KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PTPN22
Full Name:
Protein-tyrosine phosphatase, non-receptor type 22
Alias:
EC 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; LyP; Lyp1; Lyp2; PEP; PTN22; PTPN8
Type:
Protein-tyrosine phosphatase
Mass (Da):
91705
Number AA:
807
UniProt ID:
Q9Y2R2
International Prot ID:
IPI00298016
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
E
A
Q
S
K
K
I
T
K
E
E
F
A
N
E
Site 2
S35
F
L
K
L
K
R
Q
S
T
K
Y
K
A
D
K
Site 3
T36
L
K
L
K
R
Q
S
T
K
Y
K
A
D
K
T
Site 4
Y38
L
K
R
Q
S
T
K
Y
K
A
D
K
T
Y
P
Site 5
T43
T
K
Y
K
A
D
K
T
Y
P
T
T
V
A
E
Site 6
Y44
K
Y
K
A
D
K
T
Y
P
T
T
V
A
E
K
Site 7
T47
A
D
K
T
Y
P
T
T
V
A
E
K
P
K
N
Site 8
Y60
K
N
I
K
K
N
R
Y
K
D
I
L
P
Y
D
Site 9
Y66
R
Y
K
D
I
L
P
Y
D
Y
S
R
V
E
L
Site 10
Y68
K
D
I
L
P
Y
D
Y
S
R
V
E
L
S
L
Site 11
S74
D
Y
S
R
V
E
L
S
L
I
T
S
D
E
D
Site 12
S78
V
E
L
S
L
I
T
S
D
E
D
S
S
Y
I
Site 13
S82
L
I
T
S
D
E
D
S
S
Y
I
N
A
N
F
Site 14
S83
I
T
S
D
E
D
S
S
Y
I
N
A
N
F
I
Site 15
Y84
T
S
D
E
D
S
S
Y
I
N
A
N
F
I
K
Site 16
T102
G
P
K
A
Y
I
A
T
Q
G
P
L
S
T
T
Site 17
T109
T
Q
G
P
L
S
T
T
L
L
D
F
W
R
M
Site 18
Y142
G
K
K
K
C
E
R
Y
W
A
E
P
G
E
M
Site 19
S157
Q
L
E
F
G
P
F
S
V
S
C
E
A
E
K
Site 20
S159
E
F
G
P
F
S
V
S
C
E
A
E
K
R
K
Site 21
S167
C
E
A
E
K
R
K
S
D
Y
I
I
R
T
L
Site 22
Y169
A
E
K
R
K
S
D
Y
I
I
R
T
L
K
V
Site 23
T173
K
S
D
Y
I
I
R
T
L
K
V
K
F
N
S
Site 24
T182
K
V
K
F
N
S
E
T
R
T
I
Y
Q
F
H
Site 25
Y186
N
S
E
T
R
T
I
Y
Q
F
H
Y
K
N
W
Site 26
S200
W
P
D
H
D
V
P
S
S
I
D
P
I
L
E
Site 27
S201
P
D
H
D
V
P
S
S
I
D
P
I
L
E
L
Site 28
Y215
L
I
W
D
V
R
C
Y
Q
E
D
D
S
V
P
Site 29
S260
P
E
N
F
S
V
F
S
L
I
R
E
M
R
T
Site 30
T267
S
L
I
R
E
M
R
T
Q
R
P
S
L
V
Q
Site 31
S271
E
M
R
T
Q
R
P
S
L
V
Q
T
Q
E
Q
Site 32
T275
Q
R
P
S
L
V
Q
T
Q
E
Q
Y
E
L
V
Site 33
S302
D
V
I
R
D
K
H
S
G
T
E
S
Q
A
K
Site 34
S306
D
K
H
S
G
T
E
S
Q
A
K
H
C
I
P
Site 35
T318
C
I
P
E
K
N
H
T
L
Q
A
D
S
Y
S
Site 36
S323
N
H
T
L
Q
A
D
S
Y
S
P
N
L
P
K
Site 37
Y324
H
T
L
Q
A
D
S
Y
S
P
N
L
P
K
S
Site 38
S325
T
L
Q
A
D
S
Y
S
P
N
L
P
K
S
T
Site 39
S331
Y
S
P
N
L
P
K
S
T
T
K
A
A
K
M
Site 40
S352
K
M
E
I
K
E
S
S
S
F
D
F
R
T
S
Site 41
S353
M
E
I
K
E
S
S
S
F
D
F
R
T
S
E
Site 42
T358
S
S
S
F
D
F
R
T
S
E
I
S
A
K
E
Site 43
S359
S
S
F
D
F
R
T
S
E
I
S
A
K
E
E
Site 44
S362
D
F
R
T
S
E
I
S
A
K
E
E
L
V
L
Site 45
S377
H
P
A
K
S
S
T
S
F
D
F
L
E
L
N
Site 46
S386
D
F
L
E
L
N
Y
S
F
D
K
N
A
D
T
Site 47
T393
S
F
D
K
N
A
D
T
T
M
K
W
Q
T
K
Site 48
S414
E
P
L
Q
K
H
Q
S
L
D
L
G
S
L
L
Site 49
S426
S
L
L
F
E
G
C
S
N
S
K
P
V
N
A
Site 50
S428
L
F
E
G
C
S
N
S
K
P
V
N
A
A
G
Site 51
Y437
P
V
N
A
A
G
R
Y
F
N
S
K
V
P
I
Site 52
T445
F
N
S
K
V
P
I
T
R
T
K
S
T
P
F
Site 53
T447
S
K
V
P
I
T
R
T
K
S
T
P
F
E
L
Site 54
S449
V
P
I
T
R
T
K
S
T
P
F
E
L
I
Q
Site 55
T450
P
I
T
R
T
K
S
T
P
F
E
L
I
Q
Q
Site 56
T460
E
L
I
Q
Q
R
E
T
K
E
V
D
S
K
E
Site 57
S465
R
E
T
K
E
V
D
S
K
E
N
F
S
Y
L
Site 58
S470
V
D
S
K
E
N
F
S
Y
L
E
S
Q
P
H
Site 59
Y471
D
S
K
E
N
F
S
Y
L
E
S
Q
P
H
D
Site 60
S474
E
N
F
S
Y
L
E
S
Q
P
H
D
S
C
F
Site 61
S494
Q
K
V
M
H
V
S
S
A
E
L
N
Y
S
L
Site 62
Y499
V
S
S
A
E
L
N
Y
S
L
P
Y
D
S
K
Site 63
S500
S
S
A
E
L
N
Y
S
L
P
Y
D
S
K
H
Site 64
Y503
E
L
N
Y
S
L
P
Y
D
S
K
H
Q
I
R
Site 65
S513
K
H
Q
I
R
N
A
S
N
V
K
H
H
D
S
Site 66
S521
N
V
K
H
H
D
S
S
A
L
G
V
Y
S
Y
Site 67
Y526
D
S
S
A
L
G
V
Y
S
Y
I
P
L
V
E
Site 68
Y528
S
A
L
G
V
Y
S
Y
I
P
L
V
E
N
P
Site 69
Y536
I
P
L
V
E
N
P
Y
F
S
S
W
P
P
S
Site 70
S538
L
V
E
N
P
Y
F
S
S
W
P
P
S
G
T
Site 71
S539
V
E
N
P
Y
F
S
S
W
P
P
S
G
T
S
Site 72
S543
Y
F
S
S
W
P
P
S
G
T
S
S
K
M
S
Site 73
T545
S
S
W
P
P
S
G
T
S
S
K
M
S
L
D
Site 74
S546
S
W
P
P
S
G
T
S
S
K
M
S
L
D
L
Site 75
S547
W
P
P
S
G
T
S
S
K
M
S
L
D
L
P
Site 76
S550
S
G
T
S
S
K
M
S
L
D
L
P
E
K
Q
Site 77
T560
L
P
E
K
Q
D
G
T
V
F
P
S
S
L
L
Site 78
S564
Q
D
G
T
V
F
P
S
S
L
L
P
T
S
S
Site 79
S565
D
G
T
V
F
P
S
S
L
L
P
T
S
S
T
Site 80
S570
P
S
S
L
L
P
T
S
S
T
S
L
F
S
Y
Site 81
S571
S
S
L
L
P
T
S
S
T
S
L
F
S
Y
Y
Site 82
T572
S
L
L
P
T
S
S
T
S
L
F
S
Y
Y
N
Site 83
S573
L
L
P
T
S
S
T
S
L
F
S
Y
Y
N
S
Site 84
S576
T
S
S
T
S
L
F
S
Y
Y
N
S
H
D
S
Site 85
Y577
S
S
T
S
L
F
S
Y
Y
N
S
H
D
S
L
Site 86
Y578
S
T
S
L
F
S
Y
Y
N
S
H
D
S
L
S
Site 87
S580
S
L
F
S
Y
Y
N
S
H
D
S
L
S
L
N
Site 88
S583
S
Y
Y
N
S
H
D
S
L
S
L
N
S
P
T
Site 89
S585
Y
N
S
H
D
S
L
S
L
N
S
P
T
N
I
Site 90
S588
H
D
S
L
S
L
N
S
P
T
N
I
S
S
L
Site 91
T590
S
L
S
L
N
S
P
T
N
I
S
S
L
L
N
Site 92
S594
N
S
P
T
N
I
S
S
L
L
N
Q
E
S
A
Site 93
S635
V
E
E
A
G
E
F
S
P
N
V
P
K
S
L
Site 94
S641
F
S
P
N
V
P
K
S
L
S
S
A
V
K
V
Site 95
S643
P
N
V
P
K
S
L
S
S
A
V
K
V
K
I
Site 96
S653
V
K
V
K
I
G
T
S
L
E
W
G
G
T
S
Site 97
T659
T
S
L
E
W
G
G
T
S
E
P
K
K
F
D
Site 98
S660
S
L
E
W
G
G
T
S
E
P
K
K
F
D
D
Site 99
S668
E
P
K
K
F
D
D
S
V
I
L
R
P
S
K
Site 100
S674
D
S
V
I
L
R
P
S
K
S
V
K
L
R
S
Site 101
S676
V
I
L
R
P
S
K
S
V
K
L
R
S
P
K
Site 102
S681
S
K
S
V
K
L
R
S
P
K
S
E
L
H
Q
Site 103
S684
V
K
L
R
S
P
K
S
E
L
H
Q
D
R
S
Site 104
S691
S
E
L
H
Q
D
R
S
S
P
P
P
P
L
P
Site 105
S692
E
L
H
Q
D
R
S
S
P
P
P
P
L
P
E
Site 106
T701
P
P
P
L
P
E
R
T
L
E
S
F
F
L
A
Site 107
S704
L
P
E
R
T
L
E
S
F
F
L
A
D
E
D
Site 108
S717
E
D
C
M
Q
A
Q
S
I
E
T
Y
S
T
S
Site 109
Y721
Q
A
Q
S
I
E
T
Y
S
T
S
Y
P
D
T
Site 110
T723
Q
S
I
E
T
Y
S
T
S
Y
P
D
T
M
E
Site 111
S724
S
I
E
T
Y
S
T
S
Y
P
D
T
M
E
N
Site 112
Y725
I
E
T
Y
S
T
S
Y
P
D
T
M
E
N
S
Site 113
T728
Y
S
T
S
Y
P
D
T
M
E
N
S
T
S
S
Site 114
S732
Y
P
D
T
M
E
N
S
T
S
S
K
Q
T
L
Site 115
S734
D
T
M
E
N
S
T
S
S
K
Q
T
L
K
T
Site 116
T738
N
S
T
S
S
K
Q
T
L
K
T
P
G
K
S
Site 117
T741
S
S
K
Q
T
L
K
T
P
G
K
S
F
T
R
Site 118
S745
T
L
K
T
P
G
K
S
F
T
R
S
K
S
L
Site 119
T747
K
T
P
G
K
S
F
T
R
S
K
S
L
K
I
Site 120
S749
P
G
K
S
F
T
R
S
K
S
L
K
I
L
R
Site 121
S751
K
S
F
T
R
S
K
S
L
K
I
L
R
N
M
Site 122
S765
M
K
K
S
I
C
N
S
C
P
P
N
K
P
A
Site 123
S774
P
P
N
K
P
A
E
S
V
Q
S
N
N
S
S
Site 124
S777
K
P
A
E
S
V
Q
S
N
N
S
S
S
F
L
Site 125
S780
E
S
V
Q
S
N
N
S
S
S
F
L
N
F
G
Site 126
S781
S
V
Q
S
N
N
S
S
S
F
L
N
F
G
F
Site 127
S782
V
Q
S
N
N
S
S
S
F
L
N
F
G
F
A
Site 128
S793
F
G
F
A
N
R
F
S
K
P
K
G
P
R
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation