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Updated November 2019
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Protein Info
Short Name:
KIAA0284
Full Name:
Protein KIAA0284
Alias:
FAM68C; K0284; Loc283638; LOC283638
Type:
Microtubule, Cytoplasm, Cytoskeleton protein
Mass (Da):
171688
Number AA:
1589
UniProt ID:
Q9Y4F5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005874
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
T
S
W
F
L
V
S
S
S
G
A
R
H
R
Site 2
S11
T
S
W
F
L
V
S
S
S
G
A
R
H
R
L
Site 3
S12
S
W
F
L
V
S
S
S
G
A
R
H
R
L
P
Site 4
S38
E
L
M
L
Q
S
R
S
V
D
K
Q
H
A
V
Site 5
T66
D
L
G
S
L
N
G
T
F
V
N
D
M
R
I
Site 6
Y78
M
R
I
P
D
Q
K
Y
V
T
L
K
L
N
D
Site 7
Y91
N
D
V
I
R
F
G
Y
D
S
N
M
Y
V
L
Site 8
Y96
F
G
Y
D
S
N
M
Y
V
L
E
R
V
Q
H
Site 9
Y115
E
A
L
K
H
E
K
Y
T
S
Q
L
Q
V
S
Site 10
S117
L
K
H
E
K
Y
T
S
Q
L
Q
V
S
V
K
Site 11
S131
K
G
L
A
P
K
R
S
E
A
L
P
E
H
T
Site 12
T138
S
E
A
L
P
E
H
T
P
Y
C
E
A
S
N
Site 13
Y140
A
L
P
E
H
T
P
Y
C
E
A
S
N
P
R
Site 14
T157
K
G
D
R
R
P
G
T
E
A
A
S
Y
R
T
Site 15
S161
R
P
G
T
E
A
A
S
Y
R
T
P
L
Y
G
Site 16
Y162
P
G
T
E
A
A
S
Y
R
T
P
L
Y
G
Q
Site 17
T164
T
E
A
A
S
Y
R
T
P
L
Y
G
Q
P
S
Site 18
Y167
A
S
Y
R
T
P
L
Y
G
Q
P
S
W
W
G
Site 19
S179
W
W
G
E
D
D
G
S
T
L
P
D
A
Q
R
Site 20
T180
W
G
E
D
D
G
S
T
L
P
D
A
Q
R
Q
Site 21
Y191
A
Q
R
Q
G
E
P
Y
P
E
R
P
K
G
P
Site 22
S218
P
A
E
P
Q
G
C
S
F
R
R
E
P
S
Y
Site 23
S224
C
S
F
R
R
E
P
S
Y
F
E
I
P
T
K
Site 24
Y225
S
F
R
R
E
P
S
Y
F
E
I
P
T
K
E
Site 25
T233
F
E
I
P
T
K
E
T
P
Q
P
S
Q
P
P
Site 26
S237
T
K
E
T
P
Q
P
S
Q
P
P
E
V
P
A
Site 27
S268
P
V
V
Q
S
H
A
S
F
T
I
E
F
D
D
Site 28
S277
T
I
E
F
D
D
C
S
P
G
K
M
K
I
K
Site 29
S291
K
D
H
I
T
K
F
S
L
R
Q
R
R
P
P
Site 30
T303
R
P
P
G
K
E
A
T
P
G
E
M
V
S
A
Site 31
S309
A
T
P
G
E
M
V
S
A
E
T
K
V
A
D
Site 32
S324
W
L
V
Q
N
D
P
S
L
L
H
R
V
G
P
Site 33
S337
G
P
G
D
D
R
H
S
T
K
S
D
L
P
V
Site 34
T338
P
G
D
D
R
H
S
T
K
S
D
L
P
V
H
Site 35
S340
D
D
R
H
S
T
K
S
D
L
P
V
H
T
R
Site 36
T348
D
L
P
V
H
T
R
T
L
K
G
H
K
H
E
Site 37
T358
G
H
K
H
E
D
G
T
Q
S
D
S
E
D
P
Site 38
S360
K
H
E
D
G
T
Q
S
D
S
E
D
P
L
A
Site 39
S362
E
D
G
T
Q
S
D
S
E
D
P
L
A
K
A
Site 40
T413
I
E
F
F
D
E
D
T
P
R
K
K
R
S
Q
Site 41
S419
D
T
P
R
K
K
R
S
Q
S
F
T
H
S
P
Site 42
S421
P
R
K
K
R
S
Q
S
F
T
H
S
P
S
G
Site 43
T423
K
K
R
S
Q
S
F
T
H
S
P
S
G
D
P
Site 44
S425
R
S
Q
S
F
T
H
S
P
S
G
D
P
K
A
Site 45
S427
Q
S
F
T
H
S
P
S
G
D
P
K
A
D
K
Site 46
T439
A
D
K
R
R
G
P
T
P
A
D
R
D
R
P
Site 47
S447
P
A
D
R
D
R
P
S
V
P
A
P
V
Q
A
Site 48
S458
P
V
Q
A
G
G
R
S
S
G
P
Q
R
A
G
Site 49
S459
V
Q
A
G
G
R
S
S
G
P
Q
R
A
G
S
Site 50
S466
S
G
P
Q
R
A
G
S
L
K
R
E
K
T
E
Site 51
T472
G
S
L
K
R
E
K
T
E
E
R
L
G
S
P
Site 52
S478
K
T
E
E
R
L
G
S
P
S
P
A
S
R
T
Site 53
S480
E
E
R
L
G
S
P
S
P
A
S
R
T
P
A
Site 54
S483
L
G
S
P
S
P
A
S
R
T
P
A
R
P
F
Site 55
T485
S
P
S
P
A
S
R
T
P
A
R
P
F
G
S
Site 56
S492
T
P
A
R
P
F
G
S
V
G
R
R
S
R
L
Site 57
S497
F
G
S
V
G
R
R
S
R
L
A
Q
D
F
M
Site 58
S511
M
A
Q
C
L
R
E
S
S
P
A
A
R
P
S
Site 59
S512
A
Q
C
L
R
E
S
S
P
A
A
R
P
S
P
Site 60
S518
S
S
P
A
A
R
P
S
P
E
K
V
P
P
V
Site 61
T531
P
V
L
P
A
P
L
T
P
H
G
T
S
P
V
Site 62
T535
A
P
L
T
P
H
G
T
S
P
V
G
P
P
T
Site 63
S536
P
L
T
P
H
G
T
S
P
V
G
P
P
T
P
Site 64
T542
T
S
P
V
G
P
P
T
P
P
P
A
P
T
D
Site 65
S563
R
K
Q
E
E
D
D
S
L
S
D
A
G
T
Y
Site 66
S565
Q
E
E
D
D
S
L
S
D
A
G
T
Y
T
I
Site 67
T569
D
S
L
S
D
A
G
T
Y
T
I
E
T
E
A
Site 68
T579
I
E
T
E
A
Q
D
T
E
V
E
E
A
R
K
Site 69
S597
Q
V
F
G
V
L
E
S
P
E
L
S
R
A
S
Site 70
S601
V
L
E
S
P
E
L
S
R
A
S
S
A
T
F
Site 71
S604
S
P
E
L
S
R
A
S
S
A
T
F
R
P
V
Site 72
S605
P
E
L
S
R
A
S
S
A
T
F
R
P
V
I
Site 73
T607
L
S
R
A
S
S
A
T
F
R
P
V
I
R
G
Site 74
S619
I
R
G
D
R
D
E
S
D
D
G
G
V
A
Q
Site 75
S636
A
L
L
Q
E
F
A
S
R
P
L
G
A
A
P
Site 76
S655
Q
G
L
P
V
P
G
S
P
G
G
Q
K
W
V
Site 77
S663
P
G
G
Q
K
W
V
S
R
W
A
S
L
A
D
Site 78
S667
K
W
V
S
R
W
A
S
L
A
D
S
Y
S
D
Site 79
S671
R
W
A
S
L
A
D
S
Y
S
D
P
G
L
T
Site 80
Y672
W
A
S
L
A
D
S
Y
S
D
P
G
L
T
E
Site 81
S673
A
S
L
A
D
S
Y
S
D
P
G
L
T
E
D
Site 82
T678
S
Y
S
D
P
G
L
T
E
D
G
L
G
R
R
Site 83
S692
R
G
G
E
P
E
G
S
L
P
V
R
M
R
R
Site 84
S706
R
R
L
P
Q
L
P
S
E
R
A
D
S
P
A
Site 85
S711
L
P
S
E
R
A
D
S
P
A
G
P
E
S
S
Site 86
S717
D
S
P
A
G
P
E
S
S
R
R
S
G
P
G
Site 87
S718
S
P
A
G
P
E
S
S
R
R
S
G
P
G
P
Site 88
S721
G
P
E
S
S
R
R
S
G
P
G
P
P
E
L
Site 89
S730
P
G
P
P
E
L
D
S
E
Q
P
S
R
L
F
Site 90
S734
E
L
D
S
E
Q
P
S
R
L
F
G
Q
E
E
Site 91
S746
Q
E
E
L
D
P
D
S
L
S
D
A
S
G
S
Site 92
S748
E
L
D
P
D
S
L
S
D
A
S
G
S
D
G
Site 93
S751
P
D
S
L
S
D
A
S
G
S
D
G
G
R
G
Site 94
S753
S
L
S
D
A
S
G
S
D
G
G
R
G
P
E
Site 95
S768
P
G
V
E
P
Q
D
S
R
R
R
S
P
Q
E
Site 96
S772
P
Q
D
S
R
R
R
S
P
Q
E
G
P
T
W
Site 97
T778
R
S
P
Q
E
G
P
T
W
S
R
G
R
R
S
Site 98
S780
P
Q
E
G
P
T
W
S
R
G
R
R
S
P
R
Site 99
S785
T
W
S
R
G
R
R
S
P
R
A
P
G
E
P
Site 100
T793
P
R
A
P
G
E
P
T
P
A
S
F
F
I
G
Site 101
S796
P
G
E
P
T
P
A
S
F
F
I
G
D
Q
N
Site 102
T825
D
G
E
G
L
G
Q
T
A
Q
P
S
P
P
A
Site 103
S829
L
G
Q
T
A
Q
P
S
P
P
A
R
D
G
V
Site 104
Y837
P
P
A
R
D
G
V
Y
V
S
A
N
G
R
M
Site 105
S853
I
Q
L
R
P
G
R
S
P
E
P
D
G
P
A
Site 106
S868
P
A
F
L
R
Q
E
S
F
T
K
E
P
A
S
Site 107
T870
F
L
R
Q
E
S
F
T
K
E
P
A
S
G
P
Site 108
S875
S
F
T
K
E
P
A
S
G
P
P
A
P
G
K
Site 109
S887
P
G
K
P
P
H
I
S
S
H
P
L
L
Q
D
Site 110
S888
G
K
P
P
H
I
S
S
H
P
L
L
Q
D
L
Site 111
S907
A
A
R
M
D
F
H
S
Q
D
T
H
L
I
L
Site 112
S932
E
A
R
L
L
S
N
S
V
D
A
E
C
E
G
Site 113
T942
A
E
C
E
G
G
S
T
P
R
P
P
E
D
A
Site 114
S951
R
P
P
E
D
A
L
S
G
D
S
D
V
D
T
Site 115
S954
E
D
A
L
S
G
D
S
D
V
D
T
A
S
T
Site 116
T958
S
G
D
S
D
V
D
T
A
S
T
V
S
L
R
Site 117
S960
D
S
D
V
D
T
A
S
T
V
S
L
R
S
G
Site 118
T961
S
D
V
D
T
A
S
T
V
S
L
R
S
G
K
Site 119
S963
V
D
T
A
S
T
V
S
L
R
S
G
K
S
G
Site 120
S966
A
S
T
V
S
L
R
S
G
K
S
G
P
S
P
Site 121
S969
V
S
L
R
S
G
K
S
G
P
S
P
T
T
P
Site 122
S972
R
S
G
K
S
G
P
S
P
T
T
P
Q
P
L
Site 123
T975
K
S
G
P
S
P
T
T
P
Q
P
L
R
A
Q
Site 124
S986
L
R
A
Q
K
E
M
S
P
S
P
P
A
A
Q
Site 125
S988
A
Q
K
E
M
S
P
S
P
P
A
A
Q
D
P
Site 126
S1002
P
G
G
T
A
L
V
S
A
R
E
Q
S
S
E
Site 127
S1007
L
V
S
A
R
E
Q
S
S
E
R
Q
H
H
P
Site 128
S1008
V
S
A
R
E
Q
S
S
E
R
Q
H
H
P
L
Site 129
S1029
R
G
E
P
V
R
R
S
A
I
R
R
G
H
R
Site 130
S1040
R
G
H
R
P
R
G
S
L
D
W
P
S
E
E
Site 131
S1045
R
G
S
L
D
W
P
S
E
E
R
G
P
V
L
Site 132
S1063
P
S
S
D
V
M
A
S
N
H
E
T
P
E
A
Site 133
T1067
V
M
A
S
N
H
E
T
P
E
A
T
G
A
G
Site 134
S1078
T
G
A
G
R
L
G
S
R
R
K
P
A
A
P
Site 135
S1088
K
P
A
A
P
P
P
S
P
A
A
R
E
E
Q
Site 136
S1096
P
A
A
R
E
E
Q
S
R
S
S
A
S
S
Q
Site 137
S1098
A
R
E
E
Q
S
R
S
S
A
S
S
Q
K
G
Site 138
S1099
R
E
E
Q
S
R
S
S
A
S
S
Q
K
G
P
Site 139
S1101
E
Q
S
R
S
S
A
S
S
Q
K
G
P
Q
A
Site 140
S1102
Q
S
R
S
S
A
S
S
Q
K
G
P
Q
A
L
Site 141
T1110
Q
K
G
P
Q
A
L
T
R
S
N
S
L
S
T
Site 142
S1112
G
P
Q
A
L
T
R
S
N
S
L
S
T
P
R
Site 143
S1114
Q
A
L
T
R
S
N
S
L
S
T
P
R
P
T
Site 144
S1116
L
T
R
S
N
S
L
S
T
P
R
P
T
R
A
Site 145
T1117
T
R
S
N
S
L
S
T
P
R
P
T
R
A
S
Site 146
T1121
S
L
S
T
P
R
P
T
R
A
S
R
L
R
R
Site 147
S1124
T
P
R
P
T
R
A
S
R
L
R
R
A
R
L
Site 148
S1135
R
A
R
L
G
D
A
S
D
T
E
A
A
D
G
Site 149
T1137
R
L
G
D
A
S
D
T
E
A
A
D
G
E
R
Site 150
S1146
A
A
D
G
E
R
G
S
L
G
N
P
E
P
V
Site 151
S1179
M
P
R
K
R
A
G
S
F
T
G
T
S
D
P
Site 152
T1181
R
K
R
A
G
S
F
T
G
T
S
D
P
E
A
Site 153
T1183
R
A
G
S
F
T
G
T
S
D
P
E
A
A
P
Site 154
S1184
A
G
S
F
T
G
T
S
D
P
E
A
A
P
A
Site 155
S1194
E
A
A
P
A
R
T
S
F
S
G
R
S
V
E
Site 156
S1196
A
P
A
R
T
S
F
S
G
R
S
V
E
L
C
Site 157
S1199
R
T
S
F
S
G
R
S
V
E
L
C
C
A
S
Site 158
T1210
C
C
A
S
R
K
P
T
M
A
E
A
R
A
V
Site 159
S1218
M
A
E
A
R
A
V
S
R
K
A
A
N
T
A
Site 160
T1224
V
S
R
K
A
A
N
T
A
T
T
T
G
P
R
Site 161
T1227
K
A
A
N
T
A
T
T
T
G
P
R
Q
P
F
Site 162
S1235
T
G
P
R
Q
P
F
S
R
A
R
S
G
S
A
Site 163
S1239
Q
P
F
S
R
A
R
S
G
S
A
R
Y
T
S
Site 164
S1241
F
S
R
A
R
S
G
S
A
R
Y
T
S
N
T
Site 165
T1245
R
S
G
S
A
R
Y
T
S
N
T
R
R
R
Q
Site 166
S1246
S
G
S
A
R
Y
T
S
N
T
R
R
R
Q
Q
Site 167
T1248
S
A
R
Y
T
S
N
T
R
R
R
Q
Q
G
S
Site 168
S1255
T
R
R
R
Q
Q
G
S
D
Y
T
S
T
S
E
Site 169
Y1257
R
R
Q
Q
G
S
D
Y
T
S
T
S
E
E
E
Site 170
T1258
R
Q
Q
G
S
D
Y
T
S
T
S
E
E
E
Y
Site 171
S1259
Q
Q
G
S
D
Y
T
S
T
S
E
E
E
Y
G
Site 172
S1261
G
S
D
Y
T
S
T
S
E
E
E
Y
G
S
R
Site 173
Y1265
T
S
T
S
E
E
E
Y
G
S
R
H
G
S
P
Site 174
S1267
T
S
E
E
E
Y
G
S
R
H
G
S
P
K
H
Site 175
S1271
E
Y
G
S
R
H
G
S
P
K
H
T
R
S
H
Site 176
T1275
R
H
G
S
P
K
H
T
R
S
H
T
S
T
A
Site 177
S1277
G
S
P
K
H
T
R
S
H
T
S
T
A
T
Q
Site 178
T1279
P
K
H
T
R
S
H
T
S
T
A
T
Q
T
P
Site 179
S1280
K
H
T
R
S
H
T
S
T
A
T
Q
T
P
R
Site 180
T1281
H
T
R
S
H
T
S
T
A
T
Q
T
P
R
A
Site 181
T1283
R
S
H
T
S
T
A
T
Q
T
P
R
A
G
S
Site 182
T1285
H
T
S
T
A
T
Q
T
P
R
A
G
S
S
S
Site 183
S1290
T
Q
T
P
R
A
G
S
S
S
R
A
R
S
R
Site 184
S1291
Q
T
P
R
A
G
S
S
S
R
A
R
S
R
A
Site 185
S1292
T
P
R
A
G
S
S
S
R
A
R
S
R
A
P
Site 186
S1296
G
S
S
S
R
A
R
S
R
A
P
G
P
R
D
Site 187
T1304
R
A
P
G
P
R
D
T
D
D
D
E
E
E
P
Site 188
Y1314
D
E
E
E
P
D
P
Y
G
F
I
V
Q
T
A
Site 189
T1353
D
V
A
G
D
G
D
T
L
G
S
S
E
P
A
Site 190
S1356
G
D
G
D
T
L
G
S
S
E
P
A
H
S
A
Site 191
S1357
D
G
D
T
L
G
S
S
E
P
A
H
S
A
S
Site 192
S1362
G
S
S
E
P
A
H
S
A
S
L
S
N
M
P
Site 193
S1364
S
E
P
A
H
S
A
S
L
S
N
M
P
S
T
Site 194
S1366
P
A
H
S
A
S
L
S
N
M
P
S
T
P
A
Site 195
S1370
A
S
L
S
N
M
P
S
T
P
A
S
T
I
S
Site 196
T1371
S
L
S
N
M
P
S
T
P
A
S
T
I
S
A
Site 197
S1374
N
M
P
S
T
P
A
S
T
I
S
A
R
E
E
Site 198
S1377
S
T
P
A
S
T
I
S
A
R
E
E
L
V
Q
Site 199
S1390
V
Q
R
I
P
E
A
S
L
N
F
Q
K
V
P
Site 200
S1400
F
Q
K
V
P
P
G
S
L
N
S
R
D
F
D
Site 201
S1441
N
L
M
L
N
P
V
S
Q
L
S
Q
A
I
R
Site 202
S1444
L
N
P
V
S
Q
L
S
Q
A
I
R
E
N
T
Site 203
T1451
S
Q
A
I
R
E
N
T
E
H
L
A
E
K
M
Site 204
T1465
M
K
I
L
F
Q
N
T
G
R
A
W
E
D
L
Site 205
S1494
T
S
N
K
E
I
S
S
I
L
K
E
L
R
R
Site 206
S1516
I
N
A
I
V
D
P
S
G
S
L
D
L
L
T
Site 207
T1523
S
G
S
L
D
L
L
T
G
N
R
S
L
A
S
Site 208
S1527
D
L
L
T
G
N
R
S
L
A
S
S
A
Q
P
Site 209
S1530
T
G
N
R
S
L
A
S
S
A
Q
P
G
L
G
Site 210
S1531
G
N
R
S
L
A
S
S
A
Q
P
G
L
G
K
Site 211
S1545
K
G
R
V
A
A
Q
S
P
P
S
P
A
S
A
Site 212
S1548
V
A
A
Q
S
P
P
S
P
A
S
A
E
A
L
Site 213
S1551
Q
S
P
P
S
P
A
S
A
E
A
L
L
P
A
Site 214
S1569
R
N
F
P
Q
R
A
S
C
G
P
P
S
L
P
Site 215
S1574
R
A
S
C
G
P
P
S
L
P
D
P
T
F
L
Site 216
T1579
P
P
S
L
P
D
P
T
F
L
P
D
A
E
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation