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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NR2E1
Full Name:
Nuclear receptor subfamily 2 group E member 1
Alias:
HTll; Nuclear receptor TLX; Protein tailless homologue; Tll; TLX
Type:
Receptor, nuclear
Mass (Da):
42589
Number AA:
385
UniProt ID:
Q9Y466
International Prot ID:
IPI00745462
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0005496
GO:0003707
PhosphoSite+
KinaseNET
Biological Process:
GO:0007399
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
K
P
A
G
S
T
S
R
I
L
D
I
Site 2
S9
S
K
P
A
G
S
T
S
R
I
L
D
I
P
C
Site 3
S24
K
V
C
G
D
R
S
S
G
K
H
Y
G
V
Y
Site 4
Y28
D
R
S
S
G
K
H
Y
G
V
Y
A
C
D
G
Site 5
Y31
S
G
K
H
Y
G
V
Y
A
C
D
G
C
S
G
Site 6
S37
V
Y
A
C
D
G
C
S
G
F
F
K
R
S
I
Site 7
S43
C
S
G
F
F
K
R
S
I
R
R
N
R
T
Y
Site 8
T49
R
S
I
R
R
N
R
T
Y
V
C
K
S
G
N
Site 9
Y50
S
I
R
R
N
R
T
Y
V
C
K
S
G
N
Q
Site 10
S97
H
E
R
G
P
R
T
S
T
I
R
K
Q
V
A
Site 11
T98
E
R
G
P
R
T
S
T
I
R
K
Q
V
A
L
Site 12
Y106
I
R
K
Q
V
A
L
Y
F
R
G
H
K
E
E
Site 13
T150
E
L
A
A
V
S
T
T
P
E
R
Q
T
L
V
Site 14
T155
S
T
T
P
E
R
Q
T
L
V
S
L
A
Q
P
Site 15
S158
P
E
R
Q
T
L
V
S
L
A
Q
P
T
P
K
Site 16
T163
L
V
S
L
A
Q
P
T
P
K
Y
P
H
E
V
Site 17
Y166
L
A
Q
P
T
P
K
Y
P
H
E
V
N
G
T
Site 18
T173
Y
P
H
E
V
N
G
T
P
M
Y
L
Y
E
V
Site 19
Y176
E
V
N
G
T
P
M
Y
L
Y
E
V
A
T
E
Site 20
Y178
N
G
T
P
M
Y
L
Y
E
V
A
T
E
S
V
Site 21
S184
L
Y
E
V
A
T
E
S
V
C
E
S
A
A
R
Site 22
T253
S
G
M
N
G
D
N
T
D
S
Q
K
L
N
K
Site 23
S255
M
N
G
D
N
T
D
S
Q
K
L
N
K
I
I
Site 24
S263
Q
K
L
N
K
I
I
S
E
I
Q
A
L
Q
E
Site 25
T283
R
Q
L
R
L
D
A
T
E
F
A
C
L
K
C
Site 26
T299
V
T
F
K
A
V
P
T
H
S
G
S
E
L
R
Site 27
S301
F
K
A
V
P
T
H
S
G
S
E
L
R
S
F
Site 28
S303
A
V
P
T
H
S
G
S
E
L
R
S
F
R
N
Site 29
S307
H
S
G
S
E
L
R
S
F
R
N
A
A
A
I
Site 30
T324
L
Q
D
E
A
Q
L
T
L
N
S
Y
I
H
T
Site 31
Y328
A
Q
L
T
L
N
S
Y
I
H
T
R
Y
P
T
Site 32
T331
T
L
N
S
Y
I
H
T
R
Y
P
T
Q
P
C
Site 33
T335
Y
I
H
T
R
Y
P
T
Q
P
C
R
F
G
K
Site 34
T357
L
R
S
I
S
P
S
T
I
E
E
V
F
F
K
Site 35
S377
V
P
I
T
R
L
L
S
D
M
Y
K
S
S
D
Site 36
Y380
T
R
L
L
S
D
M
Y
K
S
S
D
I
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation