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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP20
Full Name:
Ubiquitin carboxyl-terminal hydrolase 20
Alias:
Deubiquitinating enzyme 20; KIAA1003; Ubiquitin specific peptidase 20; Ubiquitin thioesterase 20; Ubiquitin thiolesterase 20; Ubiquitin-specific processing protease 20; Ubiquitin-specific-processing protease 20; UBP20; VHL-interacting deubiquitinating enzyme 2
Type:
EC 3.1.2.15; Ubiquitin conjugating system; Protease
Mass (Da):
102003
Number AA:
914
UniProt ID:
Q9Y2K6
International Prot ID:
IPI00328285
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0008234
GO:0004221
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0016579
GO:0006511
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
D
L
C
P
H
L
D
S
I
G
E
V
T
K
E
Site 2
S26
K
E
D
L
L
L
K
S
K
G
T
C
Q
S
C
Site 3
S32
K
S
K
G
T
C
Q
S
C
G
V
T
G
P
N
Site 4
S56
P
Y
V
G
C
G
E
S
F
A
D
H
S
T
I
Site 5
S61
G
E
S
F
A
D
H
S
T
I
H
A
Q
A
K
Site 6
T73
Q
A
K
K
H
N
L
T
V
N
L
T
T
F
R
Site 7
S103
L
A
A
P
L
L
G
S
S
S
K
F
S
E
Q
Site 8
S104
A
A
P
L
L
G
S
S
S
K
F
S
E
Q
D
Site 9
S105
A
P
L
L
G
S
S
S
K
F
S
E
Q
D
S
Site 10
S108
L
G
S
S
S
K
F
S
E
Q
D
S
P
P
P
Site 11
S112
S
K
F
S
E
Q
D
S
P
P
P
S
H
P
L
Site 12
S116
E
Q
D
S
P
P
P
S
H
P
L
K
A
V
P
Site 13
S132
A
V
A
D
E
G
E
S
E
S
E
D
D
D
L
Site 14
S134
A
D
E
G
E
S
E
S
E
D
D
D
L
K
P
Site 15
T145
D
L
K
P
R
G
L
T
G
M
K
N
L
G
N
Site 16
Y155
K
N
L
G
N
S
C
Y
M
N
A
A
L
Q
A
Site 17
S164
N
A
A
L
Q
A
L
S
N
C
P
P
L
T
Q
Site 18
S191
K
K
P
A
L
C
K
S
Y
Q
K
L
V
S
E
Site 19
S206
V
W
H
K
K
R
P
S
Y
V
V
P
T
S
L
Site 20
Y207
W
H
K
K
R
P
S
Y
V
V
P
T
S
L
S
Site 21
Y227
V
N
P
M
F
R
G
Y
A
Q
Q
D
T
Q
E
Site 22
T232
R
G
Y
A
Q
Q
D
T
Q
E
F
L
R
C
L
Site 23
T258
V
V
A
T
V
A
L
T
E
A
R
D
S
D
S
Site 24
S263
A
L
T
E
A
R
D
S
D
S
S
D
T
D
E
Site 25
S265
T
E
A
R
D
S
D
S
S
D
T
D
E
K
R
Site 26
S266
E
A
R
D
S
D
S
S
D
T
D
E
K
R
E
Site 27
T268
R
D
S
D
S
S
D
T
D
E
K
R
E
G
D
Site 28
S277
E
K
R
E
G
D
R
S
P
S
E
D
E
F
L
Site 29
S279
R
E
G
D
R
S
P
S
E
D
E
F
L
S
C
Site 30
S285
P
S
E
D
E
F
L
S
C
D
S
S
S
D
R
Site 31
S288
D
E
F
L
S
C
D
S
S
S
D
R
G
E
G
Site 32
S289
E
F
L
S
C
D
S
S
S
D
R
G
E
G
D
Site 33
S290
F
L
S
C
D
S
S
S
D
R
G
E
G
D
G
Site 34
S305
Q
G
R
G
G
G
S
S
Q
A
E
T
E
L
L
Site 35
T309
G
G
S
S
Q
A
E
T
E
L
L
I
P
D
E
Site 36
S322
D
E
A
G
R
A
I
S
E
K
E
R
M
K
D
Site 37
S333
R
M
K
D
R
K
F
S
W
G
Q
Q
R
T
N
Site 38
T339
F
S
W
G
Q
Q
R
T
N
S
E
Q
V
D
E
Site 39
S341
W
G
Q
Q
R
T
N
S
E
Q
V
D
E
D
A
Site 40
T352
D
E
D
A
D
V
D
T
A
M
A
A
L
D
D
Site 41
S368
P
A
E
A
Q
P
P
S
P
R
S
S
S
P
C
Site 42
S371
A
Q
P
P
S
P
R
S
S
S
P
C
R
T
P
Site 43
S372
Q
P
P
S
P
R
S
S
S
P
C
R
T
P
E
Site 44
S373
P
P
S
P
R
S
S
S
P
C
R
T
P
E
P
Site 45
T377
R
S
S
S
P
C
R
T
P
E
P
D
N
D
A
Site 46
S388
D
N
D
A
H
L
R
S
S
S
R
P
C
S
P
Site 47
S389
N
D
A
H
L
R
S
S
S
R
P
C
S
P
V
Site 48
S390
D
A
H
L
R
S
S
S
R
P
C
S
P
V
H
Site 49
S394
R
S
S
S
R
P
C
S
P
V
H
H
H
E
G
Site 50
S406
H
E
G
H
A
K
L
S
S
S
P
P
R
A
S
Site 51
S407
E
G
H
A
K
L
S
S
S
P
P
R
A
S
P
Site 52
S408
G
H
A
K
L
S
S
S
P
P
R
A
S
P
V
Site 53
S413
S
S
S
P
P
R
A
S
P
V
R
M
A
P
S
Site 54
Y421
P
V
R
M
A
P
S
Y
V
L
K
K
A
Q
V
Site 55
S430
L
K
K
A
Q
V
L
S
A
G
S
R
R
R
K
Site 56
S433
A
Q
V
L
S
A
G
S
R
R
R
K
E
Q
R
Site 57
Y441
R
R
R
K
E
Q
R
Y
R
S
V
I
S
D
I
Site 58
S443
R
K
E
Q
R
Y
R
S
V
I
S
D
I
F
D
Site 59
T467
L
T
C
D
R
V
S
T
T
V
E
T
F
Q
D
Site 60
T471
R
V
S
T
T
V
E
T
F
Q
D
L
S
L
P
Site 61
S476
V
E
T
F
Q
D
L
S
L
P
I
P
G
K
E
Site 62
S490
E
D
L
A
K
L
H
S
A
I
Y
Q
N
V
P
Site 63
Y493
A
K
L
H
S
A
I
Y
Q
N
V
P
A
K
P
Site 64
S506
K
P
G
A
C
G
D
S
Y
A
A
Q
G
W
L
Site 65
Y507
P
G
A
C
G
D
S
Y
A
A
Q
G
W
L
A
Site 66
Y558
E
L
K
G
D
N
M
Y
S
C
E
R
C
K
K
Site 67
Y572
K
L
R
N
G
V
K
Y
C
K
V
L
R
L
P
Site 68
Y595
R
F
R
H
E
V
M
Y
S
F
K
I
N
S
H
Site 69
S601
M
Y
S
F
K
I
N
S
H
V
S
F
P
L
E
Site 70
S604
F
K
I
N
S
H
V
S
F
P
L
E
G
L
D
Site 71
Y647
G
S
G
H
Y
I
A
Y
C
Q
N
V
I
N
G
Site 72
Y663
W
Y
E
F
D
D
Q
Y
V
T
E
V
H
E
T
Site 73
T670
Y
V
T
E
V
H
E
T
V
V
Q
N
A
E
G
Site 74
Y678
V
V
Q
N
A
E
G
Y
V
L
F
Y
R
K
S
Site 75
S685
Y
V
L
F
Y
R
K
S
S
E
E
A
M
R
E
Site 76
S686
V
L
F
Y
R
K
S
S
E
E
A
M
R
E
R
Site 77
S698
R
E
R
Q
Q
V
V
S
L
A
A
M
R
E
P
Site 78
Y711
E
P
S
L
L
R
F
Y
V
S
R
E
W
L
N
Site 79
S713
S
L
L
R
F
Y
V
S
R
E
W
L
N
K
F
Site 80
T722
E
W
L
N
K
F
N
T
F
A
E
P
G
P
I
Site 81
T733
P
G
P
I
T
N
Q
T
F
L
C
S
H
G
G
Site 82
Y746
G
G
I
P
P
H
K
Y
H
Y
I
D
D
L
V
Site 83
Y765
Q
N
V
W
E
H
L
Y
N
R
F
G
G
G
P
Site 84
T800
R
R
R
I
E
I
D
T
F
I
K
L
N
K
A
Site 85
S846
P
P
G
P
I
D
N
S
R
I
A
Q
V
K
G
Site 86
Y865
Q
L
K
Q
G
A
D
Y
G
Q
I
S
E
E
T
Site 87
T874
Q
I
S
E
E
T
W
T
Y
L
N
S
L
Y
G
Site 88
Y875
I
S
E
E
T
W
T
Y
L
N
S
L
Y
G
G
Site 89
S878
E
T
W
T
Y
L
N
S
L
Y
G
G
G
P
E
Site 90
S891
P
E
I
A
I
R
Q
S
V
A
Q
P
L
G
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation