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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TXNDC14
Full Name:
Thioredoxin-related transmembrane protein 2 precursor
Alias:
CGI-31; Growth-inhibiting gene 11; PDIA12; PIG26; Proliferation-inducing gene 26 protein; Protein disulfide isomerase family A, member 12; Thioredoxin domain containing 14; Thioredoxin domain-containing protein 14; Thioredoxin-related transmembrane protein 2; TMX2; TXD14
Type:
Mass (Da):
34038
Number AA:
296
UniProt ID:
Q9Y320
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0045454
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
V
Y
S
V
P
R
L
S
R
W
L
A
Q
P
Y
Site 2
S83
V
M
M
K
N
R
R
S
I
T
V
E
Q
H
I
Site 3
T85
M
K
N
R
R
S
I
T
V
E
Q
H
I
G
N
Site 4
Y132
M
T
C
K
P
P
L
Y
M
G
P
E
Y
I
K
Site 5
Y137
P
L
Y
M
G
P
E
Y
I
K
Y
F
N
D
K
Site 6
Y140
M
G
P
E
Y
I
K
Y
F
N
D
K
T
I
D
Site 7
T145
I
K
Y
F
N
D
K
T
I
D
E
E
L
E
R
Site 8
T157
L
E
R
D
K
R
V
T
W
I
V
E
F
F
A
Site 9
S172
N
W
S
N
D
C
Q
S
F
A
P
I
Y
A
D
Site 10
S181
A
P
I
Y
A
D
L
S
L
K
Y
N
C
T
G
Site 11
Y184
Y
A
D
L
S
L
K
Y
N
C
T
G
L
N
F
Site 12
T187
L
S
L
K
Y
N
C
T
G
L
N
F
G
K
V
Site 13
Y199
G
K
V
D
V
G
R
Y
T
D
V
S
T
R
Y
Site 14
T200
K
V
D
V
G
R
Y
T
D
V
S
T
R
Y
K
Site 15
S203
V
G
R
Y
T
D
V
S
T
R
Y
K
V
S
T
Site 16
T204
G
R
Y
T
D
V
S
T
R
Y
K
V
S
T
S
Site 17
Y206
Y
T
D
V
S
T
R
Y
K
V
S
T
S
P
L
Site 18
S209
V
S
T
R
Y
K
V
S
T
S
P
L
T
K
Q
Site 19
T210
S
T
R
Y
K
V
S
T
S
P
L
T
K
Q
L
Site 20
S211
T
R
Y
K
V
S
T
S
P
L
T
K
Q
L
P
Site 21
S243
D
K
K
G
R
A
V
S
W
T
F
S
E
E
N
Site 22
T245
K
G
R
A
V
S
W
T
F
S
E
E
N
V
I
Site 23
S247
R
A
V
S
W
T
F
S
E
E
N
V
I
R
E
Site 24
Y261
E
F
N
L
N
E
L
Y
Q
R
A
K
K
L
S
Site 25
S268
Y
Q
R
A
K
K
L
S
K
A
G
D
N
I
P
Site 26
S282
P
E
E
Q
P
V
A
S
T
P
T
T
V
S
D
Site 27
T283
E
E
Q
P
V
A
S
T
P
T
T
V
S
D
G
Site 28
T285
Q
P
V
A
S
T
P
T
T
V
S
D
G
E
N
Site 29
T286
P
V
A
S
T
P
T
T
V
S
D
G
E
N
K
Site 30
S288
A
S
T
P
T
T
V
S
D
G
E
N
K
K
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation