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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RAD54L2
Full Name:
Helicase ARIP4
Alias:
Helicase ARIP4; RAD54-like protein 2; SRISNF2L
Type:
Transcription, coactivator/corepressor, Nuclear receptor co-regulator, Helicase
Mass (Da):
162796
Number AA:
1467
UniProt ID:
Q9Y4B4
International Prot ID:
IPI00294787
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0004386
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
D
E
S
A
S
G
S
D
P
D
Site 2
S9
S
D
E
S
A
S
G
S
D
P
D
L
D
P
D
Site 3
S49
E
D
L
L
D
D
P
S
L
E
G
M
C
G
T
Site 4
T72
G
Q
Q
P
P
R
C
T
S
T
T
S
S
Q
S
Site 5
S73
Q
Q
P
P
R
C
T
S
T
T
S
S
Q
S
E
Site 6
T74
Q
P
P
R
C
T
S
T
T
S
S
Q
S
E
P
Site 7
T75
P
P
R
C
T
S
T
T
S
S
Q
S
E
P
S
Site 8
S76
P
R
C
T
S
T
T
S
S
Q
S
E
P
S
E
Site 9
S77
R
C
T
S
T
T
S
S
Q
S
E
P
S
E
Q
Site 10
S79
Q
E
V
I
C
L
D
S
S
S
G
S
E
D
E
Site 11
S82
T
S
S
Q
S
E
P
S
E
Q
L
R
R
H
Q
Site 12
S107
K
K
R
A
Q
K
P
S
H
M
R
R
N
I
R
Site 13
Y147
L
E
Q
Q
R
K
D
Y
A
A
P
I
P
T
V
Site 14
S168
E
E
I
A
L
R
A
S
D
G
P
Q
L
P
P
Site 15
S187
Q
E
V
I
C
L
D
S
S
S
G
S
E
D
E
Site 16
S188
E
V
I
C
L
D
S
S
S
G
S
E
D
E
K
Site 17
S189
V
I
C
L
D
S
S
S
G
S
E
D
E
K
S
Site 18
S191
C
L
D
S
S
S
G
S
E
D
E
K
S
S
R
Site 19
S196
S
G
S
E
D
E
K
S
S
R
D
E
V
I
E
Site 20
S205
R
D
E
V
I
E
L
S
S
G
E
E
D
T
L
Site 21
T211
L
S
S
G
E
E
D
T
L
H
I
V
D
S
S
Site 22
S217
D
T
L
H
I
V
D
S
S
E
S
V
S
E
D
Site 23
S218
T
L
H
I
V
D
S
S
E
S
V
S
E
D
D
Site 24
S220
H
I
V
D
S
S
E
S
V
S
E
D
D
E
E
Site 25
S222
V
D
S
S
E
S
V
S
E
D
D
E
E
E
E
Site 26
T233
E
E
E
E
K
G
G
T
H
V
N
D
V
L
N
Site 27
S289
L
Y
D
N
L
V
E
S
L
E
R
F
K
T
S
Site 28
T295
E
S
L
E
R
F
K
T
S
S
G
F
G
C
I
Site 29
S395
K
V
M
A
D
W
V
S
E
G
G
V
L
L
M
Site 30
Y404
G
G
V
L
L
M
G
Y
E
M
Y
R
L
L
T
Site 31
Y407
L
L
M
G
Y
E
M
Y
R
L
L
T
L
K
K
Site 32
T411
Y
E
M
Y
R
L
L
T
L
K
K
S
F
A
T
Site 33
S415
R
L
L
T
L
K
K
S
F
A
T
G
R
P
K
Site 34
T424
A
T
G
R
P
K
K
T
K
K
R
S
H
P
V
Site 35
S428
P
K
K
T
K
K
R
S
H
P
V
I
I
D
L
Site 36
S474
R
I
K
N
C
Q
A
S
T
S
Q
A
L
K
N
Site 37
S476
K
N
C
Q
A
S
T
S
Q
A
L
K
N
I
R
Site 38
S484
Q
A
L
K
N
I
R
S
R
R
R
V
V
L
T
Site 39
T491
S
R
R
R
V
V
L
T
G
Y
P
L
Q
N
N
Site 40
S536
L
N
G
Q
C
I
D
S
T
P
Q
D
V
R
L
Site 41
T537
N
G
Q
C
I
D
S
T
P
Q
D
V
R
L
M
Site 42
Y546
Q
D
V
R
L
M
R
Y
R
S
H
V
L
H
S
Site 43
T565
F
V
Q
R
R
G
H
T
V
L
K
I
H
L
P
Site 44
Y591
S
K
I
Q
R
D
L
Y
T
Q
F
M
D
R
F
Site 45
S603
D
R
F
R
D
C
G
S
S
G
W
L
G
L
N
Site 46
S604
R
F
R
D
C
G
S
S
G
W
L
G
L
N
P
Site 47
Y629
W
N
H
P
D
V
L
Y
E
A
L
Q
K
E
S
Site 48
S650
L
D
V
E
E
L
G
S
A
G
T
S
A
R
C
Site 49
S654
E
L
G
S
A
G
T
S
A
R
C
P
P
Q
G
Site 50
S669
T
K
G
K
G
E
D
S
T
L
A
S
S
M
G
Site 51
T670
K
G
K
G
E
D
S
T
L
A
S
S
M
G
E
Site 52
S673
G
E
D
S
T
L
A
S
S
M
G
E
A
T
N
Site 53
S674
E
D
S
T
L
A
S
S
M
G
E
A
T
N
S
Site 54
T679
A
S
S
M
G
E
A
T
N
S
K
F
L
Q
G
Site 55
S681
S
M
G
E
A
T
N
S
K
F
L
Q
G
V
G
Site 56
Y702
R
G
N
N
I
V
T
Y
E
W
A
K
D
L
L
Site 57
T710
E
W
A
K
D
L
L
T
N
Y
Q
T
G
V
L
Site 58
Y712
A
K
D
L
L
T
N
Y
Q
T
G
V
L
E
N
Site 59
S781
Q
K
W
V
R
N
I
S
Y
F
R
L
D
G
S
Site 60
Y782
K
W
V
R
N
I
S
Y
F
R
L
D
G
S
T
Site 61
S788
S
Y
F
R
L
D
G
S
T
P
A
F
E
R
E
Site 62
T789
Y
F
R
L
D
G
S
T
P
A
F
E
R
E
R
Site 63
T809
N
D
P
S
N
L
T
T
W
L
F
L
L
S
T
Site 64
Y851
A
Q
A
V
C
R
V
Y
R
Y
G
Q
K
K
P
Site 65
Y853
A
V
C
R
V
Y
R
Y
G
Q
K
K
P
C
Y
Site 66
Y860
Y
G
Q
K
K
P
C
Y
I
Y
R
L
V
A
D
Site 67
Y868
I
Y
R
L
V
A
D
Y
T
L
E
K
K
I
Y
Site 68
T869
Y
R
L
V
A
D
Y
T
L
E
K
K
I
Y
D
Site 69
Y875
Y
T
L
E
K
K
I
Y
D
R
Q
I
S
K
Q
Site 70
S880
K
I
Y
D
R
Q
I
S
K
Q
G
M
S
D
R
Site 71
S885
Q
I
S
K
Q
G
M
S
D
R
V
V
D
D
L
Site 72
S919
K
E
P
A
P
Q
V
S
L
N
V
K
G
I
K
Site 73
T942
L
K
Y
P
H
L
I
T
K
E
P
F
E
H
E
Site 74
S971
E
K
K
A
A
K
K
S
Y
E
E
D
K
R
T
Site 75
Y972
K
K
A
A
K
K
S
Y
E
E
D
K
R
T
S
Site 76
T978
S
Y
E
E
D
K
R
T
S
V
P
Y
T
R
P
Site 77
S979
Y
E
E
D
K
R
T
S
V
P
Y
T
R
P
S
Site 78
Y982
D
K
R
T
S
V
P
Y
T
R
P
S
Y
A
Q
Site 79
T983
K
R
T
S
V
P
Y
T
R
P
S
Y
A
Q
Y
Site 80
S986
S
V
P
Y
T
R
P
S
Y
A
Q
Y
Y
P
A
Site 81
Y987
V
P
Y
T
R
P
S
Y
A
Q
Y
Y
P
A
S
Site 82
Y990
T
R
P
S
Y
A
Q
Y
Y
P
A
S
D
Q
S
Site 83
Y991
R
P
S
Y
A
Q
Y
Y
P
A
S
D
Q
S
L
Site 84
S994
Y
A
Q
Y
Y
P
A
S
D
Q
S
L
T
S
I
Site 85
S997
Y
Y
P
A
S
D
Q
S
L
T
S
I
P
A
F
Site 86
T999
P
A
S
D
Q
S
L
T
S
I
P
A
F
S
Q
Site 87
S1000
A
S
D
Q
S
L
T
S
I
P
A
F
S
Q
R
Site 88
S1005
L
T
S
I
P
A
F
S
Q
R
N
W
Q
P
T
Site 89
T1012
S
Q
R
N
W
Q
P
T
L
K
G
D
E
K
P
Site 90
S1022
G
D
E
K
P
V
A
S
V
R
P
V
Q
S
T
Site 91
S1028
A
S
V
R
P
V
Q
S
T
P
I
P
M
M
P
Site 92
T1029
S
V
R
P
V
Q
S
T
P
I
P
M
M
P
R
Site 93
S1043
R
H
V
P
L
G
G
S
V
S
S
A
S
S
T
Site 94
S1045
V
P
L
G
G
S
V
S
S
A
S
S
T
N
P
Site 95
S1046
P
L
G
G
S
V
S
S
A
S
S
T
N
P
S
Site 96
S1048
G
G
S
V
S
S
A
S
S
T
N
P
S
M
N
Site 97
S1049
G
S
V
S
S
A
S
S
T
N
P
S
M
N
F
Site 98
T1050
S
V
S
S
A
S
S
T
N
P
S
M
N
F
P
Site 99
S1053
S
A
S
S
T
N
P
S
M
N
F
P
I
N
Y
Site 100
T1104
S
I
H
I
I
R
G
T
K
G
T
Y
I
R
T
Site 101
T1107
I
I
R
G
T
K
G
T
Y
I
R
T
S
D
G
Site 102
Y1108
I
R
G
T
K
G
T
Y
I
R
T
S
D
G
R
Site 103
S1112
K
G
T
Y
I
R
T
S
D
G
R
I
F
A
V
Site 104
T1122
R
I
F
A
V
R
A
T
G
K
P
K
V
P
E
Site 105
S1136
E
D
G
R
M
A
A
S
G
S
Q
G
P
S
C
Site 106
S1138
G
R
M
A
A
S
G
S
Q
G
P
S
C
E
S
Site 107
S1142
A
S
G
S
Q
G
P
S
C
E
S
T
S
N
G
Site 108
S1145
S
Q
G
P
S
C
E
S
T
S
N
G
R
H
S
Site 109
T1146
Q
G
P
S
C
E
S
T
S
N
G
R
H
S
A
Site 110
S1147
G
P
S
C
E
S
T
S
N
G
R
H
S
A
S
Site 111
S1152
S
T
S
N
G
R
H
S
A
S
S
P
K
A
P
Site 112
S1154
S
N
G
R
H
S
A
S
S
P
K
A
P
D
P
Site 113
S1155
N
G
R
H
S
A
S
S
P
K
A
P
D
P
E
Site 114
S1169
E
G
L
A
R
P
V
S
P
D
S
P
E
I
I
Site 115
S1172
A
R
P
V
S
P
D
S
P
E
I
I
S
E
L
Site 116
S1177
P
D
S
P
E
I
I
S
E
L
Q
Q
Y
A
D
Site 117
Y1182
I
I
S
E
L
Q
Q
Y
A
D
V
A
A
A
R
Site 118
S1191
D
V
A
A
A
R
E
S
R
Q
S
S
P
S
T
Site 119
S1194
A
A
R
E
S
R
Q
S
S
P
S
T
N
A
A
Site 120
S1195
A
R
E
S
R
Q
S
S
P
S
T
N
A
A
L
Site 121
S1197
E
S
R
Q
S
S
P
S
T
N
A
A
L
P
G
Site 122
T1198
S
R
Q
S
S
P
S
T
N
A
A
L
P
G
P
Site 123
S1212
P
P
A
Q
L
M
D
S
S
A
V
P
G
T
A
Site 124
T1238
L
N
S
S
L
L
V
T
G
Q
P
C
G
D
R
Site 125
T1260
G
H
K
R
K
L
A
T
P
P
A
A
Q
E
S
Site 126
S1267
T
P
P
A
A
Q
E
S
S
R
R
R
S
R
K
Site 127
S1268
P
P
A
A
Q
E
S
S
R
R
R
S
R
K
G
Site 128
S1272
Q
E
S
S
R
R
R
S
R
K
G
H
L
P
A
Site 129
Y1284
L
P
A
P
V
Q
P
Y
E
H
G
Y
P
V
S
Site 130
Y1288
V
Q
P
Y
E
H
G
Y
P
V
S
G
G
F
A
Site 131
S1291
Y
E
H
G
Y
P
V
S
G
G
F
A
M
P
P
Site 132
T1306
V
S
L
N
H
N
L
T
T
P
F
T
S
Q
A
Site 133
T1307
S
L
N
H
N
L
T
T
P
F
T
S
Q
A
G
Site 134
S1311
N
L
T
T
P
F
T
S
Q
A
G
E
N
S
L
Site 135
S1317
T
S
Q
A
G
E
N
S
L
F
M
G
S
T
P
Site 136
T1323
N
S
L
F
M
G
S
T
P
S
Y
Y
Q
L
S
Site 137
S1325
L
F
M
G
S
T
P
S
Y
Y
Q
L
S
N
L
Site 138
Y1326
F
M
G
S
T
P
S
Y
Y
Q
L
S
N
L
L
Site 139
Y1327
M
G
S
T
P
S
Y
Y
Q
L
S
N
L
L
A
Site 140
S1330
T
P
S
Y
Y
Q
L
S
N
L
L
A
D
A
R
Site 141
S1356
P
A
G
P
V
S
S
S
S
T
A
T
S
V
T
Site 142
T1358
G
P
V
S
S
S
S
T
A
T
S
V
T
A
S
Site 143
T1360
V
S
S
S
S
T
A
T
S
V
T
A
S
N
P
Site 144
S1361
S
S
S
S
T
A
T
S
V
T
A
S
N
P
S
Site 145
T1363
S
S
T
A
T
S
V
T
A
S
N
P
S
F
M
Site 146
S1387
P
S
Y
S
L
P
F
S
Q
P
L
L
S
E
P
Site 147
S1392
P
F
S
Q
P
L
L
S
E
P
R
M
F
A
P
Site 148
S1407
F
P
S
P
V
L
P
S
N
L
S
R
G
M
S
Site 149
S1410
P
V
L
P
S
N
L
S
R
G
M
S
I
Y
P
Site 150
S1414
S
N
L
S
R
G
M
S
I
Y
P
G
Y
M
S
Site 151
Y1416
L
S
R
G
M
S
I
Y
P
G
Y
M
S
P
H
Site 152
Y1419
G
M
S
I
Y
P
G
Y
M
S
P
H
A
G
Y
Site 153
S1421
S
I
Y
P
G
Y
M
S
P
H
A
G
Y
P
A
Site 154
Y1426
Y
M
S
P
H
A
G
Y
P
A
G
G
L
L
R
Site 155
S1434
P
A
G
G
L
L
R
S
Q
V
P
P
F
D
S
Site 156
S1441
S
Q
V
P
P
F
D
S
H
E
V
A
E
V
G
Site 157
S1450
E
V
A
E
V
G
F
S
S
N
D
D
E
D
K
Site 158
S1451
V
A
E
V
G
F
S
S
N
D
D
E
D
K
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation