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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
JMJD1A
Full Name:
Lysine-specific demethylase 3A
Alias:
JHD2A; JHMD2A; JMJ1A; JmjC domain-containing histone demethylation protein 2A; JMJD1; Jumonji C domain-containing histone demethylase 2A; Jumonji domain-containing protein 1A; KIAA0742; Lysine (K)-specific demethylase 3A; TSGA
Type:
EC 1.14.11.-; Oxidoreductase; Demethylase
Mass (Da):
147327
Number AA:
1321
UniProt ID:
Q9Y4C1
International Prot ID:
IPI00479545
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0005102
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006081
GO:0006139
GO:0006325
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
G
R
R
F
L
S
L
S
A
A
D
G
S
D
G
Site 2
S26
S
L
S
A
A
D
G
S
D
G
S
H
D
S
W
Site 3
S29
A
A
D
G
S
D
G
S
H
D
S
W
D
V
E
Site 4
S32
G
S
D
G
S
H
D
S
W
D
V
E
R
V
A
Site 5
T47
E
W
P
W
L
S
G
T
I
R
A
V
S
H
T
Site 6
S52
S
G
T
I
R
A
V
S
H
T
D
V
T
K
K
Site 7
T54
T
I
R
A
V
S
H
T
D
V
T
K
K
D
L
Site 8
S71
C
V
E
F
D
G
E
S
W
R
K
R
R
W
I
Site 9
Y81
K
R
R
W
I
E
V
Y
S
L
L
R
R
A
F
Site 10
S82
R
R
W
I
E
V
Y
S
L
L
R
R
A
F
L
Site 11
S101
L
V
L
A
E
R
K
S
P
E
I
S
E
R
I
Site 12
S105
E
R
K
S
P
E
I
S
E
R
I
V
Q
W
P
Site 13
S155
K
P
I
Q
D
V
N
S
L
R
L
S
L
T
D
Site 14
S159
D
V
N
S
L
R
L
S
L
T
D
N
Q
I
V
Site 15
T161
N
S
L
R
L
S
L
T
D
N
Q
I
V
S
K
Site 16
Y198
V
G
S
E
V
K
I
Y
S
L
D
P
S
T
Q
Site 17
S199
G
S
E
V
K
I
Y
S
L
D
P
S
T
Q
W
Site 18
S203
K
I
Y
S
L
D
P
S
T
Q
W
F
S
A
T
Site 19
T204
I
Y
S
L
D
P
S
T
Q
W
F
S
A
T
V
Site 20
T210
S
T
Q
W
F
S
A
T
V
V
N
G
N
P
A
Site 21
S218
V
V
N
G
N
P
A
S
K
T
L
Q
V
N
C
Site 22
T220
N
G
N
P
A
S
K
T
L
Q
V
N
C
E
E
Site 23
S264
I
G
A
V
K
R
K
S
S
E
N
N
G
T
L
Site 24
S265
G
A
V
K
R
K
S
S
E
N
N
G
T
L
V
Site 25
T270
K
S
S
E
N
N
G
T
L
V
S
K
Q
A
K
Site 26
S273
E
N
N
G
T
L
V
S
K
Q
A
K
S
C
S
Site 27
S278
L
V
S
K
Q
A
K
S
C
S
E
A
S
P
S
Site 28
S280
S
K
Q
A
K
S
C
S
E
A
S
P
S
M
C
Site 29
S283
A
K
S
C
S
E
A
S
P
S
M
C
P
V
Q
Site 30
S285
S
C
S
E
A
S
P
S
M
C
P
V
Q
S
V
Site 31
T308
L
L
G
C
T
A
A
T
P
P
S
K
D
P
R
Site 32
S311
C
T
A
A
T
P
P
S
K
D
P
R
Q
Q
S
Site 33
S318
S
K
D
P
R
Q
Q
S
T
P
Q
A
A
N
S
Site 34
T319
K
D
P
R
Q
Q
S
T
P
Q
A
A
N
S
P
Site 35
S325
S
T
P
Q
A
A
N
S
P
P
N
L
G
A
K
Site 36
S341
P
Q
G
C
H
K
Q
S
L
P
E
E
I
S
S
Site 37
S347
Q
S
L
P
E
E
I
S
S
C
L
N
T
K
S
Site 38
S348
S
L
P
E
E
I
S
S
C
L
N
T
K
S
E
Site 39
T352
E
I
S
S
C
L
N
T
K
S
E
A
L
R
T
Site 40
S354
S
S
C
L
N
T
K
S
E
A
L
R
T
K
P
Site 41
T359
T
K
S
E
A
L
R
T
K
P
D
V
C
K
A
Site 42
S372
K
A
G
L
L
S
K
S
S
Q
I
G
T
G
D
Site 43
S373
A
G
L
L
S
K
S
S
Q
I
G
T
G
D
L
Site 44
T377
S
K
S
S
Q
I
G
T
G
D
L
K
I
L
T
Site 45
T384
T
G
D
L
K
I
L
T
E
P
K
G
S
C
T
Site 46
T395
G
S
C
T
Q
P
K
T
N
T
D
Q
E
N
R
Site 47
S405
D
Q
E
N
R
L
E
S
V
P
Q
A
L
T
G
Site 48
T411
E
S
V
P
Q
A
L
T
G
L
P
K
E
C
L
Site 49
T420
L
P
K
E
C
L
P
T
K
A
S
S
K
A
E
Site 50
S423
E
C
L
P
T
K
A
S
S
K
A
E
L
E
I
Site 51
S445
K
H
L
E
H
A
P
S
P
S
D
V
S
N
S
Site 52
S447
L
E
H
A
P
S
P
S
D
V
S
N
A
P
E
Site 53
S450
A
P
S
P
S
D
V
S
N
A
P
E
V
K
A
Site 54
S461
E
V
K
A
G
V
N
S
D
S
P
N
N
C
S
Site 55
S463
K
A
G
V
N
S
D
S
P
N
N
C
S
G
K
Site 56
S468
S
D
S
P
N
N
C
S
G
K
K
V
E
P
S
Site 57
S481
P
S
A
L
A
C
R
S
Q
N
L
K
E
S
S
Site 58
S495
S
V
K
V
D
N
E
S
C
C
S
R
S
N
N
Site 59
S498
V
D
N
E
S
C
C
S
R
S
N
N
K
I
Q
Site 60
S512
Q
N
A
P
S
R
K
S
V
L
T
D
P
A
K
Site 61
T515
P
S
R
K
S
V
L
T
D
P
A
K
L
K
K
Site 62
S526
K
L
K
K
L
Q
Q
S
G
E
A
F
V
Q
D
Site 63
S553
C
R
E
C
R
L
D
S
L
R
K
D
K
E
Q
Site 64
S564
D
K
E
Q
Q
K
D
S
P
V
F
C
R
F
F
Site 65
T591
L
R
V
E
G
F
L
T
P
N
K
Y
D
N
E
Site 66
Y595
G
F
L
T
P
N
K
Y
D
N
E
A
I
G
L
Site 67
S641
I
S
E
K
E
A
M
S
T
I
E
P
H
R
Q
Site 68
T642
S
E
K
E
A
M
S
T
I
E
P
H
R
Q
V
Site 69
Y701
N
C
Q
Q
G
A
A
Y
K
T
F
S
W
L
K
Site 70
S712
S
W
L
K
C
V
K
S
Q
I
H
E
P
E
N
Site 71
S762
N
R
Q
F
K
L
F
S
K
P
A
S
K
E
D
Site 72
S766
K
L
F
S
K
P
A
S
K
E
D
L
K
Q
T
Site 73
S804
A
V
G
G
E
A
A
S
K
P
A
G
S
M
K
Site 74
S809
A
A
S
K
P
A
G
S
M
K
P
A
C
P
A
Site 75
S817
M
K
P
A
C
P
A
S
T
S
P
L
N
W
L
Site 76
S819
P
A
C
P
A
S
T
S
P
L
N
W
L
A
D
Site 77
S829
N
W
L
A
D
L
T
S
G
N
V
N
K
E
N
Site 78
T842
E
N
K
E
K
Q
P
T
M
P
I
L
K
N
E
Site 79
S860
L
P
P
L
P
P
L
S
K
S
S
T
V
L
H
Site 80
S862
P
L
P
P
L
S
K
S
S
T
V
L
H
T
F
Site 81
T864
P
P
L
S
K
S
S
T
V
L
H
T
F
N
S
Site 82
T875
T
F
N
S
T
I
L
T
P
V
S
N
N
N
S
Site 83
S878
S
T
I
L
T
P
V
S
N
N
N
S
G
F
L
Site 84
S882
T
P
V
S
N
N
N
S
G
F
L
R
N
L
L
Site 85
S891
F
L
R
N
L
L
N
S
S
T
G
K
T
E
N
Site 86
T903
T
E
N
G
L
K
N
T
P
K
I
L
D
D
I
Site 87
T919
A
S
L
V
Q
N
K
T
T
S
D
L
S
K
R
Site 88
S924
N
K
T
T
S
D
L
S
K
R
P
Q
G
L
T
Site 89
T931
S
K
R
P
Q
G
L
T
I
K
P
S
I
L
G
Site 90
Y944
L
G
F
D
T
P
H
Y
W
L
C
D
N
R
L
Site 91
S994
S
E
L
W
K
P
E
S
F
R
K
E
F
G
E
Site 92
Y1074
A
N
I
P
L
P
E
Y
T
R
R
D
G
K
L
Site 93
Y1090
L
A
S
R
L
P
N
Y
F
V
R
P
D
L
G
Site 94
Y1101
P
D
L
G
P
K
M
Y
N
A
Y
G
L
I
T
Site 95
Y1104
G
P
K
M
Y
N
A
Y
G
L
I
T
P
E
D
Site 96
T1108
Y
N
A
Y
G
L
I
T
P
E
D
R
K
Y
G
Site 97
Y1114
I
T
P
E
D
R
K
Y
G
T
T
N
L
H
L
Site 98
T1117
E
D
R
K
Y
G
T
T
N
L
H
L
D
V
S
Site 99
T1149
Q
E
E
E
V
L
K
T
I
Q
D
G
D
S
D
Site 100
S1155
K
T
I
Q
D
G
D
S
D
E
L
T
I
K
R
Site 101
T1159
D
G
D
S
D
E
L
T
I
K
R
F
I
E
G
Site 102
Y1177
P
G
A
L
W
H
I
Y
A
A
K
D
T
E
K
Site 103
Y1213
P
I
H
D
Q
S
W
Y
L
D
R
S
L
R
K
Site 104
S1217
Q
S
W
Y
L
D
R
S
L
R
K
R
L
H
Q
Site 105
Y1226
R
K
R
L
H
Q
E
Y
G
V
Q
G
W
A
I
Site 106
Y1255
P
H
Q
V
H
N
L
Y
S
C
I
K
V
A
E
Site 107
S1266
K
V
A
E
D
F
V
S
P
E
H
V
K
H
C
Site 108
T1277
V
K
H
C
F
W
L
T
Q
E
F
R
Y
L
S
Site 109
Y1282
W
L
T
Q
E
F
R
Y
L
S
Q
T
H
T
N
Site 110
S1284
T
Q
E
F
R
Y
L
S
Q
T
H
T
N
H
E
Site 111
T1286
E
F
R
Y
L
S
Q
T
H
T
N
H
E
D
K
Site 112
T1288
R
Y
L
S
Q
T
H
T
N
H
E
D
K
L
Q
Site 113
S1314
A
V
A
M
L
K
A
S
E
S
S
F
G
K
P
Site 114
S1316
A
M
L
K
A
S
E
S
S
F
G
K
P
_
_
Site 115
S1317
M
L
K
A
S
E
S
S
F
G
K
P
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation