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Updated November 2019
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Protein Info
Short Name:
EPB41L3
Full Name:
Band 4.1-like protein 3
Alias:
4.1B; DAL1; DAL1P; Differentially expressed in adenocarcinoma of the lung protein 1; E41L3; E4L3; EPB4.1L3; Erythrocyte membrane protein band 4.1-like 3; KIAA0987; MDAL-1
Type:
Cytoskeletal protein
Mass (Da):
120678
Number AA:
1087
UniProt ID:
Q9Y2J2
International Prot ID:
IPI00032230
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005911
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0030866
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T2
_
_
_
_
_
_
M
T
T
E
S
G
S
D
S
Site 2
S5
_
_
_
M
T
T
E
S
G
S
D
S
E
S
K
Site 3
S7
_
M
T
T
E
S
G
S
D
S
E
S
K
P
D
Site 4
S9
T
T
E
S
G
S
D
S
E
S
K
P
D
Q
E
Site 5
S11
E
S
G
S
D
S
E
S
K
P
D
Q
E
A
E
Site 6
S55
F
A
A
A
A
A
H
S
T
P
V
R
R
E
V
Site 7
T56
A
A
A
A
A
H
S
T
P
V
R
R
E
V
T
Site 8
T63
T
P
V
R
R
E
V
T
D
K
E
Q
E
F
A
Site 9
Y79
R
A
A
K
Q
L
E
Y
Q
Q
L
E
D
D
K
Site 10
S88
Q
L
E
D
D
K
L
S
Q
K
S
S
S
S
K
Site 11
S91
D
D
K
L
S
Q
K
S
S
S
S
K
L
S
R
Site 12
S92
D
K
L
S
Q
K
S
S
S
S
K
L
S
R
S
Site 13
S93
K
L
S
Q
K
S
S
S
S
K
L
S
R
S
P
Site 14
S94
L
S
Q
K
S
S
S
S
K
L
S
R
S
P
L
Site 15
S97
K
S
S
S
S
K
L
S
R
S
P
L
K
I
V
Site 16
S99
S
S
S
K
L
S
R
S
P
L
K
I
V
K
K
Site 17
S109
K
I
V
K
K
P
K
S
M
Q
C
K
V
I
L
Site 18
Y122
I
L
L
D
G
S
E
Y
T
C
D
V
E
K
R
Site 19
Y150
L
N
L
L
E
K
D
Y
F
G
L
T
Y
R
D
Site 20
T154
E
K
D
Y
F
G
L
T
Y
R
D
A
E
N
Q
Site 21
Y189
F
S
F
N
V
K
F
Y
P
P
D
P
A
Q
L
Site 22
S197
P
P
D
P
A
Q
L
S
E
D
I
T
R
Y
Y
Site 23
T201
A
Q
L
S
E
D
I
T
R
Y
Y
L
C
L
Q
Site 24
Y203
L
S
E
D
I
T
R
Y
Y
L
C
L
Q
L
R
Site 25
Y204
S
E
D
I
T
R
Y
Y
L
C
L
Q
L
R
D
Site 26
S215
Q
L
R
D
D
I
V
S
G
R
L
P
C
S
F
Site 27
Y240
V
Q
S
E
L
G
D
Y
D
P
D
E
C
G
S
Site 28
S247
Y
D
P
D
E
C
G
S
D
Y
I
S
E
F
R
Site 29
Y249
P
D
E
C
G
S
D
Y
I
S
E
F
R
F
A
Site 30
S251
E
C
G
S
D
Y
I
S
E
F
R
F
A
P
N
Site 31
S273
K
V
I
E
L
H
K
S
H
R
G
M
T
P
A
Site 32
T278
H
K
S
H
R
G
M
T
P
A
E
A
E
M
H
Site 33
Y296
N
A
K
K
L
S
M
Y
G
V
D
L
H
H
A
Site 34
Y323
C
A
S
G
L
L
I
Y
R
D
R
L
R
I
N
Site 35
Y342
P
K
V
L
K
I
S
Y
K
R
N
N
F
Y
I
Site 36
Y348
S
Y
K
R
N
N
F
Y
I
K
I
R
P
G
E
Site 37
S361
G
E
F
E
Q
F
E
S
T
I
G
F
K
L
P
Site 38
T362
E
F
E
Q
F
E
S
T
I
G
F
K
L
P
N
Site 39
T401
A
P
P
K
K
F
L
T
L
G
S
K
F
R
Y
Site 40
S404
K
K
F
L
T
L
G
S
K
F
R
Y
S
G
R
Site 41
Y408
T
L
G
S
K
F
R
Y
S
G
R
T
Q
A
Q
Site 42
S409
L
G
S
K
F
R
Y
S
G
R
T
Q
A
Q
T
Site 43
T412
K
F
R
Y
S
G
R
T
Q
A
Q
T
R
R
A
Site 44
T416
S
G
R
T
Q
A
Q
T
R
R
A
S
A
L
I
Site 45
S420
Q
A
Q
T
R
R
A
S
A
L
I
D
R
P
A
Site 46
Y429
L
I
D
R
P
A
P
Y
F
E
R
S
S
S
K
Site 47
S433
P
A
P
Y
F
E
R
S
S
S
K
R
Y
T
M
Site 48
S434
A
P
Y
F
E
R
S
S
S
K
R
Y
T
M
S
Site 49
S435
P
Y
F
E
R
S
S
S
K
R
Y
T
M
S
R
Site 50
Y438
E
R
S
S
S
K
R
Y
T
M
S
R
S
L
D
Site 51
T439
R
S
S
S
K
R
Y
T
M
S
R
S
L
D
G
Site 52
S441
S
S
K
R
Y
T
M
S
R
S
L
D
G
E
V
Site 53
S443
K
R
Y
T
M
S
R
S
L
D
G
E
V
G
T
Site 54
Y453
G
E
V
G
T
G
Q
Y
A
T
T
K
G
I
S
Site 55
S460
Y
A
T
T
K
G
I
S
Q
T
N
L
I
T
T
Site 56
T462
T
T
K
G
I
S
Q
T
N
L
I
T
T
V
T
Site 57
T466
I
S
Q
T
N
L
I
T
T
V
T
P
E
K
K
Site 58
T467
S
Q
T
N
L
I
T
T
V
T
P
E
K
K
A
Site 59
T469
T
N
L
I
T
T
V
T
P
E
K
K
A
E
E
Site 60
T492
R
R
K
G
E
E
V
T
P
I
S
A
I
R
H
Site 61
S495
G
E
E
V
T
P
I
S
A
I
R
H
E
G
K
Site 62
S503
A
I
R
H
E
G
K
S
P
G
L
G
T
D
S
Site 63
T508
G
K
S
P
G
L
G
T
D
S
C
P
L
S
P
Site 64
S510
S
P
G
L
G
T
D
S
C
P
L
S
P
P
S
Site 65
S514
G
T
D
S
C
P
L
S
P
P
S
T
H
C
A
Site 66
S517
S
C
P
L
S
P
P
S
T
H
C
A
P
T
S
Site 67
T518
C
P
L
S
P
P
S
T
H
C
A
P
T
S
P
Site 68
S524
S
T
H
C
A
P
T
S
P
T
E
L
R
R
R
Site 69
Y542
N
D
C
K
L
P
G
Y
E
P
S
R
A
E
H
Site 70
S545
K
L
P
G
Y
E
P
S
R
A
E
H
L
P
G
Site 71
S558
P
G
E
P
A
L
D
S
D
G
P
G
R
P
Y
Site 72
Y565
S
D
G
P
G
R
P
Y
L
G
D
Q
D
V
A
Site 73
S574
G
D
Q
D
V
A
F
S
Y
R
Q
Q
T
G
K
Site 74
Y575
D
Q
D
V
A
F
S
Y
R
Q
Q
T
G
K
G
Site 75
T579
A
F
S
Y
R
Q
Q
T
G
K
G
T
T
L
F
Site 76
T583
R
Q
Q
T
G
K
G
T
T
L
F
S
F
S
L
Site 77
S587
G
K
G
T
T
L
F
S
F
S
L
Q
L
P
E
Site 78
S595
F
S
L
Q
L
P
E
S
F
P
S
L
L
D
D
Site 79
S598
Q
L
P
E
S
F
P
S
L
L
D
D
D
G
Y
Site 80
Y605
S
L
L
D
D
D
G
Y
L
S
F
P
N
L
S
Site 81
S607
L
D
D
D
G
Y
L
S
F
P
N
L
S
E
T
Site 82
S612
Y
L
S
F
P
N
L
S
E
T
N
L
L
P
Q
Site 83
S620
E
T
N
L
L
P
Q
S
L
Q
H
Y
L
P
I
Site 84
Y624
L
P
Q
S
L
Q
H
Y
L
P
I
R
S
P
S
Site 85
S673
Y
L
E
P
K
A
A
S
L
S
A
S
L
D
N
Site 86
S675
E
P
K
A
A
S
L
S
A
S
L
D
N
D
P
Site 87
S677
K
A
A
S
L
S
A
S
L
D
N
D
P
S
D
Site 88
S683
A
S
L
D
N
D
P
S
D
S
S
E
E
E
T
Site 89
S685
L
D
N
D
P
S
D
S
S
E
E
E
T
D
S
Site 90
S686
D
N
D
P
S
D
S
S
E
E
E
T
D
S
E
Site 91
T690
S
D
S
S
E
E
E
T
D
S
E
R
T
D
T
Site 92
S692
S
S
E
E
E
T
D
S
E
R
T
D
T
A
A
Site 93
T697
T
D
S
E
R
T
D
T
A
A
D
G
E
T
T
Site 94
T703
D
T
A
A
D
G
E
T
T
A
T
E
S
D
Q
Site 95
T704
T
A
A
D
G
E
T
T
A
T
E
S
D
Q
E
Site 96
T706
A
D
G
E
T
T
A
T
E
S
D
Q
E
E
D
Site 97
S708
G
E
T
T
A
T
E
S
D
Q
E
E
D
A
E
Site 98
T724
K
A
Q
E
L
E
K
T
Q
D
D
L
M
K
H
Site 99
T733
D
D
L
M
K
H
Q
T
N
I
S
E
L
K
R
Site 100
S736
M
K
H
Q
T
N
I
S
E
L
K
R
T
F
L
Site 101
T741
N
I
S
E
L
K
R
T
F
L
E
T
S
T
D
Site 102
T745
L
K
R
T
F
L
E
T
S
T
D
T
A
V
T
Site 103
S746
K
R
T
F
L
E
T
S
T
D
T
A
V
T
N
Site 104
S760
N
E
W
E
K
R
L
S
T
S
P
V
R
L
A
Site 105
T761
E
W
E
K
R
L
S
T
S
P
V
R
L
A
A
Site 106
S762
W
E
K
R
L
S
T
S
P
V
R
L
A
A
R
Site 107
T784
E
P
L
V
P
E
E
T
K
Q
S
S
G
E
K
Site 108
S787
V
P
E
E
T
K
Q
S
S
G
E
K
L
M
D
Site 109
S796
G
E
K
L
M
D
G
S
E
I
F
S
L
L
E
Site 110
S800
M
D
G
S
E
I
F
S
L
L
E
S
A
R
K
Site 111
S804
E
I
F
S
L
L
E
S
A
R
K
P
T
E
F
Site 112
T809
L
E
S
A
R
K
P
T
E
F
I
G
G
V
T
Site 113
S817
E
F
I
G
G
V
T
S
T
S
Q
S
W
V
Q
Site 114
S819
I
G
G
V
T
S
T
S
Q
S
W
V
Q
K
M
Site 115
S821
G
V
T
S
T
S
Q
S
W
V
Q
K
M
E
T
Site 116
T828
S
W
V
Q
K
M
E
T
K
T
E
S
S
G
I
Site 117
T830
V
Q
K
M
E
T
K
T
E
S
S
G
I
E
T
Site 118
T837
T
E
S
S
G
I
E
T
E
P
T
V
H
H
L
Site 119
T840
S
G
I
E
T
E
P
T
V
H
H
L
P
L
S
Site 120
S847
T
V
H
H
L
P
L
S
T
E
K
V
V
Q
E
Site 121
T855
T
E
K
V
V
Q
E
T
V
L
V
E
E
R
R
Site 122
S867
E
R
R
V
V
H
A
S
G
D
A
S
Y
S
A
Site 123
S871
V
H
A
S
G
D
A
S
Y
S
A
G
D
S
G
Site 124
Y872
H
A
S
G
D
A
S
Y
S
A
G
D
S
G
D
Site 125
S873
A
S
G
D
A
S
Y
S
A
G
D
S
G
D
A
Site 126
S877
A
S
Y
S
A
G
D
S
G
D
A
A
A
Q
P
Site 127
S895
G
I
K
G
K
E
G
S
A
L
T
E
G
A
K
Site 128
T919
A
V
L
E
Q
E
E
T
A
A
A
S
R
E
R
Site 129
S931
R
E
R
Q
E
E
Q
S
A
A
I
H
I
S
E
Site 130
T939
A
A
I
H
I
S
E
T
L
E
Q
K
P
H
F
Site 131
T950
K
P
H
F
E
S
S
T
V
K
T
E
T
I
S
Site 132
T953
F
E
S
S
T
V
K
T
E
T
I
S
F
G
S
Site 133
T955
S
S
T
V
K
T
E
T
I
S
F
G
S
V
S
Site 134
S957
T
V
K
T
E
T
I
S
F
G
S
V
S
P
G
Site 135
S960
T
E
T
I
S
F
G
S
V
S
P
G
G
V
K
Site 136
S962
T
I
S
F
G
S
V
S
P
G
G
V
K
L
E
Site 137
T984
V
V
H
T
E
T
K
T
I
T
Y
E
S
S
Q
Site 138
T986
H
T
E
T
K
T
I
T
Y
E
S
S
Q
V
D
Site 139
Y987
T
E
T
K
T
I
T
Y
E
S
S
Q
V
D
P
Site 140
S990
K
T
I
T
Y
E
S
S
Q
V
D
P
G
T
D
Site 141
T996
S
S
Q
V
D
P
G
T
D
L
E
P
G
V
L
Site 142
S1011
M
S
A
Q
T
I
T
S
E
T
T
S
T
T
T
Site 143
S1015
T
I
T
S
E
T
T
S
T
T
T
T
T
H
I
Site 144
T1016
I
T
S
E
T
T
S
T
T
T
T
T
H
I
T
Site 145
T1019
E
T
T
S
T
T
T
T
T
H
I
T
K
T
V
Site 146
T1025
T
T
T
H
I
T
K
T
V
K
G
G
I
S
E
Site 147
S1031
K
T
V
K
G
G
I
S
E
T
R
I
E
K
R
Site 148
S1068
K
E
Q
H
P
D
M
S
V
T
K
V
V
V
H
Site 149
T1081
V
H
K
E
T
E
I
T
P
E
D
G
E
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation