KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
WDR45
Full Name:
WD repeat domain phosphoinositide-interacting protein 4
Alias:
WD repeat-containing protein 45
Type:
Mass (Da):
39868
Number AA:
360
UniProt ID:
Q9Y484
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
Q
Q
P
L
R
G
V
T
S
L
R
F
N
Q
D
Site 2
S11
Q
P
L
R
G
V
T
S
L
R
F
N
Q
D
Q
Site 3
Y32
M
E
T
G
V
R
I
Y
N
V
E
P
L
M
E
Site 4
S71
A
L
V
G
G
G
S
S
P
K
F
S
E
I
S
Site 5
S91
D
A
R
E
G
K
D
S
K
E
K
L
V
L
E
Site 6
S107
T
F
T
K
P
V
L
S
V
R
M
R
H
D
K
Site 7
Y124
I
V
L
K
N
R
I
Y
V
Y
S
F
P
D
N
Site 8
Y126
L
K
N
R
I
Y
V
Y
S
F
P
D
N
P
R
Site 9
S127
K
N
R
I
Y
V
Y
S
F
P
D
N
P
R
K
Site 10
S176
L
Q
L
V
D
L
A
S
T
K
P
G
T
S
S
Site 11
S182
A
S
T
K
P
G
T
S
S
A
P
F
T
I
N
Site 12
S183
S
T
K
P
G
T
S
S
A
P
F
T
I
N
A
Site 13
T187
G
T
S
S
A
P
F
T
I
N
A
H
Q
S
D
Site 14
T215
A
S
A
S
Q
K
G
T
L
I
R
L
F
D
T
Site 15
T222
T
L
I
R
L
F
D
T
Q
S
K
E
K
L
V
Site 16
S224
I
R
L
F
D
T
Q
S
K
E
K
L
V
E
L
Site 17
T235
L
V
E
L
R
R
G
T
D
P
A
T
L
Y
C
Site 18
T239
R
R
G
T
D
P
A
T
L
Y
C
I
N
F
S
Site 19
Y241
G
T
D
P
A
T
L
Y
C
I
N
F
S
H
D
Site 20
S250
I
N
F
S
H
D
S
S
F
L
C
A
S
S
D
Site 21
S255
D
S
S
F
L
C
A
S
S
D
K
G
T
V
H
Site 22
S275
D
T
R
L
N
R
R
S
A
L
A
R
V
G
K
Site 23
Y290
V
G
P
M
I
G
Q
Y
V
D
S
Q
W
S
L
Site 24
S296
Q
Y
V
D
S
Q
W
S
L
A
S
F
T
V
P
Site 25
S299
D
S
Q
W
S
L
A
S
F
T
V
P
A
E
S
Site 26
T316
I
C
A
F
G
R
N
T
S
K
N
V
N
S
V
Site 27
S317
C
A
F
G
R
N
T
S
K
N
V
N
S
V
I
Site 28
Y335
V
D
G
T
F
H
K
Y
V
F
T
P
D
G
N
Site 29
T338
T
F
H
K
Y
V
F
T
P
D
G
N
C
N
R
Site 30
Y351
N
R
E
A
F
D
V
Y
L
D
I
C
D
D
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation