PhosphoNET

           
Protein Info 
   
Short Name:  Wnk2
Full Name:  Serine/threonine-protein kinase WNK2
Alias:  Antigen NY-CO-43; EC 2.7.11.1; KIAA1760; NY-CO-43; P,OKcl.13; P/OKcl.13; PRKWNK2; Protein kinase with no lysine 2; Protein kinase, lysine-deficient 2; SDCCAG43; Serologically defined colon cancer antigen 43; WNK lysine deficient protein kinase 2
Type:  EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; Wnk family
Mass (Da):  242676
Number AA:  2297
UniProt ID:  Q9Y3S1
International Prot ID:  IPI00398808
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0005515  GO:0004674 PhosphoSite+ KinaseNET
Biological Process:  GO:0006468  GO:0007243   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T13GRRDVPGTLMEPGRG
Site 2S45PQRFLRRSVVESDQE
Site 3S49LRRSVVESDQEEPPG
Site 4T121AGPEPVGTQEPGPDP
Site 5T150PREEAAATVRKEDEG
Site 6T168AKPEPGRTRRDEPEE
Site 7S205DIELGRGSFKTVYKG
Site 8T208LGRGSFKTVYKGLDT
Site 9Y210RGSFKTVYKGLDTET
Site 10T232ELQDRKLTKLERQRF
Site 11Y258HPNIVRFYDFWESSA
Site 12T282TELMTSGTLKTYLKR
Site 13Y286TSGTLKTYLKRFKVM
Site 14T316LLFLHTRTPPIIHRD
Site 15T347IGDLGLATLKRASFA
Site 16S352LATLKRASFAKSVIG
Site 17S356KRASFAKSVIGTPEF
Site 18Y373PEMYEEHYDESVDVY
Site 19Y394LEMATSEYPYSECQN
Site 20S397ATSEYPYSECQNAAQ
Site 21T410AQIYRKVTCGIKPAS
Site 22S417TCGIKPASFEKVHDP
Site 23Y442CKNKEERYEIKDLLS
Site 24S449YEIKDLLSHAFFAED
Site 25S472EEDHGRKSTIALRLW
Site 26T473EDHGRKSTIALRLWV
Site 27T506TFDLEKETPDEVAQE
Site 28S517VAQEMIESGFFHESD
Site 29S523ESGFFHESDVKIVAK
Site 30S560KEQQDVGSPDKARGP
Site 31Y577PLQVQVTYHAQAGQP
Site 32T602DQHLLPPTLPTSATS
Site 33S606LPPTLPTSATSLASD
Site 34T608PTLPTSATSLASDST
Site 35S609TLPTSATSLASDSTF
Site 36S612TSATSLASDSTFDSG
Site 37S614ATSLASDSTFDSGQG
Site 38T615TSLASDSTFDSGQGS
Site 39S618ASDSTFDSGQGSTVY
Site 40S622TFDSGQGSTVYSDSQ
Site 41T623FDSGQGSTVYSDSQS
Site 42Y625SGQGSTVYSDSQSSQ
Site 43S626GQGSTVYSDSQSSQQ
Site 44S628GSTVYSDSQSSQQSV
Site 45S630TVYSDSQSSQQSVML
Site 46S631VYSDSQSSQQSVMLG
Site 47S634DSQSSQQSVMLGSLA
Site 48S653SPAQCVCSPPVSEGP
Site 49S665EGPVLPQSLPSLGAY
Site 50S668VLPQSLPSLGAYQQP
Site 51Y672SLPSLGAYQQPTAAP
Site 52S694PAPACPPSLQQHFPD
Site 53S714APVLPPPSTPMPTGP
Site 54T715PVLPPPSTPMPTGPG
Site 55S767PPYLAPASQVGAPAQ
Site 56Y912QLPGQPVYPAAFPQM
Site 57T922AFPQMAPTDVPPSPH
Site 58S927APTDVPPSPHHTVQN
Site 59T931VPPSPHHTVQNMRAT
Site 60T938TVQNMRATPPQPALP
Site 61T949PALPPQPTLPPQPVL
Site 62T973PVLPPQPTRPPQPVL
Site 63T1089SVPTQTATLLPPANP
Site 64T1114PCPTVQLTVEPVQEE
Site 65S1124PVQEEQASQDKPPGL
Site 66S1134KPPGLPQSCESYGGS
Site 67S1137GLPQSCESYGGSDVT
Site 68S1141SCESYGGSDVTSGKE
Site 69T1144SYGGSDVTSGKELSD
Site 70S1145YGGSDVTSGKELSDS
Site 71S1150VTSGKELSDSCEGAF
Site 72S1152SGKELSDSCEGAFGG
Site 73S1174ARKHHRRSTRARSRQ
Site 74T1175RKHHRRSTRARSRQE
Site 75S1179RRSTRARSRQERASR
Site 76S1185RSRQERASRPRLTIL
Site 77T1190RASRPRLTILNVCNT
Site 78T1245ILQAERETFIEQMKD
Site 79S1262DKAEDMLSEDTDADR
Site 80T1265EDMLSEDTDADRGSD
Site 81S1271DTDADRGSDPGTSPP
Site 82T1275DRGSDPGTSPPHLST
Site 83S1276RGSDPGTSPPHLSTC
Site 84S1281GTSPPHLSTCGLGTG
Site 85S1294TGEESRQSQANAPVY
Site 86Y1301SQANAPVYQQNVLHT
Site 87S1329PAPEAPESSPPLPLS
Site 88S1330APEAPESSPPLPLSS
Site 89S1336SSPPLPLSSLPPEAS
Site 90S1337SPPLPLSSLPPEASQ
Site 91S1343SSLPPEASQGPCRGL
Site 92T1351QGPCRGLTLPCLPWR
Site 93S1374LSLFSAESAQSKQPP
Site 94S1377FSAESAQSKQPPDSA
Site 95S1383QSKQPPDSAPYKDQL
Site 96S1391APYKDQLSSKEQPSF
Site 97S1397LSSKEQPSFLASQQL
Site 98S1401EQPSFLASQQLLSQA
Site 99S1406LASQQLLSQAGPSNP
Site 100S1411LLSQAGPSNPPGAPP
Site 101T1429APSSPPVTALPQDGA
Site 102S1441DGAAPATSTMPEPAS
Site 103S1448STMPEPASGTASQAG
Site 104S1452EPASGTASQAGGPGT
Site 105T1459SQAGGPGTPQGLTSE
Site 106S1470LTSELETSQPLAETH
Site 107S1501TPAPEAASTRDASAP
Site 108T1502PAPEAASTRDASAPR
Site 109S1506AASTRDASAPREPLP
Site 110S1520PPPAPEPSPHSGTPQ
Site 111S1523APEPSPHSGTPQPAL
Site 112T1525EPSPHSGTPQPALGQ
Site 113T1559PSPPLGPTVPPQPPS
Site 114S1566TVPPQPPSALESDGE
Site 115S1570QPPSALESDGEGPPP
Site 116S1584PRVGFVDSTIKSLDE
Site 117T1585RVGFVDSTIKSLDEK
Site 118S1588FVDSTIKSLDEKLRT
Site 119T1595SLDEKLRTLLYQEHV
Site 120Y1598EKLRTLLYQEHVPTS
Site 121T1604LYQEHVPTSSASAGT
Site 122S1605YQEHVPTSSASAGTP
Site 123S1606QEHVPTSSASAGTPV
Site 124T1611TSSASAGTPVEVGDR
Site 125T1621EVGDRDFTLEPLRGD
Site 126S1632LRGDQPRSEVCGGDL
Site 127S1650PVPKEAVSGRVQLPQ
Site 128S1663PQPLVEKSELAPTRG
Site 129T1668EKSELAPTRGAVMEQ
Site 130S1680MEQGTSSSMTAESSP
Site 131T1682QGTSSSMTAESSPRS
Site 132S1685SSSMTAESSPRSMLG
Site 133S1686SSMTAESSPRSMLGY
Site 134S1689TAESSPRSMLGYDRD
Site 135Y1693SPRSMLGYDRDGRQV
Site 136S1702RDGRQVASDSHVVPS
Site 137S1704GRQVASDSHVVPSVP
Site 138S1709SDSHVVPSVPQDVPA
Site 139T1726RPARVEPTDRDGGEA
Site 140S1736DGGEAGESSAEPPPS
Site 141S1737GGEAGESSAEPPPSD
Site 142S1743SSAEPPPSDMGTVGG
Site 143T1747PPPSDMGTVGGQASH
Site 144S1753GTVGGQASHPQTLGA
Site 145T1757GQASHPQTLGARALG
Site 146S1765LGARALGSPRKRPEQ
Site 147S1776RPEQQDVSSPAKTVG
Site 148S1777PEQQDVSSPAKTVGR
Site 149S1786AKTVGRFSVVSTQDE
Site 150S1789VGRFSVVSTQDEWTL
Site 151T1790GRFSVVSTQDEWTLA
Site 152T1795VSTQDEWTLASPHSL
Site 153S1798QDEWTLASPHSLRYS
Site 154S1801WTLASPHSLRYSAPP
Site 155Y1804ASPHSLRYSAPPDVY
Site 156S1805SPHSLRYSAPPDVYL
Site 157Y1811YSAPPDVYLDEAPSS
Site 158S1817VYLDEAPSSPDVKLA
Site 159S1818YLDEAPSSPDVKLAV
Site 160T1830LAVRRAQTASSIEVG
Site 161S1832VRRAQTASSIEVGVG
Site 162S1833RRAQTASSIEVGVGE
Site 163S1843VGVGEPVSSDSGDEG
Site 164S1844GVGEPVSSDSGDEGP
Site 165S1846GEPVSSDSGDEGPRA
Site 166S1862PPVQKQASLPVSGSV
Site 167S1866KQASLPVSGSVAGDF
Site 168S1885TAFLQRPSRAGSLGP
Site 169S1889QRPSRAGSLGPETPS
Site 170T1894AGSLGPETPSRVGMK
Site 171S1896SLGPETPSRVGMKVP
Site 172S1906GMKVPTISVTSFHSQ
Site 173T1908KVPTISVTSFHSQSS
Site 174S1909VPTISVTSFHSQSSY
Site 175S1912ISVTSFHSQSSYISS
Site 176S1914VTSFHSQSSYISSDN
Site 177S1915TSFHSQSSYISSDND
Site 178Y1916SFHSQSSYISSDNDS
Site 179S1918HSQSSYISSDNDSEL
Site 180S1919SQSSYISSDNDSELE
Site 181S1923YISSDNDSELEDADI
Site 182S1936DIKKELQSLREKHLK
Site 183S1950KEISELQSQQKQEIE
Site 184Y1960KQEIEALYRRLGKPL
Site 185T1976PNVGFFHTAPPTGRR
Site 186T1980FFHTAPPTGRRRKTS
Site 187T1986PTGRRRKTSKSKLKA
Site 188S1987TGRRRKTSKSKLKAG
Site 189S1989RRRKTSKSKLKAGKL
Site 190S2009RQLKVVASSTGHLAD
Site 191S2017STGHLADSSRGPPAK
Site 192S2018TGHLADSSRGPPAKD
Site 193S2041TADSTGLSGKAVQTQ
Site 194T2047LSGKAVQTQQPCSVR
Site 195S2052VQTQQPCSVRASLSS
Site 196S2056QPCSVRASLSSDICS
Site 197S2063SLSSDICSGLASDGG
Site 198S2067DICSGLASDGGGARG
Site 199T2078GARGQGWTVYHPTSE
Site 200Y2080RGQGWTVYHPTSERV
Site 201T2088HPTSERVTYKSSSKP
Site 202Y2089PTSERVTYKSSSKPR
Site 203S2091SERVTYKSSSKPRAR
Site 204S2093RVTYKSSSKPRARFL
Site 205S2101KPRARFLSGPVSVSI
Site 206S2122LCLGKEHSSRSSTSS
Site 207S2123CLGKEHSSRSSTSSL
Site 208S2125GKEHSSRSSTSSLAP
Site 209S2126KEHSSRSSTSSLAPG
Site 210T2127EHSSRSSTSSLAPGP
Site 211S2128HSSRSSTSSLAPGPE
Site 212S2129SSRSSTSSLAPGPEP
Site 213T2157NSNNKKGTFTDDLHK
Site 214T2159NNKKGTFTDDLHKLV
Site 215T2170HKLVDEWTSKTVGAA
Site 216T2173VDEWTSKTVGAAQLK
Site 217T2211PGEARAMTAPRAGVG
Site 218S2242PGAAPTLSVPTPDGA
Site 219T2252TPDGALGTARRNQVW
Site 220S2273PTACCGHSTQPRGGQ
Site 221T2274TACCGHSTQPRGGQR
Site 222S2284RGGQRVGSKTASFAA
Site 223T2286GQRVGSKTASFAASD
Site 224S2288RVGSKTASFAASDPV
Site 225S2292KTASFAASDPVRS__
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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