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Updated November 2019
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Protein Info
Short Name:
MRF
Full Name:
Myelin gene regulatory factor
Alias:
Type:
Mass (Da):
124397
Number AA:
1151
UniProt ID:
Q9Y2G1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T30
L
E
P
S
N
I
D
T
S
I
L
E
E
Y
I
Site 2
S31
E
P
S
N
I
D
T
S
I
L
E
E
Y
I
S
Site 3
Y36
D
T
S
I
L
E
E
Y
I
S
K
E
D
A
S
Site 4
S38
S
I
L
E
E
Y
I
S
K
E
D
A
S
D
L
Site 5
S43
Y
I
S
K
E
D
A
S
D
L
C
F
P
D
I
Site 6
S55
P
D
I
S
A
P
A
S
S
A
S
Y
S
H
G
Site 7
S56
D
I
S
A
P
A
S
S
A
S
Y
S
H
G
Q
Site 8
S58
S
A
P
A
S
S
A
S
Y
S
H
G
Q
P
A
Site 9
Y59
A
P
A
S
S
A
S
Y
S
H
G
Q
P
A
M
Site 10
S60
P
A
S
S
A
S
Y
S
H
G
Q
P
A
M
P
Site 11
S69
G
Q
P
A
M
P
G
S
S
G
V
H
H
L
S
Site 12
S70
Q
P
A
M
P
G
S
S
G
V
H
H
L
S
P
Site 13
S76
S
S
G
V
H
H
L
S
P
P
G
G
G
P
S
Site 14
S83
S
P
P
G
G
G
P
S
P
G
R
H
G
P
L
Site 15
Y95
G
P
L
P
P
P
G
Y
G
T
P
L
N
C
N
Site 16
T97
L
P
P
P
G
Y
G
T
P
L
N
C
N
N
N
Site 17
T134
K
A
P
Y
A
P
G
T
L
P
D
S
P
P
D
Site 18
S138
A
P
G
T
L
P
D
S
P
P
D
S
G
S
E
Site 19
S142
L
P
D
S
P
P
D
S
G
S
E
A
Y
S
P
Site 20
S144
D
S
P
P
D
S
G
S
E
A
Y
S
P
Q
Q
Site 21
Y147
P
D
S
G
S
E
A
Y
S
P
Q
Q
V
N
E
Site 22
S148
D
S
G
S
E
A
Y
S
P
Q
Q
V
N
E
P
Site 23
T160
N
E
P
H
L
L
R
T
I
T
P
E
T
L
C
Site 24
S173
L
C
H
V
G
V
P
S
R
L
E
H
P
P
P
Site 25
Y198
P
P
P
P
P
P
H
Y
P
V
L
Q
R
D
L
Site 26
Y206
P
V
L
Q
R
D
L
Y
M
K
A
E
P
P
I
Site 27
Y216
A
E
P
P
I
P
H
Y
A
A
M
G
Q
G
L
Site 28
S253
A
E
L
P
T
H
P
S
K
K
R
K
H
S
E
Site 29
S259
P
S
K
K
R
K
H
S
E
S
P
P
S
T
L
Site 30
S261
K
K
R
K
H
S
E
S
P
P
S
T
L
N
A
Site 31
S264
K
H
S
E
S
P
P
S
T
L
N
A
Q
M
L
Site 32
T265
H
S
E
S
P
P
S
T
L
N
A
Q
M
L
N
Site 33
T290
T
A
L
P
L
H
P
T
R
A
P
S
P
P
W
Site 34
S294
L
H
P
T
R
A
P
S
P
P
W
P
P
Q
G
Site 35
S304
W
P
P
Q
G
P
L
S
P
G
P
G
S
L
P
Site 36
T319
L
S
I
A
R
V
Q
T
P
P
W
H
P
P
G
Site 37
S329
W
H
P
P
G
A
P
S
P
G
L
L
Q
D
S
Site 38
S336
S
P
G
L
L
Q
D
S
D
S
L
S
G
S
Y
Site 39
S338
G
L
L
Q
D
S
D
S
L
S
G
S
Y
L
D
Site 40
S340
L
Q
D
S
D
S
L
S
G
S
Y
L
D
P
N
Site 41
S342
D
S
D
S
L
S
G
S
Y
L
D
P
N
Y
Q
Site 42
Y343
S
D
S
L
S
G
S
Y
L
D
P
N
Y
Q
S
Site 43
Y348
G
S
Y
L
D
P
N
Y
Q
S
I
K
W
Q
P
Site 44
Y365
Q
N
K
W
A
T
L
Y
D
A
N
Y
K
E
L
Site 45
Y369
A
T
L
Y
D
A
N
Y
K
E
L
P
M
L
T
Site 46
T376
Y
K
E
L
P
M
L
T
Y
R
V
D
A
D
K
Site 47
S388
A
D
K
G
F
N
F
S
V
G
D
D
A
F
V
Site 48
Y416
G
M
L
G
E
P
K
Y
V
K
T
P
E
G
L
Site 49
T419
G
E
P
K
Y
V
K
T
P
E
G
L
K
P
L
Site 50
S450
Q
S
I
N
I
E
Q
S
Q
S
D
R
S
K
R
Site 51
S452
I
N
I
E
Q
S
Q
S
D
R
S
K
R
P
F
Site 52
S455
E
Q
S
Q
S
D
R
S
K
R
P
F
N
P
V
Site 53
T463
K
R
P
F
N
P
V
T
V
N
L
P
P
E
Q
Site 54
S482
T
V
G
R
L
H
F
S
E
T
T
A
N
N
M
Site 55
T484
G
R
L
H
F
S
E
T
T
A
N
N
M
R
K
Site 56
Y501
K
P
N
P
D
Q
R
Y
F
M
L
V
V
A
L
Site 57
S532
E
R
I
I
V
R
A
S
N
P
G
Q
F
E
S
Site 58
S539
S
N
P
G
Q
F
E
S
D
S
D
V
L
W
Q
Site 59
S541
P
G
Q
F
E
S
D
S
D
V
L
W
Q
R
A
Site 60
T553
Q
R
A
Q
V
P
D
T
V
F
H
H
G
R
V
Site 61
T564
H
G
R
V
G
I
N
T
D
R
P
D
E
A
L
Site 62
S582
G
N
V
K
V
M
G
S
L
M
H
P
S
D
L
Site 63
S587
M
G
S
L
M
H
P
S
D
L
R
A
K
E
H
Site 64
T601
H
V
Q
E
V
D
T
T
E
Q
L
K
R
I
S
Site 65
S608
T
E
Q
L
K
R
I
S
R
M
R
L
V
H
Y
Site 66
Y615
S
R
M
R
L
V
H
Y
R
Y
K
P
E
F
A
Site 67
Y617
M
R
L
V
H
Y
R
Y
K
P
E
F
A
A
S
Site 68
S624
Y
K
P
E
F
A
A
S
A
G
I
E
A
T
A
Site 69
S703
I
D
E
L
E
R
W
S
H
K
L
A
K
L
R
Site 70
S714
A
K
L
R
R
L
D
S
L
K
S
T
G
S
S
Site 71
S717
R
R
L
D
S
L
K
S
T
G
S
S
G
A
F
Site 72
T718
R
L
D
S
L
K
S
T
G
S
S
G
A
F
S
Site 73
S720
D
S
L
K
S
T
G
S
S
G
A
F
S
H
A
Site 74
S721
S
L
K
S
T
G
S
S
G
A
F
S
H
A
G
Site 75
S725
T
G
S
S
G
A
F
S
H
A
G
S
Q
F
S
Site 76
S729
G
A
F
S
H
A
G
S
Q
F
S
R
A
G
S
Site 77
S732
S
H
A
G
S
Q
F
S
R
A
G
S
V
P
H
Site 78
S736
S
Q
F
S
R
A
G
S
V
P
H
K
K
R
P
Site 79
S748
K
R
P
P
K
V
A
S
K
S
S
S
V
V
P
Site 80
S750
P
P
K
V
A
S
K
S
S
S
V
V
P
D
Q
Site 81
S752
K
V
A
S
K
S
S
S
V
V
P
D
Q
A
C
Site 82
S761
V
P
D
Q
A
C
I
S
Q
R
F
L
Q
G
T
Site 83
T768
S
Q
R
F
L
Q
G
T
I
I
A
L
V
V
V
Site 84
S790
M
S
T
L
Y
V
L
S
L
R
T
E
E
D
L
Site 85
S823
R
P
Q
P
P
G
G
S
E
A
L
C
P
W
S
Site 86
S830
S
E
A
L
C
P
W
S
S
Q
S
F
G
T
T
Site 87
S831
E
A
L
C
P
W
S
S
Q
S
F
G
T
T
Q
Site 88
S833
L
C
P
W
S
S
Q
S
F
G
T
T
Q
L
R
Site 89
T837
S
S
Q
S
F
G
T
T
Q
L
R
Q
S
P
L
Site 90
S842
G
T
T
Q
L
R
Q
S
P
L
T
T
G
L
P
Site 91
T845
Q
L
R
Q
S
P
L
T
T
G
L
P
G
I
Q
Site 92
T846
L
R
Q
S
P
L
T
T
G
L
P
G
I
Q
P
Site 93
T873
A
P
G
S
A
V
R
T
L
D
M
C
S
S
H
Site 94
T891
V
I
C
C
S
S
P
T
T
N
P
T
T
G
P
Site 95
T892
I
C
C
S
S
P
T
T
N
P
T
T
G
P
S
Site 96
T895
S
S
P
T
T
N
P
T
T
G
P
S
L
G
P
Site 97
T896
S
P
T
T
N
P
T
T
G
P
S
L
G
P
S
Site 98
S899
T
N
P
T
T
G
P
S
L
G
P
S
F
N
P
Site 99
S903
T
G
P
S
L
G
P
S
F
N
P
G
H
V
L
Site 100
S911
F
N
P
G
H
V
L
S
P
S
P
S
P
S
T
Site 101
S913
P
G
H
V
L
S
P
S
P
S
P
S
T
N
R
Site 102
S915
H
V
L
S
P
S
P
S
P
S
T
N
R
S
G
Site 103
S917
L
S
P
S
P
S
P
S
T
N
R
S
G
P
S
Site 104
T918
S
P
S
P
S
P
S
T
N
R
S
G
P
S
Q
Site 105
S921
P
S
P
S
T
N
R
S
G
P
S
Q
M
A
L
Site 106
S924
S
T
N
R
S
G
P
S
Q
M
A
L
L
P
V
Site 107
S938
V
T
N
I
R
A
K
S
W
G
L
S
V
N
G
Site 108
S942
R
A
K
S
W
G
L
S
V
N
G
I
G
H
S
Site 109
S949
S
V
N
G
I
G
H
S
K
H
H
K
S
L
E
Site 110
S954
G
H
S
K
H
H
K
S
L
E
P
L
A
S
P
Site 111
S975
G
Q
G
K
A
K
N
S
P
S
L
G
F
H
G
Site 112
S977
G
K
A
K
N
S
P
S
L
G
F
H
G
R
A
Site 113
S991
A
R
R
G
A
L
Q
S
S
V
G
P
A
E
P
Site 114
S992
R
R
G
A
L
Q
S
S
V
G
P
A
E
P
T
Site 115
S1007
W
A
Q
G
Q
S
A
S
L
L
A
E
P
V
P
Site 116
S1025
S
I
Q
V
L
E
N
S
M
S
I
T
S
Q
Y
Site 117
S1027
Q
V
L
E
N
S
M
S
I
T
S
Q
Y
C
A
Site 118
T1029
L
E
N
S
M
S
I
T
S
Q
Y
C
A
P
G
Site 119
S1030
E
N
S
M
S
I
T
S
Q
Y
C
A
P
G
D
Site 120
Y1032
S
M
S
I
T
S
Q
Y
C
A
P
G
D
A
C
Site 121
T1045
A
C
R
P
G
N
F
T
Y
H
I
P
V
S
S
Site 122
Y1046
C
R
P
G
N
F
T
Y
H
I
P
V
S
S
G
Site 123
S1052
T
Y
H
I
P
V
S
S
G
T
P
L
H
L
S
Site 124
S1059
S
G
T
P
L
H
L
S
L
T
L
Q
M
N
S
Site 125
T1061
T
P
L
H
L
S
L
T
L
Q
M
N
S
S
S
Site 126
S1076
P
V
S
V
V
L
C
S
L
R
S
K
E
E
P
Site 127
S1079
V
V
L
C
S
L
R
S
K
E
E
P
C
E
E
Site 128
S1088
E
E
P
C
E
E
G
S
L
P
Q
S
L
H
T
Site 129
S1092
E
E
G
S
L
P
Q
S
L
H
T
H
Q
D
T
Site 130
T1099
S
L
H
T
H
Q
D
T
Q
G
T
S
H
R
W
Site 131
T1102
T
H
Q
D
T
Q
G
T
S
H
R
W
P
I
T
Site 132
S1103
H
Q
D
T
Q
G
T
S
H
R
W
P
I
T
I
Site 133
T1109
T
S
H
R
W
P
I
T
I
L
S
F
R
E
F
Site 134
Y1118
L
S
F
R
E
F
T
Y
H
F
R
V
A
L
L
Site 135
Y1142
L
A
Q
P
A
T
D
Y
H
F
H
F
Y
R
L
Site 136
Y1147
T
D
Y
H
F
H
F
Y
R
L
C
D
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation