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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
INVS
Full Name:
Alias:
Inversion of embryo turning homolog;Nephrocystin-2
Type:
Mass (Da):
117826
Number AA:
1065
UniProt ID:
Q9Y283
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S38
Q
R
L
I
V
G
N
S
A
L
K
D
K
E
D
Site 2
T50
K
E
D
Q
F
G
R
T
P
L
M
Y
C
V
L
Site 3
T77
A
G
A
D
V
N
K
T
D
H
S
Q
R
T
A
Site 4
S80
D
V
N
K
T
D
H
S
Q
R
T
A
L
H
L
Site 5
T116
Q
K
D
L
E
E
M
T
P
L
H
L
T
T
R
Site 6
T121
E
M
T
P
L
H
L
T
T
R
H
R
S
P
K
Site 7
T122
M
T
P
L
H
L
T
T
R
H
R
S
P
K
C
Site 8
S126
H
L
T
T
R
H
R
S
P
K
C
L
A
L
L
Site 9
Y158
T
A
L
H
W
S
A
Y
Y
N
N
P
E
H
V
Site 10
Y159
A
L
H
W
S
A
Y
Y
N
N
P
E
H
V
K
Site 11
S173
K
L
L
I
K
H
D
S
N
I
G
I
P
D
V
Site 12
T200
K
D
P
S
A
V
H
T
V
R
C
I
L
D
A
Site 13
S212
L
D
A
A
P
T
E
S
L
L
N
W
Q
D
Y
Site 14
Y219
S
L
L
N
W
Q
D
Y
E
G
R
T
P
L
H
Site 15
T223
W
Q
D
Y
E
G
R
T
P
L
H
F
A
V
A
Site 16
S245
D
V
L
T
S
Y
E
S
C
N
I
T
S
Y
D
Site 17
Y251
E
S
C
N
I
T
S
Y
D
N
L
F
R
T
P
Site 18
T257
S
Y
D
N
L
F
R
T
P
L
H
W
A
A
L
Site 19
S280
L
L
L
E
R
N
K
S
G
T
I
P
S
D
S
Site 20
T282
L
E
R
N
K
S
G
T
I
P
S
D
S
Q
G
Site 21
S285
N
K
S
G
T
I
P
S
D
S
Q
G
A
T
P
Site 22
S287
S
G
T
I
P
S
D
S
Q
G
A
T
P
L
H
Site 23
T291
P
S
D
S
Q
G
A
T
P
L
H
Y
A
A
Q
Site 24
Y295
Q
G
A
T
P
L
H
Y
A
A
Q
S
N
F
A
Site 25
T304
A
Q
S
N
F
A
E
T
V
K
V
F
L
K
H
Site 26
S313
K
V
F
L
K
H
P
S
V
K
D
D
S
D
L
Site 27
S318
H
P
S
V
K
D
D
S
D
L
E
G
R
T
S
Site 28
S325
S
D
L
E
G
R
T
S
F
M
W
A
A
G
K
Site 29
S346
R
T
M
L
S
L
K
S
D
I
D
I
N
M
A
Site 30
Y356
D
I
N
M
A
D
K
Y
G
G
T
A
L
H
A
Site 31
T392
A
T
D
V
M
K
H
T
P
L
F
R
A
C
E
Site 32
Y454
I
N
P
N
V
Q
D
Y
A
G
R
T
P
L
Q
Site 33
T458
V
Q
D
Y
A
G
R
T
P
L
Q
C
A
A
Y
Site 34
T526
E
N
N
E
E
R
Y
T
P
L
D
Y
A
L
L
Site 35
Y530
E
R
Y
T
P
L
D
Y
A
L
L
G
E
R
H
Site 36
S614
E
Q
Q
K
G
R
R
S
P
D
S
C
R
P
Q
Site 37
S617
K
G
R
R
S
P
D
S
C
R
P
Q
A
L
P
Site 38
S628
Q
A
L
P
C
L
P
S
T
Q
D
V
P
S
R
Site 39
T629
A
L
P
C
L
P
S
T
Q
D
V
P
S
R
Q
Site 40
S634
P
S
T
Q
D
V
P
S
R
Q
S
R
A
P
S
Site 41
S637
Q
D
V
P
S
R
Q
S
R
A
P
S
K
Q
P
Site 42
S641
S
R
Q
S
R
A
P
S
K
Q
P
P
A
G
N
Site 43
S658
Q
G
P
E
P
R
D
S
R
G
S
P
G
G
S
Site 44
S661
E
P
R
D
S
R
G
S
P
G
G
S
L
G
G
Site 45
S665
S
R
G
S
P
G
G
S
L
G
G
A
L
Q
K
Site 46
S678
Q
K
E
Q
H
V
S
S
D
L
Q
G
T
N
S
Site 47
T683
V
S
S
D
L
Q
G
T
N
S
R
R
P
N
E
Site 48
S685
S
D
L
Q
G
T
N
S
R
R
P
N
E
T
A
Site 49
T691
N
S
R
R
P
N
E
T
A
R
E
H
S
K
G
Site 50
S696
N
E
T
A
R
E
H
S
K
G
Q
S
A
C
V
Site 51
S700
R
E
H
S
K
G
Q
S
A
C
V
H
F
R
P
Site 52
S711
H
F
R
P
N
E
G
S
D
G
S
R
H
P
G
Site 53
S714
P
N
E
G
S
D
G
S
R
H
P
G
V
P
S
Site 54
S721
S
R
H
P
G
V
P
S
V
E
K
S
R
G
E
Site 55
S725
G
V
P
S
V
E
K
S
R
G
E
T
A
G
D
Site 56
T729
V
E
K
S
R
G
E
T
A
G
D
E
R
C
A
Site 57
S746
K
G
F
V
K
Q
P
S
C
I
R
V
A
G
P
Site 58
S760
P
D
E
K
G
E
D
S
R
R
A
A
A
S
L
Site 59
S766
D
S
R
R
A
A
A
S
L
P
P
H
D
S
H
Site 60
S772
A
S
L
P
P
H
D
S
H
W
K
P
S
R
R
Site 61
S777
H
D
S
H
W
K
P
S
R
R
H
D
T
E
P
Site 62
T782
K
P
S
R
R
H
D
T
E
P
K
A
K
C
A
Site 63
T795
C
A
P
Q
K
R
R
T
Q
E
L
R
G
G
R
Site 64
S804
E
L
R
G
G
R
C
S
P
A
G
S
S
R
P
Site 65
S808
G
R
C
S
P
A
G
S
S
R
P
G
S
A
R
Site 66
S809
R
C
S
P
A
G
S
S
R
P
G
S
A
R
G
Site 67
S813
A
G
S
S
R
P
G
S
A
R
G
E
A
V
H
Site 68
T830
Q
N
P
P
H
H
R
T
P
R
N
K
V
T
Q
Site 69
Y845
A
K
L
T
G
G
L
Y
S
H
L
P
Q
S
T
Site 70
S846
K
L
T
G
G
L
Y
S
H
L
P
Q
S
T
E
Site 71
S851
L
Y
S
H
L
P
Q
S
T
E
E
L
R
S
G
Site 72
S857
Q
S
T
E
E
L
R
S
G
A
R
R
L
E
T
Site 73
T864
S
G
A
R
R
L
E
T
S
T
L
S
E
D
F
Site 74
S865
G
A
R
R
L
E
T
S
T
L
S
E
D
F
Q
Site 75
T866
A
R
R
L
E
T
S
T
L
S
E
D
F
Q
V
Site 76
S868
R
L
E
T
S
T
L
S
E
D
F
Q
V
S
K
Site 77
S885
D
P
A
P
G
P
L
S
G
Q
S
V
N
I
D
Site 78
Y930
I
Q
R
A
W
R
S
Y
Q
L
R
K
H
L
S
Site 79
S957
V
D
R
W
R
Q
E
S
T
A
L
L
L
Q
V
Site 80
T976
L
E
L
K
F
P
Q
T
T
A
V
S
K
A
P
Site 81
S980
F
P
Q
T
T
A
V
S
K
A
P
K
S
P
S
Site 82
S985
A
V
S
K
A
P
K
S
P
S
K
G
T
S
G
Site 83
S987
S
K
A
P
K
S
P
S
K
G
T
S
G
T
K
Site 84
S991
K
S
P
S
K
G
T
S
G
T
K
S
T
K
H
Site 85
T993
P
S
K
G
T
S
G
T
K
S
T
K
H
S
V
Site 86
S995
K
G
T
S
G
T
K
S
T
K
H
S
V
L
K
Site 87
S999
G
T
K
S
T
K
H
S
V
L
K
Q
I
Y
G
Site 88
Y1005
H
S
V
L
K
Q
I
Y
G
C
S
H
E
G
K
Site 89
T1017
E
G
K
I
H
H
P
T
R
S
V
K
A
S
S
Site 90
S1019
K
I
H
H
P
T
R
S
V
K
A
S
S
V
L
Site 91
S1023
P
T
R
S
V
K
A
S
S
V
L
R
L
N
S
Site 92
S1024
T
R
S
V
K
A
S
S
V
L
R
L
N
S
V
Site 93
S1043
C
I
H
L
L
E
N
S
G
R
S
K
N
F
S
Site 94
S1050
S
G
R
S
K
N
F
S
Y
N
L
Q
S
A
T
Site 95
Y1051
G
R
S
K
N
F
S
Y
N
L
Q
S
A
T
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation