KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TDRKH
Full Name:
Tudor and KH domain-containing protein
Alias:
TDRD2; Tudor and KH domain containing; Tudor and KH domain containing protein; Tudor domain containing 2
Type:
Unknown function
Mass (Da):
67025
Number AA:
606
UniProt ID:
Q9Y2W6
International Prot ID:
IPI00009982
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
S
T
E
R
T
S
W
T
S
L
S
T
Site 2
S7
_
M
S
T
E
R
T
S
W
T
S
L
S
T
I
Site 3
S10
T
E
R
T
S
W
T
S
L
S
T
I
Q
K
I
Site 4
S12
R
T
S
W
T
S
L
S
T
I
Q
K
I
A
L
Site 5
Y34
A
T
V
A
Y
I
L
Y
R
R
Y
R
E
S
R
Site 6
Y37
A
Y
I
L
Y
R
R
Y
R
E
S
R
E
E
R
Site 7
S40
L
Y
R
R
Y
R
E
S
R
E
E
R
L
T
F
Site 8
T46
E
S
R
E
E
R
L
T
F
V
G
E
D
D
I
Site 9
T82
I
K
Q
L
R
K
Q
T
G
A
R
I
D
V
D
Site 10
T90
G
A
R
I
D
V
D
T
E
D
V
G
D
E
R
Site 11
T123
H
Q
I
L
T
E
N
T
P
V
S
E
Q
L
S
Site 12
S126
L
T
E
N
T
P
V
S
E
Q
L
S
V
P
Q
Site 13
S130
T
P
V
S
E
Q
L
S
V
P
Q
R
S
V
G
Site 14
S135
Q
L
S
V
P
Q
R
S
V
G
R
I
I
G
R
Site 15
S149
R
G
G
E
T
I
R
S
I
C
K
A
S
G
A
Site 16
S164
K
I
T
C
D
K
E
S
E
G
T
L
L
L
S
Site 17
T167
C
D
K
E
S
E
G
T
L
L
L
S
R
L
I
Site 18
S177
L
S
R
L
I
K
I
S
G
T
Q
K
E
V
A
Site 19
S219
V
P
R
K
Q
P
I
S
V
R
R
E
D
M
T
Site 20
T226
S
V
R
R
E
D
M
T
E
P
G
G
A
G
E
Site 21
S241
P
A
L
W
K
N
T
S
S
S
M
E
P
T
A
Site 22
S242
A
L
W
K
N
T
S
S
S
M
E
P
T
A
P
Site 23
S243
L
W
K
N
T
S
S
S
M
E
P
T
A
P
L
Site 24
T247
T
S
S
S
M
E
P
T
A
P
L
V
T
P
P
Site 25
T252
E
P
T
A
P
L
V
T
P
P
P
K
G
G
G
Site 26
S266
G
D
M
A
V
V
V
S
K
E
G
S
W
E
K
Site 27
S270
V
V
V
S
K
E
G
S
W
E
K
P
S
D
D
Site 28
S275
E
G
S
W
E
K
P
S
D
D
S
F
Q
K
S
Site 29
S278
W
E
K
P
S
D
D
S
F
Q
K
S
E
A
Q
Site 30
S282
S
D
D
S
F
Q
K
S
E
A
Q
A
I
P
E
Site 31
S297
M
P
M
F
E
I
P
S
P
D
F
S
F
H
A
Site 32
S301
E
I
P
S
P
D
F
S
F
H
A
D
E
Y
L
Site 33
Y311
A
D
E
Y
L
E
V
Y
V
S
A
S
E
H
P
Site 34
S313
E
Y
L
E
V
Y
V
S
A
S
E
H
P
N
H
Site 35
T341
D
K
L
V
N
E
M
T
Q
H
Y
E
N
S
V
Site 36
Y344
V
N
E
M
T
Q
H
Y
E
N
S
V
P
E
D
Site 37
S347
M
T
Q
H
Y
E
N
S
V
P
E
D
L
T
V
Site 38
S369
A
P
L
P
T
N
G
S
W
Y
R
A
R
V
L
Site 39
Y371
L
P
T
N
G
S
W
Y
R
A
R
V
L
G
T
Site 40
Y387
E
N
G
N
L
D
L
Y
F
V
D
F
G
D
N
Site 41
S407
K
D
L
R
A
L
R
S
D
F
L
S
L
P
F
Site 42
T461
K
I
S
S
Y
V
Q
T
G
I
S
T
W
P
K
Site 43
Y470
I
S
T
W
P
K
I
Y
L
Y
D
T
S
N
G
Site 44
Y472
T
W
P
K
I
Y
L
Y
D
T
S
N
G
K
K
Site 45
T474
P
K
I
Y
L
Y
D
T
S
N
G
K
K
L
D
Site 46
S475
K
I
Y
L
Y
D
T
S
N
G
K
K
L
D
I
Site 47
T514
D
M
L
K
D
M
A
T
E
T
D
A
S
L
S
Site 48
T516
L
K
D
M
A
T
E
T
D
A
S
L
S
T
L
Site 49
S519
M
A
T
E
T
D
A
S
L
S
T
L
L
T
E
Site 50
T525
A
S
L
S
T
L
L
T
E
T
K
K
S
S
G
Site 51
T527
L
S
T
L
L
T
E
T
K
K
S
S
G
E
I
Site 52
S530
L
L
T
E
T
K
K
S
S
G
E
I
T
H
T
Site 53
T535
K
K
S
S
G
E
I
T
H
T
L
S
C
L
S
Site 54
S548
L
S
L
S
E
A
A
S
M
S
G
D
D
N
L
Site 55
S550
L
S
E
A
A
S
M
S
G
D
D
N
L
E
D
Site 56
Y559
D
D
N
L
E
D
D
Y
L
L
G
S
L
G
F
Site 57
Y601
Q
S
S
V
G
N
L
Y
S
L
E
V
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation