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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDE10A
Full Name:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Alias:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; PDE10; phosphodiesterase 10A
Type:
Phosphodiesterase; EC 3.1.4.17; Nucleotide Metabolism - purine
Mass (Da):
88410
Number AA:
UniProt ID:
Q9Y233
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0047555
GO:0030552
GO:0030553
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
R
I
E
E
R
K
S
Q
H
L
T
G
L
T
Site 2
T12
E
R
K
S
Q
H
L
T
G
L
T
D
E
K
V
Site 3
Y22
T
D
E
K
V
K
A
Y
L
S
L
H
P
Q
V
Site 4
S24
E
K
V
K
A
Y
L
S
L
H
P
Q
V
L
D
Site 5
S35
Q
V
L
D
E
F
V
S
E
S
V
S
A
E
T
Site 6
S37
L
D
E
F
V
S
E
S
V
S
A
E
T
V
E
Site 7
S39
E
F
V
S
E
S
V
S
A
E
T
V
E
K
W
Site 8
T42
S
E
S
V
S
A
E
T
V
E
K
W
L
K
R
Site 9
S54
L
K
R
K
N
N
K
S
E
D
E
S
A
P
K
Site 10
S58
N
N
K
S
E
D
E
S
A
P
K
E
V
S
R
Site 11
Y66
A
P
K
E
V
S
R
Y
Q
D
T
N
M
Q
G
Site 12
T69
E
V
S
R
Y
Q
D
T
N
M
Q
G
V
V
Y
Site 13
Y76
T
N
M
Q
G
V
V
Y
E
L
N
S
Y
I
E
Site 14
Y81
V
V
Y
E
L
N
S
Y
I
E
Q
R
L
D
T
Site 15
T88
Y
I
E
Q
R
L
D
T
G
G
D
N
Q
L
L
Site 16
Y115
K
A
D
G
F
A
L
Y
F
L
G
E
C
N
N
Site 17
T128
N
N
S
L
C
I
F
T
P
P
G
I
K
E
G
Site 18
S152
I
T
Q
G
T
T
V
S
A
Y
V
A
K
S
R
Site 19
Y154
Q
G
T
T
V
S
A
Y
V
A
K
S
R
K
T
Site 20
T177
D
E
R
F
P
R
G
T
G
L
E
S
G
T
R
Site 21
S218
G
K
E
A
F
C
L
S
H
Q
E
V
A
T
A
Site 22
Y300
D
H
K
N
K
E
L
Y
S
D
L
F
D
I
G
Site 23
T319
G
K
P
V
F
K
K
T
K
E
I
R
F
S
I
Site 24
S325
K
T
K
E
I
R
F
S
I
E
K
G
I
A
G
Site 25
Y347
V
L
N
I
P
D
A
Y
A
D
P
R
F
N
R
Site 26
Y359
F
N
R
E
V
D
L
Y
T
G
Y
T
T
R
N
Site 27
Y362
E
V
D
L
Y
T
G
Y
T
T
R
N
I
L
C
Site 28
T396
S
G
S
A
F
S
K
T
D
E
N
N
F
K
M
Site 29
Y418
A
L
H
C
A
N
M
Y
H
R
I
R
H
S
E
Site 30
Y428
I
R
H
S
E
C
I
Y
R
V
T
M
E
K
L
Site 31
T431
S
E
C
I
Y
R
V
T
M
E
K
L
S
Y
H
Site 32
S436
R
V
T
M
E
K
L
S
Y
H
S
I
C
T
S
Site 33
Y437
V
T
M
E
K
L
S
Y
H
S
I
C
T
S
E
Site 34
S491
V
H
R
S
C
G
T
S
C
F
E
L
E
K
L
Site 35
Y509
I
M
S
V
K
K
N
Y
R
R
V
P
Y
H
N
Site 36
Y514
K
N
Y
R
R
V
P
Y
H
N
W
K
H
A
V
Site 37
T536
A
I
L
Q
N
N
H
T
L
F
T
D
L
E
R
Site 38
S561
D
L
D
H
R
G
F
S
N
S
Y
L
Q
K
F
Site 39
S563
D
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
Site 40
Y564
H
R
G
F
S
N
S
Y
L
Q
K
F
D
H
P
Site 41
S577
H
P
L
A
A
L
Y
S
T
S
T
M
E
Q
H
Site 42
S579
L
A
A
L
Y
S
T
S
T
M
E
Q
H
H
F
Site 43
S587
T
M
E
Q
H
H
F
S
Q
T
V
S
I
L
Q
Site 44
S591
H
H
F
S
Q
T
V
S
I
L
Q
L
E
G
H
Site 45
S602
L
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
Site 46
T603
E
G
H
N
I
F
S
T
L
S
S
S
E
Y
E
Site 47
S605
H
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
Site 48
S606
N
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
Site 49
S607
I
F
S
T
L
S
S
S
E
Y
E
Q
V
L
E
Site 50
Y609
S
T
L
S
S
S
E
Y
E
Q
V
L
E
I
I
Site 51
Y639
R
K
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
Site 52
T641
Q
L
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Site 53
S643
E
E
M
Y
Q
T
G
S
L
N
L
N
N
Q
S
Site 54
S650
S
L
N
L
N
N
Q
S
H
R
D
R
V
I
G
Site 55
T661
R
V
I
G
L
M
M
T
A
C
D
L
C
S
V
Site 56
T669
A
C
D
L
C
S
V
T
K
L
W
P
V
T
K
Site 57
Y683
K
L
T
A
N
D
I
Y
A
E
F
W
A
E
G
Site 58
S750
K
A
C
R
D
N
L
S
Q
W
E
K
V
I
R
Site 59
T763
I
R
G
E
E
T
A
T
W
I
S
S
P
S
V
Site 60
S766
E
E
T
A
T
W
I
S
S
P
S
V
A
Q
K
Site 61
S767
E
T
A
T
W
I
S
S
P
S
V
A
Q
K
A
Site 62
S769
A
T
W
I
S
S
P
S
V
A
Q
K
A
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation