
S
E
A
S
P
I
G
K
Site 40
S523
V
Q
E
G
S
E
A
S
P
I
G
K
S
P
Y
Site 41
S528
E
A
S
P
I
G
K
S
P
Y
T
L
D
S
L
Site 42
Y530
S
P
I
G
K
S
P
Y
T
L
D
S
L
Y
W
Site 43
T531
P
I
G
K
S
P
Y
T
L
D
S
L
Y
W
S
Site 44
S534
K
S
P
Y
T
L
D
S
L
Y
W
S
V
K
P
Site 45
Y536
P
Y
T
L
D
S
L
Y
W
S
V
K
P
A
S
Site 46
S538
T
L
D
S
L
Y
W
S
V
K
P
A
S
S
S
Site 47
S543
Y
W
S
V
K
P
A
S
S
S
F
G
S
E
A
Site 48
S544
W
S
V
K
P
A
S
S
S
F
G
S
E
A
K
Site 49
S545
S
V
K
P
A
S
S
S
F
G
S
E
A
K
A
Site 50
S548
P
A
S
S
S
F
G
S
E
A
K
A
Q
Q
Q
Site 51
S560
Q
Q
Q
E
E
Q
G
S
V
N
D
V
K
E
E
Site 52
S612
R
M
E
V
G
P
F
S
T
G
Q
E
S
P
T
Site 53
S617
P
F
S
T
G
Q
E
S
P
T
A
E
N
A
R
Site 54
T619
S
T
G
Q
E
S
P
T
A
E
N
A
R
L
L
Site 55
S636
K
R
G
A
L
Q
G
S
A
W
Q
V
S
S
E
Site 56
S641
Q
G
S
A
W
Q
V
S
S
E
D
V
R
W
D
Site 57
T649
S
E
D
V
R
W
D
T
F
P
L
G
R
M
P
Site 58
T659
L
G
R
M
P
G
Q
T
E
D
P
A
E
L
M
Site 59
Y670
A
E
L
M
L
E
N
Y
D
T
M
Y
L
L
D
Site 60
T672
L
M
L
E
N
Y
D
T
M
Y
L
L
D
Q
P
Site 61
Y674
L
E
N
Y
D
T
M
Y
L
L
D
Q
P
V
L
Site 62
T689
E
Q
R
L
E
P
S
T
C
K
T
D
T
L
G
Site 63
T692
L
E
P
S
T
C
K
T
D
T
L
G
L
S
C
Site 64
S698
K
T
D
T
L
G
L
S
C
G
V
G
S
G
N
Site 65
S703
G
L
S
C
G
V
G
S
G
N
C
S
N
S
S
Site 66
S707
G
V
G
S
G
N
C
S
N
S
S
S
S
N
F
Site 67
S709
G
S
G
N
C
S
N
S
S
S
S
N
F
E
G
Site 68
S710
S
G
N
C
S
N
S
S
S
S
N
F
E
G
L
Site 69
S711
G
N
C
S
N
S
S
S
S
N
F
E
G
L
L
Site 70
S712
N
C
S
N
S
S
S
S
N
F
E
G
L
L
W
Site 71
S720
N
F
E
G
L
L
W
S
Q
G
Q
L
H
G
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation