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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BTRC
Full Name:
F-box/WD repeat-containing protein 1A
Alias:
Beta-TRCP; E3RSIkappaB; F-box and WD-repeats protein Beta-TrCP; F-box/WD-repeat protein 1A; FBW1A; PIkappaBalpha-E3 receptor subunit
Type:
Ubiquitin conjugating system
Mass (Da):
68867
Number AA:
605
UniProt ID:
Q9Y297
International Prot ID:
IPI00413142
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0044419
GO:0051437
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
R
S
L
W
L
G
C
S
S
L
A
D
S
M
P
Site 2
S36
S
L
A
D
S
M
P
S
L
R
C
L
Y
N
P
Site 3
T45
R
C
L
Y
N
P
G
T
G
A
L
T
A
F
Q
Site 4
S54
A
L
T
A
F
Q
N
S
S
E
R
E
D
C
N
Site 5
S55
L
T
A
F
Q
N
S
S
E
R
E
D
C
N
N
Site 6
S75
K
I
I
P
E
K
N
S
L
R
Q
T
Y
N
S
Site 7
T79
E
K
N
S
L
R
Q
T
Y
N
S
C
A
R
L
Site 8
Y80
K
N
S
L
R
Q
T
Y
N
S
C
A
R
L
C
Site 9
S82
S
L
R
Q
T
Y
N
S
C
A
R
L
C
L
N
Site 10
S116
T
K
L
A
N
G
T
S
S
M
I
V
P
K
Q
Site 11
S117
K
L
A
N
G
T
S
S
M
I
V
P
K
Q
R
Site 12
S127
V
P
K
Q
R
K
L
S
A
S
Y
E
K
E
K
Site 13
S129
K
Q
R
K
L
S
A
S
Y
E
K
E
K
E
L
Site 14
Y140
E
K
E
L
C
V
K
Y
F
E
Q
W
S
E
S
Site 15
Y171
Q
H
G
H
I
N
S
Y
L
K
P
M
L
Q
R
Site 16
Y216
E
L
V
C
K
E
W
Y
R
V
T
S
D
G
M
Site 17
S237
E
R
M
V
R
T
D
S
L
W
R
G
L
A
E
Site 18
Y251
E
R
R
G
W
G
Q
Y
L
F
K
N
K
P
P
Site 19
S266
D
G
N
A
P
P
N
S
F
Y
R
A
L
Y
P
Site 20
Y272
N
S
F
Y
R
A
L
Y
P
K
I
I
Q
D
I
Site 21
T281
K
I
I
Q
D
I
E
T
I
E
S
N
W
R
C
Site 22
S300
L
Q
R
I
H
C
R
S
E
T
S
K
G
V
Y
Site 23
T302
R
I
H
C
R
S
E
T
S
K
G
V
Y
C
L
Site 24
Y307
S
E
T
S
K
G
V
Y
C
L
Q
Y
D
D
Q
Site 25
Y311
K
G
V
Y
C
L
Q
Y
D
D
Q
K
I
V
S
Site 26
T324
V
S
G
L
R
D
N
T
I
K
I
W
D
K
N
Site 27
T332
I
K
I
W
D
K
N
T
L
E
C
K
R
I
L
Site 28
T364
I
T
G
S
S
D
S
T
V
R
V
W
D
V
N
Site 29
Y438
V
V
D
F
D
D
K
Y
I
V
S
A
S
G
D
Site 30
S443
D
K
Y
I
V
S
A
S
G
D
R
T
I
K
V
Site 31
T447
V
S
A
S
G
D
R
T
I
K
V
W
N
T
S
Site 32
T461
S
T
C
E
F
V
R
T
L
N
G
H
K
R
G
Site 33
Y474
R
G
I
A
C
L
Q
Y
R
D
R
L
V
V
S
Site 34
S481
Y
R
D
R
L
V
V
S
G
S
S
D
N
T
I
Site 35
S483
D
R
L
V
V
S
G
S
S
D
N
T
I
R
L
Site 36
T487
V
S
G
S
S
D
N
T
I
R
L
W
D
I
E
Site 37
S521
F
D
N
K
R
I
V
S
G
A
Y
D
G
K
I
Site 38
Y524
K
R
I
V
S
G
A
Y
D
G
K
I
K
V
W
Site 39
T550
A
G
T
L
C
L
R
T
L
V
E
H
S
G
R
Site 40
S555
L
R
T
L
V
E
H
S
G
R
V
F
R
L
Q
Site 41
S595
A
Q
A
E
P
P
R
S
P
S
R
T
Y
T
Y
Site 42
S597
A
E
P
P
R
S
P
S
R
T
Y
T
Y
I
S
Site 43
T599
P
P
R
S
P
S
R
T
Y
T
Y
I
S
R
_
Site 44
Y600
P
R
S
P
S
R
T
Y
T
Y
I
S
R
_
_
Site 45
T601
R
S
P
S
R
T
Y
T
Y
I
S
R
_
_
_
Site 46
Y602
S
P
S
R
T
Y
T
Y
I
S
R
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation