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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNF6
Full Name:
Alias:
Type:
Mass (Da):
78091
Number AA:
685
UniProt ID:
Q9Y252
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
N
Q
S
R
S
R
S
D
G
G
S
E
Site 2
S8
M
N
Q
S
R
S
R
S
D
G
G
S
E
E
T
Site 3
S12
R
S
R
S
D
G
G
S
E
E
T
L
P
Q
D
Site 4
Y41
L
H
R
E
E
A
Y
Y
Q
F
I
N
E
L
N
Site 5
Y52
N
E
L
N
D
E
D
Y
R
L
M
R
D
H
N
Site 6
T63
R
D
H
N
L
L
G
T
P
G
E
I
T
S
E
Site 7
S69
G
T
P
G
E
I
T
S
E
E
L
Q
Q
R
L
Site 8
S85
G
V
K
E
Q
L
A
S
Q
P
D
L
R
D
G
Site 9
T93
Q
P
D
L
R
D
G
T
N
Y
R
D
S
E
V
Site 10
Y95
D
L
R
D
G
T
N
Y
R
D
S
E
V
P
R
Site 11
S98
D
G
T
N
Y
R
D
S
E
V
P
R
E
S
S
Site 12
S104
D
S
E
V
P
R
E
S
S
H
E
D
S
L
L
Site 13
S105
S
E
V
P
R
E
S
S
H
E
D
S
L
L
E
Site 14
S109
R
E
S
S
H
E
D
S
L
L
E
W
L
N
T
Site 15
T116
S
L
L
E
W
L
N
T
F
R
R
T
G
N
A
Site 16
T120
W
L
N
T
F
R
R
T
G
N
A
T
R
S
G
Site 17
T124
F
R
R
T
G
N
A
T
R
S
G
Q
N
G
N
Site 18
T133
S
G
Q
N
G
N
Q
T
W
R
A
V
S
R
T
Site 19
S138
N
Q
T
W
R
A
V
S
R
T
N
P
N
N
G
Site 20
T140
T
W
R
A
V
S
R
T
N
P
N
N
G
E
F
Site 21
Y169
F
E
I
H
G
E
D
Y
T
D
I
P
L
S
D
Site 22
T170
E
I
H
G
E
D
Y
T
D
I
P
L
S
D
S
Site 23
S175
D
Y
T
D
I
P
L
S
D
S
N
R
D
H
T
Site 24
S177
T
D
I
P
L
S
D
S
N
R
D
H
T
A
N
Site 25
T182
S
D
S
N
R
D
H
T
A
N
R
Q
Q
R
S
Site 26
T190
A
N
R
Q
Q
R
S
T
S
P
V
A
R
R
T
Site 27
S191
N
R
Q
Q
R
S
T
S
P
V
A
R
R
T
R
Site 28
T197
T
S
P
V
A
R
R
T
R
S
Q
T
S
V
N
Site 29
S199
P
V
A
R
R
T
R
S
Q
T
S
V
N
F
N
Site 30
T201
A
R
R
T
R
S
Q
T
S
V
N
F
N
G
S
Site 31
S202
R
R
T
R
S
Q
T
S
V
N
F
N
G
S
S
Site 32
S208
T
S
V
N
F
N
G
S
S
S
N
I
P
R
T
Site 33
S210
V
N
F
N
G
S
S
S
N
I
P
R
T
R
L
Site 34
T215
S
S
S
N
I
P
R
T
R
L
A
S
R
G
Q
Site 35
S219
I
P
R
T
R
L
A
S
R
G
Q
N
P
A
E
Site 36
S228
G
Q
N
P
A
E
G
S
F
S
T
L
G
R
L
Site 37
S230
N
P
A
E
G
S
F
S
T
L
G
R
L
R
N
Site 38
S251
G
I
P
R
A
N
A
S
R
T
N
F
S
S
H
Site 39
T253
P
R
A
N
A
S
R
T
N
F
S
S
H
T
N
Site 40
S257
A
S
R
T
N
F
S
S
H
T
N
Q
S
G
G
Site 41
S262
F
S
S
H
T
N
Q
S
G
G
S
E
L
R
Q
Site 42
T290
N
G
A
R
S
N
V
T
V
R
N
T
N
Q
R
Site 43
T294
S
N
V
T
V
R
N
T
N
Q
R
L
E
P
I
Site 44
S305
L
E
P
I
R
L
R
S
T
S
N
S
R
S
R
Site 45
T306
E
P
I
R
L
R
S
T
S
N
S
R
S
R
S
Site 46
S307
P
I
R
L
R
S
T
S
N
S
R
S
R
S
P
Site 47
S309
R
L
R
S
T
S
N
S
R
S
R
S
P
I
Q
Site 48
S311
R
S
T
S
N
S
R
S
R
S
P
I
Q
R
Q
Site 49
S313
T
S
N
S
R
S
R
S
P
I
Q
R
Q
S
G
Site 50
S319
R
S
P
I
Q
R
Q
S
G
T
V
Y
H
N
S
Site 51
T321
P
I
Q
R
Q
S
G
T
V
Y
H
N
S
Q
R
Site 52
Y323
Q
R
Q
S
G
T
V
Y
H
N
S
Q
R
E
S
Site 53
S326
S
G
T
V
Y
H
N
S
Q
R
E
S
R
P
V
Site 54
S330
Y
H
N
S
Q
R
E
S
R
P
V
Q
Q
T
T
Site 55
T336
E
S
R
P
V
Q
Q
T
T
R
R
S
V
R
R
Site 56
S340
V
Q
Q
T
T
R
R
S
V
R
R
R
G
R
T
Site 57
T347
S
V
R
R
R
G
R
T
R
V
F
L
E
Q
D
Site 58
T362
R
E
R
E
R
R
G
T
A
Y
T
P
F
S
N
Site 59
Y364
R
E
R
R
G
T
A
Y
T
P
F
S
N
S
R
Site 60
T365
E
R
R
G
T
A
Y
T
P
F
S
N
S
R
L
Site 61
S368
G
T
A
Y
T
P
F
S
N
S
R
L
V
S
R
Site 62
S370
A
Y
T
P
F
S
N
S
R
L
V
S
R
I
T
Site 63
S374
F
S
N
S
R
L
V
S
R
I
T
V
E
E
G
Site 64
T377
S
R
L
V
S
R
I
T
V
E
E
G
E
E
S
Site 65
S384
T
V
E
E
G
E
E
S
S
R
S
S
T
A
V
Site 66
S387
E
G
E
E
S
S
R
S
S
T
A
V
R
R
H
Site 67
S388
G
E
E
S
S
R
S
S
T
A
V
R
R
H
P
Site 68
T389
E
E
S
S
R
S
S
T
A
V
R
R
H
P
T
Site 69
T396
T
A
V
R
R
H
P
T
I
T
L
D
L
Q
V
Site 70
T398
V
R
R
H
P
T
I
T
L
D
L
Q
V
R
R
Site 71
S416
G
E
N
R
D
R
D
S
I
A
N
R
T
R
S
Site 72
S423
S
I
A
N
R
T
R
S
R
V
G
L
A
E
N
Site 73
T431
R
V
G
L
A
E
N
T
V
T
I
E
S
N
S
Site 74
T433
G
L
A
E
N
T
V
T
I
E
S
N
S
G
G
Site 75
T444
N
S
G
G
F
R
R
T
I
S
R
L
E
R
S
Site 76
S446
G
G
F
R
R
T
I
S
R
L
E
R
S
G
I
Site 77
S451
T
I
S
R
L
E
R
S
G
I
R
T
Y
V
S
Site 78
Y456
E
R
S
G
I
R
T
Y
V
S
T
I
T
V
P
Site 79
T461
R
T
Y
V
S
T
I
T
V
P
L
R
R
I
S
Site 80
S468
T
V
P
L
R
R
I
S
E
N
E
L
V
E
P
Site 81
S476
E
N
E
L
V
E
P
S
S
V
A
L
R
S
I
Site 82
S495
M
T
G
F
G
E
L
S
S
L
M
E
A
D
S
Site 83
S496
T
G
F
G
E
L
S
S
L
M
E
A
D
S
E
Site 84
S502
S
S
L
M
E
A
D
S
E
S
E
L
Q
R
N
Site 85
S504
L
M
E
A
D
S
E
S
E
L
Q
R
N
G
Q
Site 86
S518
Q
H
L
P
D
M
H
S
E
L
S
N
L
G
T
Site 87
T525
S
E
L
S
N
L
G
T
D
N
N
R
S
Q
H
Site 88
S530
L
G
T
D
N
N
R
S
Q
H
R
E
G
S
S
Site 89
S536
R
S
Q
H
R
E
G
S
S
Q
D
R
Q
A
Q
Site 90
S537
S
Q
H
R
E
G
S
S
Q
D
R
Q
A
Q
G
Site 91
S546
D
R
Q
A
Q
G
D
S
T
E
M
H
G
E
N
Site 92
T547
R
Q
A
Q
G
D
S
T
E
M
H
G
E
N
E
Site 93
T556
M
H
G
E
N
E
T
T
Q
P
H
T
R
N
S
Site 94
S563
T
Q
P
H
T
R
N
S
D
S
R
G
G
R
Q
Site 95
S565
P
H
T
R
N
S
D
S
R
G
G
R
Q
L
R
Site 96
S597
H
F
F
L
L
N
E
S
D
D
D
D
R
I
R
Site 97
T607
D
D
R
I
R
G
L
T
K
E
Q
I
D
N
L
Site 98
Y619
D
N
L
S
T
R
H
Y
E
H
N
S
I
D
S
Site 99
T641
V
C
I
S
D
Y
V
T
G
N
K
L
R
Q
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation