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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MED16
Full Name:
Mediator of RNA polymerase II transcription subunit 16
Alias:
Mediator complex subunit 16
Type:
Mass (Da):
96775
Number AA:
877
UniProt ID:
Q9Y2X0
International Prot ID:
IPI00037401
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000119
GO:0005634
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0003712
GO:0003713
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006351
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T28
W
E
K
W
S
K
S
T
H
C
P
S
V
P
L
Site 2
S32
S
K
S
T
H
C
P
S
V
P
L
A
C
A
W
Site 3
S53
A
F
T
M
D
L
R
S
D
D
Q
D
L
T
R
Site 4
T59
R
S
D
D
Q
D
L
T
R
M
I
H
I
L
D
Site 5
S75
E
H
P
W
D
L
H
S
I
P
S
E
H
H
E
Site 6
S92
T
C
L
E
W
D
Q
S
G
S
R
L
L
S
A
Site 7
S98
Q
S
G
S
R
L
L
S
A
D
A
D
G
Q
I
Site 8
S117
M
A
D
H
L
A
N
S
W
E
S
S
V
G
S
Site 9
S120
H
L
A
N
S
W
E
S
S
V
G
S
L
V
E
Site 10
S121
L
A
N
S
W
E
S
S
V
G
S
L
V
E
G
Site 11
S124
S
W
E
S
S
V
G
S
L
V
E
G
D
P
I
Site 12
S150
L
A
L
H
V
E
K
S
G
A
S
S
F
G
E
Site 13
S154
V
E
K
S
G
A
S
S
F
G
E
K
F
S
R
Site 14
S160
S
S
F
G
E
K
F
S
R
V
K
F
S
P
S
Site 15
S165
K
F
S
R
V
K
F
S
P
S
L
T
L
F
G
Site 16
S167
S
R
V
K
F
S
P
S
L
T
L
F
G
G
K
Site 17
T201
K
P
S
G
Q
V
L
T
S
T
E
S
L
C
R
Site 18
S202
P
S
G
Q
V
L
T
S
T
E
S
L
C
R
L
Site 19
T203
S
G
Q
V
L
T
S
T
E
S
L
C
R
L
R
Site 20
S205
Q
V
L
T
S
T
E
S
L
C
R
L
R
G
R
Site 21
S237
T
A
D
G
S
S
A
S
P
V
Q
F
Y
K
V
Site 22
T257
S
E
K
C
R
I
D
T
E
I
L
P
S
L
F
Site 23
T268
P
S
L
F
M
R
C
T
T
D
L
N
R
K
D
Site 24
T269
S
L
F
M
R
C
T
T
D
L
N
R
K
D
K
Site 25
S310
S
S
I
V
E
C
W
S
L
R
K
E
G
L
P
Site 26
S326
N
N
I
F
Q
Q
I
S
P
V
V
G
D
K
Q
Site 27
S343
I
L
K
W
R
I
L
S
A
T
N
D
L
D
R
Site 28
T345
K
W
R
I
L
S
A
T
N
D
L
D
R
V
S
Site 29
S362
A
L
P
K
L
P
I
S
L
T
N
T
D
L
K
Site 30
S372
N
T
D
L
K
V
A
S
D
T
Q
F
Y
P
G
Site 31
T374
D
L
K
V
A
S
D
T
Q
F
Y
P
G
L
G
Site 32
T424
P
A
M
K
R
P
R
T
A
G
P
A
V
H
L
Site 33
S453
I
D
S
H
G
K
L
S
V
L
R
L
S
P
S
Site 34
S502
V
Q
P
S
M
V
Q
S
L
V
E
K
L
H
E
Site 35
T515
H
E
E
Y
T
R
Q
T
A
A
L
Q
Q
V
L
Site 36
T571
L
R
P
H
F
L
N
T
P
D
K
S
P
G
D
Site 37
S575
F
L
N
T
P
D
K
S
P
G
D
R
L
T
E
Site 38
T581
K
S
P
G
D
R
L
T
E
I
C
T
K
I
T
Site 39
S637
A
S
L
P
N
Q
G
S
L
L
R
P
G
H
S
Site 40
S644
S
L
L
R
P
G
H
S
F
L
R
D
G
T
S
Site 41
T650
H
S
F
L
R
D
G
T
S
L
G
M
L
R
E
Site 42
S651
S
F
L
R
D
G
T
S
L
G
M
L
R
E
L
Site 43
Y676
K
P
S
C
L
P
V
Y
T
A
T
S
D
T
Q
Site 44
T682
V
Y
T
A
T
S
D
T
Q
D
S
M
S
L
L
Site 45
S685
A
T
S
D
T
Q
D
S
M
S
L
L
F
R
L
Site 46
S687
S
D
T
Q
D
S
M
S
L
L
F
R
L
L
T
Site 47
S707
C
R
D
E
G
P
A
S
E
P
D
E
A
L
V
Site 48
T757
L
Q
F
G
R
A
P
T
L
P
G
S
A
A
T
Site 49
S761
R
A
P
T
L
P
G
S
A
A
T
L
Q
L
D
Site 50
T814
L
K
S
P
N
R
T
T
A
V
K
Q
W
E
Q
Site 51
T840
R
G
P
D
A
C
V
T
S
R
A
S
E
E
A
Site 52
S841
G
P
D
A
C
V
T
S
R
A
S
E
E
A
P
Site 53
S857
F
V
Q
L
G
P
Q
S
T
H
H
S
P
R
T
Site 54
S861
G
P
Q
S
T
H
H
S
P
R
T
P
R
S
L
Site 55
T864
S
T
H
H
S
P
R
T
P
R
S
L
D
H
L
Site 56
S867
H
S
P
R
T
P
R
S
L
D
H
L
H
P
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation