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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYH15
Full Name:
Myosin-15
Alias:
KIAA1000; Myosin heavy chain 15; Myosin, heavy chain 15
Type:
Motor protein
Mass (Da):
224645
Number AA:
1946
UniProt ID:
Q9Y2K3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030016
GO:0032982
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003779
GO:0005516
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S71
I
E
A
E
V
K
G
S
E
D
D
G
T
V
I
Site 2
T76
K
G
S
E
D
D
G
T
V
I
V
E
T
A
D
Site 3
S86
V
E
T
A
D
G
E
S
L
S
I
K
E
D
K
Site 4
S88
T
A
D
G
E
S
L
S
I
K
E
D
K
I
Q
Site 5
S118
L
T
H
L
N
E
A
S
V
L
H
T
L
K
R
Site 6
T122
N
E
A
S
V
L
H
T
L
K
R
R
Y
G
Q
Site 7
Y127
L
H
T
L
K
R
R
Y
G
Q
W
M
I
Y
T
Site 8
Y152
P
Y
K
W
L
P
V
Y
Q
K
E
V
M
A
A
Site 9
S166
A
Y
K
G
K
R
R
S
E
A
P
P
H
I
F
Site 10
T195
E
N
Q
S
I
L
F
T
G
E
S
G
A
G
K
Site 11
S198
S
I
L
F
T
G
E
S
G
A
G
K
T
V
N
Site 12
T203
G
E
S
G
A
G
K
T
V
N
S
K
H
I
I
Site 13
T248
E
A
F
G
N
A
K
T
L
R
N
D
N
S
S
Site 14
S254
K
T
L
R
N
D
N
S
S
R
F
G
K
F
I
Site 15
S255
T
L
R
N
D
N
S
S
R
F
G
K
F
I
R
Site 16
Y279
S
S
V
D
I
D
I
Y
L
L
E
K
S
R
V
Site 17
S284
D
I
Y
L
L
E
K
S
R
V
I
F
Q
Q
A
Site 18
Y296
Q
Q
A
G
E
R
N
Y
H
I
F
Y
Q
I
L
Site 19
Y300
E
R
N
Y
H
I
F
Y
Q
I
L
S
G
Q
K
Site 20
Y359
G
F
L
P
D
E
K
Y
G
C
Y
K
L
T
G
Site 21
Y362
P
D
E
K
Y
G
C
Y
K
L
T
G
A
I
M
Site 22
T390
E
Q
L
E
A
D
G
T
E
N
A
D
K
A
A
Site 23
Y422
R
I
K
V
G
N
E
Y
V
T
R
G
Q
T
I
Site 24
T428
E
Y
V
T
R
G
Q
T
I
E
Q
V
T
C
A
Site 25
S440
T
C
A
V
G
A
L
S
K
S
M
Y
E
R
M
Site 26
S442
A
V
G
A
L
S
K
S
M
Y
E
R
M
F
K
Site 27
Y444
G
A
L
S
K
S
M
Y
E
R
M
F
K
W
L
Site 28
Y482
T
G
F
E
I
L
E
Y
N
S
L
E
Q
L
C
Site 29
T493
E
Q
L
C
I
N
F
T
N
E
K
L
Q
Q
F
Site 30
Y504
L
Q
Q
F
F
N
W
Y
M
F
V
L
E
Q
E
Site 31
Y513
F
V
L
E
Q
E
E
Y
K
K
E
S
I
E
W
Site 32
S517
Q
E
E
Y
K
K
E
S
I
E
W
V
S
I
G
Site 33
T559
F
P
K
A
T
D
L
T
F
K
T
K
L
F
D
Site 34
T562
A
T
D
L
T
F
K
T
K
L
F
D
N
H
F
Site 35
T616
N
K
D
L
L
N
E
T
V
V
A
V
F
Q
K
Site 36
S631
S
S
N
R
L
L
A
S
L
F
E
N
Y
M
S
Site 37
S638
S
L
F
E
N
Y
M
S
T
D
S
A
I
P
F
Site 38
T639
L
F
E
N
Y
M
S
T
D
S
A
I
P
F
G
Site 39
S641
E
N
Y
M
S
T
D
S
A
I
P
F
G
E
K
Site 40
S655
K
K
R
K
K
G
A
S
F
Q
T
V
A
S
L
Site 41
T658
K
K
G
A
S
F
Q
T
V
A
S
L
H
K
E
Site 42
S661
A
S
F
Q
T
V
A
S
L
H
K
E
N
L
N
Site 43
T672
E
N
L
N
K
L
M
T
N
L
K
S
T
A
P
Site 44
S676
K
L
M
T
N
L
K
S
T
A
P
H
F
V
R
Site 45
Y727
G
F
P
N
R
L
Q
Y
A
D
F
K
Q
R
Y
Site 46
Y734
Y
A
D
F
K
Q
R
Y
C
I
L
N
P
R
T
Site 47
T741
Y
C
I
L
N
P
R
T
F
P
K
S
K
F
V
Site 48
S745
N
P
R
T
F
P
K
S
K
F
V
S
S
R
K
Site 49
S749
F
P
K
S
K
F
V
S
S
R
K
A
A
E
E
Site 50
S760
A
A
E
E
L
L
G
S
L
E
I
D
H
T
Q
Site 51
T766
G
S
L
E
I
D
H
T
Q
Y
R
F
G
I
T
Site 52
S794
A
I
R
D
E
R
L
S
K
V
F
T
L
F
Q
Site 53
T798
E
R
L
S
K
V
F
T
L
F
Q
A
R
A
Q
Site 54
S854
K
I
K
P
L
V
K
S
S
E
V
G
E
E
V
Site 55
S855
I
K
P
L
V
K
S
S
E
V
G
E
E
V
A
Site 56
S878
L
Q
K
A
L
E
K
S
E
F
Q
R
E
E
L
Site 57
S935
E
A
R
V
K
E
L
S
E
R
V
E
E
E
E
Site 58
S946
E
E
E
E
E
I
N
S
E
L
T
A
R
G
R
Site 59
T971
K
E
I
D
D
L
E
T
M
L
V
K
S
E
K
Site 60
T983
S
E
K
E
K
R
T
T
E
H
K
V
K
N
L
Site 61
S1002
E
F
L
N
E
D
I
S
K
L
N
R
A
A
K
Site 62
S1030
H
M
E
E
E
K
L
S
S
L
S
K
A
N
L
Site 63
S1031
M
E
E
E
K
L
S
S
L
S
K
A
N
L
K
Site 64
S1077
N
L
K
L
N
R
E
S
M
E
N
L
E
S
S
Site 65
S1083
E
S
M
E
N
L
E
S
S
Q
R
H
L
A
E
Site 66
S1084
S
M
E
N
L
E
S
S
Q
R
H
L
A
E
E
Site 67
S1100
R
K
K
E
L
E
L
S
Q
M
N
S
K
V
E
Site 68
S1104
L
E
L
S
Q
M
N
S
K
V
E
N
E
K
G
Site 69
T1119
L
V
A
Q
L
Q
K
T
V
K
E
L
Q
T
Q
Site 70
T1125
K
T
V
K
E
L
Q
T
Q
I
K
D
L
K
E
Site 71
T1139
E
K
L
E
A
E
R
T
T
R
A
K
M
E
R
Site 72
T1140
K
L
E
A
E
R
T
T
R
A
K
M
E
R
E
Site 73
T1152
E
R
E
R
A
D
L
T
Q
D
L
A
D
L
N
Site 74
T1199
E
A
T
L
H
F
E
T
T
S
A
S
L
K
K
Site 75
S1203
H
F
E
T
T
S
A
S
L
K
K
R
H
A
D
Site 76
S1211
L
K
K
R
H
A
D
S
L
A
E
L
E
G
Q
Site 77
S1234
Q
K
L
E
K
D
K
S
D
L
Q
L
E
V
D
Site 78
T1245
L
E
V
D
D
L
L
T
R
V
E
Q
M
T
R
Site 79
T1262
A
N
A
E
K
L
C
T
L
Y
E
E
R
L
H
Site 80
Y1264
A
E
K
L
C
T
L
Y
E
E
R
L
H
E
A
Site 81
T1290
N
D
L
A
A
Q
K
T
K
L
W
S
E
S
G
Site 82
S1296
K
T
K
L
W
S
E
S
G
E
F
L
R
R
L
Site 83
S1314
E
A
L
I
N
Q
L
S
R
E
K
S
N
F
T
Site 84
S1318
N
Q
L
S
R
E
K
S
N
F
T
R
Q
I
E
Site 85
T1335
R
G
Q
L
E
K
E
T
K
S
Q
S
A
L
A
Site 86
S1337
Q
L
E
K
E
T
K
S
Q
S
A
L
A
H
A
Site 87
Y1359
C
D
L
L
R
E
Q
Y
E
E
E
Q
E
V
K
Site 88
T1372
V
K
A
E
L
H
R
T
L
S
K
V
N
A
E
Site 89
S1374
A
E
L
H
R
T
L
S
K
V
N
A
E
M
V
Site 90
S1425
V
A
N
A
R
N
A
S
L
E
R
A
R
H
Q
Site 91
S1442
L
E
L
G
D
A
L
S
D
L
G
K
V
R
S
Site 92
S1449
S
D
L
G
K
V
R
S
A
A
A
R
L
D
Q
Site 93
S1461
L
D
Q
K
Q
L
Q
S
G
K
A
L
A
D
W
Site 94
S1482
S
Q
A
L
L
D
A
S
Q
K
E
V
Q
A
L
Site 95
T1499
E
L
L
K
L
K
N
T
Y
E
E
S
I
V
G
Site 96
T1509
E
S
I
V
G
Q
E
T
L
R
R
E
N
K
N
Site 97
T1532
T
N
Q
V
R
E
G
T
K
N
L
T
E
M
E
Site 98
T1550
K
L
I
E
E
E
K
T
E
V
Q
V
T
L
E
Site 99
T1555
E
K
T
E
V
Q
V
T
L
E
E
T
E
G
A
Site 100
S1568
G
A
L
E
R
N
E
S
K
I
L
H
F
Q
L
Site 101
S1589
A
E
L
E
R
K
L
S
E
K
D
E
E
I
E
Site 102
T1605
F
R
R
K
Q
Q
C
T
I
D
S
L
Q
S
S
Site 103
S1608
K
Q
Q
C
T
I
D
S
L
Q
S
S
L
D
S
Site 104
S1611
C
T
I
D
S
L
Q
S
S
L
D
S
E
A
K
Site 105
S1612
T
I
D
S
L
Q
S
S
L
D
S
E
A
K
S
Site 106
S1615
S
L
Q
S
S
L
D
S
E
A
K
S
R
I
E
Site 107
S1619
S
L
D
S
E
A
K
S
R
I
E
V
T
R
L
Site 108
S1642
N
E
M
E
L
Q
L
S
C
A
N
R
Q
V
S
Site 109
S1649
S
C
A
N
R
Q
V
S
E
A
T
K
S
L
G
Site 110
S1654
Q
V
S
E
A
T
K
S
L
G
Q
L
Q
I
Q
Site 111
S1672
L
Q
M
Q
L
D
D
S
T
Q
L
N
S
D
L
Site 112
T1673
Q
M
Q
L
D
D
S
T
Q
L
N
S
D
L
K
Site 113
S1691
A
V
A
E
R
R
N
S
L
L
Q
S
E
L
E
Site 114
S1695
R
R
N
S
L
L
Q
S
E
L
E
D
L
R
S
Site 115
S1702
S
E
L
E
D
L
R
S
L
Q
E
Q
T
E
R
Site 116
T1707
L
R
S
L
Q
E
Q
T
E
R
G
R
R
L
S
Site 117
S1714
T
E
R
G
R
R
L
S
E
E
E
L
L
E
A
Site 118
T1722
E
E
E
L
L
E
A
T
E
R
I
N
L
F
Y
Site 119
Y1729
T
E
R
I
N
L
F
Y
T
Q
N
T
S
L
L
Site 120
T1730
E
R
I
N
L
F
Y
T
Q
N
T
S
L
L
S
Site 121
S1734
L
F
Y
T
Q
N
T
S
L
L
S
Q
K
K
K
Site 122
S1737
T
Q
N
T
S
L
L
S
Q
K
K
K
L
E
A
Site 123
S1778
A
I
E
A
A
N
L
S
E
E
L
K
K
K
Q
Site 124
T1803
E
N
M
E
Q
T
I
T
D
L
Q
K
R
L
A
Site 125
S1829
K
Q
I
Q
K
L
E
S
R
V
R
E
L
E
G
Site 126
S1845
L
E
G
E
I
R
R
S
A
E
A
Q
R
G
A
Site 127
Y1864
R
C
I
K
E
L
T
Y
Q
A
E
E
D
K
K
Site 128
T1878
K
N
L
S
R
M
Q
T
Q
M
D
K
L
Q
L
Site 129
Y1890
L
Q
L
K
V
Q
N
Y
K
Q
Q
V
E
V
A
Site 130
T1899
Q
Q
V
E
V
A
E
T
Q
A
N
Q
Y
L
S
Site 131
Y1908
A
N
Q
Y
L
S
K
Y
K
K
Q
Q
H
E
L
Site 132
S1927
E
R
A
E
V
A
E
S
Q
V
N
K
L
K
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation