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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HIF3A
Full Name:
Hypoxia-inducible factor 3 alpha
Alias:
HIF-3 alpha; HIF3 alpha 1; HIF-3A; HIF-3A4; Hypoxia inducible factor 3, alpha; Inhibitory PAS domain protein; IPAS; MOP7; PASD7
Type:
Cytoplasm, Nucleus protein
Mass (Da):
72433
Number AA:
669
UniProt ID:
Q9Y2N7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004871
GO:0030528
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0007165
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
L
G
L
Q
R
A
R
S
T
T
E
L
R
K
E
Site 2
T11
G
L
Q
R
A
R
S
T
T
E
L
R
K
E
K
Site 3
T12
L
Q
R
A
R
S
T
T
E
L
R
K
E
K
S
Site 4
S19
T
E
L
R
K
E
K
S
R
D
A
A
R
S
R
Site 5
S25
K
S
R
D
A
A
R
S
R
R
S
Q
E
T
E
Site 6
S28
D
A
A
R
S
R
R
S
Q
E
T
E
V
L
Y
Site 7
T31
R
S
R
R
S
Q
E
T
E
V
L
Y
Q
L
A
Site 8
Y35
S
Q
E
T
E
V
L
Y
Q
L
A
H
T
L
P
Site 9
S48
L
P
F
A
R
G
V
S
A
H
L
D
K
A
S
Site 10
Y108
T
A
E
G
D
M
A
Y
L
S
E
N
V
S
K
Site 11
S110
E
G
D
M
A
Y
L
S
E
N
V
S
K
H
L
Site 12
S114
A
Y
L
S
E
N
V
S
K
H
L
G
L
S
Q
Site 13
T146
E
E
L
Q
D
A
L
T
P
Q
Q
T
L
S
R
Site 14
T150
D
A
L
T
P
Q
Q
T
L
S
R
R
K
V
E
Site 15
S152
L
T
P
Q
Q
T
L
S
R
R
K
V
E
A
P
Site 16
T160
R
R
K
V
E
A
P
T
E
R
C
F
S
L
R
Site 17
S165
A
P
T
E
R
C
F
S
L
R
M
K
S
T
L
Site 18
S170
C
F
S
L
R
M
K
S
T
L
T
S
R
G
R
Site 19
T171
F
S
L
R
M
K
S
T
L
T
S
R
G
R
T
Site 20
T173
L
R
M
K
S
T
L
T
S
R
G
R
T
L
N
Site 21
S174
R
M
K
S
T
L
T
S
R
G
R
T
L
N
L
Site 22
T178
T
L
T
S
R
G
R
T
L
N
L
K
A
A
T
Site 23
Y198
C
S
G
H
M
R
A
Y
K
P
P
A
Q
T
S
Site 24
S205
Y
K
P
P
A
Q
T
S
P
A
G
S
P
D
S
Site 25
S209
A
Q
T
S
P
A
G
S
P
D
S
E
P
P
L
Site 26
S212
S
P
A
G
S
P
D
S
E
P
P
L
Q
C
L
Site 27
S231
E
A
I
P
H
P
G
S
L
E
P
P
L
G
R
Site 28
S243
L
G
R
G
A
F
L
S
R
H
S
L
D
M
K
Site 29
S246
G
A
F
L
S
R
H
S
L
D
M
K
F
T
Y
Site 30
Y253
S
L
D
M
K
F
T
Y
C
D
D
R
I
A
E
Site 31
Y264
R
I
A
E
V
A
G
Y
S
P
D
D
L
I
G
Site 32
Y277
I
G
C
S
A
Y
E
Y
I
H
A
L
D
S
D
Site 33
S283
E
Y
I
H
A
L
D
S
D
A
V
S
K
S
I
Site 34
S289
D
S
D
A
V
S
K
S
I
H
T
L
L
S
K
Site 35
S295
K
S
I
H
T
L
L
S
K
G
Q
A
V
T
G
Site 36
S310
Q
Y
R
F
L
A
R
S
G
G
Y
L
W
T
Q
Site 37
T318
G
G
Y
L
W
T
Q
T
Q
A
T
V
V
S
G
Site 38
T321
L
W
T
Q
T
Q
A
T
V
V
S
G
G
R
G
Site 39
S331
S
G
G
R
G
P
Q
S
E
S
I
V
C
V
H
Site 40
S352
E
E
T
G
V
V
L
S
L
E
Q
T
E
Q
H
Site 41
T356
V
V
L
S
L
E
Q
T
E
Q
H
S
R
R
P
Site 42
S360
L
E
Q
T
E
Q
H
S
R
R
P
I
Q
R
G
Site 43
S370
P
I
Q
R
G
A
P
S
Q
K
D
T
P
N
P
Site 44
T374
G
A
P
S
Q
K
D
T
P
N
P
G
D
S
L
Site 45
S380
D
T
P
N
P
G
D
S
L
D
T
P
G
P
R
Site 46
T383
N
P
G
D
S
L
D
T
P
G
P
R
I
L
A
Site 47
S411
A
D
P
R
R
F
C
S
P
D
L
R
R
L
L
Site 48
S432
A
S
V
A
A
T
P
S
T
P
L
A
T
R
H
Site 49
T433
S
V
A
A
T
P
S
T
P
L
A
T
R
H
P
Site 50
S442
L
A
T
R
H
P
Q
S
P
L
S
A
D
L
P
Site 51
S445
R
H
P
Q
S
P
L
S
A
D
L
P
D
E
L
Site 52
T464
E
N
V
H
R
L
F
T
S
G
K
D
T
E
A
Site 53
T469
L
F
T
S
G
K
D
T
E
A
V
E
T
D
L
Site 54
T474
K
D
T
E
A
V
E
T
D
L
D
I
A
Q
D
Site 55
S495
E
M
L
A
P
Y
I
S
M
D
D
D
F
Q
L
Site 56
Y512
S
E
Q
L
P
R
A
Y
H
R
P
L
G
A
V
Site 57
S526
V
P
R
P
R
A
R
S
F
H
G
L
S
P
P
Site 58
S531
A
R
S
F
H
G
L
S
P
P
A
L
E
P
S
Site 59
S538
S
P
P
A
L
E
P
S
L
L
P
R
W
G
S
Site 60
S545
S
L
L
P
R
W
G
S
D
P
R
L
S
C
S
Site 61
S550
W
G
S
D
P
R
L
S
C
S
S
P
S
R
G
Site 62
S552
S
D
P
R
L
S
C
S
S
P
S
R
G
D
P
Site 63
S553
D
P
R
L
S
C
S
S
P
S
R
G
D
P
S
Site 64
S555
R
L
S
C
S
S
P
S
R
G
D
P
S
A
S
Site 65
S560
S
P
S
R
G
D
P
S
A
S
S
P
M
A
G
Site 66
S562
S
R
G
D
P
S
A
S
S
P
M
A
G
A
R
Site 67
S563
R
G
D
P
S
A
S
S
P
M
A
G
A
R
K
Site 68
T572
M
A
G
A
R
K
R
T
L
A
Q
S
S
E
D
Site 69
S576
R
K
R
T
L
A
Q
S
S
E
D
E
D
E
G
Site 70
S595
G
V
R
P
P
K
R
S
P
S
P
E
H
E
N
Site 71
S597
R
P
P
K
R
S
P
S
P
E
H
E
N
F
L
Site 72
S622
T
G
G
P
A
P
G
S
L
Q
D
P
S
T
P
Site 73
S627
P
G
S
L
Q
D
P
S
T
P
L
L
N
L
N
Site 74
T628
G
S
L
Q
D
P
S
T
P
L
L
N
L
N
E
Site 75
S642
E
P
L
G
L
G
P
S
L
L
S
P
Y
S
D
Site 76
S645
G
L
G
P
S
L
L
S
P
Y
S
D
E
D
T
Site 77
S648
P
S
L
L
S
P
Y
S
D
E
D
T
T
Q
P
Site 78
T652
S
P
Y
S
D
E
D
T
T
Q
P
G
G
P
F
Site 79
T653
P
Y
S
D
E
D
T
T
Q
P
G
G
P
F
Q
Site 80
S665
P
F
Q
P
R
A
G
S
A
Q
A
D
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation