PhosphoNET

           
Protein Info 
   
Short Name:  HCN4
Full Name:  Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Alias:  Hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Type:  Membrane, Integral membrane protein
Mass (Da):  129042
Number AA:  1203
UniProt ID:  Q9Y3Q4
International Prot ID:  IPI00023164
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0016021     Uniprot OncoNet
Molecular Function:  GO:0030552  GO:0030955  GO:0005515 PhosphoSite+ KinaseNET
Biological Process:  GO:0008015  GO:0006936  GO:0006813 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S7_MDKLPPSMRKRLYS
Site 2Y13PSMRKRLYSLPQQVG
Site 3S14SMRKRLYSLPQQVGA
Site 4S44AGGRQDPSRRSIRLR
Site 5S47RQDPSRRSIRLRPLP
Site 6S55IRLRPLPSPSPSAAA
Site 7S57LRPLPSPSPSAAAGG
Site 8S59PLPSPSPSAAAGGTE
Site 9T65PSAAAGGTESRSSAL
Site 10S67AAAGGTESRSSALGA
Site 11S69AGGTESRSSALGAAD
Site 12S70GGTESRSSALGAADS
Site 13S77SALGAADSEGPARGA
Site 14S87PARGAGKSSTNGDCR
Site 15S88ARGAGKSSTNGDCRR
Site 16T89RGAGKSSTNGDCRRF
Site 17S99DCRRFRGSLASLGSR
Site 18S102RFRGSLASLGSRGGG
Site 19S105GSLASLGSRGGGSGG
Site 20S110LGSRGGGSGGTGSGS
Site 21T113RGGGSGGTGSGSSHG
Site 22S115GGSGGTGSGSSHGHL
Site 23S117SGGTGSGSSHGHLHD
Site 24S118GGTGSGSSHGHLHDS
Site 25S125SHGHLHDSAEERRLI
Site 26S138LIAEGDASPGEDRTP
Site 27T144ASPGEDRTPPGLAAE
Site 28S158EPERPGASAQPAASP
Site 29S164ASAQPAASPPPPQQP
Site 30S176QQPPQPASASCEQPS
Site 31S178PPQPASASCEQPSVD
Site 32S230QPGVNKFSLRMFGSQ
Site 33S236FSLRMFGSQKAVERE
Site 34S249REQERVKSAGFWIIH
Site 35Y264PYSDFRFYWDLTMLL
Site 36Y337PQRIKMKYLKSWFMV
Site 37S365IVETRIDSEVYKTAR
Site 38Y467SWGKQYSYALFKAMS
Site 39S519HATALIQSLDSSRRQ
Site 40S522ALIQSLDSSRRQYQE
Site 41S523LIQSLDSSRRQYQEK
Site 42Y527LDSSRRQYQEKYKQV
Site 43Y531RRQYQEKYKQVEQYM
Site 44S539KQVEQYMSFHKLPPD
Site 45T547FHKLPPDTRQRIHDY
Site 46Y554TRQRIHDYYEHRYQG
Site 47Y555RQRIHDYYEHRYQGK
Site 48S568GKMFDEESILGELSE
Site 49S574ESILGELSEPLREEI
Site 50Y621EVFQPGDYIIREGTI
Site 51T627DYIIREGTIGKKMYF
Site 52T650LTKGNKETKLADGSY
Site 53T665FGEICLLTRGRRTAS
Site 54T670LLTRGRRTASVRADT
Site 55S672TRGRRTASVRADTYC
Site 56T677TASVRADTYCRLYSL
Site 57Y678ASVRADTYCRLYSLS
Site 58Y682ADTYCRLYSLSVDNF
Site 59S683DTYCRLYSLSVDNFN
Site 60S685YCRLYSLSVDNFNEV
Site 61Y696FNEVLEEYPMMRRAF
Site 62T705MMRRAFETVALDRLD
Site 63Y736LNSGVFNYQENEIIQ
Site 64S764HRVQAAASATPTPTP
Site 65T822GNLGAGQTPRHLKRL
Site 66S831RHLKRLQSLIPSALG
Site 67S841PSALGSASPASSPSQ
Site 68S844LGSASPASSPSQVDT
Site 69S845GSASPASSPSQVDTP
Site 70S847ASPASSPSQVDTPSS
Site 71T851SSPSQVDTPSSSSFH
Site 72S853PSQVDTPSSSSFHIQ
Site 73S854SQVDTPSSSSFHIQQ
Site 74S856VDTPSSSSFHIQQLA
Site 75S877GLSPLLPSSSSSPPP
Site 76S878LSPLLPSSSSSPPPG
Site 77S879SPLLPSSSSSPPPGA
Site 78S880PLLPSSSSSPPPGAC
Site 79S881LLPSSSSSPPPGACG
Site 80S889PPPGACGSPSAPTPS
Site 81S891PGACGSPSAPTPSAG
Site 82S896SPSAPTPSAGVAATT
Site 83S917FHKALGGSLSSSDSP
Site 84S919KALGGSLSSSDSPLL
Site 85S921LGGSLSSSDSPLLTP
Site 86S923GSLSSSDSPLLTPLQ
Site 87T927SSDSPLLTPLQPGAR
Site 88S935PLQPGARSPQAAQPS
Site 89S942SPQAAQPSPAPPGAR
Site 90S964HFLPPPPSSRSPSSS
Site 91S965FLPPPPSSRSPSSSP
Site 92S967PPPPSSRSPSSSPGQ
Site 93S969PPSSRSPSSSPGQLG
Site 94S970PSSRSPSSSPGQLGQ
Site 95S971SSRSPSSSPGQLGQP
Site 96S983GQPPGELSLGLATGP
Site 97S992GLATGPLSTPETPPR
Site 98T993LATGPLSTPETPPRQ
Site 99T996GPLSTPETPPRQPEP
Site 100S1005PRQPEPPSLVAGASG
Site 101S1015AGASGGASPVGFTPR
Site 102T1020GASPVGFTPRGGLSP
Site 103S1026FTPRGGLSPPGHSPG
Site 104S1031GLSPPGHSPGPPRTF
Site 105T1037HSPGPPRTFPSAPPR
Site 106S1040GPPRTFPSAPPRASG
Site 107S1046PSAPPRASGSHGSLL
Site 108S1048APPRASGSHGSLLLP
Site 109S1051RASGSHGSLLLPPAS
Site 110S1058SLLLPPASSPPPPQV
Site 111S1059LLLPPASSPPPPQVP
Site 112T1071QVPQRRGTPPLTPGR
Site 113T1075RRGTPPLTPGRLTQD
Site 114T1080PLTPGRLTQDLKLIS
Site 115S1087TQDLKLISASQPALP
Site 116S1089DLKLISASQPALPQD
Site 117T1100LPQDGAQTLRRASPH
Site 118S1105AQTLRRASPHSSGES
Site 119S1108LRRASPHSSGESMAA
Site 120S1109RRASPHSSGESMAAF
Site 121S1112SPHSSGESMAAFPLF
Site 122S1126FPRAGGGSGGSGSSG
Site 123S1129AGGGSGGSGSSGGLG
Site 124S1131GGSGGSGSSGGLGPP
Site 125S1132GSGGSGSSGGLGPPG
Site 126Y1142LGPPGRPYGAIPGQH
Site 127T1151AIPGQHVTLPRKTSS
Site 128T1156HVTLPRKTSSGSLPP
Site 129S1157VTLPRKTSSGSLPPP
Site 130S1158TLPRKTSSGSLPPPL
Site 131S1160PRKTSSGSLPPPLSL
Site 132T1173SLFGARATSSGGPPL
Site 133S1174LFGARATSSGGPPLT
Site 134S1175FGARATSSGGPPLTA
Site 135T1181SSGGPPLTAGPQREP
Site 136S1197ARPEPVRSKLPSNL_
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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