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Updated November 2019
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Protein Info
Short Name:
PIP5K
Full Name:
1-phosphatidylinositol-3-phosphate 5-kinase
Alias:
1- phosphatidylinositol-4-phosphate 5-kinase; EC 2.7.1.68; FYV1; FYVE finger-containing phosphoinositide kinase; FYVE finger-containing PI kinase; KIAA0981; Kiaa0981; MGC40423; P235; Phosphoinositide kinase, FYVE finger containing; PIKfyve; PIP5K3; PtdIns(4)P-5- kinase; PtdIns(4)P-5-kinase
Type:
Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid
Mass (Da):
237108
Number AA:
2098
UniProt ID:
Q9Y2I7
International Prot ID:
IPI00396145
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031901
GO:0045121
Uniprot
OncoNet
Molecular Function:
GO:0016308
GO:0005524
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0044267
GO:0007242
GO:0046488
Phosida
TranscriptoNet
STRING
Kinexus Products
1-phosphatidylinositol-3-phosphate 5-kinase S307 phosphosite-specific antibody AB-PK762#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK762#1-phosphatidylinositol-3-phosphate 5-kinase (R304-N310, human) pS307 phosphopeptide - Powder PE-04AOO99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AOO99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
A
T
D
D
K
T
S
P
T
L
D
S
A
Site 2
S8
M
A
T
D
D
K
T
S
P
T
L
D
S
A
N
Site 3
S13
K
T
S
P
T
L
D
S
A
N
D
L
P
R
S
Site 4
S20
S
A
N
D
L
P
R
S
P
T
S
P
S
H
L
Site 5
T22
N
D
L
P
R
S
P
T
S
P
S
H
L
T
H
Site 6
S23
D
L
P
R
S
P
T
S
P
S
H
L
T
H
F
Site 7
S25
P
R
S
P
T
S
P
S
H
L
T
H
F
K
P
Site 8
T28
P
T
S
P
S
H
L
T
H
F
K
P
L
T
P
Site 9
T34
L
T
H
F
K
P
L
T
P
D
Q
D
E
P
P
Site 10
S44
Q
D
E
P
P
F
K
S
A
Y
S
S
F
V
N
Site 11
Y46
E
P
P
F
K
S
A
Y
S
S
F
V
N
L
F
Site 12
S48
P
F
K
S
A
Y
S
S
F
V
N
L
F
R
F
Site 13
S71
Q
G
E
Q
Q
P
L
S
G
S
W
T
S
P
Q
Site 14
S73
E
Q
Q
P
L
S
G
S
W
T
S
P
Q
L
P
Site 15
T75
Q
P
L
S
G
S
W
T
S
P
Q
L
P
S
R
Site 16
S76
P
L
S
G
S
W
T
S
P
Q
L
P
S
R
T
Site 17
S81
W
T
S
P
Q
L
P
S
R
T
Q
S
V
R
S
Site 18
T83
S
P
Q
L
P
S
R
T
Q
S
V
R
S
P
T
Site 19
S85
Q
L
P
S
R
T
Q
S
V
R
S
P
T
P
Y
Site 20
S88
S
R
T
Q
S
V
R
S
P
T
P
Y
K
K
Q
Site 21
T90
T
Q
S
V
R
S
P
T
P
Y
K
K
Q
L
N
Site 22
Y92
S
V
R
S
P
T
P
Y
K
K
Q
L
N
E
E
Site 23
S104
N
E
E
L
Q
R
R
S
S
A
L
D
T
R
R
Site 24
S105
E
E
L
Q
R
R
S
S
A
L
D
T
R
R
K
Site 25
T109
R
R
S
S
A
L
D
T
R
R
K
A
E
P
T
Site 26
T116
T
R
R
K
A
E
P
T
F
G
G
H
D
P
R
Site 27
T124
F
G
G
H
D
P
R
T
A
V
Q
L
R
S
L
Site 28
S130
R
T
A
V
Q
L
R
S
L
S
T
V
L
K
R
Site 29
T133
V
Q
L
R
S
L
S
T
V
L
K
R
L
K
E
Site 30
S146
K
E
I
M
E
G
K
S
Q
D
S
D
L
K
Q
Site 31
Y154
Q
D
S
D
L
K
Q
Y
W
M
P
D
S
Q
C
Site 32
Y165
D
S
Q
C
K
E
C
Y
D
C
S
E
K
F
T
Site 33
Y212
G
D
L
R
A
C
T
Y
C
R
K
I
A
L
S
Site 34
S219
Y
C
R
K
I
A
L
S
Y
A
H
S
T
D
S
Site 35
S223
I
A
L
S
Y
A
H
S
T
D
S
N
S
I
G
Site 36
T224
A
L
S
Y
A
H
S
T
D
S
N
S
I
G
E
Site 37
S226
S
Y
A
H
S
T
D
S
N
S
I
G
E
D
L
Site 38
S228
A
H
S
T
D
S
N
S
I
G
E
D
L
N
A
Site 39
S237
G
E
D
L
N
A
L
S
D
S
A
C
S
V
S
Site 40
S244
S
D
S
A
C
S
V
S
V
L
D
P
S
E
P
Site 41
S249
S
V
S
V
L
D
P
S
E
P
R
T
P
V
G
Site 42
T253
L
D
P
S
E
P
R
T
P
V
G
S
R
K
A
Site 43
S257
E
P
R
T
P
V
G
S
R
K
A
S
R
N
I
Site 44
S261
P
V
G
S
R
K
A
S
R
N
I
F
L
E
D
Site 45
S274
E
D
D
L
A
W
Q
S
L
I
H
P
D
S
S
Site 46
S280
Q
S
L
I
H
P
D
S
S
N
T
P
L
S
T
Site 47
S281
S
L
I
H
P
D
S
S
N
T
P
L
S
T
R
Site 48
T283
I
H
P
D
S
S
N
T
P
L
S
T
R
L
V
Site 49
S286
D
S
S
N
T
P
L
S
T
R
L
V
S
V
Q
Site 50
S291
P
L
S
T
R
L
V
S
V
Q
E
D
A
G
K
Site 51
S299
V
Q
E
D
A
G
K
S
P
A
R
N
R
S
A
Site 52
S305
K
S
P
A
R
N
R
S
A
S
I
T
N
L
S
Site 53
S307
P
A
R
N
R
S
A
S
I
T
N
L
S
L
D
1-phosphatidylinositol-3-phosphate 5-kinase S307 phosphosite-specific antibody AB-PK762#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK762#1-phosphatidylinositol-3-phosphate 5-kinase (R304-N310, human) pS307 phosphopeptide - Powder PE-04AOO99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AOO99
Site 54
T309
R
N
R
S
A
S
I
T
N
L
S
L
D
R
S
Site 55
S312
S
A
S
I
T
N
L
S
L
D
R
S
G
S
P
Site 56
S316
T
N
L
S
L
D
R
S
G
S
P
M
V
P
S
Site 57
S318
L
S
L
D
R
S
G
S
P
M
V
P
S
Y
E
Site 58
S323
S
G
S
P
M
V
P
S
Y
E
T
S
V
S
P
Site 59
Y324
G
S
P
M
V
P
S
Y
E
T
S
V
S
P
Q
Site 60
T326
P
M
V
P
S
Y
E
T
S
V
S
P
Q
A
N
Site 61
S327
M
V
P
S
Y
E
T
S
V
S
P
Q
A
N
R
Site 62
S329
P
S
Y
E
T
S
V
S
P
Q
A
N
R
T
Y
Site 63
T335
V
S
P
Q
A
N
R
T
Y
V
R
T
E
T
T
Site 64
Y336
S
P
Q
A
N
R
T
Y
V
R
T
E
T
T
E
Site 65
T339
A
N
R
T
Y
V
R
T
E
T
T
E
D
E
R
Site 66
T341
R
T
Y
V
R
T
E
T
T
E
D
E
R
K
I
Site 67
T342
T
Y
V
R
T
E
T
T
E
D
E
R
K
I
L
Site 68
S352
E
R
K
I
L
L
D
S
V
Q
L
K
D
L
W
Site 69
S366
W
K
K
I
C
H
H
S
S
G
M
E
F
Q
D
Site 70
S367
K
K
I
C
H
H
S
S
G
M
E
F
Q
D
H
Site 71
Y433
D
Q
L
F
R
D
E
Y
A
L
Y
R
P
L
Q
Site 72
Y436
F
R
D
E
Y
A
L
Y
R
P
L
Q
S
T
E
Site 73
S441
A
L
Y
R
P
L
Q
S
T
E
F
S
E
T
P
Site 74
T442
L
Y
R
P
L
Q
S
T
E
F
S
E
T
P
S
Site 75
S445
P
L
Q
S
T
E
F
S
E
T
P
S
P
D
S
Site 76
T447
Q
S
T
E
F
S
E
T
P
S
P
D
S
D
S
Site 77
S449
T
E
F
S
E
T
P
S
P
D
S
D
S
V
N
Site 78
S452
S
E
T
P
S
P
D
S
D
S
V
N
S
V
E
Site 79
S454
T
P
S
P
D
S
D
S
V
N
S
V
E
G
H
Site 80
S457
P
D
S
D
S
V
N
S
V
E
G
H
S
E
P
Site 81
S475
K
D
I
K
F
D
D
S
D
T
E
Q
I
A
E
Site 82
T477
I
K
F
D
D
S
D
T
E
Q
I
A
E
E
G
Site 83
S491
G
D
D
N
L
A
N
S
A
S
P
S
K
R
T
Site 84
S493
D
N
L
A
N
S
A
S
P
S
K
R
T
S
V
Site 85
S495
L
A
N
S
A
S
P
S
K
R
T
S
V
S
S
Site 86
T498
S
A
S
P
S
K
R
T
S
V
S
S
F
Q
S
Site 87
S499
A
S
P
S
K
R
T
S
V
S
S
F
Q
S
T
Site 88
S501
P
S
K
R
T
S
V
S
S
F
Q
S
T
V
D
Site 89
S502
S
K
R
T
S
V
S
S
F
Q
S
T
V
D
S
Site 90
S505
T
S
V
S
S
F
Q
S
T
V
D
S
D
S
A
Site 91
T506
S
V
S
S
F
Q
S
T
V
D
S
D
S
A
A
Site 92
S509
S
F
Q
S
T
V
D
S
D
S
A
A
S
I
S
Site 93
S511
Q
S
T
V
D
S
D
S
A
A
S
I
S
L
N
Site 94
S516
S
D
S
A
A
S
I
S
L
N
V
E
L
D
N
Site 95
Y534
H
I
K
K
P
S
K
Y
P
H
V
P
P
H
P
Site 96
S550
D
Q
K
E
Y
L
I
S
D
T
G
G
Q
Q
L
Site 97
T552
K
E
Y
L
I
S
D
T
G
G
Q
Q
L
S
I
Site 98
S558
D
T
G
G
Q
Q
L
S
I
S
D
A
F
I
K
Site 99
S560
G
G
Q
Q
L
S
I
S
D
A
F
I
K
E
S
Site 100
S567
S
D
A
F
I
K
E
S
L
F
N
R
R
V
E
Site 101
S577
N
R
R
V
E
E
K
S
K
E
L
P
F
T
P
Site 102
T583
K
S
K
E
L
P
F
T
P
L
G
W
H
H
N
Site 103
S626
L
L
Q
Q
L
L
H
S
D
S
L
S
S
S
W
Site 104
S628
Q
Q
L
L
H
S
D
S
L
S
S
S
W
R
D
Site 105
S630
L
L
H
S
D
S
L
S
S
S
W
R
D
I
I
Site 106
S632
H
S
D
S
L
S
S
S
W
R
D
I
I
V
S
Site 107
Y713
L
L
K
C
S
I
E
Y
L
Y
R
E
E
T
K
Site 108
Y715
K
C
S
I
E
Y
L
Y
R
E
E
T
K
F
T
Site 109
T719
E
Y
L
Y
R
E
E
T
K
F
T
C
I
D
P
Site 110
T722
Y
R
E
E
T
K
F
T
C
I
D
P
I
V
L
Site 111
Y738
E
R
E
F
L
K
N
Y
V
Q
R
I
V
D
V
Site 112
S784
S
Q
V
L
E
R
I
S
R
M
T
Q
G
D
L
Site 113
T787
L
E
R
I
S
R
M
T
Q
G
D
L
V
M
S
Site 114
T822
F
Q
L
P
N
E
Q
T
K
T
L
M
F
F
E
Site 115
T824
L
P
N
E
Q
T
K
T
L
M
F
F
E
G
C
Site 116
S845
T
I
K
L
R
G
G
S
D
Y
E
L
A
R
V
Site 117
Y847
K
L
R
G
G
S
D
Y
E
L
A
R
V
K
E
Site 118
S871
Y
H
S
Q
L
E
I
S
F
L
M
D
E
F
A
Site 119
T882
D
E
F
A
M
P
P
T
L
M
Q
N
P
S
F
Site 120
S888
P
T
L
M
Q
N
P
S
F
H
S
L
I
E
G
Site 121
S891
M
Q
N
P
S
F
H
S
L
I
E
G
R
G
H
Site 122
Y906
E
G
A
V
Q
E
Q
Y
G
G
G
S
I
P
W
Site 123
S910
Q
E
Q
Y
G
G
G
S
I
P
W
D
P
D
I
Site 124
S921
D
P
D
I
P
P
E
S
L
P
C
D
D
S
S
Site 125
S927
E
S
L
P
C
D
D
S
S
L
L
E
S
R
I
Site 126
S928
S
L
P
C
D
D
S
S
L
L
E
S
R
I
V
Site 127
S932
D
D
S
S
L
L
E
S
R
I
V
F
E
K
G
Site 128
S959
S
V
K
H
Q
E
H
S
T
T
A
C
P
A
G
Site 129
T961
K
H
Q
E
H
S
T
T
A
C
P
A
G
L
P
Site 130
S993
D
Q
Q
D
A
L
G
S
E
L
P
E
S
L
Q
Site 131
T1002
L
P
E
S
L
Q
Q
T
V
V
L
Q
D
P
K
Site 132
S1010
V
V
L
Q
D
P
K
S
Q
I
R
A
F
R
D
Site 133
T1023
R
D
P
L
Q
D
D
T
G
L
Y
V
T
E
E
Site 134
Y1026
L
Q
D
D
T
G
L
Y
V
T
E
E
V
T
S
Site 135
S1034
V
T
E
E
V
T
S
S
E
D
K
R
K
T
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T1040
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Y1041
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Site 138
S1042
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E
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Site 139
S1076
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Y
F
A
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Site 140
T1077
E
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E
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Site 141
Y1086
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Y
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N
K
Site 142
S1088
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Site 143
S1111
K
Q
L
L
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G
Site 144
S1119
G
L
Q
G
M
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G
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K
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I
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Site 145
S1124
N
G
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Site 146
S1135
L
P
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Site 147
T1136
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Site 148
S1145
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Site 149
S1147
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Site 150
Y1155
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R
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Site 151
S1167
G
R
I
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A
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Site 152
S1173
N
S
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A
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S
Site 153
S1177
F
A
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Site 154
S1178
A
H
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A
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Site 155
T1179
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G
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Site 156
S1180
S
K
D
A
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S
K
Site 157
S1181
K
D
A
S
S
T
S
S
G
K
S
G
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K
N
Site 158
S1184
S
S
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K
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G
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K
N
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G
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Site 159
S1199
E
E
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A
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W
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Site 160
S1223
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A
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S
S
Site 161
S1224
R
L
C
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S
A
Q
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S
N
Site 162
S1226
C
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A
Q
S
S
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A
P
Site 163
S1229
F
S
S
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S
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A
P
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A
C
Site 164
S1230
S
S
S
S
A
Q
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S
N
A
P
S
A
C
V
Site 165
S1234
A
Q
S
S
N
A
P
S
A
C
V
S
P
W
I
Site 166
T1253
F
Y
G
K
N
D
L
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F
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E
R
Site 167
Y1261
L
G
I
F
L
E
R
Y
C
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R
P
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Y
Q
Site 168
S1301
I
I
L
K
E
L
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G
Y
Q
H
Site 169
Y1306
L
D
S
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Site 170
T1309
P
V
P
G
Y
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T
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L
T
Y
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W
C
Site 171
S1336
S
N
E
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S
M
S
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A
K
Y
L
E
L
Site 172
Y1340
W
S
M
S
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A
K
Y
L
E
L
R
F
Y
G
Site 173
Y1346
K
Y
L
E
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R
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Y
G
H
Q
Y
T
R
R
Site 174
Y1350
L
R
F
Y
G
H
Q
Y
T
R
R
A
N
A
E
Site 175
S1379
S
Y
N
Q
M
V
A
S
F
S
Y
S
P
I
R
Site 176
Y1424
F
Q
K
V
S
Q
V
Y
V
A
I
D
E
R
L
Site 177
S1433
A
I
D
E
R
L
A
S
L
K
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D
T
F
S
Site 178
T1436
E
R
L
A
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L
K
T
D
T
F
S
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T
R
Site 179
T1438
L
A
S
L
K
T
D
T
F
S
K
T
R
E
E
Site 180
S1440
S
L
K
T
D
T
F
S
K
T
R
E
E
K
M
Site 181
T1442
K
T
D
T
F
S
K
T
R
E
E
K
M
E
D
Site 182
S1474
K
M
Q
A
R
L
M
S
S
S
V
D
T
P
Q
Site 183
S1475
M
Q
A
R
L
M
S
S
S
V
D
T
P
Q
Q
Site 184
S1476
Q
A
R
L
M
S
S
S
V
D
T
P
Q
Q
L
Site 185
T1479
L
M
S
S
S
V
D
T
P
Q
Q
L
Q
S
V
Site 186
S1485
D
T
P
Q
Q
L
Q
S
V
F
E
S
L
I
A
Site 187
S1489
Q
L
Q
S
V
F
E
S
L
I
A
K
K
Q
S
Site 188
S1496
S
L
I
A
K
K
Q
S
L
C
E
V
L
Q
A
Site 189
S1522
E
K
G
R
K
R
P
S
V
P
P
S
P
G
R
Site 190
S1526
K
R
P
S
V
P
P
S
P
G
R
L
R
Q
G
Site 191
S1536
R
L
R
Q
G
E
E
S
K
I
S
A
M
D
A
Site 192
S1539
Q
G
E
E
S
K
I
S
A
M
D
A
S
P
R
Site 193
S1544
K
I
S
A
M
D
A
S
P
R
N
I
S
P
G
Site 194
S1549
D
A
S
P
R
N
I
S
P
G
L
Q
N
G
E
Site 195
T1563
E
K
E
D
R
F
L
T
T
L
S
S
Q
S
S
Site 196
T1564
K
E
D
R
F
L
T
T
L
S
S
Q
S
S
T
Site 197
S1566
D
R
F
L
T
T
L
S
S
Q
S
S
T
S
S
Site 198
S1567
R
F
L
T
T
L
S
S
Q
S
S
T
S
S
T
Site 199
S1569
L
T
T
L
S
S
Q
S
S
T
S
S
T
H
L
Site 200
S1570
T
T
L
S
S
Q
S
S
T
S
S
T
H
L
Q
Site 201
T1571
T
L
S
S
Q
S
S
T
S
S
T
H
L
Q
L
Site 202
S1573
S
S
Q
S
S
T
S
S
T
H
L
Q
L
P
T
Site 203
T1574
S
Q
S
S
T
S
S
T
H
L
Q
L
P
T
P
Site 204
T1580
S
T
H
L
Q
L
P
T
P
P
E
V
M
S
E
Site 205
S1586
P
T
P
P
E
V
M
S
E
Q
S
V
G
G
P
Site 206
T1598
G
G
P
P
E
L
D
T
A
S
S
S
E
D
V
Site 207
S1600
P
P
E
L
D
T
A
S
S
S
E
D
V
F
D
Site 208
S1601
P
E
L
D
T
A
S
S
S
E
D
V
F
D
G
Site 209
S1602
E
L
D
T
A
S
S
S
E
D
V
F
D
G
H
Site 210
S1616
H
L
L
G
S
T
D
S
Q
V
K
E
K
S
T
Site 211
S1622
D
S
Q
V
K
E
K
S
T
M
K
A
I
F
A
Site 212
S1636
A
N
L
L
P
G
N
S
Y
N
P
I
P
F
P
Site 213
Y1650
P
F
D
P
D
K
H
Y
L
M
Y
E
H
E
R
Site 214
Y1680
F
A
L
S
C
K
E
Y
R
N
A
L
E
E
L
Site 215
T1702
S
A
E
E
G
L
P
T
N
S
T
S
D
S
R
Site 216
S1704
E
E
G
L
P
T
N
S
T
S
D
S
R
P
K
Site 217
T1705
E
G
L
P
T
N
S
T
S
D
S
R
P
K
S
Site 218
S1706
G
L
P
T
N
S
T
S
D
S
R
P
K
S
S
Site 219
S1708
P
T
N
S
T
S
D
S
R
P
K
S
S
S
P
Site 220
S1712
T
S
D
S
R
P
K
S
S
S
P
I
R
L
P
Site 221
S1713
S
D
S
R
P
K
S
S
S
P
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R
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P
E
Site 222
S1714
D
S
R
P
K
S
S
S
P
I
R
L
P
E
M
Site 223
S1722
P
I
R
L
P
E
M
S
G
G
Q
T
N
R
T
Site 224
T1726
P
E
M
S
G
G
Q
T
N
R
T
T
E
T
E
Site 225
T1729
S
G
G
Q
T
N
R
T
T
E
T
E
P
Q
P
Site 226
T1730
G
G
Q
T
N
R
T
T
E
T
E
P
Q
P
T
Site 227
T1737
T
E
T
E
P
Q
P
T
K
K
A
S
G
M
L
Site 228
S1741
P
Q
P
T
K
K
A
S
G
M
L
S
F
F
R
Site 229
S1745
K
K
A
S
G
M
L
S
F
F
R
G
T
A
G
Site 230
T1750
M
L
S
F
F
R
G
T
A
G
K
S
P
D
L
Site 231
S1754
F
R
G
T
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G
K
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L
S
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Q
K
Site 232
S1758
A
G
K
S
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L
S
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K
R
E
T
L
Site 233
S1759
G
K
S
P
D
L
S
S
Q
K
R
E
T
L
R
Site 234
T1764
L
S
S
Q
K
R
E
T
L
R
G
A
D
S
A
Site 235
S1770
E
T
L
R
G
A
D
S
A
Y
Y
Q
V
G
Q
Site 236
Y1772
L
R
G
A
D
S
A
Y
Y
Q
V
G
Q
T
G
Site 237
Y1773
R
G
A
D
S
A
Y
Y
Q
V
G
Q
T
G
K
Site 238
T1799
D
E
V
D
G
G
D
T
Q
K
K
Q
L
I
N
Site 239
S1814
P
H
V
E
L
Q
F
S
D
A
N
A
K
F
Y
Site 240
Y1821
S
D
A
N
A
K
F
Y
C
R
L
Y
Y
A
G
Site 241
Y1825
A
K
F
Y
C
R
L
Y
Y
A
G
E
F
H
K
Site 242
Y1826
K
F
Y
C
R
L
Y
Y
A
G
E
F
H
K
M
Site 243
S1840
M
R
E
V
I
L
D
S
S
E
E
D
F
I
R
Site 244
S1841
R
E
V
I
L
D
S
S
E
E
D
F
I
R
S
Site 245
S1848
S
E
E
D
F
I
R
S
L
S
H
S
S
P
W
Site 246
S1850
E
D
F
I
R
S
L
S
H
S
S
P
W
Q
A
Site 247
S1852
F
I
R
S
L
S
H
S
S
P
W
Q
A
R
G
Site 248
S1853
I
R
S
L
S
H
S
S
P
W
Q
A
R
G
G
Site 249
S1862
W
Q
A
R
G
G
K
S
G
A
A
F
Y
A
T
Site 250
T1869
S
G
A
A
F
Y
A
T
E
D
D
R
F
I
L
Site 251
S1886
M
P
R
L
E
V
Q
S
F
L
D
F
A
P
H
Site 252
T1908
A
V
Q
Q
K
R
P
T
A
L
A
K
I
L
G
Site 253
Y1921
L
G
V
Y
R
I
G
Y
K
N
S
Q
N
N
T
Site 254
S1924
Y
R
I
G
Y
K
N
S
Q
N
N
T
E
K
K
Site 255
T1928
Y
K
N
S
Q
N
N
T
E
K
K
L
D
L
L
Site 256
S1955
Q
V
F
D
L
K
G
S
L
R
N
R
N
V
K
Site 257
T1963
L
R
N
R
N
V
K
T
D
T
G
K
E
S
C
Site 258
T1965
N
R
N
V
K
T
D
T
G
K
E
S
C
D
V
Site 259
S1969
K
T
D
T
G
K
E
S
C
D
V
V
L
L
D
Site 260
Y1989
M
V
R
D
N
P
L
Y
I
R
S
H
S
K
A
Site 261
S1992
D
N
P
L
Y
I
R
S
H
S
K
A
V
L
R
Site 262
S1994
P
L
Y
I
R
S
H
S
K
A
V
L
R
T
S
Site 263
S2001
S
K
A
V
L
R
T
S
I
H
S
D
S
H
F
Site 264
S2004
V
L
R
T
S
I
H
S
D
S
H
F
L
S
S
Site 265
S2006
R
T
S
I
H
S
D
S
H
F
L
S
S
H
L
Site 266
S2010
H
S
D
S
H
F
L
S
S
H
L
I
I
D
Y
Site 267
T2040
G
I
I
D
Y
I
R
T
F
T
W
D
K
K
L
Site 268
T2042
I
D
Y
I
R
T
F
T
W
D
K
K
L
E
M
Site 269
T2065
G
G
Q
G
K
M
P
T
V
V
S
P
E
L
Y
Site 270
S2068
G
K
M
P
T
V
V
S
P
E
L
Y
R
T
R
Site 271
Y2072
T
V
V
S
P
E
L
Y
R
T
R
F
C
E
A
Site 272
T2074
V
S
P
E
L
Y
R
T
R
F
C
E
A
M
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation