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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FRMD4B
Full Name:
FERM domain-containing protein 4B
Alias:
FERM domain containing 4B; FRM4B; GRP1-binding protein GRSP1; GRSP1; KIAA1013; YA13
Type:
Cytoskeletal protein
Mass (Da):
111630
Number AA:
980
UniProt ID:
Q9Y2L6
International Prot ID:
IPI00217948
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S36
E
L
L
D
L
V
A
S
H
F
N
L
K
E
K
Site 2
Y45
F
N
L
K
E
K
E
Y
F
G
I
T
F
I
D
Site 3
T49
E
K
E
Y
F
G
I
T
F
I
D
D
T
G
Q
Site 4
S92
R
F
Y
I
E
S
I
S
F
L
K
D
K
T
T
Site 5
Y138
L
Q
E
A
K
G
D
Y
T
S
D
E
N
A
R
Site 6
S140
E
A
K
G
D
Y
T
S
D
E
N
A
R
K
D
Site 7
T150
N
A
R
K
D
L
K
T
L
P
A
F
P
T
K
Site 8
T158
L
P
A
F
P
T
K
T
L
Q
E
H
P
S
L
Site 9
S164
K
T
L
Q
E
H
P
S
L
A
Y
C
E
D
R
Site 10
Y176
E
D
R
V
I
E
H
Y
L
K
I
K
G
L
T
Site 11
Y205
L
P
T
Y
G
V
H
Y
Y
A
V
K
D
K
Q
Site 12
Y206
P
T
Y
G
V
H
Y
Y
A
V
K
D
K
Q
G
Site 13
Y222
P
W
W
L
G
I
S
Y
K
G
I
G
Q
Y
D
Site 14
Y249
W
K
Q
L
E
N
L
Y
F
R
E
K
K
F
A
Site 15
S266
V
H
D
P
R
R
I
S
V
S
R
R
T
F
G
Site 16
S268
D
P
R
R
I
S
V
S
R
R
T
F
G
Q
S
Site 17
T271
R
I
S
V
S
R
R
T
F
G
Q
S
G
L
F
Site 18
S275
S
R
R
T
F
G
Q
S
G
L
F
V
Q
T
W
Site 19
Y303
A
I
S
Q
H
Q
F
Y
L
D
R
K
Q
S
K
Site 20
S309
F
Y
L
D
R
K
Q
S
K
A
K
I
P
S
A
Site 21
S315
Q
S
K
A
K
I
P
S
A
R
S
L
D
E
I
Site 22
S318
A
K
I
P
S
A
R
S
L
D
E
I
A
M
D
Site 23
T327
D
E
I
A
M
D
L
T
E
T
G
T
Q
R
A
Site 24
T331
M
D
L
T
E
T
G
T
Q
R
A
S
K
L
V
Site 25
S335
E
T
G
T
Q
R
A
S
K
L
V
T
L
E
A
Site 26
T339
Q
R
A
S
K
L
V
T
L
E
A
K
S
Q
F
Site 27
S350
K
S
Q
F
I
M
A
S
N
G
S
L
I
S
S
Site 28
S357
S
N
G
S
L
I
S
S
G
S
Q
D
S
E
V
Site 29
S359
G
S
L
I
S
S
G
S
Q
D
S
E
V
S
E
Site 30
S362
I
S
S
G
S
Q
D
S
E
V
S
E
E
Q
K
Site 31
T405
C
L
R
E
A
E
L
T
G
K
M
P
K
E
Y
Site 32
Y412
T
G
K
M
P
K
E
Y
P
L
N
I
G
E
K
Site 33
T429
Q
V
R
R
R
V
G
T
A
F
K
L
D
D
N
Site 34
S440
L
D
D
N
L
L
P
S
E
E
D
P
A
L
Q
Site 35
T475
N
E
P
D
L
C
K
T
V
K
K
K
R
K
Q
Site 36
Y484
K
K
K
R
K
Q
D
Y
T
D
A
M
K
K
L
Site 37
T485
K
K
R
K
Q
D
Y
T
D
A
M
K
K
L
Q
Site 38
Y501
I
E
N
A
I
N
E
Y
R
I
R
C
G
K
K
Site 39
T514
K
K
P
S
Q
K
A
T
V
L
P
E
D
I
I
Site 40
S523
L
P
E
D
I
I
P
S
E
S
S
S
L
S
D
Site 41
S525
E
D
I
I
P
S
E
S
S
S
L
S
D
T
T
Site 42
S527
I
I
P
S
E
S
S
S
L
S
D
T
T
T
Y
Site 43
S529
P
S
E
S
S
S
L
S
D
T
T
T
Y
D
D
Site 44
T531
E
S
S
S
L
S
D
T
T
T
Y
D
D
P
S
Site 45
T532
S
S
S
L
S
D
T
T
T
Y
D
D
P
S
D
Site 46
T533
S
S
L
S
D
T
T
T
Y
D
D
P
S
D
A
Site 47
Y534
S
L
S
D
T
T
T
Y
D
D
P
S
D
A
F
Site 48
S538
T
T
T
Y
D
D
P
S
D
A
F
T
F
P
G
Site 49
T542
D
D
P
S
D
A
F
T
F
P
G
Q
R
S
S
Site 50
S548
F
T
F
P
G
Q
R
S
S
S
V
P
H
S
P
Site 51
S549
T
F
P
G
Q
R
S
S
S
V
P
H
S
P
R
Site 52
S550
F
P
G
Q
R
S
S
S
V
P
H
S
P
R
I
Site 53
S554
R
S
S
S
V
P
H
S
P
R
I
L
P
P
K
Site 54
S562
P
R
I
L
P
P
K
S
L
G
I
E
R
I
H
Site 55
S573
E
R
I
H
F
R
K
S
S
I
N
E
Q
F
V
Site 56
S574
R
I
H
F
R
K
S
S
I
N
E
Q
F
V
D
Site 57
S585
Q
F
V
D
T
R
Q
S
R
E
M
L
S
T
H
Site 58
S590
R
Q
S
R
E
M
L
S
T
H
S
S
P
Y
K
Site 59
T591
Q
S
R
E
M
L
S
T
H
S
S
P
Y
K
T
Site 60
S594
E
M
L
S
T
H
S
S
P
Y
K
T
L
E
R
Site 61
T598
T
H
S
S
P
Y
K
T
L
E
R
R
P
Q
G
Site 62
S608
R
R
P
Q
G
G
R
S
M
P
T
T
P
V
L
Site 63
T612
G
G
R
S
M
P
T
T
P
V
L
T
R
N
A
Site 64
Y620
P
V
L
T
R
N
A
Y
S
S
S
H
L
E
P
Site 65
S621
V
L
T
R
N
A
Y
S
S
S
H
L
E
P
E
Site 66
S622
L
T
R
N
A
Y
S
S
S
H
L
E
P
E
S
Site 67
S623
T
R
N
A
Y
S
S
S
H
L
E
P
E
S
S
Site 68
S629
S
S
H
L
E
P
E
S
S
S
Q
H
C
R
Q
Site 69
S630
S
H
L
E
P
E
S
S
S
Q
H
C
R
Q
R
Site 70
S631
H
L
E
P
E
S
S
S
Q
H
C
R
Q
R
S
Site 71
S638
S
Q
H
C
R
Q
R
S
G
S
L
E
S
Q
S
Site 72
S640
H
C
R
Q
R
S
G
S
L
E
S
Q
S
H
L
Site 73
S643
Q
R
S
G
S
L
E
S
Q
S
H
L
L
S
E
Site 74
S645
S
G
S
L
E
S
Q
S
H
L
L
S
E
M
D
Site 75
S649
E
S
Q
S
H
L
L
S
E
M
D
S
D
K
P
Site 76
S653
H
L
L
S
E
M
D
S
D
K
P
F
F
S
L
Site 77
S659
D
S
D
K
P
F
F
S
L
S
K
S
Q
R
S
Site 78
S661
D
K
P
F
F
S
L
S
K
S
Q
R
S
S
S
Site 79
S663
P
F
F
S
L
S
K
S
Q
R
S
S
S
T
E
Site 80
S667
L
S
K
S
Q
R
S
S
S
T
E
I
L
D
D
Site 81
S668
S
K
S
Q
R
S
S
S
T
E
I
L
D
D
G
Site 82
S676
T
E
I
L
D
D
G
S
S
Y
T
S
Q
S
S
Site 83
S677
E
I
L
D
D
G
S
S
Y
T
S
Q
S
S
T
Site 84
Y678
I
L
D
D
G
S
S
Y
T
S
Q
S
S
T
E
Site 85
T679
L
D
D
G
S
S
Y
T
S
Q
S
S
T
E
Y
Site 86
S680
D
D
G
S
S
Y
T
S
Q
S
S
T
E
Y
Y
Site 87
S682
G
S
S
Y
T
S
Q
S
S
T
E
Y
Y
C
V
Site 88
T684
S
Y
T
S
Q
S
S
T
E
Y
Y
C
V
T
P
Site 89
Y686
T
S
Q
S
S
T
E
Y
Y
C
V
T
P
V
T
Site 90
Y687
S
Q
S
S
T
E
Y
Y
C
V
T
P
V
T
G
Site 91
T690
S
T
E
Y
Y
C
V
T
P
V
T
G
P
Y
Y
Site 92
Y697
T
P
V
T
G
P
Y
Y
T
T
Q
T
L
D
T
Site 93
T701
G
P
Y
Y
T
T
Q
T
L
D
T
R
T
R
G
Site 94
S712
R
T
R
G
R
R
R
S
K
K
Q
N
V
S
T
Site 95
S718
R
S
K
K
Q
N
V
S
T
S
N
S
G
S
M
Site 96
T719
S
K
K
Q
N
V
S
T
S
N
S
G
S
M
P
Site 97
S720
K
K
Q
N
V
S
T
S
N
S
G
S
M
P
N
Site 98
S722
Q
N
V
S
T
S
N
S
G
S
M
P
N
L
A
Site 99
S724
V
S
T
S
N
S
G
S
M
P
N
L
A
Q
K
Site 100
S733
P
N
L
A
Q
K
D
S
L
R
N
G
V
Y
S
Site 101
S740
S
L
R
N
G
V
Y
S
K
S
Q
E
P
P
S
Site 102
S742
R
N
G
V
Y
S
K
S
Q
E
P
P
S
S
S
Site 103
S747
S
K
S
Q
E
P
P
S
S
S
Y
Y
I
A
G
Site 104
S748
K
S
Q
E
P
P
S
S
S
Y
Y
I
A
G
Y
Site 105
S749
S
Q
E
P
P
S
S
S
Y
Y
I
A
G
Y
T
Site 106
Y751
E
P
P
S
S
S
Y
Y
I
A
G
Y
T
P
Y
Site 107
Y755
S
S
Y
Y
I
A
G
Y
T
P
Y
A
E
C
D
Site 108
Y758
Y
I
A
G
Y
T
P
Y
A
E
C
D
F
Y
Y
Site 109
Y764
P
Y
A
E
C
D
F
Y
Y
S
G
G
Y
V
Y
Site 110
Y765
Y
A
E
C
D
F
Y
Y
S
G
G
Y
V
Y
E
Site 111
Y769
D
F
Y
Y
S
G
G
Y
V
Y
E
N
D
T
E
Site 112
Y771
Y
Y
S
G
G
Y
V
Y
E
N
D
T
E
G
Q
Site 113
T775
G
Y
V
Y
E
N
D
T
E
G
Q
Y
S
V
N
Site 114
Y779
E
N
D
T
E
G
Q
Y
S
V
N
P
S
Y
R
Site 115
S780
N
D
T
E
G
Q
Y
S
V
N
P
S
Y
R
S
Site 116
S784
G
Q
Y
S
V
N
P
S
Y
R
S
S
A
H
Y
Site 117
Y785
Q
Y
S
V
N
P
S
Y
R
S
S
A
H
Y
G
Site 118
S788
V
N
P
S
Y
R
S
S
A
H
Y
G
Y
E
R
Site 119
Y791
S
Y
R
S
S
A
H
Y
G
Y
E
R
Q
R
D
Site 120
Y793
R
S
S
A
H
Y
G
Y
E
R
Q
R
D
Y
S
Site 121
Y799
G
Y
E
R
Q
R
D
Y
S
R
S
F
H
E
D
Site 122
S800
Y
E
R
Q
R
D
Y
S
R
S
F
H
E
D
E
Site 123
S802
R
Q
R
D
Y
S
R
S
F
H
E
D
E
V
D
Site 124
Y816
D
R
V
P
H
N
P
Y
A
T
L
R
L
P
R
Site 125
S829
P
R
K
A
A
A
K
S
E
H
I
T
K
N
I
Site 126
Y849
A
E
H
L
R
G
W
Y
Q
R
A
S
G
Q
K
Site 127
S853
R
G
W
Y
Q
R
A
S
G
Q
K
D
Q
G
H
Site 128
S861
G
Q
K
D
Q
G
H
S
P
Q
T
S
F
D
S
Site 129
T864
D
Q
G
H
S
P
Q
T
S
F
D
S
D
R
G
Site 130
S865
Q
G
H
S
P
Q
T
S
F
D
S
D
R
G
S
Site 131
S868
S
P
Q
T
S
F
D
S
D
R
G
S
Q
R
C
Site 132
S872
S
F
D
S
D
R
G
S
Q
R
C
L
G
F
A
Site 133
S886
A
G
L
Q
V
P
C
S
P
S
S
R
A
S
L
Site 134
S888
L
Q
V
P
C
S
P
S
S
R
A
S
L
Y
S
Site 135
S889
Q
V
P
C
S
P
S
S
R
A
S
L
Y
S
S
Site 136
S892
C
S
P
S
S
R
A
S
L
Y
S
S
V
S
S
Site 137
Y894
P
S
S
R
A
S
L
Y
S
S
V
S
S
T
N
Site 138
S895
S
S
R
A
S
L
Y
S
S
V
S
S
T
N
A
Site 139
S896
S
R
A
S
L
Y
S
S
V
S
S
T
N
A
S
Site 140
S898
A
S
L
Y
S
S
V
S
S
T
N
A
S
G
N
Site 141
S899
S
L
Y
S
S
V
S
S
T
N
A
S
G
N
W
Site 142
T900
L
Y
S
S
V
S
S
T
N
A
S
G
N
W
R
Site 143
S903
S
V
S
S
T
N
A
S
G
N
W
R
T
Q
L
Site 144
T911
G
N
W
R
T
Q
L
T
I
G
L
S
D
Y
E
Site 145
S915
T
Q
L
T
I
G
L
S
D
Y
E
T
P
A
H
Site 146
Y917
L
T
I
G
L
S
D
Y
E
T
P
A
H
S
S
Site 147
T919
I
G
L
S
D
Y
E
T
P
A
H
S
S
Y
T
Site 148
S923
D
Y
E
T
P
A
H
S
S
Y
T
S
C
Y
G
Site 149
Y925
E
T
P
A
H
S
S
Y
T
S
C
Y
G
N
V
Site 150
Y929
H
S
S
Y
T
S
C
Y
G
N
V
Y
N
P
L
Site 151
Y933
T
S
C
Y
G
N
V
Y
N
P
L
P
S
P
S
Site 152
S938
N
V
Y
N
P
L
P
S
P
S
R
Q
Y
T
E
Site 153
S940
Y
N
P
L
P
S
P
S
R
Q
Y
T
E
I
S
Site 154
Y943
L
P
S
P
S
R
Q
Y
T
E
I
S
Q
L
D
Site 155
T944
P
S
P
S
R
Q
Y
T
E
I
S
Q
L
D
G
Site 156
S947
S
R
Q
Y
T
E
I
S
Q
L
D
G
T
D
G
Site 157
T952
E
I
S
Q
L
D
G
T
D
G
N
Q
L
E
D
Site 158
S974
R
L
F
W
H
E
D
S
K
P
G
T
L
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation