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Updated November 2019
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Protein Info
Short Name:
KIAA0423
Full Name:
Protein FAM179B
Alias:
DKFZp686D12126; Family with sequence similarity 179, member B; K0423; LOC23116
Type:
Unknown function
Mass (Da):
189390
Number AA:
UniProt ID:
Q9Y4F4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
L
P
P
F
P
V
L
S
T
Y
R
L
Q
S
R
Site 2
T19
P
P
F
P
V
L
S
T
Y
R
L
Q
S
R
S
Site 3
Y20
P
F
P
V
L
S
T
Y
R
L
Q
S
R
S
R
Site 4
S24
L
S
T
Y
R
L
Q
S
R
S
R
P
S
A
P
Site 5
S26
T
Y
R
L
Q
S
R
S
R
P
S
A
P
E
T
Site 6
S29
L
Q
S
R
S
R
P
S
A
P
E
T
D
D
S
Site 7
T33
S
R
P
S
A
P
E
T
D
D
S
R
V
G
G
Site 8
S36
S
A
P
E
T
D
D
S
R
V
G
G
I
M
R
Site 9
Y48
I
M
R
G
E
K
N
Y
Y
F
R
G
A
A
G
Site 10
Y49
M
R
G
E
K
N
Y
Y
F
R
G
A
A
G
D
Site 11
S59
G
A
A
G
D
H
G
S
C
P
T
T
T
S
P
Site 12
T63
D
H
G
S
C
P
T
T
T
S
P
L
A
S
A
Site 13
S79
L
M
P
S
E
A
V
S
S
S
W
S
E
S
G
Site 14
S80
M
P
S
E
A
V
S
S
S
W
S
E
S
G
G
Site 15
S81
P
S
E
A
V
S
S
S
W
S
E
S
G
G
G
Site 16
S83
E
A
V
S
S
S
W
S
E
S
G
G
G
L
S
Site 17
S85
V
S
S
S
W
S
E
S
G
G
G
L
S
G
G
Site 18
S90
S
E
S
G
G
G
L
S
G
G
D
E
E
D
T
Site 19
T97
S
G
G
D
E
E
D
T
R
L
L
Q
L
L
R
Site 20
T105
R
L
L
Q
L
L
R
T
A
R
D
P
S
E
A
Site 21
S110
L
R
T
A
R
D
P
S
E
A
F
Q
A
L
Q
Site 22
Y137
P
R
R
K
E
A
L
Y
R
A
L
G
R
V
L
Site 23
S149
R
V
L
V
E
G
G
S
D
E
K
R
L
C
L
Site 24
S210
L
H
I
C
L
K
R
S
P
G
E
V
L
R
T
Site 25
T217
S
P
G
E
V
L
R
T
L
I
Q
Q
G
L
E
Site 26
T269
R
K
L
G
D
Q
E
T
E
E
E
S
E
T
A
Site 27
S273
D
Q
E
T
E
E
E
S
E
T
A
F
S
A
L
Site 28
T275
E
T
E
E
E
S
E
T
A
F
S
A
L
Q
Q
Site 29
S278
E
E
S
E
T
A
F
S
A
L
Q
Q
I
G
E
Site 30
S294
L
G
Q
D
R
F
Q
S
Y
I
S
R
L
P
S
Site 31
Y295
G
Q
D
R
F
Q
S
Y
I
S
R
L
P
S
A
Site 32
S297
D
R
F
Q
S
Y
I
S
R
L
P
S
A
L
R
Site 33
S301
S
Y
I
S
R
L
P
S
A
L
R
R
H
Y
N
Site 34
Y307
P
S
A
L
R
R
H
Y
N
R
R
L
E
S
Q
Site 35
S313
H
Y
N
R
R
L
E
S
Q
F
G
S
Q
V
P
Site 36
S317
R
L
E
S
Q
F
G
S
Q
V
P
Y
Y
L
E
Site 37
Y321
Q
F
G
S
Q
V
P
Y
Y
L
E
L
E
A
S
Site 38
Y322
F
G
S
Q
V
P
Y
Y
L
E
L
E
A
S
G
Site 39
S328
Y
Y
L
E
L
E
A
S
G
F
P
E
D
P
L
Site 40
T340
D
P
L
P
C
A
V
T
L
S
N
S
N
L
K
Site 41
Y365
R
L
L
D
Q
E
D
Y
K
N
R
T
Q
A
V
Site 42
S385
V
L
G
K
F
N
P
S
S
T
P
H
S
S
L
Site 43
S386
L
G
K
F
N
P
S
S
T
P
H
S
S
L
V
Site 44
T387
G
K
F
N
P
S
S
T
P
H
S
S
L
V
G
Site 45
S390
N
P
S
S
T
P
H
S
S
L
V
G
F
I
S
Site 46
S406
L
Y
N
L
L
D
D
S
N
F
K
V
V
H
G
Site 47
S484
E
H
L
K
H
K
H
S
R
V
R
E
E
V
V
Site 48
S503
C
S
L
L
T
Y
P
S
E
D
F
D
L
P
K
Site 49
S522
L
A
P
A
L
V
D
S
K
R
R
V
R
Q
A
Site 50
T577
Q
A
R
L
A
R
K
T
L
P
R
L
T
E
Q
Site 51
T582
R
K
T
L
P
R
L
T
E
Q
G
F
V
E
Y
Site 52
S596
Y
A
V
L
M
P
S
S
A
G
G
R
S
N
H
Site 53
Y637
V
R
D
S
M
H
I
Y
G
S
Y
S
P
T
I
Site 54
T646
S
Y
S
P
T
I
C
T
R
R
V
L
S
A
G
Site 55
S651
I
C
T
R
R
V
L
S
A
G
K
G
K
N
K
Site 56
S675
I
M
G
E
N
Q
T
S
T
S
K
D
I
E
Q
Site 57
S684
S
K
D
I
E
Q
F
S
T
Y
D
F
I
P
S
Site 58
T685
K
D
I
E
Q
F
S
T
Y
D
F
I
P
S
A
Site 59
Y686
D
I
E
Q
F
S
T
Y
D
F
I
P
S
A
K
Site 60
S691
S
T
Y
D
F
I
P
S
A
K
L
K
L
S
Q
Site 61
S697
P
S
A
K
L
K
L
S
Q
G
M
P
V
N
D
Site 62
S709
V
N
D
D
L
C
F
S
R
K
R
V
S
R
N
Site 63
S714
C
F
S
R
K
R
V
S
R
N
L
F
Q
N
S
Site 64
S721
S
R
N
L
F
Q
N
S
R
D
F
N
P
D
C
Site 65
S745
G
T
H
Q
T
N
L
S
G
K
C
A
Q
L
G
Site 66
S754
K
C
A
Q
L
G
F
S
Q
I
C
G
K
T
G
Site 67
T760
F
S
Q
I
C
G
K
T
G
S
V
G
S
D
L
Site 68
S762
Q
I
C
G
K
T
G
S
V
G
S
D
L
Q
F
Site 69
S765
G
K
T
G
S
V
G
S
D
L
Q
F
L
G
T
Site 70
T772
S
D
L
Q
F
L
G
T
T
S
S
H
Q
E
K
Site 71
S775
Q
F
L
G
T
T
S
S
H
Q
E
K
V
Y
A
Site 72
Y781
S
S
H
Q
E
K
V
Y
A
S
L
N
F
G
S
Site 73
T790
S
L
N
F
G
S
K
T
Q
Q
T
F
G
S
Q
Site 74
T793
F
G
S
K
T
Q
Q
T
F
G
S
Q
T
E
C
Site 75
S796
K
T
Q
Q
T
F
G
S
Q
T
E
C
T
S
S
Site 76
T798
Q
Q
T
F
G
S
Q
T
E
C
T
S
S
N
G
Site 77
S803
S
Q
T
E
C
T
S
S
N
G
Q
N
P
S
P
Site 78
S809
S
S
N
G
Q
N
P
S
P
G
A
Y
I
L
P
Site 79
Y813
Q
N
P
S
P
G
A
Y
I
L
P
S
Y
P
V
Site 80
S817
P
G
A
Y
I
L
P
S
Y
P
V
S
S
P
R
Site 81
Y818
G
A
Y
I
L
P
S
Y
P
V
S
S
P
R
T
Site 82
S821
I
L
P
S
Y
P
V
S
S
P
R
T
S
P
K
Site 83
S822
L
P
S
Y
P
V
S
S
P
R
T
S
P
K
H
Site 84
T825
Y
P
V
S
S
P
R
T
S
P
K
H
T
S
P
Site 85
S826
P
V
S
S
P
R
T
S
P
K
H
T
S
P
L
Site 86
T830
P
R
T
S
P
K
H
T
S
P
L
I
I
S
P
Site 87
S831
R
T
S
P
K
H
T
S
P
L
I
I
S
P
K
Site 88
S836
H
T
S
P
L
I
I
S
P
K
K
S
Q
D
N
Site 89
S840
L
I
I
S
P
K
K
S
Q
D
N
S
V
N
F
Site 90
S844
P
K
K
S
Q
D
N
S
V
N
F
S
N
S
W
Site 91
S848
Q
D
N
S
V
N
F
S
N
S
W
P
L
K
S
Site 92
S850
N
S
V
N
F
S
N
S
W
P
L
K
S
F
E
Site 93
S855
S
N
S
W
P
L
K
S
F
E
G
L
S
K
P
Site 94
S860
L
K
S
F
E
G
L
S
K
P
S
P
Q
K
K
Site 95
S863
F
E
G
L
S
K
P
S
P
Q
K
K
L
V
S
Site 96
S870
S
P
Q
K
K
L
V
S
Q
K
S
S
D
P
T
Site 97
S873
K
K
L
V
S
Q
K
S
S
D
P
T
G
R
N
Site 98
S874
K
L
V
S
Q
K
S
S
D
P
T
G
R
N
H
Site 99
T877
S
Q
K
S
S
D
P
T
G
R
N
H
G
E
N
Site 100
S885
G
R
N
H
G
E
N
S
Q
E
K
P
P
V
Q
Site 101
T894
E
K
P
P
V
Q
L
T
P
A
L
V
R
S
P
Site 102
S900
L
T
P
A
L
V
R
S
P
S
S
R
R
G
L
Site 103
S902
P
A
L
V
R
S
P
S
S
R
R
G
L
N
G
Site 104
S903
A
L
V
R
S
P
S
S
R
R
G
L
N
G
T
Site 105
T910
S
R
R
G
L
N
G
T
K
P
V
P
P
I
P
Site 106
S921
P
P
I
P
R
G
I
S
L
L
P
D
K
A
D
Site 107
S930
L
P
D
K
A
D
L
S
T
V
G
H
K
K
K
Site 108
T931
P
D
K
A
D
L
S
T
V
G
H
K
K
K
E
Site 109
S949
I
W
K
C
E
K
D
S
L
P
I
D
L
S
E
Site 110
S955
D
S
L
P
I
D
L
S
E
L
N
F
K
D
K
Site 111
S971
L
D
Q
E
E
M
H
S
S
L
R
S
L
R
N
Site 112
S972
D
Q
E
E
M
H
S
S
L
R
S
L
R
N
S
Site 113
S975
E
M
H
S
S
L
R
S
L
R
N
S
A
A
K
Site 114
S979
S
L
R
S
L
R
N
S
A
A
K
K
R
A
K
Site 115
S988
A
K
K
R
A
K
L
S
G
S
T
L
D
L
E
Site 116
S990
K
R
A
K
L
S
G
S
T
L
D
L
E
S
P
Site 117
S996
G
S
T
L
D
L
E
S
P
D
S
A
M
K
L
Site 118
S999
L
D
L
E
S
P
D
S
A
M
K
L
D
L
T
Site 119
T1006
S
A
M
K
L
D
L
T
M
D
S
P
S
L
S
Site 120
S1009
K
L
D
L
T
M
D
S
P
S
L
S
S
S
P
Site 121
S1011
D
L
T
M
D
S
P
S
L
S
S
S
P
N
I
Site 122
S1013
T
M
D
S
P
S
L
S
S
S
P
N
I
N
S
Site 123
S1014
M
D
S
P
S
L
S
S
S
P
N
I
N
S
Y
Site 124
S1015
D
S
P
S
L
S
S
S
P
N
I
N
S
Y
S
Site 125
S1020
S
S
S
P
N
I
N
S
Y
S
E
S
G
V
Y
Site 126
Y1021
S
S
P
N
I
N
S
Y
S
E
S
G
V
Y
S
Site 127
S1022
S
P
N
I
N
S
Y
S
E
S
G
V
Y
S
Q
Site 128
S1024
N
I
N
S
Y
S
E
S
G
V
Y
S
Q
E
S
Site 129
Y1027
S
Y
S
E
S
G
V
Y
S
Q
E
S
L
T
S
Site 130
S1028
Y
S
E
S
G
V
Y
S
Q
E
S
L
T
S
S
Site 131
S1031
S
G
V
Y
S
Q
E
S
L
T
S
S
L
S
T
Site 132
T1033
V
Y
S
Q
E
S
L
T
S
S
L
S
T
T
P
Site 133
S1034
Y
S
Q
E
S
L
T
S
S
L
S
T
T
P
Q
Site 134
S1035
S
Q
E
S
L
T
S
S
L
S
T
T
P
Q
G
Site 135
S1037
E
S
L
T
S
S
L
S
T
T
P
Q
G
K
R
Site 136
T1038
S
L
T
S
S
L
S
T
T
P
Q
G
K
R
I
Site 137
T1039
L
T
S
S
L
S
T
T
P
Q
G
K
R
I
M
Site 138
S1047
P
Q
G
K
R
I
M
S
D
I
F
P
T
F
G
Site 139
S1055
D
I
F
P
T
F
G
S
K
P
C
P
T
R
L
Site 140
T1060
F
G
S
K
P
C
P
T
R
L
S
S
A
K
K
Site 141
S1063
K
P
C
P
T
R
L
S
S
A
K
K
K
I
S
Site 142
S1064
P
C
P
T
R
L
S
S
A
K
K
K
I
S
H
Site 143
S1070
S
S
A
K
K
K
I
S
H
I
A
E
Q
S
P
Site 144
S1076
I
S
H
I
A
E
Q
S
P
S
A
G
S
S
S
Site 145
S1078
H
I
A
E
Q
S
P
S
A
G
S
S
S
N
P
Site 146
S1082
Q
S
P
S
A
G
S
S
S
N
P
Q
Q
I
S
Site 147
S1083
S
P
S
A
G
S
S
S
N
P
Q
Q
I
S
S
Site 148
S1089
S
S
N
P
Q
Q
I
S
S
F
D
F
T
T
T
Site 149
S1090
S
N
P
Q
Q
I
S
S
F
D
F
T
T
T
K
Site 150
T1094
Q
I
S
S
F
D
F
T
T
T
K
A
L
S
E
Site 151
T1095
I
S
S
F
D
F
T
T
T
K
A
L
S
E
D
Site 152
T1096
S
S
F
D
F
T
T
T
K
A
L
S
E
D
S
Site 153
S1125
A
P
A
T
C
S
Q
S
V
I
S
S
V
E
N
Site 154
S1129
C
S
Q
S
V
I
S
S
V
E
N
G
D
T
F
Site 155
T1135
S
S
V
E
N
G
D
T
F
S
I
K
Q
S
I
Site 156
S1137
V
E
N
G
D
T
F
S
I
K
Q
S
I
E
P
Site 157
S1141
D
T
F
S
I
K
Q
S
I
E
P
P
S
G
I
Site 158
S1146
K
Q
S
I
E
P
P
S
G
I
Y
G
R
S
V
Site 159
S1152
P
S
G
I
Y
G
R
S
V
Q
Q
N
I
S
S
Site 160
Y1160
V
Q
Q
N
I
S
S
Y
L
D
V
E
N
E
K
Site 161
S1172
N
E
K
D
A
K
V
S
I
S
K
S
T
Y
N
Site 162
S1176
A
K
V
S
I
S
K
S
T
Y
N
K
M
R
Q
Site 163
Y1178
V
S
I
S
K
S
T
Y
N
K
M
R
Q
K
R
Site 164
T1211
S
W
E
R
M
R
H
T
G
T
E
K
M
A
S
Site 165
S1218
T
G
T
E
K
M
A
S
E
S
E
T
P
T
G
Site 166
S1220
T
E
K
M
A
S
E
S
E
T
P
T
G
A
I
Site 167
T1222
K
M
A
S
E
S
E
T
P
T
G
A
I
S
Q
Site 168
T1224
A
S
E
S
E
T
P
T
G
A
I
S
Q
Y
K
Site 169
S1228
E
T
P
T
G
A
I
S
Q
Y
K
E
R
M
P
Site 170
Y1230
P
T
G
A
I
S
Q
Y
K
E
R
M
P
S
V
Site 171
S1236
Q
Y
K
E
R
M
P
S
V
T
H
S
P
E
I
Site 172
T1238
K
E
R
M
P
S
V
T
H
S
P
E
I
M
D
Site 173
S1240
R
M
P
S
V
T
H
S
P
E
I
M
D
L
S
Site 174
S1247
S
P
E
I
M
D
L
S
E
L
R
P
F
S
K
Site 175
S1253
L
S
E
L
R
P
F
S
K
P
E
I
A
L
T
Site 176
T1294
F
H
S
E
I
L
N
T
K
L
H
E
T
N
F
Site 177
Y1328
C
L
S
D
L
F
T
Y
L
K
K
S
M
D
Q
Site 178
S1332
L
F
T
Y
L
K
K
S
M
D
Q
E
L
D
T
Site 179
T1339
S
M
D
Q
E
L
D
T
T
V
K
V
L
L
H
Site 180
T1340
M
D
Q
E
L
D
T
T
V
K
V
L
L
H
K
Site 181
T1353
H
K
A
G
E
S
N
T
F
I
R
E
D
V
D
Site 182
S1378
T
P
A
R
A
V
V
S
L
I
N
G
G
Q
R
Site 183
Y1386
L
I
N
G
G
Q
R
Y
Y
G
R
K
M
L
F
Site 184
Y1387
I
N
G
G
Q
R
Y
Y
G
R
K
M
L
F
F
Site 185
Y1408
F
E
K
M
L
E
K
Y
V
P
S
K
D
L
P
Site 186
Y1416
V
P
S
K
D
L
P
Y
I
K
D
S
V
R
N
Site 187
S1420
D
L
P
Y
I
K
D
S
V
R
N
L
Q
Q
K
Site 188
T1436
L
G
E
I
P
L
D
T
P
S
A
K
G
R
R
Site 189
S1438
E
I
P
L
D
T
P
S
A
K
G
R
R
S
H
Site 190
S1444
P
S
A
K
G
R
R
S
H
T
G
S
V
G
N
Site 191
T1446
A
K
G
R
R
S
H
T
G
S
V
G
N
T
R
Site 192
S1448
G
R
R
S
H
T
G
S
V
G
N
T
R
S
S
Site 193
T1452
H
T
G
S
V
G
N
T
R
S
S
S
V
S
R
Site 194
S1454
G
S
V
G
N
T
R
S
S
S
V
S
R
D
A
Site 195
S1455
S
V
G
N
T
R
S
S
S
V
S
R
D
A
F
Site 196
S1456
V
G
N
T
R
S
S
S
V
S
R
D
A
F
N
Site 197
S1458
N
T
R
S
S
S
V
S
R
D
A
F
N
S
A
Site 198
S1464
V
S
R
D
A
F
N
S
A
E
R
A
V
T
E
Site 199
T1470
N
S
A
E
R
A
V
T
E
V
R
E
V
T
R
Site 200
T1476
V
T
E
V
R
E
V
T
R
K
S
V
P
R
N
Site 201
S1479
V
R
E
V
T
R
K
S
V
P
R
N
S
L
E
Site 202
S1484
R
K
S
V
P
R
N
S
L
E
S
A
E
Y
L
Site 203
S1487
V
P
R
N
S
L
E
S
A
E
Y
L
K
L
I
Site 204
S1515
N
G
I
K
Q
L
L
S
D
T
E
N
N
Q
D
Site 205
S1537
K
I
F
D
A
F
K
S
R
L
H
D
S
N
S
Site 206
S1542
F
K
S
R
L
H
D
S
N
S
K
V
N
L
V
Site 207
S1544
S
R
L
H
D
S
N
S
K
V
N
L
V
A
L
Site 208
S1600
T
N
V
V
Q
A
L
S
Q
H
V
D
N
Y
L
Site 209
T1628
G
K
A
K
Q
D
M
T
E
K
L
A
D
I
V
Site 210
T1636
E
K
L
A
D
I
V
T
E
L
Y
Q
R
K
P
Site 211
Y1639
A
D
I
V
T
E
L
Y
Q
R
K
P
H
A
T
Site 212
T1646
Y
Q
R
K
P
H
A
T
E
Q
K
V
L
V
V
Site 213
T1662
W
H
L
L
G
N
M
T
N
S
G
S
L
P
G
Site 214
S1666
G
N
M
T
N
S
G
S
L
P
G
A
G
G
N
Site 215
T1678
G
G
N
I
R
T
A
T
A
K
L
S
K
A
L
Site 216
S1699
N
L
L
N
Q
A
A
S
Q
P
P
H
I
K
K
Site 217
S1707
Q
P
P
H
I
K
K
S
L
E
E
L
L
D
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation