KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
NckAP1
Full Name:
Nck-associated protein 1
Alias:
HEM2; Membrane-associated protein HEM-2; NAP 1; NAP1; NAP125; NCKP1; P125Nap1
Type:
Apoptosis
Mass (Da):
128790
Number AA:
1128
UniProt ID:
Q9Y2A7
International Prot ID:
IPI00031982
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0042995
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0007417
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
S
R
S
V
L
Q
P
S
Q
Q
Site 2
S9
S
R
S
V
L
Q
P
S
Q
Q
K
L
A
E
K
Site 3
T18
Q
K
L
A
E
K
L
T
I
L
N
D
R
G
V
Site 4
T29
D
R
G
V
G
M
L
T
R
L
Y
N
I
K
K
Site 5
Y32
V
G
M
L
T
R
L
Y
N
I
K
K
A
C
G
Site 6
Y47
D
P
K
A
K
P
S
Y
L
I
D
K
N
L
E
Site 7
S84
A
Q
L
Q
K
E
K
S
E
I
L
K
N
L
A
Site 8
T141
L
D
L
I
I
T
Y
T
T
L
M
I
L
L
S
Site 9
T142
D
L
I
I
T
Y
T
T
L
M
I
L
L
S
R
Site 10
S148
T
T
L
M
I
L
L
S
R
I
E
E
R
K
A
Site 11
Y160
R
K
A
I
I
G
L
Y
N
Y
A
H
E
M
T
Site 12
S171
H
E
M
T
H
G
A
S
D
R
E
Y
P
R
L
Site 13
Y175
H
G
A
S
D
R
E
Y
P
R
L
G
Q
M
I
Site 14
Y185
L
G
Q
M
I
V
D
Y
E
N
P
L
K
K
M
Site 15
S200
M
E
E
F
V
P
H
S
K
S
L
S
D
A
L
Site 16
S202
E
F
V
P
H
S
K
S
L
S
D
A
L
I
S
Site 17
S204
V
P
H
S
K
S
L
S
D
A
L
I
S
L
Q
Site 18
S220
V
Y
P
R
R
N
L
S
A
D
Q
W
R
N
A
Site 19
S231
W
R
N
A
Q
L
L
S
L
I
S
A
P
S
T
Site 20
T238
S
L
I
S
A
P
S
T
M
L
N
P
A
Q
S
Site 21
T247
L
N
P
A
Q
S
D
T
M
P
C
E
Y
L
S
Site 22
Y252
S
D
T
M
P
C
E
Y
L
S
L
D
A
M
E
Site 23
S291
K
L
A
L
Q
S
S
S
C
L
S
L
F
R
D
Site 24
Y317
L
F
V
N
I
R
G
Y
N
K
R
I
N
D
I
Site 25
S333
E
C
K
E
A
A
V
S
H
A
G
S
M
H
R
Site 26
S337
A
A
V
S
H
A
G
S
M
H
R
E
R
R
K
Site 27
S348
E
R
R
K
F
L
R
S
A
L
K
E
L
A
T
Site 28
T355
S
A
L
K
E
L
A
T
V
L
S
D
Q
P
G
Site 29
S396
A
D
N
M
P
K
K
S
A
D
D
F
I
D
K
Site 30
Y422
L
R
A
H
V
R
K
Y
G
P
V
M
Q
R
Y
Site 31
Y429
Y
G
P
V
M
Q
R
Y
Y
V
Q
Y
L
S
G
Site 32
Y430
G
P
V
M
Q
R
Y
Y
V
Q
Y
L
S
G
F
Site 33
Y433
M
Q
R
Y
Y
V
Q
Y
L
S
G
F
D
A
V
Site 34
S450
N
E
L
V
Q
N
L
S
V
C
P
E
D
E
S
Site 35
S461
E
D
E
S
I
I
M
S
S
F
V
N
T
M
T
Site 36
S469
S
F
V
N
T
M
T
S
L
S
V
K
Q
V
E
Site 37
S471
V
N
T
M
T
S
L
S
V
K
Q
V
E
D
G
Site 38
Y496
D
W
F
R
L
Q
A
Y
T
S
V
S
K
A
S
Site 39
T497
W
F
R
L
Q
A
Y
T
S
V
S
K
A
S
L
Site 40
S498
F
R
L
Q
A
Y
T
S
V
S
K
A
S
L
G
Site 41
S561
Q
Q
C
L
E
L
P
S
Q
S
R
Y
S
I
A
Site 42
Y565
E
L
P
S
Q
S
R
Y
S
I
A
F
P
L
L
Site 43
T619
N
L
I
T
D
I
C
T
E
Q
C
T
L
S
D
Site 44
T623
D
I
C
T
E
Q
C
T
L
S
D
Q
L
L
P
Site 45
S625
C
T
E
Q
C
T
L
S
D
Q
L
L
P
K
H
Site 46
S638
K
H
C
A
K
T
I
S
Q
A
V
N
K
K
S
Site 47
S645
S
Q
A
V
N
K
K
S
K
K
Q
T
G
K
K
Site 48
S664
R
E
K
P
G
V
E
S
M
R
K
N
R
L
V
Site 49
Y691
E
L
C
F
S
I
N
Y
V
P
N
M
V
V
W
Site 50
T703
V
V
W
E
H
T
F
T
P
R
E
Y
L
T
S
Site 51
Y707
H
T
F
T
P
R
E
Y
L
T
S
H
L
E
I
Site 52
S710
T
P
R
E
Y
L
T
S
H
L
E
I
R
F
T
Site 53
Y726
S
I
V
G
M
T
M
Y
N
Q
A
T
Q
E
I
Site 54
T741
A
K
P
S
E
L
L
T
S
V
R
A
Y
M
T
Site 55
S742
K
P
S
E
L
L
T
S
V
R
A
Y
M
T
V
Site 56
T748
T
S
V
R
A
Y
M
T
V
L
Q
S
I
E
N
Site 57
Y756
V
L
Q
S
I
E
N
Y
V
Q
I
D
I
T
R
Site 58
S778
Q
Q
T
Q
H
L
D
S
H
G
E
P
T
I
T
Site 59
T785
S
H
G
E
P
T
I
T
S
L
Y
T
N
W
Y
Site 60
Y788
E
P
T
I
T
S
L
Y
T
N
W
Y
L
E
T
Site 61
Y792
T
S
L
Y
T
N
W
Y
L
E
T
L
L
R
Q
Site 62
S801
E
T
L
L
R
Q
V
S
N
G
H
I
A
Y
F
Site 63
T824
L
P
T
E
N
E
L
T
F
N
A
E
E
Y
S
Site 64
Y830
L
T
F
N
A
E
E
Y
S
D
I
S
E
M
R
Site 65
S831
T
F
N
A
E
E
Y
S
D
I
S
E
M
R
S
Site 66
S834
A
E
E
Y
S
D
I
S
E
M
R
S
L
S
E
Site 67
S838
S
D
I
S
E
M
R
S
L
S
E
L
L
G
P
Site 68
S840
I
S
E
M
R
S
L
S
E
L
L
G
P
Y
G
Site 69
S852
P
Y
G
M
K
F
L
S
E
S
L
M
W
H
I
Site 70
S854
G
M
K
F
L
S
E
S
L
M
W
H
I
S
S
Site 71
S860
E
S
L
M
W
H
I
S
S
Q
V
A
E
L
K
Site 72
S861
S
L
M
W
H
I
S
S
Q
V
A
E
L
K
K
Site 73
T878
V
E
N
V
D
V
L
T
Q
M
R
T
S
F
D
Site 74
S883
V
L
T
Q
M
R
T
S
F
D
K
P
D
Q
M
Site 75
S899
A
L
F
K
R
L
S
S
V
D
S
V
L
K
R
Site 76
S902
K
R
L
S
S
V
D
S
V
L
K
R
M
T
I
Site 77
T908
D
S
V
L
K
R
M
T
I
I
G
V
I
L
S
Site 78
S938
H
I
P
F
L
V
S
S
I
E
D
F
K
D
H
Site 79
T950
K
D
H
I
P
R
E
T
D
M
K
V
A
M
N
Site 80
Y959
M
K
V
A
M
N
V
Y
E
L
S
S
A
A
G
Site 81
S984
V
A
L
S
S
Q
K
S
E
N
I
S
P
E
E
Site 82
S988
S
Q
K
S
E
N
I
S
P
E
E
E
Y
K
I
Site 83
S1016
T
L
A
S
N
V
M
S
Q
Y
S
P
A
I
E
Site 84
S1019
S
N
V
M
S
Q
Y
S
P
A
I
E
G
H
C
Site 85
T1045
Q
I
A
A
A
L
F
T
I
H
K
G
S
I
E
Site 86
S1050
L
F
T
I
H
K
G
S
I
E
D
R
L
K
E
Site 87
S1065
F
L
A
L
A
S
S
S
L
L
K
I
G
Q
E
Site 88
T1076
I
G
Q
E
T
D
K
T
T
T
R
N
R
E
S
Site 89
T1077
G
Q
E
T
D
K
T
T
T
R
N
R
E
S
V
Site 90
S1083
T
T
T
R
N
R
E
S
V
Y
L
L
L
D
M
Site 91
Y1116
Y
V
L
L
R
N
A
Y
H
A
V
Y
K
Q
S
Site 92
Y1120
R
N
A
Y
H
A
V
Y
K
Q
S
V
T
S
S
Site 93
S1123
Y
H
A
V
Y
K
Q
S
V
T
S
S
A
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation