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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLH
Full Name:
DNA polymerase eta
Alias:
Polymerase (DNA directed) eta; RAD30; RAD30A; Xeroderma pigmentosum variant type protein; XP-V
Type:
Transferase; DNA repair; EC 2.7.7.7
Mass (Da):
78413
Number AA:
713
UniProt ID:
Q9Y253
International Prot ID:
IPI00008011
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003887
GO:0003684
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0000731
GO:0006282
GO:0010225
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y39
K
P
C
A
V
V
Q
Y
K
S
W
K
G
G
G
Site 2
T60
E
A
R
A
F
G
V
T
R
S
M
W
A
D
D
Site 3
S62
R
A
F
G
V
T
R
S
M
W
A
D
D
A
K
Site 4
S83
L
L
A
Q
V
R
E
S
R
G
K
A
N
L
T
Site 5
T90
S
R
G
K
A
N
L
T
K
Y
R
E
A
S
V
Site 6
Y92
G
K
A
N
L
T
K
Y
R
E
A
S
V
E
V
Site 7
S96
L
T
K
Y
R
E
A
S
V
E
V
M
E
I
M
Site 8
T122
D
E
A
Y
V
D
L
T
S
A
V
Q
E
R
L
Site 9
S138
K
L
Q
G
Q
P
I
S
A
D
L
L
P
S
T
Site 10
T145
S
A
D
L
L
P
S
T
Y
I
E
G
L
P
Q
Site 11
Y146
A
D
L
L
P
S
T
Y
I
E
G
L
P
Q
G
Site 12
T160
G
P
T
T
A
E
E
T
V
Q
K
E
G
M
R
Site 13
T184
S
L
Q
I
D
N
L
T
S
P
D
L
Q
L
T
Site 14
T208
R
A
A
I
E
R
E
T
G
F
Q
C
S
A
G
Site 15
S213
R
E
T
G
F
Q
C
S
A
G
I
S
H
N
K
Site 16
S217
F
Q
C
S
A
G
I
S
H
N
K
V
L
A
K
Site 17
T236
L
N
K
P
N
R
Q
T
L
V
S
H
G
S
V
Site 18
S239
P
N
R
Q
T
L
V
S
H
G
S
V
P
Q
L
Site 19
S242
Q
T
L
V
S
H
G
S
V
P
Q
L
F
S
Q
Site 20
S248
G
S
V
P
Q
L
F
S
Q
M
P
I
R
K
I
Site 21
S257
M
P
I
R
K
I
R
S
L
G
G
K
L
G
A
Site 22
S284
E
L
T
Q
F
T
E
S
Q
L
Q
S
H
F
G
Site 23
S288
F
T
E
S
Q
L
Q
S
H
F
G
E
K
N
G
Site 24
Y299
E
K
N
G
S
W
L
Y
A
M
C
R
G
I
E
Site 25
T318
K
P
R
Q
L
P
K
T
I
G
C
S
K
N
F
Site 26
T353
Q
E
L
E
E
R
L
T
K
D
R
N
D
N
D
Site 27
T364
N
D
N
D
R
V
A
T
Q
L
V
V
S
I
R
Site 28
S369
V
A
T
Q
L
V
V
S
I
R
V
Q
G
D
K
Site 29
S379
V
Q
G
D
K
R
L
S
S
L
R
R
C
C
A
Site 30
S380
Q
G
D
K
R
L
S
S
L
R
R
C
C
A
L
Site 31
T413
C
N
T
S
G
I
Q
T
E
W
S
P
P
L
T
Site 32
S432
C
A
T
K
F
S
A
S
A
P
S
S
S
T
D
Site 33
S436
F
S
A
S
A
P
S
S
S
T
D
I
T
S
F
Site 34
S437
S
A
S
A
P
S
S
S
T
D
I
T
S
F
L
Site 35
T438
A
S
A
P
S
S
S
T
D
I
T
S
F
L
S
Site 36
T441
P
S
S
S
T
D
I
T
S
F
L
S
S
D
P
Site 37
S442
S
S
S
T
D
I
T
S
F
L
S
S
D
P
S
Site 38
S445
T
D
I
T
S
F
L
S
S
D
P
S
S
L
P
Site 39
S446
D
I
T
S
F
L
S
S
D
P
S
S
L
P
K
Site 40
S449
S
F
L
S
S
D
P
S
S
L
P
K
V
P
V
Site 41
S450
F
L
S
S
D
P
S
S
L
P
K
V
P
V
T
Site 42
S459
P
K
V
P
V
T
S
S
E
A
K
T
Q
G
S
Site 43
T463
V
T
S
S
E
A
K
T
Q
G
S
G
P
A
V
Site 44
S466
S
E
A
K
T
Q
G
S
G
P
A
V
T
A
T
Site 45
T473
S
G
P
A
V
T
A
T
K
K
A
T
T
S
L
Site 46
S479
A
T
K
K
A
T
T
S
L
E
S
F
F
Q
K
Site 47
S482
K
A
T
T
S
L
E
S
F
F
Q
K
A
A
E
Site 48
S497
R
Q
K
V
K
E
A
S
L
S
S
L
T
A
P
Site 49
S499
K
V
K
E
A
S
L
S
S
L
T
A
P
T
Q
Site 50
T505
L
S
S
L
T
A
P
T
Q
A
P
M
S
N
S
Site 51
S510
A
P
T
Q
A
P
M
S
N
S
P
S
K
P
S
Site 52
S512
T
Q
A
P
M
S
N
S
P
S
K
P
S
L
P
Site 53
S514
A
P
M
S
N
S
P
S
K
P
S
L
P
F
Q
Site 54
S517
S
N
S
P
S
K
P
S
L
P
F
Q
T
S
Q
Site 55
S523
P
S
L
P
F
Q
T
S
Q
S
T
G
T
E
P
Site 56
S536
E
P
F
F
K
Q
K
S
L
L
L
K
Q
K
Q
Site 57
S547
K
Q
K
Q
L
N
N
S
S
V
S
S
P
Q
Q
Site 58
S548
Q
K
Q
L
N
N
S
S
V
S
S
P
Q
Q
N
Site 59
S551
L
N
N
S
S
V
S
S
P
Q
Q
N
P
W
S
Site 60
S566
N
C
K
A
L
P
N
S
L
P
T
E
Y
P
G
Site 61
T569
A
L
P
N
S
L
P
T
E
Y
P
G
C
V
P
Site 62
Y571
P
N
S
L
P
T
E
Y
P
G
C
V
P
V
C
Site 63
S582
V
P
V
C
E
G
V
S
K
L
E
E
S
S
K
Site 64
S587
G
V
S
K
L
E
E
S
S
K
A
T
P
A
E
Site 65
T591
L
E
E
S
S
K
A
T
P
A
E
M
D
L
A
Site 66
S601
E
M
D
L
A
H
N
S
Q
S
M
H
A
S
S
Site 67
S603
D
L
A
H
N
S
Q
S
M
H
A
S
S
A
S
Site 68
S607
N
S
Q
S
M
H
A
S
S
A
S
K
S
V
L
Site 69
S608
S
Q
S
M
H
A
S
S
A
S
K
S
V
L
E
Site 70
S610
S
M
H
A
S
S
A
S
K
S
V
L
E
V
T
Site 71
S612
H
A
S
S
A
S
K
S
V
L
E
V
T
Q
K
Site 72
T617
S
K
S
V
L
E
V
T
Q
K
A
T
P
N
P
Site 73
T621
L
E
V
T
Q
K
A
T
P
N
P
S
L
L
A
Site 74
Y653
D
M
P
E
H
M
D
Y
H
F
A
L
E
L
Q
Site 75
S662
F
A
L
E
L
Q
K
S
F
L
Q
P
H
S
S
Site 76
S668
K
S
F
L
Q
P
H
S
S
N
P
Q
V
V
S
Site 77
S669
S
F
L
Q
P
H
S
S
N
P
Q
V
V
S
A
Site 78
S675
S
S
N
P
Q
V
V
S
A
V
S
H
Q
G
K
Site 79
S678
P
Q
V
V
S
A
V
S
H
Q
G
K
R
N
P
Site 80
S687
Q
G
K
R
N
P
K
S
P
L
A
C
T
N
K
Site 81
T703
P
R
P
E
G
M
Q
T
L
E
S
F
F
K
P
Site 82
S706
E
G
M
Q
T
L
E
S
F
F
K
P
L
T
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation