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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TLN2
Full Name:
Talin-2
Alias:
ILWEQ; KIAA0320; Talin 2
Type:
Cytoskeletal protein
Mass (Da):
271613
Number AA:
2542
UniProt ID:
Q9Y4G6
International Prot ID:
IPI00219299
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001726
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005198
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
GO:0006461
GO:0006996
GO:0007010
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y28
F
E
P
S
T
A
V
Y
D
A
C
R
V
I
R
Site 2
S47
E
A
Q
T
G
Q
A
S
D
Y
G
L
F
L
S
Site 3
Y49
Q
T
G
Q
A
S
D
Y
G
L
F
L
S
D
E
Site 4
S54
S
D
Y
G
L
F
L
S
D
E
D
P
R
K
G
Site 5
T69
I
W
L
E
A
G
R
T
L
D
Y
Y
M
L
R
Site 6
Y72
E
A
G
R
T
L
D
Y
Y
M
L
R
N
G
D
Site 7
Y73
A
G
R
T
L
D
Y
Y
M
L
R
N
G
D
I
Site 8
T101
M
L
D
G
S
V
K
T
V
M
V
D
D
S
K
Site 9
S107
K
T
V
M
V
D
D
S
K
T
V
G
E
L
L
Site 10
Y126
S
R
I
G
I
T
N
Y
E
E
Y
S
L
I
Q
Site 11
T146
K
K
E
E
G
T
G
T
L
K
K
D
R
T
L
Site 12
T152
G
T
L
K
K
D
R
T
L
L
R
D
E
R
K
Site 13
S179
D
L
N
W
L
D
H
S
R
T
F
R
E
Q
G
Site 14
T181
N
W
L
D
H
S
R
T
F
R
E
Q
G
V
D
Site 15
Y201
L
L
R
R
K
F
F
Y
S
D
Q
N
V
D
S
Site 16
S202
L
R
R
K
F
F
Y
S
D
Q
N
V
D
S
R
Site 17
S208
Y
S
D
Q
N
V
D
S
R
D
P
V
Q
L
N
Site 18
S229
R
D
D
I
L
N
G
S
H
P
V
S
F
E
K
Site 19
S233
L
N
G
S
H
P
V
S
F
E
K
A
C
E
F
Site 20
Y301
E
I
E
A
K
V
K
Y
V
K
L
A
R
S
L
Site 21
S307
K
Y
V
K
L
A
R
S
L
R
T
Y
G
V
S
Site 22
T310
K
L
A
R
S
L
R
T
Y
G
V
S
F
F
L
Site 23
S314
S
L
R
T
Y
G
V
S
F
F
L
V
K
E
K
Site 24
T336
V
P
R
L
L
G
I
T
K
D
S
V
M
R
V
Site 25
S339
L
L
G
I
T
K
D
S
V
M
R
V
D
E
K
Site 26
T347
V
M
R
V
D
E
K
T
K
E
V
L
Q
E
W
Site 27
T357
V
L
Q
E
W
P
L
T
T
V
K
R
W
A
A
Site 28
S365
T
V
K
R
W
A
A
S
P
K
S
F
T
L
D
Site 29
S368
R
W
A
A
S
P
K
S
F
T
L
D
F
G
E
Site 30
Y376
F
T
L
D
F
G
E
Y
Q
E
S
Y
Y
S
V
Site 31
S379
D
F
G
E
Y
Q
E
S
Y
Y
S
V
Q
T
T
Site 32
Y380
F
G
E
Y
Q
E
S
Y
Y
S
V
Q
T
T
E
Site 33
Y381
G
E
Y
Q
E
S
Y
Y
S
V
Q
T
T
E
G
Site 34
S382
E
Y
Q
E
S
Y
Y
S
V
Q
T
T
E
G
E
Site 35
T386
S
Y
Y
S
V
Q
T
T
E
G
E
Q
I
S
Q
Site 36
S392
T
T
E
G
E
Q
I
S
Q
L
I
A
G
Y
I
Site 37
S408
I
I
L
K
K
K
Q
S
K
D
R
F
G
L
E
Site 38
S420
G
L
E
G
D
E
E
S
T
M
L
E
E
S
V
Site 39
S426
E
S
T
M
L
E
E
S
V
S
P
K
K
S
T
Site 40
S428
T
M
L
E
E
S
V
S
P
K
K
S
T
I
L
Site 41
S432
E
S
V
S
P
K
K
S
T
I
L
Q
Q
Q
F
Site 42
S458
A
L
P
A
V
M
R
S
G
S
S
G
P
E
T
Site 43
S460
P
A
V
M
R
S
G
S
S
G
P
E
T
F
N
Site 44
T465
S
G
S
S
G
P
E
T
F
N
V
G
S
M
P
Site 45
S470
P
E
T
F
N
V
G
S
M
P
S
P
Q
Q
Q
Site 46
S473
F
N
V
G
S
M
P
S
P
Q
Q
Q
V
M
V
Site 47
T492
R
G
H
M
P
P
L
T
S
A
Q
Q
A
L
M
Site 48
S517
Q
Q
A
Q
D
D
L
S
E
L
D
S
L
P
P
Site 49
S521
D
D
L
S
E
L
D
S
L
P
P
L
G
Q
D
Site 50
S531
P
L
G
Q
D
M
A
S
R
V
W
V
Q
N
K
Site 51
S548
E
S
K
H
E
I
H
S
Q
V
D
A
I
T
A
Site 52
T588
T
T
I
S
S
N
L
T
E
M
S
K
G
V
K
Site 53
S591
S
S
N
L
T
E
M
S
K
G
V
K
L
L
A
Site 54
S607
L
M
D
D
E
V
G
S
G
E
D
L
L
R
A
Site 55
S623
R
T
L
A
G
A
V
S
D
L
L
K
A
V
Q
Site 56
T632
L
L
K
A
V
Q
P
T
S
G
E
P
R
Q
T
Site 57
S633
L
K
A
V
Q
P
T
S
G
E
P
R
Q
T
V
Site 58
T639
T
S
G
E
P
R
Q
T
V
L
T
A
A
G
S
Site 59
T642
E
P
R
Q
T
V
L
T
A
A
G
S
I
G
Q
Site 60
S651
A
G
S
I
G
Q
A
S
G
D
L
L
R
Q
I
Site 61
S673
R
F
Q
D
V
L
M
S
L
A
K
A
V
A
N
Site 62
S731
K
V
V
S
P
T
I
S
S
P
V
C
Q
E
Q
Site 63
S749
A
G
K
L
V
D
R
S
V
E
N
C
V
R
A
Site 64
Y801
R
G
E
P
I
G
R
Y
D
Q
A
T
D
T
I
Site 65
T807
R
Y
D
Q
A
T
D
T
I
M
C
V
T
E
S
Site 66
S818
V
T
E
S
I
F
S
S
M
G
D
A
G
E
M
Site 67
S845
D
L
V
N
A
M
R
S
D
A
E
A
E
I
D
Site 68
T904
A
E
G
L
R
V
A
T
N
A
A
A
Q
N
A
Site 69
S938
A
T
Q
T
I
A
A
S
Q
N
A
A
V
S
N
Site 70
S975
L
V
Q
G
V
R
G
S
Q
A
Q
A
E
D
L
Site 71
S1000
Q
N
F
L
Q
P
G
S
K
M
V
S
S
A
K
Site 72
S1004
Q
P
G
S
K
M
V
S
S
A
K
A
A
V
P
Site 73
S1040
L
A
E
L
R
T
A
S
Q
K
A
H
E
A
C
Site 74
S1054
C
G
P
M
E
I
D
S
A
L
N
T
V
Q
T
Site 75
T1058
E
I
D
S
A
L
N
T
V
Q
T
L
K
N
E
Site 76
T1061
S
A
L
N
T
V
Q
T
L
K
N
E
L
Q
D
Site 77
S1076
A
K
M
A
A
V
E
S
Q
L
K
P
L
P
G
Site 78
S1095
K
C
A
Q
D
L
G
S
T
S
K
A
V
G
S
Site 79
S1097
A
Q
D
L
G
S
T
S
K
A
V
G
S
S
M
Site 80
T1109
S
S
M
A
Q
L
L
T
C
A
A
Q
G
N
E
Site 81
Y1118
A
A
Q
G
N
E
H
Y
T
G
V
A
A
R
E
Site 82
T1132
E
T
A
Q
A
L
K
T
L
A
Q
A
A
R
G
Site 83
S1156
A
A
H
A
M
L
D
S
A
R
D
V
M
E
G
Site 84
S1217
D
V
D
V
A
L
K
S
I
G
E
S
S
K
K
Site 85
S1221
A
L
K
S
I
G
E
S
S
K
K
L
L
V
D
Site 86
S1229
S
K
K
L
L
V
D
S
L
P
P
S
T
K
P
Site 87
S1233
L
V
D
S
L
P
P
S
T
K
P
F
Q
E
A
Site 88
T1262
A
G
E
V
V
H
A
T
R
G
Q
S
G
E
L
Site 89
S1266
V
H
A
T
R
G
Q
S
G
E
L
A
A
A
S
Site 90
S1273
S
G
E
L
A
A
A
S
G
K
F
S
D
D
F
Site 91
S1277
A
A
A
S
G
K
F
S
D
D
F
D
E
F
L
Site 92
T1353
E
S
I
N
Q
L
I
T
L
C
T
Q
Q
A
P
Site 93
T1374
N
A
L
R
E
L
E
T
V
K
G
M
L
D
N
Site 94
S1387
D
N
P
N
E
P
V
S
D
L
S
Y
F
D
C
Site 95
S1390
N
E
P
V
S
D
L
S
Y
F
D
C
I
E
S
Site 96
Y1391
E
P
V
S
D
L
S
Y
F
D
C
I
E
S
V
Site 97
S1408
N
S
K
V
L
G
E
S
M
A
G
I
S
Q
N
Site 98
S1413
G
E
S
M
A
G
I
S
Q
N
A
K
T
G
D
Site 99
S1452
A
A
Y
L
V
G
I
S
D
P
N
S
Q
A
G
Site 100
S1456
V
G
I
S
D
P
N
S
Q
A
G
H
Q
G
L
Site 101
S1488
Q
N
L
V
D
P
G
S
S
P
S
Q
V
L
S
Site 102
S1489
N
L
V
D
P
G
S
S
P
S
Q
V
L
S
A
Site 103
S1491
V
D
P
G
S
S
P
S
Q
V
L
S
A
A
T
Site 104
S1515
C
N
A
C
R
I
A
S
S
K
T
A
N
P
V
Site 105
S1530
A
K
R
H
F
V
Q
S
A
K
E
V
A
N
S
Site 106
S1553
K
A
L
D
G
D
F
S
E
D
N
R
N
K
C
Site 107
S1585
A
S
N
P
E
F
V
S
I
P
A
Q
I
S
S
Site 108
S1591
V
S
I
P
A
Q
I
S
S
E
G
S
Q
A
Q
Site 109
S1592
S
I
P
A
Q
I
S
S
E
G
S
Q
A
Q
E
Site 110
S1595
A
Q
I
S
S
E
G
S
Q
A
Q
E
P
I
L
Site 111
S1611
S
A
K
T
M
L
E
S
S
S
Y
L
I
R
T
Site 112
S1613
K
T
M
L
E
S
S
S
Y
L
I
R
T
A
R
Site 113
Y1614
T
M
L
E
S
S
S
Y
L
I
R
T
A
R
S
Site 114
T1618
S
S
S
Y
L
I
R
T
A
R
S
L
A
I
N
Site 115
T1631
I
N
P
K
D
P
P
T
W
S
V
L
A
G
H
Site 116
S1633
P
K
D
P
P
T
W
S
V
L
A
G
H
S
H
Site 117
S1639
W
S
V
L
A
G
H
S
H
T
V
S
D
S
I
Site 118
T1641
V
L
A
G
H
S
H
T
V
S
D
S
I
K
S
Site 119
S1643
A
G
H
S
H
T
V
S
D
S
I
K
S
L
I
Site 120
S1645
H
S
H
T
V
S
D
S
I
K
S
L
I
T
S
Site 121
S1648
T
V
S
D
S
I
K
S
L
I
T
S
I
R
D
Site 122
S1652
S
I
K
S
L
I
T
S
I
R
D
K
A
P
G
Site 123
Y1665
P
G
Q
R
E
C
D
Y
S
I
D
G
I
N
R
Site 124
S1666
G
Q
R
E
C
D
Y
S
I
D
G
I
N
R
C
Site 125
S1681
I
R
D
I
E
Q
A
S
L
A
A
V
S
Q
S
Site 126
S1686
Q
A
S
L
A
A
V
S
Q
S
L
A
T
R
D
Site 127
S1696
L
A
T
R
D
D
I
S
V
E
A
L
Q
E
Q
Site 128
T1705
E
A
L
Q
E
Q
L
T
S
V
V
Q
E
I
G
Site 129
S1706
A
L
Q
E
Q
L
T
S
V
V
Q
E
I
G
H
Site 130
T1734
A
Q
L
G
H
K
V
T
Q
L
A
S
Y
F
E
Site 131
T1762
L
D
H
Q
Q
Q
M
T
V
L
D
Q
T
K
T
Site 132
T1769
T
V
L
D
Q
T
K
T
L
A
E
S
A
L
Q
Site 133
Y1779
E
S
A
L
Q
M
L
Y
A
A
K
E
G
G
G
Site 134
T1793
G
N
P
K
A
Q
H
T
H
D
A
I
T
E
A
Site 135
T1798
Q
H
T
H
D
A
I
T
E
A
A
Q
L
M
K
Site 136
T1843
M
S
K
L
D
E
G
T
P
P
E
P
K
G
T
Site 137
T1850
T
P
P
E
P
K
G
T
F
V
D
Y
Q
T
T
Site 138
Y1854
P
K
G
T
F
V
D
Y
Q
T
T
V
V
K
Y
Site 139
T1856
G
T
F
V
D
Y
Q
T
T
V
V
K
Y
S
K
Site 140
S1876
A
Q
E
M
M
T
K
S
V
T
N
P
E
E
L
Site 141
S1888
E
E
L
G
G
L
A
S
Q
M
T
S
D
Y
G
Site 142
S1892
G
L
A
S
Q
M
T
S
D
Y
G
H
L
A
F
Site 143
Y1894
A
S
Q
M
T
S
D
Y
G
H
L
A
F
Q
G
Site 144
T1907
Q
G
Q
M
A
A
A
T
A
E
P
E
E
I
G
Site 145
S1945
L
Q
V
C
P
T
D
S
Y
T
K
R
E
L
I
Site 146
Y1946
Q
V
C
P
T
D
S
Y
T
K
R
E
L
I
E
Site 147
T1947
V
C
P
T
D
S
Y
T
K
R
E
L
I
E
C
Site 148
S2010
G
T
L
N
A
E
N
S
E
T
F
A
D
H
R
Site 149
T2012
L
N
A
E
N
S
E
T
F
A
D
H
R
E
N
Site 150
S2036
E
D
T
K
L
L
V
S
G
A
A
S
T
P
D
Site 151
S2072
L
G
A
A
S
L
G
S
D
D
P
E
T
Q
V
Site 152
T2077
L
G
S
D
D
P
E
T
Q
V
V
L
I
N
A
Site 153
S2093
K
D
V
A
K
A
L
S
D
L
I
S
A
T
K
Site 154
S2111
S
K
P
V
D
D
P
S
M
Y
Q
L
K
G
A
Site 155
Y2113
P
V
D
D
P
S
M
Y
Q
L
K
G
A
A
K
Site 156
S2128
V
M
V
T
N
V
T
S
L
L
K
T
V
K
A
Site 157
T2132
N
V
T
S
L
L
K
T
V
K
A
V
E
D
E
Site 158
T2141
K
A
V
E
D
E
A
T
R
G
T
R
A
L
E
Site 159
T2144
E
D
E
A
T
R
G
T
R
A
L
E
A
T
I
Site 160
T2150
G
T
R
A
L
E
A
T
I
E
C
I
K
Q
E
Site 161
T2159
E
C
I
K
Q
E
L
T
V
F
Q
S
K
D
V
Site 162
T2170
S
K
D
V
P
E
K
T
S
S
P
E
E
S
I
Site 163
S2172
D
V
P
E
K
T
S
S
P
E
E
S
I
R
M
Site 164
S2176
K
T
S
S
P
E
E
S
I
R
M
T
K
G
I
Site 165
T2180
P
E
E
S
I
R
M
T
K
G
I
T
M
A
T
Site 166
S2196
K
A
V
A
A
G
N
S
C
R
Q
E
D
V
I
Site 167
S2224
L
T
A
C
K
Q
A
S
F
H
P
D
V
S
D
Site 168
S2230
A
S
F
H
P
D
V
S
D
E
V
R
T
R
A
Site 169
T2263
L
V
I
L
Q
K
P
T
P
E
F
K
Q
Q
L
Site 170
T2282
K
R
V
A
G
A
V
T
E
L
I
Q
A
A
E
Site 171
T2303
W
V
D
P
E
D
P
T
V
I
A
E
T
E
L
Site 172
T2339
K
P
K
Q
A
D
E
T
L
D
F
E
E
Q
I
Site 173
S2358
K
S
I
A
A
A
T
S
A
L
V
K
S
A
S
Site 174
S2391
A
A
D
D
G
Q
W
S
Q
G
L
I
S
A
A
Site 175
S2421
A
S
V
Q
G
H
A
S
E
E
K
L
I
S
S
Site 176
S2427
A
S
E
E
K
L
I
S
S
A
K
Q
V
A
A
Site 177
S2451
K
V
K
A
D
Q
D
S
E
A
M
R
R
L
Q
Site 178
S2468
G
N
A
V
K
R
A
S
D
N
L
V
R
A
A
Site 179
Y2530
A
Q
I
R
Q
Q
Q
Y
K
F
L
P
T
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation