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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
eIF3S6IP
Full Name:
Eukaryotic translation initiation factor 3 subunit L
Alias:
EIF3EIP; EIF3S11; EIF3S6IP; Eukaryotic translation initiation factor 3 subunit 6 interacting protein; eukaryotic translation initiation factor 3, subunit L; HSPC021; HSPC021/HSPC025; HSPC025; IF3EI; IF3I
Type:
Translation
Mass (Da):
66727
Number AA:
564
UniProt ID:
Q9Y262
International Prot ID:
IPI00745266
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005852
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003743
PhosphoSite+
KinaseNET
Biological Process:
GO:0006413
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
S
Y
P
A
D
D
Y
E
S
E
A
A
Y
D
Site 2
S10
Y
P
A
D
D
Y
E
S
E
A
A
Y
D
P
Y
Site 3
Y14
D
Y
E
S
E
A
A
Y
D
P
Y
A
Y
P
S
Site 4
Y17
S
E
A
A
Y
D
P
Y
A
Y
P
S
D
Y
D
Site 5
Y19
A
A
Y
D
P
Y
A
Y
P
S
D
Y
D
M
H
Site 6
S21
Y
D
P
Y
A
Y
P
S
D
Y
D
M
H
T
G
Site 7
Y23
P
Y
A
Y
P
S
D
Y
D
M
H
T
G
D
P
Site 8
T27
P
S
D
Y
D
M
H
T
G
D
P
K
Q
D
L
Site 9
Y36
D
P
K
Q
D
L
A
Y
E
R
Q
Y
E
Q
Q
Site 10
Y40
D
L
A
Y
E
R
Q
Y
E
Q
Q
T
Y
Q
V
Site 11
T44
E
R
Q
Y
E
Q
Q
T
Y
Q
V
I
P
E
V
Site 12
Y45
R
Q
Y
E
Q
Q
T
Y
Q
V
I
P
E
V
I
Site 13
Y58
V
I
K
N
F
I
Q
Y
F
H
K
T
V
S
D
Site 14
Y72
D
L
I
D
Q
K
V
Y
E
L
Q
A
S
R
V
Site 15
S77
K
V
Y
E
L
Q
A
S
R
V
S
S
D
V
I
Site 16
S80
E
L
Q
A
S
R
V
S
S
D
V
I
D
Q
K
Site 17
S81
L
Q
A
S
R
V
S
S
D
V
I
D
Q
K
V
Site 18
Y89
D
V
I
D
Q
K
V
Y
E
I
Q
D
I
Y
E
Site 19
Y95
V
Y
E
I
Q
D
I
Y
E
N
S
W
T
K
L
Site 20
T103
E
N
S
W
T
K
L
T
E
R
F
F
K
N
T
Site 21
T110
T
E
R
F
F
K
N
T
P
W
P
E
A
E
A
Site 22
Y136
L
I
L
Y
K
E
L
Y
Y
R
H
I
Y
A
K
Site 23
Y141
E
L
Y
Y
R
H
I
Y
A
K
V
S
G
G
P
Site 24
S145
R
H
I
Y
A
K
V
S
G
G
P
S
L
E
Q
Site 25
S149
A
K
V
S
G
G
P
S
L
E
Q
R
F
E
S
Site 26
Y158
E
Q
R
F
E
S
Y
Y
N
Y
C
N
L
F
N
Site 27
Y160
R
F
E
S
Y
Y
N
Y
C
N
L
F
N
Y
I
Site 28
Y166
N
Y
C
N
L
F
N
Y
I
L
N
A
D
G
P
Site 29
Y192
D
I
I
D
E
F
I
Y
Q
F
Q
S
F
S
Q
Site 30
Y200
Q
F
Q
S
F
S
Q
Y
R
C
K
T
A
K
K
Site 31
T204
F
S
Q
Y
R
C
K
T
A
K
K
S
E
E
E
Site 32
S208
R
C
K
T
A
K
K
S
E
E
E
I
D
F
L
Site 33
S238
L
H
S
L
V
D
K
S
N
I
N
R
Q
L
E
Site 34
Y247
I
N
R
Q
L
E
V
Y
T
S
G
G
D
P
E
Site 35
S249
R
Q
L
E
V
Y
T
S
G
G
D
P
E
S
V
Site 36
S255
T
S
G
G
D
P
E
S
V
A
G
E
Y
G
R
Site 37
Y260
P
E
S
V
A
G
E
Y
G
R
H
S
L
Y
K
Site 38
S264
A
G
E
Y
G
R
H
S
L
Y
K
M
L
G
Y
Site 39
Y266
E
Y
G
R
H
S
L
Y
K
M
L
G
Y
F
S
Site 40
Y287
L
H
S
L
L
G
D
Y
Y
Q
A
I
K
V
L
Site 41
Y288
H
S
L
L
G
D
Y
Y
Q
A
I
K
V
L
E
Site 42
Y305
E
L
N
K
K
S
M
Y
S
R
V
P
E
C
Q
Site 43
Y316
P
E
C
Q
V
T
T
Y
Y
Y
V
G
F
A
Y
Site 44
Y318
C
Q
V
T
T
Y
Y
Y
V
G
F
A
Y
L
M
Site 45
Y323
Y
Y
Y
V
G
F
A
Y
L
M
M
R
R
Y
Q
Site 46
Y329
A
Y
L
M
M
R
R
Y
Q
D
A
I
R
V
F
Site 47
Y342
V
F
A
N
I
L
L
Y
I
Q
R
T
K
S
M
Site 48
Y355
S
M
F
Q
R
T
T
Y
K
Y
E
M
I
N
K
Site 49
Y357
F
Q
R
T
T
Y
K
Y
E
M
I
N
K
Q
N
Site 50
Y394
H
L
Q
L
R
E
K
Y
G
D
K
M
L
R
M
Site 51
Y409
Q
K
G
D
P
Q
V
Y
E
E
L
F
S
Y
S
Site 52
S414
Q
V
Y
E
E
L
F
S
Y
S
C
P
K
F
L
Site 53
Y415
V
Y
E
E
L
F
S
Y
S
C
P
K
F
L
S
Site 54
S416
Y
E
E
L
F
S
Y
S
C
P
K
F
L
S
P
Site 55
S422
Y
S
C
P
K
F
L
S
P
V
V
P
N
Y
D
Site 56
Y428
L
S
P
V
V
P
N
Y
D
N
V
H
P
N
Y
Site 57
Y435
Y
D
N
V
H
P
N
Y
H
K
E
P
F
L
Q
Site 58
S448
L
Q
Q
L
K
V
F
S
D
E
V
Q
Q
Q
A
Site 59
S458
V
Q
Q
Q
A
Q
L
S
T
I
R
S
F
L
K
Site 60
T459
Q
Q
Q
A
Q
L
S
T
I
R
S
F
L
K
L
Site 61
T482
L
A
G
F
L
D
L
T
E
Q
E
F
R
I
Q
Site 62
S515
A
L
D
G
E
F
Q
S
A
S
E
V
D
F
Y
Site 63
S517
D
G
E
F
Q
S
A
S
E
V
D
F
Y
I
D
Site 64
Y522
S
A
S
E
V
D
F
Y
I
D
K
D
M
I
H
Site 65
T533
D
M
I
H
I
A
D
T
K
V
A
R
R
Y
G
Site 66
Y539
D
T
K
V
A
R
R
Y
G
D
F
F
I
R
Q
Site 67
T556
K
F
E
E
L
N
R
T
L
K
K
M
G
Q
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation