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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYO5A
Full Name:
Myosin-Va
Alias:
dilute myosin heavy chain, non-muscle; GS1; heavy chain 12, myoxin; MYH12; MYO5; myosin heavy chain 12; myosin V; myosin Va; myosin, heavy polypeptide kinase; myosin-5A; myoxin; MYR12
Type:
Motor protein
Mass (Da):
215421
Number AA:
1855
UniProt ID:
Q9Y4I1
International Prot ID:
IPI00000807
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0030426
GO:0016459
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0051015
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
GO:0030048
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
D
P
E
E
V
W
K
S
A
E
L
L
K
D
Y
Site 2
Y31
S
A
E
L
L
K
D
Y
K
P
G
D
K
V
L
Site 3
Y50
E
E
G
K
D
L
E
Y
H
L
D
P
K
T
K
Site 4
T56
E
Y
H
L
D
P
K
T
K
E
L
P
H
L
R
Site 5
T75
L
V
G
E
N
D
L
T
A
L
S
Y
L
H
E
Site 6
S78
E
N
D
L
T
A
L
S
Y
L
H
E
P
A
V
Site 7
Y119
P
Y
E
Q
L
P
I
Y
G
E
D
I
I
N
A
Site 8
S158
A
R
D
E
R
N
Q
S
I
I
V
S
G
E
S
Site 9
S162
R
N
Q
S
I
I
V
S
G
E
S
G
A
G
K
Site 10
T170
G
E
S
G
A
G
K
T
V
S
A
K
Y
A
M
Site 11
S172
S
G
A
G
K
T
V
S
A
K
Y
A
M
R
Y
Site 12
Y175
G
K
T
V
S
A
K
Y
A
M
R
Y
F
A
T
Site 13
Y179
S
A
K
Y
A
M
R
Y
F
A
T
V
S
G
S
Site 14
T182
Y
A
M
R
Y
F
A
T
V
S
G
S
A
S
E
Site 15
S184
M
R
Y
F
A
T
V
S
G
S
A
S
E
A
N
Site 16
S188
A
T
V
S
G
S
A
S
E
A
N
V
E
E
K
Site 17
T198
N
V
E
E
K
V
L
T
S
N
P
I
M
E
S
Site 18
T211
E
S
I
G
N
A
K
T
T
R
N
D
N
S
S
Site 19
T212
S
I
G
N
A
K
T
T
R
N
D
N
S
S
R
Site 20
S217
K
T
T
R
N
D
N
S
S
R
F
G
K
Y
I
Site 21
S218
T
T
R
N
D
N
S
S
R
F
G
K
Y
I
E
Site 22
Y223
N
S
S
R
F
G
K
Y
I
E
I
G
F
D
K
Site 23
Y232
E
I
G
F
D
K
R
Y
R
I
I
G
A
N
M
Site 24
Y242
I
G
A
N
M
R
T
Y
L
L
E
K
S
R
V
Site 25
S247
R
T
Y
L
L
E
K
S
R
V
V
F
Q
A
E
Site 26
Y259
Q
A
E
E
E
R
N
Y
H
I
F
Y
Q
L
C
Site 27
Y263
E
R
N
Y
H
I
F
Y
Q
L
C
A
S
A
K
Site 28
Y287
G
N
A
D
N
F
N
Y
T
K
Q
G
G
S
P
Site 29
S293
N
Y
T
K
Q
G
G
S
P
V
I
E
G
V
D
Site 30
S347
F
T
S
R
D
A
D
S
C
T
I
P
P
K
H
Site 31
T349
S
R
D
A
D
S
C
T
I
P
P
K
H
E
P
Site 32
S392
E
T
Y
I
K
P
I
S
K
L
Q
A
T
N
A
Site 33
T443
L
D
I
Y
G
F
E
T
F
E
I
N
S
F
E
Site 34
Y477
F
K
L
E
Q
E
E
Y
M
K
E
Q
I
P
W
Site 35
Y528
D
T
W
A
Q
K
L
Y
N
T
H
L
N
K
C
Site 36
S544
L
F
E
K
P
R
L
S
N
K
A
F
I
I
Q
Site 37
Y559
H
F
A
D
K
V
E
Y
Q
C
E
G
F
L
E
Site 38
T571
F
L
E
K
N
K
D
T
V
F
E
E
Q
I
K
Site 39
S582
E
Q
I
K
V
L
K
S
S
K
F
K
M
L
P
Site 40
S583
Q
I
K
V
L
K
S
S
K
F
K
M
L
P
E
Site 41
S600
Q
D
D
E
K
A
I
S
P
T
S
A
T
S
S
Site 42
T602
D
E
K
A
I
S
P
T
S
A
T
S
S
G
R
Site 43
S603
E
K
A
I
S
P
T
S
A
T
S
S
G
R
T
Site 44
S607
S
P
T
S
A
T
S
S
G
R
T
P
L
T
R
Site 45
T610
S
A
T
S
S
G
R
T
P
L
T
R
T
P
A
Site 46
T613
S
S
G
R
T
P
L
T
R
T
P
A
K
P
T
Site 47
T615
G
R
T
P
L
T
R
T
P
A
K
P
T
K
G
Site 48
T634
M
A
K
E
H
K
K
T
V
G
H
Q
F
R
N
Site 49
S642
V
G
H
Q
F
R
N
S
L
H
L
L
M
E
T
Site 50
T649
S
L
H
L
L
M
E
T
L
N
A
T
T
P
H
Site 51
Y657
L
N
A
T
T
P
H
Y
V
R
C
I
K
P
N
Site 52
T671
N
D
F
K
F
P
F
T
F
D
E
K
R
A
V
Site 53
T702
A
G
F
P
S
R
W
T
Y
Q
E
F
F
S
R
Site 54
Y703
G
F
P
S
R
W
T
Y
Q
E
F
F
S
R
Y
Site 55
S721
M
K
Q
K
D
V
L
S
D
R
K
Q
T
C
K
Site 56
T726
V
L
S
D
R
K
Q
T
C
K
N
V
L
E
K
Site 57
Y741
L
I
L
D
K
D
K
Y
Q
F
G
K
T
K
I
Site 58
Y757
F
R
A
G
Q
V
A
Y
L
E
K
L
R
A
D
Site 59
Y786
G
W
L
L
R
K
K
Y
L
R
M
R
K
A
A
Site 60
T795
R
M
R
K
A
A
I
T
M
Q
R
Y
V
R
G
Site 61
Y799
A
A
I
T
M
Q
R
Y
V
R
G
Y
Q
A
R
Site 62
Y803
M
Q
R
Y
V
R
G
Y
Q
A
R
C
Y
A
K
Site 63
Y808
R
G
Y
Q
A
R
C
Y
A
K
F
L
R
R
T
Site 64
T815
Y
A
K
F
L
R
R
T
K
A
A
T
I
I
Q
Site 65
T819
L
R
R
T
K
A
A
T
I
I
Q
K
Y
W
R
Site 66
Y828
I
Q
K
Y
W
R
M
Y
V
V
R
R
R
Y
K
Site 67
Y834
M
Y
V
V
R
R
R
Y
K
I
R
R
A
A
T
Site 68
Y857
G
F
L
A
R
N
R
Y
R
K
I
L
R
E
H
Site 69
T880
V
R
G
W
L
A
R
T
H
Y
K
R
S
M
H
Site 70
Y882
G
W
L
A
R
T
H
Y
K
R
S
M
H
A
I
Site 71
Y918
E
A
R
S
V
E
R
Y
K
K
L
H
I
G
M
Site 72
Y943
V
D
E
Q
N
K
D
Y
K
C
L
V
E
K
L
Site 73
T951
K
C
L
V
E
K
L
T
N
L
E
G
I
Y
N
Site 74
S959
N
L
E
G
I
Y
N
S
E
T
E
K
L
R
S
Site 75
T961
E
G
I
Y
N
S
E
T
E
K
L
R
S
D
L
Site 76
S966
S
E
T
E
K
L
R
S
D
L
E
R
L
Q
L
Site 77
S974
D
L
E
R
L
Q
L
S
E
E
E
A
K
V
A
Site 78
S987
V
A
T
G
R
V
L
S
L
Q
E
E
I
A
K
Site 79
S1004
K
D
L
E
Q
T
R
S
E
K
K
C
I
E
E
Site 80
Y1016
I
E
E
H
A
D
R
Y
K
Q
E
T
E
Q
L
Site 81
T1020
A
D
R
Y
K
Q
E
T
E
Q
L
V
S
N
L
Site 82
S1025
Q
E
T
E
Q
L
V
S
N
L
K
E
E
N
T
Site 83
T1032
S
N
L
K
E
E
N
T
L
L
K
Q
E
K
E
Site 84
T1055
Q
A
K
E
M
T
E
T
M
E
K
K
L
V
E
Site 85
Y1078
L
N
D
E
R
L
R
Y
Q
N
L
L
N
E
F
Site 86
S1086
Q
N
L
L
N
E
F
S
R
L
E
E
R
Y
D
Site 87
Y1092
F
S
R
L
E
E
R
Y
D
D
L
K
E
E
M
Site 88
T1100
D
D
L
K
E
E
M
T
L
M
V
H
V
P
K
Site 89
T1113
P
K
P
G
H
K
R
T
D
S
T
H
S
S
N
Site 90
S1115
P
G
H
K
R
T
D
S
T
H
S
S
N
E
S
Site 91
T1116
G
H
K
R
T
D
S
T
H
S
S
N
E
S
E
Site 92
S1118
K
R
T
D
S
T
H
S
S
N
E
S
E
Y
I
Site 93
S1119
R
T
D
S
T
H
S
S
N
E
S
E
Y
I
F
Site 94
S1122
S
T
H
S
S
N
E
S
E
Y
I
F
S
S
E
Site 95
Y1124
H
S
S
N
E
S
E
Y
I
F
S
S
E
I
A
Site 96
S1127
N
E
S
E
Y
I
F
S
S
E
I
A
E
M
E
Site 97
S1128
E
S
E
Y
I
F
S
S
E
I
A
E
M
E
D
Site 98
S1138
A
E
M
E
D
I
P
S
R
T
E
E
P
S
E
Site 99
T1140
M
E
D
I
P
S
R
T
E
E
P
S
E
K
K
Site 100
S1144
P
S
R
T
E
E
P
S
E
K
K
V
P
L
D
Site 101
S1153
K
K
V
P
L
D
M
S
L
F
L
K
L
Q
K
Site 102
T1163
L
K
L
Q
K
R
V
T
E
L
E
Q
E
K
Q
Site 103
Y1203
I
R
G
A
E
L
E
Y
E
S
L
K
R
Q
E
Site 104
S1213
L
K
R
Q
E
L
E
S
E
N
K
K
L
K
N
Site 105
S1230
N
E
L
R
K
A
L
S
E
K
S
A
P
E
V
Site 106
S1233
R
K
A
L
S
E
K
S
A
P
E
V
T
A
P
Site 107
Y1245
T
A
P
G
A
P
A
Y
R
V
L
M
E
Q
L
Site 108
T1253
R
V
L
M
E
Q
L
T
S
V
S
E
E
L
D
Site 109
S1271
E
E
V
L
I
L
R
S
Q
L
V
S
Q
K
E
Site 110
S1275
I
L
R
S
Q
L
V
S
Q
K
E
A
I
Q
P
Site 111
T1288
Q
P
K
D
D
K
N
T
M
T
D
S
T
I
L
Site 112
T1290
K
D
D
K
N
T
M
T
D
S
T
I
L
L
E
Site 113
Y1312
K
G
E
I
A
Q
A
Y
I
G
L
K
E
T
N
Site 114
T1318
A
Y
I
G
L
K
E
T
N
R
S
S
A
L
D
Site 115
S1322
L
K
E
T
N
R
S
S
A
L
D
Y
H
E
L
Site 116
Y1326
N
R
S
S
A
L
D
Y
H
E
L
N
E
D
G
Site 117
Y1339
D
G
E
L
W
L
V
Y
E
G
L
K
Q
A
N
Site 118
S1351
Q
A
N
R
L
L
E
S
Q
L
Q
S
Q
K
R
Site 119
S1355
L
L
E
S
Q
L
Q
S
Q
K
R
S
H
E
N
Site 120
S1359
Q
L
Q
S
Q
K
R
S
H
E
N
E
A
E
A
Site 121
S1373
A
L
R
G
E
I
Q
S
L
K
E
E
N
N
R
Site 122
T1409
Q
H
E
I
T
R
L
T
N
E
N
L
D
L
M
Site 123
T1425
Q
L
E
K
Q
D
K
T
V
R
K
L
K
K
Q
Site 124
S1452
V
G
Q
M
E
N
I
S
P
G
Q
I
I
D
E
Site 125
Y1522
M
C
V
R
H
A
D
Y
L
N
D
D
Q
K
V
Site 126
S1531
N
D
D
Q
K
V
R
S
L
L
T
S
T
I
N
Site 127
T1534
Q
K
V
R
S
L
L
T
S
T
I
N
S
I
K
Site 128
S1535
K
V
R
S
L
L
T
S
T
I
N
S
I
K
K
Site 129
T1536
V
R
S
L
L
T
S
T
I
N
S
I
K
K
V
Site 130
S1539
L
L
T
S
T
I
N
S
I
K
K
V
L
K
K
Site 131
T1553
K
R
G
D
D
F
E
T
V
S
F
W
L
S
N
Site 132
S1572
L
H
C
L
K
Q
Y
S
G
E
E
G
F
M
K
Site 133
T1591
R
Q
N
E
H
C
L
T
N
F
D
L
A
E
Y
Site 134
T1634
S
G
M
L
E
H
E
T
I
Q
G
V
S
G
V
Site 135
T1650
P
T
G
L
R
K
R
T
S
S
I
A
D
E
G
Site 136
S1651
T
G
L
R
K
R
T
S
S
I
A
D
E
G
T
Site 137
S1652
G
L
R
K
R
T
S
S
I
A
D
E
G
T
Y
Site 138
T1658
S
S
I
A
D
E
G
T
Y
T
L
D
S
I
L
Site 139
Y1659
S
I
A
D
E
G
T
Y
T
L
D
S
I
L
R
Site 140
T1660
I
A
D
E
G
T
Y
T
L
D
S
I
L
R
Q
Site 141
S1663
E
G
T
Y
T
L
D
S
I
L
R
Q
L
N
S
Site 142
S1670
S
I
L
R
Q
L
N
S
F
H
S
V
M
C
Q
Site 143
Y1721
S
K
G
M
Q
I
R
Y
N
V
S
Q
L
E
E
Site 144
S1724
M
Q
I
R
Y
N
V
S
Q
L
E
E
W
L
R
Site 145
T1743
M
N
S
G
A
K
E
T
L
E
P
L
I
Q
A
Site 146
T1787
V
K
V
L
N
L
Y
T
P
V
N
E
F
E
E
Site 147
S1797
N
E
F
E
E
R
V
S
V
S
F
I
R
T
I
Site 148
S1814
R
L
R
D
R
K
D
S
P
Q
L
L
M
D
A
Site 149
T1828
A
K
H
I
F
P
V
T
F
P
F
N
P
S
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation