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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
C21orf25
Full Name:
C2 domain-containing protein 2
Alias:
C2 calcium-dependent domain containing 2; C21orf258; Chromosome 21 open reading frame 25; CU025; DKFZP586F0422; LOC25966; TMEM24 related geme; TMEM24L; TMEM24-like
Type:
Mass (Da):
75533
Number AA:
696
UniProt ID:
Q9Y426
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005576
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S60
G
E
G
P
R
P
G
S
D
A
L
L
S
W
I
Site 2
S99
K
G
G
P
P
F
L
S
F
E
E
D
P
R
Q
Site 3
S118
L
V
V
Q
E
V
S
S
V
L
R
S
A
E
E
Site 4
S159
R
L
Y
D
M
R
L
S
P
F
H
L
Q
L
E
Site 5
S179
K
R
E
D
L
Q
I
S
W
S
F
I
S
V
P
Site 6
S181
E
D
L
Q
I
S
W
S
F
I
S
V
P
E
M
Site 7
S247
Q
N
L
Q
C
A
A
S
T
A
Q
E
S
C
P
Site 8
S252
A
A
S
T
A
Q
E
S
C
P
P
K
P
P
R
Site 9
S300
N
D
P
V
Q
R
F
S
S
T
L
T
K
N
T
Site 10
S301
D
P
V
Q
R
F
S
S
T
L
T
K
N
T
P
Site 11
T302
P
V
Q
R
F
S
S
T
L
T
K
N
T
P
D
Site 12
T304
Q
R
F
S
S
T
L
T
K
N
T
P
D
L
M
Site 13
T307
S
S
T
L
T
K
N
T
P
D
L
M
W
E
E
Site 14
T317
L
M
W
E
E
E
F
T
F
E
L
N
A
K
S
Site 15
S324
T
F
E
L
N
A
K
S
K
E
L
H
L
Q
I
Site 16
S332
K
E
L
H
L
Q
I
S
E
A
G
R
S
S
E
Site 17
S337
Q
I
S
E
A
G
R
S
S
E
G
L
L
A
T
Site 18
S338
I
S
E
A
G
R
S
S
E
G
L
L
A
T
A
Site 19
S357
D
L
F
K
K
Q
P
S
G
P
Q
S
F
T
L
Site 20
S361
K
Q
P
S
G
P
Q
S
F
T
L
T
S
G
S
Site 21
T363
P
S
G
P
Q
S
F
T
L
T
S
G
S
A
C
Site 22
T365
G
P
Q
S
F
T
L
T
S
G
S
A
C
G
S
Site 23
S366
P
Q
S
F
T
L
T
S
G
S
A
C
G
S
S
Site 24
S383
G
S
V
T
A
E
F
S
Y
M
E
P
G
E
L
Site 25
Y384
S
V
T
A
E
F
S
Y
M
E
P
G
E
L
K
Site 26
S392
M
E
P
G
E
L
K
S
W
P
I
P
P
P
V
Site 27
T409
A
K
I
E
K
D
R
T
V
M
P
C
G
T
V
Site 28
S435
R
V
D
V
G
R
A
S
P
L
S
S
D
S
P
Site 29
S438
V
G
R
A
S
P
L
S
S
D
S
P
V
K
T
Site 30
S439
G
R
A
S
P
L
S
S
D
S
P
V
K
T
P
Site 31
S441
A
S
P
L
S
S
D
S
P
V
K
T
P
I
K
Site 32
T445
S
S
D
S
P
V
K
T
P
I
K
V
K
V
I
Site 33
S469
A
C
R
S
A
P
V
S
K
T
L
S
S
S
D
Site 34
T471
R
S
A
P
V
S
K
T
L
S
S
S
D
T
E
Site 35
S473
A
P
V
S
K
T
L
S
S
S
D
T
E
L
L
Site 36
T477
K
T
L
S
S
S
D
T
E
L
L
V
L
N
G
Site 37
S497
E
V
A
I
R
Q
L
S
E
S
S
K
L
K
L
Site 38
S499
A
I
R
Q
L
S
E
S
S
K
L
K
L
K
S
Site 39
S506
S
S
K
L
K
L
K
S
P
R
K
K
S
T
I
Site 40
S511
L
K
S
P
R
K
K
S
T
I
I
I
S
G
I
Site 41
T512
K
S
P
R
K
K
S
T
I
I
I
S
G
I
S
Site 42
T521
I
I
S
G
I
S
K
T
S
L
S
Q
D
H
D
Site 43
S522
I
S
G
I
S
K
T
S
L
S
Q
D
H
D
A
Site 44
S524
G
I
S
K
T
S
L
S
Q
D
H
D
A
A
L
Site 45
S538
L
M
Q
G
Y
T
A
S
V
D
S
T
H
Q
E
Site 46
S541
G
Y
T
A
S
V
D
S
T
H
Q
E
D
A
P
Site 47
T542
Y
T
A
S
V
D
S
T
H
Q
E
D
A
P
S
Site 48
S549
T
H
Q
E
D
A
P
S
H
P
E
R
A
A
A
Site 49
S565
A
P
P
E
E
A
E
S
A
Q
A
S
L
A
P
Site 50
S569
E
A
E
S
A
Q
A
S
L
A
P
K
P
Q
E
Site 51
S581
P
Q
E
D
E
L
D
S
W
D
L
E
K
E
P
Site 52
S595
P
Q
A
A
A
W
S
S
Q
V
L
L
D
P
D
Site 53
S607
D
P
D
G
D
E
L
S
E
S
S
M
S
V
L
Site 54
S609
D
G
D
E
L
S
E
S
S
M
S
V
L
E
P
Site 55
S610
G
D
E
L
S
E
S
S
M
S
V
L
E
P
G
Site 56
S612
E
L
S
E
S
S
M
S
V
L
E
P
G
T
A
Site 57
S647
Q
Q
K
D
P
G
M
S
Q
S
H
N
D
L
V
Site 58
S649
K
D
P
G
M
S
Q
S
H
N
D
L
V
F
L
Site 59
T668
G
S
R
R
K
G
I
T
L
T
R
I
L
N
K
Site 60
S679
I
L
N
K
K
L
L
S
R
H
R
N
K
N
T
Site 61
T686
S
R
H
R
N
K
N
T
M
N
G
A
P
V
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation