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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CARD8
Full Name:
Alias:
Apoptotic protein NDPP1;CARD-inhibitor of NF-kappa-B-activating ligand;DACAR;Tumor up-regulated CARD-containing antagonist of CASP9
Type:
Mass (Da):
48933
Number AA:
431
UniProt ID:
Q9Y2G2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
M
R
Q
R
Q
S
H
Y
C
S
V
L
F
L
S
Site 2
S11
Q
R
Q
S
H
Y
C
S
V
L
F
L
S
V
N
Site 3
S30
T
F
P
G
D
I
C
S
E
E
N
Q
I
V
S
Site 4
S38
E
E
N
Q
I
V
S
S
Y
A
S
K
V
C
F
Site 5
Y51
C
F
E
I
E
E
D
Y
K
N
R
Q
F
L
G
Site 6
S71
D
V
E
L
I
D
K
S
T
N
R
Y
S
V
W
Site 7
T72
V
E
L
I
D
K
S
T
N
R
Y
S
V
W
F
Site 8
Y75
I
D
K
S
T
N
R
Y
S
V
W
F
P
T
A
Site 9
S76
D
K
S
T
N
R
Y
S
V
W
F
P
T
A
G
Site 10
T133
G
G
P
L
F
D
V
T
A
E
P
E
E
A
V
Site 11
Y182
P
A
R
V
E
P
F
Y
A
V
L
E
S
P
S
Site 12
T213
S
I
P
I
T
S
N
T
L
I
Y
Y
H
P
H
Site 13
Y216
I
T
S
N
T
L
I
Y
Y
H
P
H
P
E
D
Site 14
Y217
T
S
N
T
L
I
Y
Y
H
P
H
P
E
D
I
Site 15
T255
F
H
G
V
R
L
Q
T
S
P
P
M
E
P
L
Site 16
S256
H
G
V
R
L
Q
T
S
P
P
M
E
P
L
N
Site 17
S267
E
P
L
N
F
G
S
S
Y
I
V
S
N
S
A
Site 18
Y268
P
L
N
F
G
S
S
Y
I
V
S
N
S
A
N
Site 19
S273
S
S
Y
I
V
S
N
S
A
N
L
K
V
M
P
Site 20
S286
M
P
K
E
L
K
L
S
Y
R
S
P
G
E
I
Site 21
Y287
P
K
E
L
K
L
S
Y
R
S
P
G
E
I
Q
Site 22
S289
E
L
K
L
S
Y
R
S
P
G
E
I
Q
H
F
Site 23
T319
I
T
E
K
R
H
G
T
L
V
W
D
T
E
V
Site 24
T388
E
L
V
E
Q
E
K
T
R
Q
S
K
N
E
A
Site 25
S391
E
Q
E
K
T
R
Q
S
K
N
E
A
L
L
S
Site 26
S398
S
K
N
E
A
L
L
S
M
V
E
K
K
G
D
Site 27
S414
A
L
D
V
L
F
R
S
I
S
E
R
D
P
Y
Site 28
S416
D
V
L
F
R
S
I
S
E
R
D
P
Y
L
V
Site 29
Y421
S
I
S
E
R
D
P
Y
L
V
S
Y
L
R
Q
Site 30
S424
E
R
D
P
Y
L
V
S
Y
L
R
Q
Q
N
L
Site 31
Y425
R
D
P
Y
L
V
S
Y
L
R
Q
Q
N
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation