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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TJ6
Full Name:
V-type proton ATPase 116 kDa subunit a isoform 2
Alias:
A2; ATP6a2; ATP6N1D; ATP6V0A2; ATPase, H+ transporting, lysosomal V0 subunit a2; Infantile malignant osteopetrosis; J6B7; Stv1; TJ6M; TJ6s; V- ATPase 116-kDa isoform a2; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2; Vph1; VPP2
Type:
Transporter; Energy Metabolism - oxidative phosphorylation
Mass (Da):
98082
Number AA:
856
UniProt ID:
Q9Y487
International Prot ID:
IPI00000425
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0010008
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0015078
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0015986
GO:0006955
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S45
R
D
L
N
Q
N
V
S
S
F
Q
R
K
F
V
Site 2
S46
D
L
N
Q
N
V
S
S
F
Q
R
K
F
V
G
Site 3
S85
P
L
P
E
G
E
A
S
P
P
A
P
P
L
K
Site 4
T112
E
V
E
L
R
E
V
T
K
N
K
E
K
L
R
Site 5
Y128
N
L
L
E
L
I
E
Y
T
H
M
L
R
V
T
Site 6
T129
L
L
E
L
I
E
Y
T
H
M
L
R
V
T
K
Site 7
T135
Y
T
H
M
L
R
V
T
K
T
F
V
K
R
N
Site 8
T137
H
M
L
R
V
T
K
T
F
V
K
R
N
V
E
Site 9
T148
R
N
V
E
F
E
P
T
Y
E
E
F
P
S
L
Site 10
Y149
N
V
E
F
E
P
T
Y
E
E
F
P
S
L
E
Site 11
S154
P
T
Y
E
E
F
P
S
L
E
S
D
S
L
L
Site 12
S157
E
E
F
P
S
L
E
S
D
S
L
L
D
Y
S
Site 13
S159
F
P
S
L
E
S
D
S
L
L
D
Y
S
C
M
Site 14
Y163
E
S
D
S
L
L
D
Y
S
C
M
Q
R
L
G
Site 15
S164
S
D
S
L
L
D
Y
S
C
M
Q
R
L
G
A
Site 16
S177
G
A
K
L
G
F
V
S
G
L
I
N
Q
G
K
Site 17
Y204
K
G
Y
T
I
V
S
Y
A
E
L
D
E
S
L
Site 18
S210
S
Y
A
E
L
D
E
S
L
E
D
P
E
T
G
Site 19
T216
E
S
L
E
D
P
E
T
G
E
V
I
K
W
Y
Site 20
Y223
T
G
E
V
I
K
W
Y
V
F
L
I
S
F
W
Site 21
Y252
Y
H
C
H
V
Y
P
Y
P
N
T
A
E
E
R
Site 22
T268
E
I
Q
E
G
L
N
T
R
I
Q
D
L
Y
T
Site 23
Y274
N
T
R
I
Q
D
L
Y
T
V
L
H
K
T
E
Site 24
T275
T
R
I
Q
D
L
Y
T
V
L
H
K
T
E
D
Site 25
Y283
V
L
H
K
T
E
D
Y
L
R
Q
V
L
C
K
Site 26
Y296
C
K
A
A
E
S
V
Y
S
R
V
I
Q
V
K
Site 27
S297
K
A
A
E
S
V
Y
S
R
V
I
Q
V
K
K
Site 28
S349
L
E
E
G
S
R
E
S
G
A
T
I
P
S
F
Site 29
T352
G
S
R
E
S
G
A
T
I
P
S
F
M
N
I
Site 30
T365
N
I
I
P
T
K
E
T
P
P
T
R
I
R
T
Site 31
T368
P
T
K
E
T
P
P
T
R
I
R
T
N
K
F
Site 32
T372
T
P
P
T
R
I
R
T
N
K
F
T
E
G
F
Site 33
T376
R
I
R
T
N
K
F
T
E
G
F
Q
N
I
V
Site 34
Y386
F
Q
N
I
V
D
A
Y
G
V
G
S
Y
R
E
Site 35
S390
V
D
A
Y
G
V
G
S
Y
R
E
V
N
P
A
Site 36
Y468
S
V
Y
T
G
L
I
Y
N
D
C
F
S
K
S
Site 37
S486
F
G
S
G
W
N
V
S
A
M
Y
S
S
S
H
Site 38
Y489
G
W
N
V
S
A
M
Y
S
S
S
H
P
P
A
Site 39
S490
W
N
V
S
A
M
Y
S
S
S
H
P
P
A
E
Site 40
S491
N
V
S
A
M
Y
S
S
S
H
P
P
A
E
H
Site 41
S492
V
S
A
M
Y
S
S
S
H
P
P
A
E
H
K
Site 42
S513
D
S
V
V
R
H
N
S
I
L
Q
L
D
P
S
Site 43
T545
N
L
A
T
N
R
L
T
F
L
N
S
F
K
M
Site 44
S549
N
R
L
T
F
L
N
S
F
K
M
K
M
S
V
Site 45
T643
S
K
T
S
G
L
Y
T
G
Q
E
Y
V
Q
R
Site 46
S686
S
C
F
G
V
N
R
S
G
Y
T
L
I
R
K
Site 47
Y688
F
G
V
N
R
S
G
Y
T
L
I
R
K
D
S
Site 48
S695
Y
T
L
I
R
K
D
S
E
E
E
V
S
L
L
Site 49
S700
K
D
S
E
E
E
V
S
L
L
G
S
Q
D
I
Site 50
S704
E
E
V
S
L
L
G
S
Q
D
I
E
E
G
N
Site 51
Y830
V
E
F
Q
N
K
F
Y
V
G
A
G
T
K
F
Site 52
S846
P
F
S
F
S
L
L
S
S
K
F
N
N
D
D
Site 53
S847
F
S
F
S
L
L
S
S
K
F
N
N
D
D
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation