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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HPSE
Full Name:
Heparanase precursor
Alias:
Endo-glucoronidase; HEP; Heparanase; Heparanase-1; HPA; HPA1; HPR1; HPSE1; HSE1
Type:
EC 3.2.-.-; Hydrolase; Extracellular matrix; Glycan Metabolism - glycosaminoglycan degradation
Mass (Da):
61177
Number AA:
543
UniProt ID:
Q9Y251
International Prot ID:
IPI00410297
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000323
GO:0005576
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0000287
GO:0003824
GO:0004553
PhosphoSite+
KinaseNET
Biological Process:
GO:0005975
GO:0006029
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
L
L
R
S
K
P
A
L
P
P
P
Site 2
T82
L
G
S
P
K
L
R
T
L
A
R
G
L
S
P
Site 3
S88
R
T
L
A
R
G
L
S
P
A
Y
L
R
F
G
Site 4
Y91
A
R
G
L
S
P
A
Y
L
R
F
G
G
T
K
Site 5
T99
L
R
F
G
G
T
K
T
D
F
L
I
F
D
P
Site 6
S110
I
F
D
P
K
K
E
S
T
F
E
E
R
S
Y
Site 7
T111
F
D
P
K
K
E
S
T
F
E
E
R
S
Y
W
Site 8
S116
E
S
T
F
E
E
R
S
Y
W
Q
S
Q
V
N
Site 9
Y117
S
T
F
E
E
R
S
Y
W
Q
S
Q
V
N
Q
Site 10
Y129
V
N
Q
D
I
C
K
Y
G
S
I
P
P
D
V
Site 11
Y146
K
L
R
L
E
W
P
Y
Q
E
Q
L
L
L
R
Site 12
Y156
Q
L
L
L
R
E
H
Y
Q
K
K
F
K
N
S
Site 13
S163
Y
Q
K
K
F
K
N
S
T
Y
S
R
S
S
V
Site 14
T164
Q
K
K
F
K
N
S
T
Y
S
R
S
S
V
D
Site 15
Y165
K
K
F
K
N
S
T
Y
S
R
S
S
V
D
V
Site 16
S166
K
F
K
N
S
T
Y
S
R
S
S
V
D
V
L
Site 17
S168
K
N
S
T
Y
S
R
S
S
V
D
V
L
Y
T
Site 18
S169
N
S
T
Y
S
R
S
S
V
D
V
L
Y
T
F
Site 19
S202
A
D
L
Q
W
N
S
S
N
A
Q
L
L
L
D
Site 20
Y210
N
A
Q
L
L
L
D
Y
C
S
S
K
G
Y
N
Site 21
S212
Q
L
L
L
D
Y
C
S
S
K
G
Y
N
I
S
Site 22
Y216
D
Y
C
S
S
K
G
Y
N
I
S
W
E
L
G
Site 23
S219
S
S
K
G
Y
N
I
S
W
E
L
G
N
E
P
Site 24
S228
E
L
G
N
E
P
N
S
F
L
K
K
A
D
I
Site 25
S256
L
H
K
L
L
R
K
S
T
F
K
N
A
K
L
Site 26
T257
H
K
L
L
R
K
S
T
F
K
N
A
K
L
Y
Site 27
Y264
T
F
K
N
A
K
L
Y
G
P
D
V
G
Q
P
Site 28
T275
V
G
Q
P
R
R
K
T
A
K
M
L
K
S
F
Site 29
S281
K
T
A
K
M
L
K
S
F
L
K
A
G
G
E
Site 30
Y298
D
S
V
T
W
H
H
Y
Y
L
N
G
R
T
A
Site 31
Y299
S
V
T
W
H
H
Y
Y
L
N
G
R
T
A
T
Site 32
T306
Y
L
N
G
R
T
A
T
R
E
D
F
L
N
P
Site 33
S332
K
V
F
Q
V
V
E
S
T
R
P
G
K
K
V
Site 34
T333
V
F
Q
V
V
E
S
T
R
P
G
K
K
V
W
Site 35
S345
K
V
W
L
G
E
T
S
S
A
Y
G
G
G
A
Site 36
S346
V
W
L
G
E
T
S
S
A
Y
G
G
G
A
P
Site 37
Y404
N
F
D
P
L
P
D
Y
W
L
S
L
L
F
K
Site 38
S422
G
T
K
V
L
M
A
S
V
Q
G
S
K
R
R
Site 39
S426
L
M
A
S
V
Q
G
S
K
R
R
K
L
R
V
Site 40
Y434
K
R
R
K
L
R
V
Y
L
H
C
T
N
T
D
Site 41
T440
V
Y
L
H
C
T
N
T
D
N
P
R
Y
K
E
Site 42
Y445
T
N
T
D
N
P
R
Y
K
E
G
D
L
T
L
Site 43
T451
R
Y
K
E
G
D
L
T
L
Y
A
I
N
L
H
Site 44
Y453
K
E
G
D
L
T
L
Y
A
I
N
L
H
N
V
Site 45
Y463
N
L
H
N
V
T
K
Y
L
R
L
P
Y
P
F
Site 46
Y468
T
K
Y
L
R
L
P
Y
P
F
S
N
K
Q
V
Site 47
S471
L
R
L
P
Y
P
F
S
N
K
Q
V
D
K
Y
Site 48
Y478
S
N
K
Q
V
D
K
Y
L
L
R
P
L
G
P
Site 49
S490
L
G
P
H
G
L
L
S
K
S
V
Q
L
N
G
Site 50
S492
P
H
G
L
L
S
K
S
V
Q
L
N
G
L
T
Site 51
T507
L
K
M
V
D
D
Q
T
L
P
P
L
M
E
K
Site 52
S520
E
K
P
L
R
P
G
S
S
L
G
L
P
A
F
Site 53
S521
K
P
L
R
P
G
S
S
L
G
L
P
A
F
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation